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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 31689

FusionGeneSummary for ROCK1_MAP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ROCK1_MAP1B
Fusion gene ID: 31689
HgeneTgene
Gene symbol

ROCK1

MAP1B

Gene ID

6093

4131

Gene nameRho associated coiled-coil containing protein kinase 1microtubule associated protein 1B
SynonymsP160ROCK|ROCK-IFUTSCH|MAP5|PPP1R102
Cytomap

18q11.1

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionrho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35microtubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102
Modification date2018052720180523
UniProtAcc

Q13464

P46821

Ensembl transtripts involved in fusion geneENST00000399799, ENST00000296755, 
ENST00000504183, 
Fusion gene scores* DoF score21 X 11 X 11=25416 X 8 X 2=96
# samples 238
** MAII scorelog2(23/2541*10)=-3.46569060910898
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROCK1 [Title/Abstract] AND MAP1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROCK1

GO:0007159

leukocyte cell-cell adhesion

12082081

HgeneROCK1

GO:0022614

membrane to membrane docking

12082081

HgeneROCK1

GO:0032091

negative regulation of protein binding

18573880

HgeneROCK1

GO:0032956

regulation of actin cytoskeleton organization

25911094

HgeneROCK1

GO:0050900

leukocyte migration

12082081

HgeneROCK1

GO:0050901

leukocyte tethering or rolling

12082081

TgeneMAP1B

GO:0009987

cellular process

19567321


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-YD-A9TA-06AROCK1chr18

18546878

-MAP1Bchr5

71479570

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000399799ENST00000296755ROCK1chr18

18546878

-MAP1Bchr5

71479570

+
5CDS-intronENST00000399799ENST00000504183ROCK1chr18

18546878

-MAP1Bchr5

71479570

+

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FusionProtFeatures for ROCK1_MAP1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROCK1

Q13464

MAP1B

P46821

Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2,MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and actssynergistically with it to promote SRC-dependent non-apoptoticplasma membrane blebbing. Phosphorylates JIP3 and regulates therecruitment of JNK to JIP3 upon UVB-induced stress. Acts as asuppressor of inflammatory cell migration by regulating PTENphosphorylation and stability. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Required forcentrosome positioning and centrosome-dependent exit from mitosis.Plays a role in terminal erythroid differentiation. May regulateclosure of the eyelids and ventral body wall by inducing theassembly of actomyosin bundles. Promotes keratinocyte terminaldifferentiation. Involved in osteoblast compaction through thefibronectin fibrillogenesis cell-mediated matrix assembly process,essential for osteoblast mineralization.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353,ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607,ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880,ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714,ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057,ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. Facilitates tyrosination of alpha-tubulin in neuronalmicrotubules (By similarity). Phosphorylated MAP1B may play a rolein the cytoskeletal changes that accompany neurite extension.Possibly MAP1B binds to at least two tubulin subunits in thepolymer, and this bridging of subunits might be involved innucleating microtubule polymerization and in stabilizingmicrotubules. Acts as a positive cofactor in DAPK1-mediatedautophagic vesicle formation and membrane blebbing. {ECO:0000250,ECO:0000269|PubMed:18195017}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-27331011_110211171355Coiled coilOntology_term=ECO:0000255
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-2733422_69211171355Coiled coilOntology_term=ECO:0000255
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-2733636_98011171355Compositional biasNote=Glu-rich
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-2733341_40911171355DomainNote=AGC-kinase C-terminal
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-2733479_55611171355DomainREM-1
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-273376_33811171355DomainProtein kinase
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-2733949_101511171355DomainRhoBD
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-273382_9011171355Nucleotide bindingATP
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-2733998_101011171355RegionNote=RHOA binding
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+17589_790952469Compositional biasNote=Lys-rich (highly basic%2C contains many KKEE and KKEI/V repeats)
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+171878_1894952469RepeatNote=MAP1B 1
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+171895_1911952469RepeatNote=MAP1B 2
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+171912_1928952469RepeatNote=MAP1B 3
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+171929_1945952469RepeatNote=MAP1B 4
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+171946_1962952469RepeatNote=MAP1B 5
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+171963_1979952469RepeatNote=MAP1B 6
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+171997_2013952469RepeatNote=MAP1B 7
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+172014_2030952469RepeatNote=MAP1B 8
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+172031_2047952469RepeatNote=MAP1B 9
TgeneMAP1Bchr18:18546878chr5:71479570ENST00000296755+172048_2064952469RepeatNote=MAP1B 10

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-27331118_131711171355DomainPH
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-27331115_135411171355RegionNote=Auto-inhibitory
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-27331228_128111171355Zinc fingerPhorbol-ester/DAG-type


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FusionGeneSequence for ROCK1_MAP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ROCK1_ENST00000399799_chr18_18546878_-_MAP1B_ENST00000296755_chr5_71479570_+_3491aa
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVTDLDFPALRKNKNIDNFLSRTKDTINKIRDLRMKAEDTEVVKVIGRGAFGEV
QLVRHKSTRKVTAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFTAFQDDRTLYMVMEYMPGGDLVNLMSNTDVPEKWARFTTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDTISPEVLKSQGGDGTTGRECDWWSVGVFLYE
MLVGDTPFTADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTTTSNRRYLSSANPNDNRTSSNADKSLQESLQKTITKLEEQLHNEMQLKDEME
QKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDTYQLQAILEAERRDRGHDSEMIGDLQAR
ITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQE
INTLLEAKRLLEFELAQLTKQTRGNEGQMRELQDQLEAEQTFSTLTKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE
SEQLARGLLEEQTFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEETKLEKEEEISNLKAAFEK
NINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPGQKILHHRSDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTG
ELILQSGSFSFQNFIEIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEMEGLSEFTETLSESVE
VPSPFDILEPPTSGGFLKLSKPCCTIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKI
AELEEEQSQGSTTNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVG
KLEMTVLNPVKSSKEMQTFMQQWTGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHL
DFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTET
KPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEI
KKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKE
KGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLK
ETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDTEEKAETEEAEEPEEDG
EEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEETEPEKMEAEDTVMAV
VDKAAEAGGAEEQTGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMST
PRDVMSDETNNEETESPSQEFVNITKTESSLTSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYC
SEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTL
EVVSPSQSVTGSAGHTPYTQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSES
ATESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLG
DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDD
SLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLH
ITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLTASLTSE
KVQSLEGEKLSPKSDISPLTPRESSPLTSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPTGFRASVLFDTMQHHLALNRDLSTPGLEK
DSGGKTPGDFSTATQKPEETTRSPDEEDTDTESTEKTTRTSDVGGTYTEKIERTTKSPSDSGYSTETIGKTTKTPEDGDTSTEIIEKTTR
TPEEGGYSTDISEKTTSPPEVSGYSTEKTERSRRLLDDISNGTDDSEDGGHTLGDPSYSTETTEKITSFPESEGTSTETSTKTTRTPDTS
TYCYETAEKITRTPQASTTSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGG
APPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVS
MVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEV
KAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLPVTLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ROCK1_ENST00000399799_chr18_18546878_-_MAP1B_ENST00000296755_chr5_71479570_+_10473nt
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG
CTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAAGAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAA
GACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATGAAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTT
CAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTCTCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTT
TTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTGTTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTAC
ATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCAACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCA
GAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACAGAGATGTGAAGCCTGATAACATGCTGCTGGATAAATCTGGA
CATTTGAAGTTAGCAGATTTTGGTACTTGTATGAAGATGAATAAGGAAGGCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTAT
ATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAAGAGAATGTGACTGGTGGTCGGTTGGGGTATTTTTATACGAA
ATGCTTGTAGGTGATACACCTTTTTATGCAGATTCTTTGGTTGGAACTTACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCT
GATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCCTTACTGACAGGGAAGTGAGGTTAGGGCGAAATGGTGTAGAA
GAAATCAAACGACATCTCTTCTTCAAAAATGACCAGTGGGCTTGGGAAACGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGT
AGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAGAGGAAGAAACATTCCCTATTCCTAAAGCTTTCGTTGGCAAT
CAACTACCTTTTGTAGGATTTACATATTATAGCAATCGTAGATACTTATCTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCA
GATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAGAACAGCTGCATAATGAAATGCAGTTAAAAGATGAAATGGAG
CAGAAGTGCAGAACCTCAAACATAAAACTAGACAAGATAATGAAAGAATTGGATGAAGAGGGAAATCAAAGAAGAAATCTAGAATCTACA
GTGTCTCAGATTGAGAAGGAGAAAATGTTGCTACAGCATAGAATTAATGAGTACCAAAGAAAAGCTGAACAGGAAAATGAGAAGAGAAGA
AATGTAGAAAATGAAGTTTCTACATTAAAGGATCAGTTGGAAGACTTAAAGAAAGTCAGTCAGAATTCACAGCTTGCTAATGAGAAGCTG
TCCCAGTTACAAAAGCAGCTAGAAGAAGCCAATGACTTACTTAGGACAGAATCGGACACAGCTGTAAGATTGAGGAAGAGTCACACAGAG
ATGAGCAAGTCAATTAGTCAGTTAGAGTCCCTGAACAGAGAGTTGCAAGAGAGAAATCGAATTTTAGAGAATTCTAAGTCACAAACAGAC
AAAGATTATTACCAGCTGCAAGCTATATTAGAAGCTGAACGAAGAGACAGAGGTCATGATTCTGAGATGATTGGAGACCTTCAAGCTCGA
ATTACATCTTTACAAGAGGAGGTGAAGCATCTCAAACATAATCTCGAAAAAGTGGAAGGAGAAAGAAAAGAGGCTCAAGACATGCTTAAT
CACTCAGAAAAGGAAAAGAATAATTTAGAGATAGATTTAAACTACAAACTTAAATCATTACAACAACGGTTAGAACAAGAGGTAAATGAA
CACAAAGTAACCAAAGCTCGTTTAACTGACAAACATCAATCTATTGAAGAGGCAAAGTCTGTGGCAATGTGTGAGATGGAAAAAAAGCTG
AAAGAAGAAAGAGAAGCTCGAGAGAAGGCTGAAAATCGGGTTGTTCAGATTGAGAAACAGTGTTCCATGCTAGACGTTGATCTGAAGCAA
TCTCAGCAGAAACTAGAACATTTGACTGGAAATAAAGAAAGGATGGAGGATGAAGTTAAGAATCTAACCCTGCAACTGGAGCAGGAATCA
AATAAGCGGCTGTTGTTACAAAATGAATTGAAGACTCAAGCATTTGAGGCAGACAATTTAAAAGGTTTAGAAAAGCAGATGAAACAGGAA
ATAAATACTTTATTGGAAGCAAAGAGATTATTAGAATTTGAGTTAGCTCAGCTTACGAAACAGTATAGAGGAAATGAAGGACAGATGCGG
GAGCTACAAGATCAGCTTGAAGCTGAGCAATATTTCTCGACACTTTATAAAACCCAGGTAAAGGAACTTAAAGAAGAAATTGAAGAAAAA
AACAGAGAAAATTTAAAGAAAATACAGGAACTACAAAATGAAAAAGAAACTCTTGCTACTCAGTTGGATCTAGCAGAAACAAAAGCTGAG
TCTGAGCAGTTGGCGCGAGGCCTTCTGGAAGAACAGTATTTTGAATTGACGCAAGAAAGCAAGAAAGCTGCTTCAAGAAATAGACAAGAG
ATTACAGATAAAGATCACACTGTTAGTCGGCTTGAAGAAGCAAACAGCATGCTAACCAAAGATATTGAAATATTAAGAAGAGAGAATGAA
GAGCTAACAGAGAAAATGAAGAAGGCAGAGGAAGAATATAAACTGGAGAAGGAGGAGGAGATCAGTAATCTTAAGGCTGCCTTTGAAAAG
AATATCAACACTGAACGAACCCTTAAAACACAGGCTGTTAACAAATTGGCAGAAATAATGAATCGAAAAGATTTTAAAATTGATAGAAAG
AAAGCTAATACACAAGATTTGAGAAAGAAAGAAAAGGAAAATCGAAAGCTGCAACTGGAACTCAACCAAGAAAGAGAGAAATTCAACCAG
ATGGTAGTGAAACATCAGAAGGAACTGAATGACATGCAAGCGCAATTGGTAGAAGAATGTGCACATAGGAATGAGCTTCAGATGCAGTTG
GCCAGCAAAGAGAGTGATATTGAGCAATTGCGTGCTAAACTTTTGGACCTCTCGGATTCTACAAGTGTTGCTAGTTTTCCTAGTGCTGAT
GAAACTGATGGTAACCTCCCAGGACAAAAGATCCTTCATCACCGAAGTGACGTTTTAGAAACAGTGGTCCTGATCAACCCTTCTGATGAA
GCAGTCAGCACCGAGGTGCGCTTAATGATCACTGATGCTGCCCGACACAAGCTGCTCGTGCTGACCGGGCAGTGCTTTGAAAATACCGGA
GAGCTCATTCTCCAGTCCGGCTCTTTCTCCTTCCAGAACTTCATAGAGATTTTCACCGATCAAGAGATCGGGGAGTTACTAAGCACCACC
CATCCTGCCAACAAAGCCAGCTTAACCCTGTTCTGTCCTGAAGAAGGGGACTGGAAGAACTCCAATCTTGACAGACACAATCTCCAAGAC
TTCATCAATATTAAACTCAATTCAGCTTCTATCTTGCCAGAAATGGAAGGACTTTCTGAGTTTACCGAGTATCTCTCAGAATCAGTGGAA
GTCCCATCTCCCTTTGACATCTTGGAACCTCCCACATCGGGTGGATTTCTGAAGCTCTCCAAGCCCTGCTGTTATATTTTTCCAGGAGGG
AGGGGCGATTCTGCCTTGTTTGCAGTGAATGGTTTCAATATGCTCATCAATGGCGGATCAGAGAGAAAATCCTGCTTCTGGAAGCTCATC
CGACACTTAGACCGAGTGGACTCCATCCTGCTCACCCACATTGGGGATGACAATTTGCCTGGAATAAACAGCATGTTACAGCGGAAAATT
GCAGAGCTCGAGGAAGAACAGTCCCAGGGCTCCACCACAAATAGTGACTGGATGAAAAACCTCATCTCCCCTGACTTAGGAGTTGTATTT
CTCAATGTACCTGAAAATCTCAAAAATCCAGAGCCAAACATCAAGATGAAGAGAAGCATAGAAGAAGCCTGCTTCACTCTCCAGTACCTA
AACAAATTGTCCATGAAACCAGAACCTCTGTTTAGAAGTGTAGGCAATACTATTGATCCTGTCATTCTTTTCCAAAAAATGGGAGTAGGT
AAACTTGAGATGTATGTGCTTAATCCAGTCAAGAGCAGCAAGGAAATGCAGTATTTTATGCAGCAGTGGACTGGTACCAACAAAGACAAG
GCTGAATTCATTCTGCCTAATGGTCAAGAAGTAGATCTCCCGATTTCCTACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCA
AACCCTGCGGAGAAAATCATCCGAGTCCTGTTTCCTGGGAACAGCACCCAGTACAACATCCTGGAAGGGTTGGAAAAGCTCAAACATCTA
GACTTTCTGAAGCAGCCACTGGCCACCCAAAAGGATCTCACTGGCCAGGTGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGG
GCTGATAGCCGAGAAAGTCTGAAGCCAGCCGCAAAACCACTTCCTAGCAAATCCGTGCGCAAGGAGTCAAAAGAAGAAACCCCTGAGGTC
ACAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTGAAAGCAAAGAAAAGGTAATGGTGAAAAAAGACAAGCCAATAAAAACAGAGACC
AAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAGAAGAGCCATCTCCAGTGAAAGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTC
AAACCCAAAGCTGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGTAAAGCCTGAAGACAAGAAAGAGGAGAAAGAAAAGCCAAAGAAA
GAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAACCAAAAAAGGAAGAGGTGAAAAAAGAAGTCAAAAAAGAGATC
AAGAAAGAAGAGAAAAAAGAACCCAAGAAAGAGGTTAAGAAAGAAACACCGCCAAAGGAAGTCAAGAAGGAAGTTAAGAAGGAAGAGAAG
AAGGAAGTGAAAAAGGAAGAAAAGGAACCCAAAAAAGAAATTAAGAAGCTCCCTAAAGACGCAAAGAAATCATCTACTCCTCTGTCTGAA
GCAAAAAAACCAGCTGCTTTAAAACCAAAAGTACCCAAGAAGGAAGAGTCTGTCAAGAAAGATTCTGTTGCTGCCGGAAAGCCAAAGGAG
AAGGGGAAAATAAAAGTCATTAAGAAGGAAGGCAAGGCCGCAGAGGCTGTCGCTGCAGCTGTCGGCACTGGAGCCACCACAGCAGCTGTC
ATGGCGGCAGCTGGAATAGCAGCCATTGGCCCTGCCAAAGAACTCGAAGCTGAGAGGTCCCTTATGTCATCTCCTGAGGATCTAACCAAG
GACTTTGAAGAGTTAAAGGCTGAAGAGGTCGATGTAACAAAGGACATCAAGCCTCAGCTGGAGCTAATCGAAGACGAAGAGAAACTGAAG
GAAACTGAGCCAGTCGAAGCCTACGTCATCCAGAAGGAGAGAGAAGTCACCAAAGGTCCTGCCGAGTCCCCTGATGAGGGAATCACTACC
ACTGAAGGGGAGGGCGAATGTGAACAGACACCTGAGGAGCTGGAGCCCGTCGAGAAGCAGGGAGTAGACGACATTGAAAAATTTGAAGAT
GAAGGAGCCGGTTTTGAAGAATCTTCAGAGACTGGAGACTATGAAGAGAAGGCAGAAACTGAGGAGGCTGAGGAGCCAGAAGAGGATGGG
GAGGAACACGTATGTGTGAGCGCCTCCAAGCACAGCCCCACTGAGGATGAGGAAAGTGCCAAGGCGGAGGCTGATGCATACATCAGGGAG
AAGAGGGAGTCTGTGGCCAGTGGGGATGACCGAGCCGAAGAAGACATGGATGAGGCCATTGAGAAAGGAGAGGCTGAACAATCTGAAGAG
GAGGCTGATGAGGAGGACAAAGCTGAAGATGCCAGAGAGGAGGAATATGAGCCGGAAAAAATGGAAGCTGAAGACTATGTGATGGCTGTG
GTCGACAAGGCTGCAGAGGCTGGTGGTGCCGAGGAGCAGTATGGATTCCTCACCACACCAACCAAGCAACTAGGAGCCCAGTCTCCTGGC
CGAGAACCTGCATCTTCAATTCATGATGAGACTTTACCTGGAGGCTCAGAGAGCGAGGCCACCGCTTCTGATGAGGAGAATCGAGAAGAC
CAGCCTGAGGAATTCACTGCCACCTCTGGCTACACTCAGTCTACTATTGAGATATCCAGTGAGCCCACCCCCATGGATGAGATGTCTACC
CCTCGAGACGTGATGAGTGATGAGACCAACAATGAAGAGACGGAGTCCCCTTCTCAGGAATTCGTAAATATCACCAAATATGAATCTTCA
TTGTATTCTCAGGAATACTCTAAACCTGCTGATGTTACACCGCTCAACGGATTTTCTGAAGGATCAAAAACAGATGCCACTGATGGCAAG
GATTACAATGCTTCAGCCTCTACCATATCACCACCCTCTTCCATGGAGGAAGACAAATTCAGCAGATCTGCTTTACGTGATGCTTACTGC
TCTGAAGTGAAAGCCAGCACCACTTTGGACATCAAAGATAGCATCTCAGCTGTTTCAAGTGAAAAGGTCAGCCCATCGAAGAGCCCGTCC
CTGAGTCCATCTCCACCATCACCCTTAGAAAAGACCCCCCTGGGTGAACGTAGTGTGAACTTCTCTCTGACGCCCAATGAGATTAAAGTC
TCTGCAGAGGCAGAAGTAGCCCCGGTGTCTCCTGAGGTGACCCAAGAAGTAGTTGAAGAACATTGTGCTAGTCCTGAGGACAAGACTCTG
GAAGTGGTGTCACCATCTCAGTCCGTGACTGGCAGTGCTGGTCACACACCTTACTATCAATCTCCTACTGACGAGAAATCCAGTCATCTC
CCTACAGAAGTCATTGAAAAACCACCAGCAGTTCCAGTGAGTTTTGAATTCAGTGATGCCAAAGATGAGAATGAAAGGGCTTCAGTAAGC
CCCATGGATGAGCCCGTGCCTGACTCAGAGTCTCCTATTGAAAAAGTTTTGTCTCCTTTACGCAGCCCGCCCCTCATTGGATCCGAGTCT
GCTTATGAAAGTTTTCTAAGTGCTGATGACAAGGCTTCTGGCAGAGGTGCCGAAAGTCCTTTTGAAGAAAAGAGTGGAAAACAAGGCTCT
CCAGACCAAGTAAGTCCAGTTTCTGAAATGACTTCTACTAGTCTTTACCAAGACAAACAGGAAGGGAAAAGCACAGACTTTGCACCAATA
AAAGAAGACTTTGGCCAAGAAAAGAAAACTGATGATGTTGAAGCCATGAGTTCTCAACCAGCACTGGCTCTGGATGAAAGGAAATTAGGA
GATGTTTCTCCCACACAAATAGATGTCAGTCAGTTTGGATCTTTTAAAGAAGACACTAAGATGTCCATTTCTGAAGGTACTGTCTCAGAC
AAGTCAGCTACTCCTGTTGATGAGGGCGTAGCAGAAGACACGTACTCTCATATGGAGGGTGTGGCCTCAGTGTCCACAGCCTCAGTGGCT
ACGAGCTCATTTCCAGAGCCAACAACAGATGATGTGTCTCCATCTCTGCATGCTGAGGTTGGCTCCCCACATTCCACAGAAGTAGATGAC
TCCCTTTCAGTGTCTGTTGTGCAAACACCTACCACATTCCAGGAAACAGAAATGTCTCCATCTAAAGAAGAATGCCCAAGACCGATGTCA
ATTTCTCCACCAGATTTCTCCCCTAAAACTGCAAAGTCCAGGACACCCGTTCAAGATCACAGATCTGAACAGTCCTCAATGTCTATTGAA
TTTGGCCAAGAATCTCCTGAGCAATCCCTTGCTATGGACTTCAGTCGACAGTCTCCAGATCACCCTACAGTGGGTGCAGGCGTGCTTCAC
ATCACTGAAAATGGGCCAACTGAAGTGGACTACAGTCCTTCTGACATGCAGGACTCCAGTTTATCACATAAGATACCACCTATGGAGGAG
CCGTCCTACACCCAAGATAATGATCTTTCTGAGCTCATCTCAGTATCTCAGGTAGAGGCCTCCCCGTCCACCTCTTCTGCTCATACCCCT
TCTCAGATCGCTTCTCCTCTCCAAGAAGATACTCTATCCGATGTTGCTCCTCCCAGAGATATGTCCTTATATGCCTCACTCACCTCTGAA
AAAGTGCAAAGTCTGGAAGGAGAGAAGCTCTCTCCAAAATCTGATATCTCTCCACTCACCCCACGAGAGTCCTCTCCTTTATATTCACCT
ACTTTTTCAGATTCTACCTCTGCAGTCAAAGAGAAAACAGCAACTTGCCACAGTTCCTCTTCTCCACCAATAGATGCAGCATCCGCAGAG
CCCTATGGCTTCCGTGCCTCAGTGTTATTCGATACAATGCAACACCATCTAGCCTTGAATAGAGATTTGTCCACACCTGGCCTGGAGAAG
GACAGTGGAGGGAAGACACCTGGTGACTTTAGCTATGCCTATCAAAAGCCTGAGGAAACAACCAGGTCCCCAGATGAAGAAGATTATGAC
TATGAGTCTTATGAGAAGACCACCCGGACCTCAGATGTGGGTGGCTATTACTATGAGAAGATAGAGAGAACCACAAAATCTCCAAGTGAC
AGTGGCTACTCCTATGAGACCATTGGGAAAACTACCAAGACCCCTGAAGATGGTGACTATTCCTATGAAATTATTGAGAAGACCACACGG
ACCCCTGAAGAGGGTGGGTACTCATATGACATAAGTGAAAAGACCACCAGCCCCCCCGAAGTGAGTGGTTACAGCTATGAAAAGACTGAG
AGGTCTAGAAGGCTTCTGGATGACATCAGCAATGGCTATGATGACTCTGAGGATGGTGGCCACACACTTGGGGACCCCAGCTACTCTTAT
GAAACCACTGAGAAAATTACCAGTTTCCCTGAGTCTGAAGGTTATTCCTATGAGACATCTACAAAGACAACACGAACCCCTGATACTTCC
ACATACTGTTACGAGACTGCAGAGAAAATCACTAGAACCCCTCAGGCATCCACATATTCCTACGAGACTTCAGACCTATGCTACACTGCA
GAAAAGAAGTCCCCCTCAGAAGCCCGTCAGGATGTCGATTTATGCCTCGTGTCCTCTTGTGAATACAAGCACCCCAAGACAGAGCTTTCA
CCCTCTTTCATTAATCCCAATCCTCTTGAGTGGTTTGCCAGTGAAGAACCCACTGAAGAATCTGAAAAGCCCCTCACTCAATCAGGGGGA
GCCCCACCGCCTCCAGGAGGAAAGCAACAGGGCCGACAGTGTGATGAAACCCCTCCCACCTCAGTCAGCGAGTCAGCCCCATCCCAGACC
GACTCTGATGTTCCCCCGGAGACTGAAGAGTGCCCCTCCATCACGGCCGATGCCAATATCGACTCTGAAGACGAGTCGGAAACCATCCCC
ACAGACAAAACTGTCACGTACAAACACATGGACCCACCTCCAGCTCCCGTGCAAGACCGCAGCCCTTCGCCACGCCACCCTGATGTGTCC
ATGGTGGACCCAGAGGCCTTGGCCATTGAGCAGAACCTGGGCAAAGCTCTAAAGAAAGATCTGAAAGAGAAGACCAAAACCAAAAAGCCA
GGTACAAAGACCAAGTCATCTTCACCTGTCAAAAAGAGTGATGGGAAGTCTAAGCCCTTGGCAGCTTCACCAAAACCAGCGGGCTTGAAA
GAATCCTCGGATAAAGTGTCCAGGGTGGCTTCTCCTAAGAAGAAAGAATCTGTGGAAAAGGCAGCAAAACCCACCACCACTCCTGAGGTC
AAAGCTGCACGTGGGGAAGAGAAAGACAAGGAGACCAAGAATGCTGCCAATGCCTCTGCATCCAAGTCGGCCAAGACCGCCACTGCAGGA
CCAGGAACTACCAAGACGACCAAGTCATCTGCTGTGCCCCCAGGCCTCCCTGTGTATTTGGACCTGTGCTACATTCCTAACCACAGCAAT
AGTAAGAATGTTGATGTGGAATTTTTCAAGAGAGTGCGGTCTTCCTACTACGTGGTGAGTGGGAATGACCCTGCTGCTGAGGAGCCCAGC
CGGGCTGTCCTGGACGCTTTGTTGGAAGGAAAGGCTCAGTGGGGCAGCAACATGCAGGTGACACTGATCCCAACTCATGACTCAGAAGTG
ATGAGGGAATGGTACCAGGAGACCCATGAGAAACAGCAAGATCTCAACATCATGGTTTTAGCAAGCAGCAGCACAGTGGTTATGCAAGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ROCK1_ENST00000399799_chr18_18546878_-_MAP1B_ENST00000296755_chr5_71479570_+_15743nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAA
GAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAAGACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATG
AAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTC
TCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTTTTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTG
TTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCA
ACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCAGAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACA
GAGATGTGAAGCCTGATAACATGCTGCTGGATAAATCTGGACATTTGAAGTTAGCAGATTTTGGTACTTGTATGAAGATGAATAAGGAAG
GCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTATATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAA
GAGAATGTGACTGGTGGTCGGTTGGGGTATTTTTATACGAAATGCTTGTAGGTGATACACCTTTTTATGCAGATTCTTTGGTTGGAACTT
ACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCTGATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCC
TTACTGACAGGGAAGTGAGGTTAGGGCGAAATGGTGTAGAAGAAATCAAACGACATCTCTTCTTCAAAAATGACCAGTGGGCTTGGGAAA
CGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGTAGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAG
AGGAAGAAACATTCCCTATTCCTAAAGCTTTCGTTGGCAATCAACTACCTTTTGTAGGATTTACATATTATAGCAATCGTAGATACTTAT
CTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCAGATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAG
AACAGCTGCATAATGAAATGCAGTTAAAAGATGAAATGGAGCAGAAGTGCAGAACCTCAAACATAAAACTAGACAAGATAATGAAAGAAT
TGGATGAAGAGGGAAATCAAAGAAGAAATCTAGAATCTACAGTGTCTCAGATTGAGAAGGAGAAAATGTTGCTACAGCATAGAATTAATG
AGTACCAAAGAAAAGCTGAACAGGAAAATGAGAAGAGAAGAAATGTAGAAAATGAAGTTTCTACATTAAAGGATCAGTTGGAAGACTTAA
AGAAAGTCAGTCAGAATTCACAGCTTGCTAATGAGAAGCTGTCCCAGTTACAAAAGCAGCTAGAAGAAGCCAATGACTTACTTAGGACAG
AATCGGACACAGCTGTAAGATTGAGGAAGAGTCACACAGAGATGAGCAAGTCAATTAGTCAGTTAGAGTCCCTGAACAGAGAGTTGCAAG
AGAGAAATCGAATTTTAGAGAATTCTAAGTCACAAACAGACAAAGATTATTACCAGCTGCAAGCTATATTAGAAGCTGAACGAAGAGACA
GAGGTCATGATTCTGAGATGATTGGAGACCTTCAAGCTCGAATTACATCTTTACAAGAGGAGGTGAAGCATCTCAAACATAATCTCGAAA
AAGTGGAAGGAGAAAGAAAAGAGGCTCAAGACATGCTTAATCACTCAGAAAAGGAAAAGAATAATTTAGAGATAGATTTAAACTACAAAC
TTAAATCATTACAACAACGGTTAGAACAAGAGGTAAATGAACACAAAGTAACCAAAGCTCGTTTAACTGACAAACATCAATCTATTGAAG
AGGCAAAGTCTGTGGCAATGTGTGAGATGGAAAAAAAGCTGAAAGAAGAAAGAGAAGCTCGAGAGAAGGCTGAAAATCGGGTTGTTCAGA
TTGAGAAACAGTGTTCCATGCTAGACGTTGATCTGAAGCAATCTCAGCAGAAACTAGAACATTTGACTGGAAATAAAGAAAGGATGGAGG
ATGAAGTTAAGAATCTAACCCTGCAACTGGAGCAGGAATCAAATAAGCGGCTGTTGTTACAAAATGAATTGAAGACTCAAGCATTTGAGG
CAGACAATTTAAAAGGTTTAGAAAAGCAGATGAAACAGGAAATAAATACTTTATTGGAAGCAAAGAGATTATTAGAATTTGAGTTAGCTC
AGCTTACGAAACAGTATAGAGGAAATGAAGGACAGATGCGGGAGCTACAAGATCAGCTTGAAGCTGAGCAATATTTCTCGACACTTTATA
AAACCCAGGTAAAGGAACTTAAAGAAGAAATTGAAGAAAAAAACAGAGAAAATTTAAAGAAAATACAGGAACTACAAAATGAAAAAGAAA
CTCTTGCTACTCAGTTGGATCTAGCAGAAACAAAAGCTGAGTCTGAGCAGTTGGCGCGAGGCCTTCTGGAAGAACAGTATTTTGAATTGA
CGCAAGAAAGCAAGAAAGCTGCTTCAAGAAATAGACAAGAGATTACAGATAAAGATCACACTGTTAGTCGGCTTGAAGAAGCAAACAGCA
TGCTAACCAAAGATATTGAAATATTAAGAAGAGAGAATGAAGAGCTAACAGAGAAAATGAAGAAGGCAGAGGAAGAATATAAACTGGAGA
AGGAGGAGGAGATCAGTAATCTTAAGGCTGCCTTTGAAAAGAATATCAACACTGAACGAACCCTTAAAACACAGGCTGTTAACAAATTGG
CAGAAATAATGAATCGAAAAGATTTTAAAATTGATAGAAAGAAAGCTAATACACAAGATTTGAGAAAGAAAGAAAAGGAAAATCGAAAGC
TGCAACTGGAACTCAACCAAGAAAGAGAGAAATTCAACCAGATGGTAGTGAAACATCAGAAGGAACTGAATGACATGCAAGCGCAATTGG
TAGAAGAATGTGCACATAGGAATGAGCTTCAGATGCAGTTGGCCAGCAAAGAGAGTGATATTGAGCAATTGCGTGCTAAACTTTTGGACC
TCTCGGATTCTACAAGTGTTGCTAGTTTTCCTAGTGCTGATGAAACTGATGGTAACCTCCCAGGACAAAAGATCCTTCATCACCGAAGTG
ACGTTTTAGAAACAGTGGTCCTGATCAACCCTTCTGATGAAGCAGTCAGCACCGAGGTGCGCTTAATGATCACTGATGCTGCCCGACACA
AGCTGCTCGTGCTGACCGGGCAGTGCTTTGAAAATACCGGAGAGCTCATTCTCCAGTCCGGCTCTTTCTCCTTCCAGAACTTCATAGAGA
TTTTCACCGATCAAGAGATCGGGGAGTTACTAAGCACCACCCATCCTGCCAACAAAGCCAGCTTAACCCTGTTCTGTCCTGAAGAAGGGG
ACTGGAAGAACTCCAATCTTGACAGACACAATCTCCAAGACTTCATCAATATTAAACTCAATTCAGCTTCTATCTTGCCAGAAATGGAAG
GACTTTCTGAGTTTACCGAGTATCTCTCAGAATCAGTGGAAGTCCCATCTCCCTTTGACATCTTGGAACCTCCCACATCGGGTGGATTTC
TGAAGCTCTCCAAGCCCTGCTGTTATATTTTTCCAGGAGGGAGGGGCGATTCTGCCTTGTTTGCAGTGAATGGTTTCAATATGCTCATCA
ATGGCGGATCAGAGAGAAAATCCTGCTTCTGGAAGCTCATCCGACACTTAGACCGAGTGGACTCCATCCTGCTCACCCACATTGGGGATG
ACAATTTGCCTGGAATAAACAGCATGTTACAGCGGAAAATTGCAGAGCTCGAGGAAGAACAGTCCCAGGGCTCCACCACAAATAGTGACT
GGATGAAAAACCTCATCTCCCCTGACTTAGGAGTTGTATTTCTCAATGTACCTGAAAATCTCAAAAATCCAGAGCCAAACATCAAGATGA
AGAGAAGCATAGAAGAAGCCTGCTTCACTCTCCAGTACCTAAACAAATTGTCCATGAAACCAGAACCTCTGTTTAGAAGTGTAGGCAATA
CTATTGATCCTGTCATTCTTTTCCAAAAAATGGGAGTAGGTAAACTTGAGATGTATGTGCTTAATCCAGTCAAGAGCAGCAAGGAAATGC
AGTATTTTATGCAGCAGTGGACTGGTACCAACAAAGACAAGGCTGAATTCATTCTGCCTAATGGTCAAGAAGTAGATCTCCCGATTTCCT
ACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCAAACCCTGCGGAGAAAATCATCCGAGTCCTGTTTCCTGGGAACAGCACCC
AGTACAACATCCTGGAAGGGTTGGAAAAGCTCAAACATCTAGACTTTCTGAAGCAGCCACTGGCCACCCAAAAGGATCTCACTGGCCAGG
TGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGGGCTGATAGCCGAGAAAGTCTGAAGCCAGCCGCAAAACCACTTCCTAGCA
AATCCGTGCGCAAGGAGTCAAAAGAAGAAACCCCTGAGGTCACAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTGAAAGCAAAGAAA
AGGTAATGGTGAAAAAAGACAAGCCAATAAAAACAGAGACCAAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAGAAGAGCCATCTC
CAGTGAAAGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTCAAACCCAAAGCTGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGTAA
AGCCTGAAGACAAGAAAGAGGAGAAAGAAAAGCCAAAGAAAGAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAAC
CAAAAAAGGAAGAGGTGAAAAAAGAAGTCAAAAAAGAGATCAAGAAAGAAGAGAAAAAAGAACCCAAGAAAGAGGTTAAGAAAGAAACAC
CGCCAAAGGAAGTCAAGAAGGAAGTTAAGAAGGAAGAGAAGAAGGAAGTGAAAAAGGAAGAAAAGGAACCCAAAAAAGAAATTAAGAAGC
TCCCTAAAGACGCAAAGAAATCATCTACTCCTCTGTCTGAAGCAAAAAAACCAGCTGCTTTAAAACCAAAAGTACCCAAGAAGGAAGAGT
CTGTCAAGAAAGATTCTGTTGCTGCCGGAAAGCCAAAGGAGAAGGGGAAAATAAAAGTCATTAAGAAGGAAGGCAAGGCCGCAGAGGCTG
TCGCTGCAGCTGTCGGCACTGGAGCCACCACAGCAGCTGTCATGGCGGCAGCTGGAATAGCAGCCATTGGCCCTGCCAAAGAACTCGAAG
CTGAGAGGTCCCTTATGTCATCTCCTGAGGATCTAACCAAGGACTTTGAAGAGTTAAAGGCTGAAGAGGTCGATGTAACAAAGGACATCA
AGCCTCAGCTGGAGCTAATCGAAGACGAAGAGAAACTGAAGGAAACTGAGCCAGTCGAAGCCTACGTCATCCAGAAGGAGAGAGAAGTCA
CCAAAGGTCCTGCCGAGTCCCCTGATGAGGGAATCACTACCACTGAAGGGGAGGGCGAATGTGAACAGACACCTGAGGAGCTGGAGCCCG
TCGAGAAGCAGGGAGTAGACGACATTGAAAAATTTGAAGATGAAGGAGCCGGTTTTGAAGAATCTTCAGAGACTGGAGACTATGAAGAGA
AGGCAGAAACTGAGGAGGCTGAGGAGCCAGAAGAGGATGGGGAGGAACACGTATGTGTGAGCGCCTCCAAGCACAGCCCCACTGAGGATG
AGGAAAGTGCCAAGGCGGAGGCTGATGCATACATCAGGGAGAAGAGGGAGTCTGTGGCCAGTGGGGATGACCGAGCCGAAGAAGACATGG
ATGAGGCCATTGAGAAAGGAGAGGCTGAACAATCTGAAGAGGAGGCTGATGAGGAGGACAAAGCTGAAGATGCCAGAGAGGAGGAATATG
AGCCGGAAAAAATGGAAGCTGAAGACTATGTGATGGCTGTGGTCGACAAGGCTGCAGAGGCTGGTGGTGCCGAGGAGCAGTATGGATTCC
TCACCACACCAACCAAGCAACTAGGAGCCCAGTCTCCTGGCCGAGAACCTGCATCTTCAATTCATGATGAGACTTTACCTGGAGGCTCAG
AGAGCGAGGCCACCGCTTCTGATGAGGAGAATCGAGAAGACCAGCCTGAGGAATTCACTGCCACCTCTGGCTACACTCAGTCTACTATTG
AGATATCCAGTGAGCCCACCCCCATGGATGAGATGTCTACCCCTCGAGACGTGATGAGTGATGAGACCAACAATGAAGAGACGGAGTCCC
CTTCTCAGGAATTCGTAAATATCACCAAATATGAATCTTCATTGTATTCTCAGGAATACTCTAAACCTGCTGATGTTACACCGCTCAACG
GATTTTCTGAAGGATCAAAAACAGATGCCACTGATGGCAAGGATTACAATGCTTCAGCCTCTACCATATCACCACCCTCTTCCATGGAGG
AAGACAAATTCAGCAGATCTGCTTTACGTGATGCTTACTGCTCTGAAGTGAAAGCCAGCACCACTTTGGACATCAAAGATAGCATCTCAG
CTGTTTCAAGTGAAAAGGTCAGCCCATCGAAGAGCCCGTCCCTGAGTCCATCTCCACCATCACCCTTAGAAAAGACCCCCCTGGGTGAAC
GTAGTGTGAACTTCTCTCTGACGCCCAATGAGATTAAAGTCTCTGCAGAGGCAGAAGTAGCCCCGGTGTCTCCTGAGGTGACCCAAGAAG
TAGTTGAAGAACATTGTGCTAGTCCTGAGGACAAGACTCTGGAAGTGGTGTCACCATCTCAGTCCGTGACTGGCAGTGCTGGTCACACAC
CTTACTATCAATCTCCTACTGACGAGAAATCCAGTCATCTCCCTACAGAAGTCATTGAAAAACCACCAGCAGTTCCAGTGAGTTTTGAAT
TCAGTGATGCCAAAGATGAGAATGAAAGGGCTTCAGTAAGCCCCATGGATGAGCCCGTGCCTGACTCAGAGTCTCCTATTGAAAAAGTTT
TGTCTCCTTTACGCAGCCCGCCCCTCATTGGATCCGAGTCTGCTTATGAAAGTTTTCTAAGTGCTGATGACAAGGCTTCTGGCAGAGGTG
CCGAAAGTCCTTTTGAAGAAAAGAGTGGAAAACAAGGCTCTCCAGACCAAGTAAGTCCAGTTTCTGAAATGACTTCTACTAGTCTTTACC
AAGACAAACAGGAAGGGAAAAGCACAGACTTTGCACCAATAAAAGAAGACTTTGGCCAAGAAAAGAAAACTGATGATGTTGAAGCCATGA
GTTCTCAACCAGCACTGGCTCTGGATGAAAGGAAATTAGGAGATGTTTCTCCCACACAAATAGATGTCAGTCAGTTTGGATCTTTTAAAG
AAGACACTAAGATGTCCATTTCTGAAGGTACTGTCTCAGACAAGTCAGCTACTCCTGTTGATGAGGGCGTAGCAGAAGACACGTACTCTC
ATATGGAGGGTGTGGCCTCAGTGTCCACAGCCTCAGTGGCTACGAGCTCATTTCCAGAGCCAACAACAGATGATGTGTCTCCATCTCTGC
ATGCTGAGGTTGGCTCCCCACATTCCACAGAAGTAGATGACTCCCTTTCAGTGTCTGTTGTGCAAACACCTACCACATTCCAGGAAACAG
AAATGTCTCCATCTAAAGAAGAATGCCCAAGACCGATGTCAATTTCTCCACCAGATTTCTCCCCTAAAACTGCAAAGTCCAGGACACCCG
TTCAAGATCACAGATCTGAACAGTCCTCAATGTCTATTGAATTTGGCCAAGAATCTCCTGAGCAATCCCTTGCTATGGACTTCAGTCGAC
AGTCTCCAGATCACCCTACAGTGGGTGCAGGCGTGCTTCACATCACTGAAAATGGGCCAACTGAAGTGGACTACAGTCCTTCTGACATGC
AGGACTCCAGTTTATCACATAAGATACCACCTATGGAGGAGCCGTCCTACACCCAAGATAATGATCTTTCTGAGCTCATCTCAGTATCTC
AGGTAGAGGCCTCCCCGTCCACCTCTTCTGCTCATACCCCTTCTCAGATCGCTTCTCCTCTCCAAGAAGATACTCTATCCGATGTTGCTC
CTCCCAGAGATATGTCCTTATATGCCTCACTCACCTCTGAAAAAGTGCAAAGTCTGGAAGGAGAGAAGCTCTCTCCAAAATCTGATATCT
CTCCACTCACCCCACGAGAGTCCTCTCCTTTATATTCACCTACTTTTTCAGATTCTACCTCTGCAGTCAAAGAGAAAACAGCAACTTGCC
ACAGTTCCTCTTCTCCACCAATAGATGCAGCATCCGCAGAGCCCTATGGCTTCCGTGCCTCAGTGTTATTCGATACAATGCAACACCATC
TAGCCTTGAATAGAGATTTGTCCACACCTGGCCTGGAGAAGGACAGTGGAGGGAAGACACCTGGTGACTTTAGCTATGCCTATCAAAAGC
CTGAGGAAACAACCAGGTCCCCAGATGAAGAAGATTATGACTATGAGTCTTATGAGAAGACCACCCGGACCTCAGATGTGGGTGGCTATT
ACTATGAGAAGATAGAGAGAACCACAAAATCTCCAAGTGACAGTGGCTACTCCTATGAGACCATTGGGAAAACTACCAAGACCCCTGAAG
ATGGTGACTATTCCTATGAAATTATTGAGAAGACCACACGGACCCCTGAAGAGGGTGGGTACTCATATGACATAAGTGAAAAGACCACCA
GCCCCCCCGAAGTGAGTGGTTACAGCTATGAAAAGACTGAGAGGTCTAGAAGGCTTCTGGATGACATCAGCAATGGCTATGATGACTCTG
AGGATGGTGGCCACACACTTGGGGACCCCAGCTACTCTTATGAAACCACTGAGAAAATTACCAGTTTCCCTGAGTCTGAAGGTTATTCCT
ATGAGACATCTACAAAGACAACACGAACCCCTGATACTTCCACATACTGTTACGAGACTGCAGAGAAAATCACTAGAACCCCTCAGGCAT
CCACATATTCCTACGAGACTTCAGACCTATGCTACACTGCAGAAAAGAAGTCCCCCTCAGAAGCCCGTCAGGATGTCGATTTATGCCTCG
TGTCCTCTTGTGAATACAAGCACCCCAAGACAGAGCTTTCACCCTCTTTCATTAATCCCAATCCTCTTGAGTGGTTTGCCAGTGAAGAAC
CCACTGAAGAATCTGAAAAGCCCCTCACTCAATCAGGGGGAGCCCCACCGCCTCCAGGAGGAAAGCAACAGGGCCGACAGTGTGATGAAA
CCCCTCCCACCTCAGTCAGCGAGTCAGCCCCATCCCAGACCGACTCTGATGTTCCCCCGGAGACTGAAGAGTGCCCCTCCATCACGGCCG
ATGCCAATATCGACTCTGAAGACGAGTCGGAAACCATCCCCACAGACAAAACTGTCACGTACAAACACATGGACCCACCTCCAGCTCCCG
TGCAAGACCGCAGCCCTTCGCCACGCCACCCTGATGTGTCCATGGTGGACCCAGAGGCCTTGGCCATTGAGCAGAACCTGGGCAAAGCTC
TAAAGAAAGATCTGAAAGAGAAGACCAAAACCAAAAAGCCAGGTACAAAGACCAAGTCATCTTCACCTGTCAAAAAGAGTGATGGGAAGT
CTAAGCCCTTGGCAGCTTCACCAAAACCAGCGGGCTTGAAAGAATCCTCGGATAAAGTGTCCAGGGTGGCTTCTCCTAAGAAGAAAGAAT
CTGTGGAAAAGGCAGCAAAACCCACCACCACTCCTGAGGTCAAAGCTGCACGTGGGGAAGAGAAAGACAAGGAGACCAAGAATGCTGCCA
ATGCCTCTGCATCCAAGTCGGCCAAGACCGCCACTGCAGGACCAGGAACTACCAAGACGACCAAGTCATCTGCTGTGCCCCCAGGCCTCC
CTGTGTATTTGGACCTGTGCTACATTCCTAACCACAGCAATAGTAAGAATGTTGATGTGGAATTTTTCAAGAGAGTGCGGTCTTCCTACT
ACGTGGTGAGTGGGAATGACCCTGCTGCTGAGGAGCCCAGCCGGGCTGTCCTGGACGCTTTGTTGGAAGGAAAGGCTCAGTGGGGCAGCA
ACATGCAGGTGACACTGATCCCAACTCATGACTCAGAAGTGATGAGGGAATGGTACCAGGAGACCCATGAGAAACAGCAAGATCTCAACA
TCATGGTTTTAGCAAGCAGCAGCACAGTGGTTATGCAAGATGAATCCTTCCCTGCATGCAAGATTGAACTGTAAAAACCAAGGCCAGCCA
CACCACAGGATCTGAACTTTGTTTCCAGAAATTCTTCAATTTGAAATCACCTTTTCTAAAAAGTCAATTCATCTAGTTAAGTCGCTGAAC
AATTACCTGCCAAATGCTATACTGTGTCATGGTGATGCAAGTCACTAAATTTCTCAGTTTTTGCTGATTGCTAAGGGAAATAACAGTATT
TCCACAATAGGGTTCAAATTCCTGCAAAATTACCTACCCCAGTTCATCTCTGCTGAACATTTGGAAACCATGCACTAGCCAACCCAACTG
ACTTCTGCTAGGTAGAGGCATTTGTCTTAGAGAGAGAGAGAGCGCGGGAGAGAGTGAGAGAGAGTGAGAGCACAAAGATAACGCAGGAGA
GAGAGAGAGAAAGAATGAGAAAGAAAAGGAATGCAAGAGAAGGAGATGTAATGACAGAGAGTTCTGGTGAGATACCCAGAGAGAAAAAGA
GAGAGCAGGGTGGGGTAAGGAGGAGAAAATAAACCAACAATTAGGTCTGCATTTTCTCAGGCAGTAGGCATTCTTTAGTCTACATAGGCA
AAGTTTTCCATTTTTGTCAGTCTGAGTCATCAAAAAGAGTCTTAATTTTCTAAAACAAGTTGGCTAGAAGAAAGTAAAAAGAACAACACT
TGTTATGAGGGCATGTGATATTTTCACATCTTAATTAAGCTCCTTCAGTTTGAAGGCTGCACACTGACATAATGTAGTGAGTGTAGACTG
GCCATGCAAGTGGTTTGGGCCCCATTCAGAACTCTCAGACTCTAAACACACAAGTAGATTGATCTAAGGCATGCTCCCAGCATTTGTCCA
CCCACTTAGTCCACTCTGAGTCGATTAACCTGCATGCAGCAACACCCAAGTCCACCCCAATTAACTGAAGCAAATACCAAAGCAGTTGGG
AGTACATATGGTAGACAATTTGCCTTAGGAAGTGACTTGAATGTACAAAGATACTTGATGCACTTATTTTTTAATGTGAGACAGCAAGTT
TATAAAACATCCATATAGGATTATAGATACTTAAAGGAACACGTGGGTGAGCGTGTGTGGGGGTACTAGAAGCTGATCTGATTGGTCCAA
CAGTTTGATGCTGAGTCATGCGTGTTGAATCCCACTTCAGTGCACCTGTGGCCTCTCAGTCAAACAAGTTGTGCCTTTCACAGCTTCTTT
ACTACTGCAAGTTCAAGACTGAAATGGCTTCTATGATCAGAACTGGGAAAACAGTGAATCTTATGGTGGAAGAGGTTCTCAGCAAGTGTA
CAGTATTTACCTTCCTTTGTCTTACATTGGCTTTTTAAATTTTCCATTAATTTCAACATAATTATGGGAACAAGTGTACAGAAGAATTTT
TTTTTTAAGATATGTGAGAACTTTTCATAGATGAACTTTTTAACAAATGTTTTCATTTACAGGAAATTGCAAAGAAAATTCTCAAGTGAT
AGTCTTTTTTTTTAAGTGTTTCGTAAGACAAAAATTGAATAATGTTTTTTGAAGTTCTGGCAAGATTGAAGTCTGATATTGCAGTAATGA
TATTTATTAAAAACCCATAACTACCAGGAATAATGATACCTCCCACCCCTTGATTCCCATAACATAAAAGTGCTACTTGAGAGTGGGGGA
GAATGGCATGGTAGGCTACTTTTCAGGGCCTTGACAAGTACATCACCCAGTGGTATCCTACATACTTCTTTCAAGATCTTCAACCATGAG
GTAAAAGAGCCAAGTTCAAAGAACCCTAGCACAAATTTGCTTTGGGATTTTCTTTTCTGGAAAAAAAAAATAAAAGAAATAGTACATTGA
AAACAAATGAATTCTCAACTCCTACGGTTCATGTAGAGTTTAGAGAAAATTTCCATCATTGTCATCATTGAACTGTGAACCTGGGAAGCC
AGATCATGATTAACACTGACATCAAGTTTCAAGTTGCAGATCAATGCACCCAGTGTTCAGATGAGGCAAACTTCTCCGTGACAACTGTGC
TGTGCTCTGTCACATTACATTTCCTGCAGACTCTAAGATCTACGGAGTAGAGAACAATGACCTCATTTTATTTTCTATGTTAGTTATTTA
TTTCAAAATTAACATTTTAGTTGATTTTTGTCTGATAAGTCTATGTTTTGCACTGCTAACTATGATGAGGGTTTAAAAAAATGCTTCTTC
AGGGTCCTTTCACTGAGGACCTATGCAGTCTACTTAATGCTGTGAATTACATTTTTCAAATGTTTAATTTTTTAAAGAAAATTAATATTC
TATTTTTGTTAGGCTTCTCTAGAAATGCAGCTTTTATTTATTACCCCATTTCTTTCAAGTCCTTGGAAAATAACATATTAAGGGTACAAG
AAATTAACACATGATGGAAAAGTCATTGTGACGCCAATGAATTTCATTGAGTATAAACTCATCTACTTCAAATTTATTTTATAACACAAC
CTAAGATACTCAAGATAATTATTTAATGGTTAGCTCTTAAGTTGAATTGGTCTACATAATGCGTGGGAAGAAAACCAGATTTTTAGCCTT
CTTGCCAAATCCAGACCTCTGGTTGATTTTTCTTTGACAGAAGATGCAAGTTATTTTCCAATTTCACAATTAAATGTATTTAACCTGAAC
ATTATTTTGCTTTAAAAACTATAAACATTGTAGGAGAATTATAGCCAGTCTTCAGTTATAACCACTCCACCCTCCTCACTTTCTCTCTCT
CTCTCTCTTTTTTTTTTTTTTTTTTTTTGCTATGGGATTTAATGGGAAAAATATGTAAAAACTGTCACTAGTCAGCTGGCTCTTTTTCCT
ATGAAATCTATCAGTACCTTTCTCCATCCGTTGTTCTCAATATGACCACAGAGCCTGAGTATACCAAGAAAACCAATATTCGCATTACAG
GTTGCTCCTGTCCTTCCAGACACCTTTCCTGCCTGTGTGACTAACCTAATTTTGCTAGTTCCATAAATACACGATTAGTTTAGTAACAGC
CATCACAATGTACCATGTACATTCATGGTGAGAGCTAAAGATCGACACAGACTTCTAGGAGCTTTGTTCATACTGATTACTTAATCCAAT
TGTATAGATTGAATATTTGAGTGGAAGGAATTTACACTCTGTTTAAATGATGGGATTCTATCGAGATAGCACTCATGATCATGACCTTTT
TGGTAGTATTCTTAAACAAAATTCTACAGAGACTAAATGTTAGCGATGATCCTCCATTTTCAATTTTAACCAATTCTGTCCCCTTTCTCA
AAACCCTGAGCCCTGTGCATGCTTTCTCAGTCTTGTGGTGGGACTGGATACAATGACTAACTTCCCCTCCTCCCCTCTTTAAACACCATT
TTCCATGGAGTTCAAAAAAATTTTTTTTCTTAACGTTACATATCATAGTGAATGGTTTCCCCAGTGTATATGAATGTTTTAAGTGTCTCC
AATAGCTTATGCAGTCTAGGAGCTTTCCAATACTCATTTAATTAAGATTTAATCATTTGCTAATGGAAATCTTACCACCTTTCATTTTCC
CTCTGTTACCAAATTTCAGCTCTTAGGAGCTGCTCTACAATTCTGAATTTGCTTTTCTTGCCTCTCTTTAGTCACCTGTCACAGGAGGTT
CCTGCTCAGTAATGATATTGTGAGTTAGGATAATAACTTTTTTTTTTTGTGCTTCAGATTTAGAAGAAAAGATCCTGTTTCCATTTGAAA
GGAACTGTAAGCTTTTATCTTTTAACCAACTGAACAATACACCAAAAGCAGCCTAGGGATGAGCATTTCTTTGAAAGCAATTAGGTTATT
CACCTGGTATTAAAACTATTTACTGTTAAAAAATCTGTGACTTCATGAAGTTGATTTTTAAAGGCAGCATCAAAAACTGAAAAGGAAGGG
AAAAAATAGGCAGCTTCTCTGCACTTGTTTGGAGCTCCCCAAAACAGGAGCCATGGAGAAGTGGCATCAAGACCGGGCTGCCCTTTCGAG
AACACCCTGTGGCAGTTCAGAGACACGCTTTTCCTACACTGCATGCAGCCCCTCTTTCCAGCACTGGAAAGAAGTGGTCTTGAGCCCAGC
TGAGAAGCACTTCACACTCCTCTCTCTTGTTCTGAATGGTGTTTGTGTCAGTCTGCAGCTGTGTATGGTATTATGTCTTATAATCCTGCA
TCACTTCTATCCTATCCAGTCATATCTAATGTAGAAAATTAGTTTCCAGTGAAAGTAATATGTAGTGCTTTTATGATATTTGTGTGCAAT


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FusionGenePPI for ROCK1_MAP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ROCK1CDC25A, PFN2, RHOA, RND3, GAB1, CFL1, LIMK2, HNRNPA1, ITSN2, ARRB1, TSG101, NOTCH1, SMURF1, SMAD2, CASP3, CASP7, CDK15, ANKFY1, MON2, FAM21A, KIAA1033, IKBKB, LMO2, MAGEB4, POLR3C, C6orf165, FAM124A, NXF1, NTRK1, MED23, XRCC5, NEIL3, TRIM15, HGS, SLC9A1, UBE2T, CDKN3, TENC1, ROCK2, ADD2, IL20RA, CYLDMAP1BANP32A, RASSF1, GAN, SNCA, MAG, RAE1, AMBRA1, ATG10, ATG12, ATG3, MAP1LC3A, MAP1LC3B, PRKAG2, RASSF5, STK4, HDAC5, ARRB1, ARRB2, SIRT7, SPP1, PINK1, MARCH5, CUL3, ACTN1, LRRK2, PARK7, EIF4A3, MAGOH, SMURF1, IQCB1, PAN2, NPM1, EEF1D, FOS, STK3, CUL7, CCDC8, EED, PPT1, ABCE1, FBXW11, MLF1, DBF4B, CRYAB, HSPB6, MAP1S, RASSF3, WHSC1, SFN, NTRK1, MED4, CACNA1B, CACNA1A, FOXK2, ALKBH3, ATOH1, CYLD, RUVBL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneROCK1chr18:18546878chr5:71479570ENST00000399799-2733368_72711171355FHOD1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ROCK1_MAP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ROCK1_MAP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource