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Fusion gene ID: 31689 |
FusionGeneSummary for ROCK1_MAP1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROCK1_MAP1B | Fusion gene ID: 31689 | Hgene | Tgene | Gene symbol | ROCK1 | MAP1B | Gene ID | 6093 | 4131 |
| Gene name | Rho associated coiled-coil containing protein kinase 1 | microtubule associated protein 1B | |
| Synonyms | P160ROCK|ROCK-I | FUTSCH|MAP5|PPP1R102 | |
| Cytomap | 18q11.1 | 5q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35 | microtubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q13464 | P46821 | |
| Ensembl transtripts involved in fusion gene | ENST00000399799, | ENST00000296755, ENST00000504183, | |
| Fusion gene scores | * DoF score | 21 X 11 X 11=2541 | 6 X 8 X 2=96 |
| # samples | 23 | 8 | |
| ** MAII score | log2(23/2541*10)=-3.46569060910898 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/96*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ROCK1 [Title/Abstract] AND MAP1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROCK1 | GO:0007159 | leukocyte cell-cell adhesion | 12082081 |
| Hgene | ROCK1 | GO:0022614 | membrane to membrane docking | 12082081 |
| Hgene | ROCK1 | GO:0032091 | negative regulation of protein binding | 18573880 |
| Hgene | ROCK1 | GO:0032956 | regulation of actin cytoskeleton organization | 25911094 |
| Hgene | ROCK1 | GO:0050900 | leukocyte migration | 12082081 |
| Hgene | ROCK1 | GO:0050901 | leukocyte tethering or rolling | 12082081 |
| Tgene | MAP1B | GO:0009987 | cellular process | 19567321 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-YD-A9TA-06A | ROCK1 | chr18 | 18546878 | - | MAP1B | chr5 | 71479570 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000399799 | ENST00000296755 | ROCK1 | chr18 | 18546878 | - | MAP1B | chr5 | 71479570 | + |
| 5CDS-intron | ENST00000399799 | ENST00000504183 | ROCK1 | chr18 | 18546878 | - | MAP1B | chr5 | 71479570 | + |
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FusionProtFeatures for ROCK1_MAP1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROCK1 | MAP1B |
| Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2,MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and actssynergistically with it to promote SRC-dependent non-apoptoticplasma membrane blebbing. Phosphorylates JIP3 and regulates therecruitment of JNK to JIP3 upon UVB-induced stress. Acts as asuppressor of inflammatory cell migration by regulating PTENphosphorylation and stability. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Required forcentrosome positioning and centrosome-dependent exit from mitosis.Plays a role in terminal erythroid differentiation. May regulateclosure of the eyelids and ventral body wall by inducing theassembly of actomyosin bundles. Promotes keratinocyte terminaldifferentiation. Involved in osteoblast compaction through thefibronectin fibrillogenesis cell-mediated matrix assembly process,essential for osteoblast mineralization.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353,ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607,ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880,ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714,ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057,ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. | Facilitates tyrosination of alpha-tubulin in neuronalmicrotubules (By similarity). Phosphorylated MAP1B may play a rolein the cytoskeletal changes that accompany neurite extension.Possibly MAP1B binds to at least two tubulin subunits in thepolymer, and this bridging of subunits might be involved innucleating microtubule polymerization and in stabilizingmicrotubules. Acts as a positive cofactor in DAPK1-mediatedautophagic vesicle formation and membrane blebbing. {ECO:0000250,ECO:0000269|PubMed:18195017}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 1011_1102 | 1117 | 1355 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 422_692 | 1117 | 1355 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 636_980 | 1117 | 1355 | Compositional bias | Note=Glu-rich |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 341_409 | 1117 | 1355 | Domain | Note=AGC-kinase C-terminal |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 479_556 | 1117 | 1355 | Domain | REM-1 |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 76_338 | 1117 | 1355 | Domain | Protein kinase |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 949_1015 | 1117 | 1355 | Domain | RhoBD |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 82_90 | 1117 | 1355 | Nucleotide binding | ATP |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 998_1010 | 1117 | 1355 | Region | Note=RHOA binding |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 589_790 | 95 | 2469 | Compositional bias | Note=Lys-rich (highly basic%2C contains many KKEE and KKEI/V repeats) |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 1878_1894 | 95 | 2469 | Repeat | Note=MAP1B 1 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 1895_1911 | 95 | 2469 | Repeat | Note=MAP1B 2 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 1912_1928 | 95 | 2469 | Repeat | Note=MAP1B 3 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 1929_1945 | 95 | 2469 | Repeat | Note=MAP1B 4 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 1946_1962 | 95 | 2469 | Repeat | Note=MAP1B 5 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 1963_1979 | 95 | 2469 | Repeat | Note=MAP1B 6 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 1997_2013 | 95 | 2469 | Repeat | Note=MAP1B 7 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 2014_2030 | 95 | 2469 | Repeat | Note=MAP1B 8 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 2031_2047 | 95 | 2469 | Repeat | Note=MAP1B 9 |
| Tgene | >MAP1B | chr18:18546878 | chr5:71479570 | ENST00000296755 | + | 1 | 7 | 2048_2064 | 95 | 2469 | Repeat | Note=MAP1B 10 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 1118_1317 | 1117 | 1355 | Domain | PH |
| Hgene | >ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 1115_1354 | 1117 | 1355 | Region | Note=Auto-inhibitory |
| Hgene | >ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 1228_1281 | 1117 | 1355 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for ROCK1_MAP1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ROCK1_ENST00000399799_chr18_18546878_-_MAP1B_ENST00000296755_chr5_71479570_+_3491aa MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEV QLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYE MLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEME QKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQAR ITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQE INTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEK NINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPGQKILHHRSDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTG ELILQSGSFSFQNFIEIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEMEGLSEFTEYLSESVE VPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKI AELEEEQSQGSTTNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVG KLEMYVLNPVKSSKEMQYFMQQWTGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHL DFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTET KPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEI KKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKE KGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLK ETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDG EEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAV VDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMST PRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYC SEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTL EVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSES AYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLG DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDD SLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLH ITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSE KVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEK DSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTR TPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTS TYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGG APPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVS MVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEV KAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ROCK1_ENST00000399799_chr18_18546878_-_MAP1B_ENST00000296755_chr5_71479570_+_10473nt ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG CTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAAGAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAA GACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATGAAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTT CAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTCTCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTT TTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTGTTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTAC ATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCAACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCA GAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACAGAGATGTGAAGCCTGATAACATGCTGCTGGATAAATCTGGA CATTTGAAGTTAGCAGATTTTGGTACTTGTATGAAGATGAATAAGGAAGGCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTAT ATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAAGAGAATGTGACTGGTGGTCGGTTGGGGTATTTTTATACGAA ATGCTTGTAGGTGATACACCTTTTTATGCAGATTCTTTGGTTGGAACTTACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCT GATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCCTTACTGACAGGGAAGTGAGGTTAGGGCGAAATGGTGTAGAA GAAATCAAACGACATCTCTTCTTCAAAAATGACCAGTGGGCTTGGGAAACGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGT AGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAGAGGAAGAAACATTCCCTATTCCTAAAGCTTTCGTTGGCAAT CAACTACCTTTTGTAGGATTTACATATTATAGCAATCGTAGATACTTATCTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCA GATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAGAACAGCTGCATAATGAAATGCAGTTAAAAGATGAAATGGAG CAGAAGTGCAGAACCTCAAACATAAAACTAGACAAGATAATGAAAGAATTGGATGAAGAGGGAAATCAAAGAAGAAATCTAGAATCTACA GTGTCTCAGATTGAGAAGGAGAAAATGTTGCTACAGCATAGAATTAATGAGTACCAAAGAAAAGCTGAACAGGAAAATGAGAAGAGAAGA AATGTAGAAAATGAAGTTTCTACATTAAAGGATCAGTTGGAAGACTTAAAGAAAGTCAGTCAGAATTCACAGCTTGCTAATGAGAAGCTG TCCCAGTTACAAAAGCAGCTAGAAGAAGCCAATGACTTACTTAGGACAGAATCGGACACAGCTGTAAGATTGAGGAAGAGTCACACAGAG ATGAGCAAGTCAATTAGTCAGTTAGAGTCCCTGAACAGAGAGTTGCAAGAGAGAAATCGAATTTTAGAGAATTCTAAGTCACAAACAGAC AAAGATTATTACCAGCTGCAAGCTATATTAGAAGCTGAACGAAGAGACAGAGGTCATGATTCTGAGATGATTGGAGACCTTCAAGCTCGA ATTACATCTTTACAAGAGGAGGTGAAGCATCTCAAACATAATCTCGAAAAAGTGGAAGGAGAAAGAAAAGAGGCTCAAGACATGCTTAAT CACTCAGAAAAGGAAAAGAATAATTTAGAGATAGATTTAAACTACAAACTTAAATCATTACAACAACGGTTAGAACAAGAGGTAAATGAA CACAAAGTAACCAAAGCTCGTTTAACTGACAAACATCAATCTATTGAAGAGGCAAAGTCTGTGGCAATGTGTGAGATGGAAAAAAAGCTG AAAGAAGAAAGAGAAGCTCGAGAGAAGGCTGAAAATCGGGTTGTTCAGATTGAGAAACAGTGTTCCATGCTAGACGTTGATCTGAAGCAA TCTCAGCAGAAACTAGAACATTTGACTGGAAATAAAGAAAGGATGGAGGATGAAGTTAAGAATCTAACCCTGCAACTGGAGCAGGAATCA AATAAGCGGCTGTTGTTACAAAATGAATTGAAGACTCAAGCATTTGAGGCAGACAATTTAAAAGGTTTAGAAAAGCAGATGAAACAGGAA ATAAATACTTTATTGGAAGCAAAGAGATTATTAGAATTTGAGTTAGCTCAGCTTACGAAACAGTATAGAGGAAATGAAGGACAGATGCGG GAGCTACAAGATCAGCTTGAAGCTGAGCAATATTTCTCGACACTTTATAAAACCCAGGTAAAGGAACTTAAAGAAGAAATTGAAGAAAAA AACAGAGAAAATTTAAAGAAAATACAGGAACTACAAAATGAAAAAGAAACTCTTGCTACTCAGTTGGATCTAGCAGAAACAAAAGCTGAG TCTGAGCAGTTGGCGCGAGGCCTTCTGGAAGAACAGTATTTTGAATTGACGCAAGAAAGCAAGAAAGCTGCTTCAAGAAATAGACAAGAG ATTACAGATAAAGATCACACTGTTAGTCGGCTTGAAGAAGCAAACAGCATGCTAACCAAAGATATTGAAATATTAAGAAGAGAGAATGAA GAGCTAACAGAGAAAATGAAGAAGGCAGAGGAAGAATATAAACTGGAGAAGGAGGAGGAGATCAGTAATCTTAAGGCTGCCTTTGAAAAG AATATCAACACTGAACGAACCCTTAAAACACAGGCTGTTAACAAATTGGCAGAAATAATGAATCGAAAAGATTTTAAAATTGATAGAAAG AAAGCTAATACACAAGATTTGAGAAAGAAAGAAAAGGAAAATCGAAAGCTGCAACTGGAACTCAACCAAGAAAGAGAGAAATTCAACCAG ATGGTAGTGAAACATCAGAAGGAACTGAATGACATGCAAGCGCAATTGGTAGAAGAATGTGCACATAGGAATGAGCTTCAGATGCAGTTG GCCAGCAAAGAGAGTGATATTGAGCAATTGCGTGCTAAACTTTTGGACCTCTCGGATTCTACAAGTGTTGCTAGTTTTCCTAGTGCTGAT GAAACTGATGGTAACCTCCCAGGACAAAAGATCCTTCATCACCGAAGTGACGTTTTAGAAACAGTGGTCCTGATCAACCCTTCTGATGAA GCAGTCAGCACCGAGGTGCGCTTAATGATCACTGATGCTGCCCGACACAAGCTGCTCGTGCTGACCGGGCAGTGCTTTGAAAATACCGGA GAGCTCATTCTCCAGTCCGGCTCTTTCTCCTTCCAGAACTTCATAGAGATTTTCACCGATCAAGAGATCGGGGAGTTACTAAGCACCACC CATCCTGCCAACAAAGCCAGCTTAACCCTGTTCTGTCCTGAAGAAGGGGACTGGAAGAACTCCAATCTTGACAGACACAATCTCCAAGAC TTCATCAATATTAAACTCAATTCAGCTTCTATCTTGCCAGAAATGGAAGGACTTTCTGAGTTTACCGAGTATCTCTCAGAATCAGTGGAA GTCCCATCTCCCTTTGACATCTTGGAACCTCCCACATCGGGTGGATTTCTGAAGCTCTCCAAGCCCTGCTGTTATATTTTTCCAGGAGGG AGGGGCGATTCTGCCTTGTTTGCAGTGAATGGTTTCAATATGCTCATCAATGGCGGATCAGAGAGAAAATCCTGCTTCTGGAAGCTCATC CGACACTTAGACCGAGTGGACTCCATCCTGCTCACCCACATTGGGGATGACAATTTGCCTGGAATAAACAGCATGTTACAGCGGAAAATT GCAGAGCTCGAGGAAGAACAGTCCCAGGGCTCCACCACAAATAGTGACTGGATGAAAAACCTCATCTCCCCTGACTTAGGAGTTGTATTT CTCAATGTACCTGAAAATCTCAAAAATCCAGAGCCAAACATCAAGATGAAGAGAAGCATAGAAGAAGCCTGCTTCACTCTCCAGTACCTA AACAAATTGTCCATGAAACCAGAACCTCTGTTTAGAAGTGTAGGCAATACTATTGATCCTGTCATTCTTTTCCAAAAAATGGGAGTAGGT AAACTTGAGATGTATGTGCTTAATCCAGTCAAGAGCAGCAAGGAAATGCAGTATTTTATGCAGCAGTGGACTGGTACCAACAAAGACAAG GCTGAATTCATTCTGCCTAATGGTCAAGAAGTAGATCTCCCGATTTCCTACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCA AACCCTGCGGAGAAAATCATCCGAGTCCTGTTTCCTGGGAACAGCACCCAGTACAACATCCTGGAAGGGTTGGAAAAGCTCAAACATCTA GACTTTCTGAAGCAGCCACTGGCCACCCAAAAGGATCTCACTGGCCAGGTGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGG GCTGATAGCCGAGAAAGTCTGAAGCCAGCCGCAAAACCACTTCCTAGCAAATCCGTGCGCAAGGAGTCAAAAGAAGAAACCCCTGAGGTC ACAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTGAAAGCAAAGAAAAGGTAATGGTGAAAAAAGACAAGCCAATAAAAACAGAGACC AAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAGAAGAGCCATCTCCAGTGAAAGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTC AAACCCAAAGCTGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGTAAAGCCTGAAGACAAGAAAGAGGAGAAAGAAAAGCCAAAGAAA GAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAACCAAAAAAGGAAGAGGTGAAAAAAGAAGTCAAAAAAGAGATC AAGAAAGAAGAGAAAAAAGAACCCAAGAAAGAGGTTAAGAAAGAAACACCGCCAAAGGAAGTCAAGAAGGAAGTTAAGAAGGAAGAGAAG AAGGAAGTGAAAAAGGAAGAAAAGGAACCCAAAAAAGAAATTAAGAAGCTCCCTAAAGACGCAAAGAAATCATCTACTCCTCTGTCTGAA GCAAAAAAACCAGCTGCTTTAAAACCAAAAGTACCCAAGAAGGAAGAGTCTGTCAAGAAAGATTCTGTTGCTGCCGGAAAGCCAAAGGAG AAGGGGAAAATAAAAGTCATTAAGAAGGAAGGCAAGGCCGCAGAGGCTGTCGCTGCAGCTGTCGGCACTGGAGCCACCACAGCAGCTGTC ATGGCGGCAGCTGGAATAGCAGCCATTGGCCCTGCCAAAGAACTCGAAGCTGAGAGGTCCCTTATGTCATCTCCTGAGGATCTAACCAAG GACTTTGAAGAGTTAAAGGCTGAAGAGGTCGATGTAACAAAGGACATCAAGCCTCAGCTGGAGCTAATCGAAGACGAAGAGAAACTGAAG GAAACTGAGCCAGTCGAAGCCTACGTCATCCAGAAGGAGAGAGAAGTCACCAAAGGTCCTGCCGAGTCCCCTGATGAGGGAATCACTACC ACTGAAGGGGAGGGCGAATGTGAACAGACACCTGAGGAGCTGGAGCCCGTCGAGAAGCAGGGAGTAGACGACATTGAAAAATTTGAAGAT GAAGGAGCCGGTTTTGAAGAATCTTCAGAGACTGGAGACTATGAAGAGAAGGCAGAAACTGAGGAGGCTGAGGAGCCAGAAGAGGATGGG GAGGAACACGTATGTGTGAGCGCCTCCAAGCACAGCCCCACTGAGGATGAGGAAAGTGCCAAGGCGGAGGCTGATGCATACATCAGGGAG AAGAGGGAGTCTGTGGCCAGTGGGGATGACCGAGCCGAAGAAGACATGGATGAGGCCATTGAGAAAGGAGAGGCTGAACAATCTGAAGAG GAGGCTGATGAGGAGGACAAAGCTGAAGATGCCAGAGAGGAGGAATATGAGCCGGAAAAAATGGAAGCTGAAGACTATGTGATGGCTGTG GTCGACAAGGCTGCAGAGGCTGGTGGTGCCGAGGAGCAGTATGGATTCCTCACCACACCAACCAAGCAACTAGGAGCCCAGTCTCCTGGC CGAGAACCTGCATCTTCAATTCATGATGAGACTTTACCTGGAGGCTCAGAGAGCGAGGCCACCGCTTCTGATGAGGAGAATCGAGAAGAC CAGCCTGAGGAATTCACTGCCACCTCTGGCTACACTCAGTCTACTATTGAGATATCCAGTGAGCCCACCCCCATGGATGAGATGTCTACC CCTCGAGACGTGATGAGTGATGAGACCAACAATGAAGAGACGGAGTCCCCTTCTCAGGAATTCGTAAATATCACCAAATATGAATCTTCA TTGTATTCTCAGGAATACTCTAAACCTGCTGATGTTACACCGCTCAACGGATTTTCTGAAGGATCAAAAACAGATGCCACTGATGGCAAG GATTACAATGCTTCAGCCTCTACCATATCACCACCCTCTTCCATGGAGGAAGACAAATTCAGCAGATCTGCTTTACGTGATGCTTACTGC TCTGAAGTGAAAGCCAGCACCACTTTGGACATCAAAGATAGCATCTCAGCTGTTTCAAGTGAAAAGGTCAGCCCATCGAAGAGCCCGTCC CTGAGTCCATCTCCACCATCACCCTTAGAAAAGACCCCCCTGGGTGAACGTAGTGTGAACTTCTCTCTGACGCCCAATGAGATTAAAGTC TCTGCAGAGGCAGAAGTAGCCCCGGTGTCTCCTGAGGTGACCCAAGAAGTAGTTGAAGAACATTGTGCTAGTCCTGAGGACAAGACTCTG GAAGTGGTGTCACCATCTCAGTCCGTGACTGGCAGTGCTGGTCACACACCTTACTATCAATCTCCTACTGACGAGAAATCCAGTCATCTC CCTACAGAAGTCATTGAAAAACCACCAGCAGTTCCAGTGAGTTTTGAATTCAGTGATGCCAAAGATGAGAATGAAAGGGCTTCAGTAAGC CCCATGGATGAGCCCGTGCCTGACTCAGAGTCTCCTATTGAAAAAGTTTTGTCTCCTTTACGCAGCCCGCCCCTCATTGGATCCGAGTCT GCTTATGAAAGTTTTCTAAGTGCTGATGACAAGGCTTCTGGCAGAGGTGCCGAAAGTCCTTTTGAAGAAAAGAGTGGAAAACAAGGCTCT CCAGACCAAGTAAGTCCAGTTTCTGAAATGACTTCTACTAGTCTTTACCAAGACAAACAGGAAGGGAAAAGCACAGACTTTGCACCAATA AAAGAAGACTTTGGCCAAGAAAAGAAAACTGATGATGTTGAAGCCATGAGTTCTCAACCAGCACTGGCTCTGGATGAAAGGAAATTAGGA GATGTTTCTCCCACACAAATAGATGTCAGTCAGTTTGGATCTTTTAAAGAAGACACTAAGATGTCCATTTCTGAAGGTACTGTCTCAGAC AAGTCAGCTACTCCTGTTGATGAGGGCGTAGCAGAAGACACGTACTCTCATATGGAGGGTGTGGCCTCAGTGTCCACAGCCTCAGTGGCT ACGAGCTCATTTCCAGAGCCAACAACAGATGATGTGTCTCCATCTCTGCATGCTGAGGTTGGCTCCCCACATTCCACAGAAGTAGATGAC TCCCTTTCAGTGTCTGTTGTGCAAACACCTACCACATTCCAGGAAACAGAAATGTCTCCATCTAAAGAAGAATGCCCAAGACCGATGTCA ATTTCTCCACCAGATTTCTCCCCTAAAACTGCAAAGTCCAGGACACCCGTTCAAGATCACAGATCTGAACAGTCCTCAATGTCTATTGAA TTTGGCCAAGAATCTCCTGAGCAATCCCTTGCTATGGACTTCAGTCGACAGTCTCCAGATCACCCTACAGTGGGTGCAGGCGTGCTTCAC ATCACTGAAAATGGGCCAACTGAAGTGGACTACAGTCCTTCTGACATGCAGGACTCCAGTTTATCACATAAGATACCACCTATGGAGGAG CCGTCCTACACCCAAGATAATGATCTTTCTGAGCTCATCTCAGTATCTCAGGTAGAGGCCTCCCCGTCCACCTCTTCTGCTCATACCCCT TCTCAGATCGCTTCTCCTCTCCAAGAAGATACTCTATCCGATGTTGCTCCTCCCAGAGATATGTCCTTATATGCCTCACTCACCTCTGAA AAAGTGCAAAGTCTGGAAGGAGAGAAGCTCTCTCCAAAATCTGATATCTCTCCACTCACCCCACGAGAGTCCTCTCCTTTATATTCACCT ACTTTTTCAGATTCTACCTCTGCAGTCAAAGAGAAAACAGCAACTTGCCACAGTTCCTCTTCTCCACCAATAGATGCAGCATCCGCAGAG CCCTATGGCTTCCGTGCCTCAGTGTTATTCGATACAATGCAACACCATCTAGCCTTGAATAGAGATTTGTCCACACCTGGCCTGGAGAAG GACAGTGGAGGGAAGACACCTGGTGACTTTAGCTATGCCTATCAAAAGCCTGAGGAAACAACCAGGTCCCCAGATGAAGAAGATTATGAC TATGAGTCTTATGAGAAGACCACCCGGACCTCAGATGTGGGTGGCTATTACTATGAGAAGATAGAGAGAACCACAAAATCTCCAAGTGAC AGTGGCTACTCCTATGAGACCATTGGGAAAACTACCAAGACCCCTGAAGATGGTGACTATTCCTATGAAATTATTGAGAAGACCACACGG ACCCCTGAAGAGGGTGGGTACTCATATGACATAAGTGAAAAGACCACCAGCCCCCCCGAAGTGAGTGGTTACAGCTATGAAAAGACTGAG AGGTCTAGAAGGCTTCTGGATGACATCAGCAATGGCTATGATGACTCTGAGGATGGTGGCCACACACTTGGGGACCCCAGCTACTCTTAT GAAACCACTGAGAAAATTACCAGTTTCCCTGAGTCTGAAGGTTATTCCTATGAGACATCTACAAAGACAACACGAACCCCTGATACTTCC ACATACTGTTACGAGACTGCAGAGAAAATCACTAGAACCCCTCAGGCATCCACATATTCCTACGAGACTTCAGACCTATGCTACACTGCA GAAAAGAAGTCCCCCTCAGAAGCCCGTCAGGATGTCGATTTATGCCTCGTGTCCTCTTGTGAATACAAGCACCCCAAGACAGAGCTTTCA CCCTCTTTCATTAATCCCAATCCTCTTGAGTGGTTTGCCAGTGAAGAACCCACTGAAGAATCTGAAAAGCCCCTCACTCAATCAGGGGGA GCCCCACCGCCTCCAGGAGGAAAGCAACAGGGCCGACAGTGTGATGAAACCCCTCCCACCTCAGTCAGCGAGTCAGCCCCATCCCAGACC GACTCTGATGTTCCCCCGGAGACTGAAGAGTGCCCCTCCATCACGGCCGATGCCAATATCGACTCTGAAGACGAGTCGGAAACCATCCCC ACAGACAAAACTGTCACGTACAAACACATGGACCCACCTCCAGCTCCCGTGCAAGACCGCAGCCCTTCGCCACGCCACCCTGATGTGTCC ATGGTGGACCCAGAGGCCTTGGCCATTGAGCAGAACCTGGGCAAAGCTCTAAAGAAAGATCTGAAAGAGAAGACCAAAACCAAAAAGCCA GGTACAAAGACCAAGTCATCTTCACCTGTCAAAAAGAGTGATGGGAAGTCTAAGCCCTTGGCAGCTTCACCAAAACCAGCGGGCTTGAAA GAATCCTCGGATAAAGTGTCCAGGGTGGCTTCTCCTAAGAAGAAAGAATCTGTGGAAAAGGCAGCAAAACCCACCACCACTCCTGAGGTC AAAGCTGCACGTGGGGAAGAGAAAGACAAGGAGACCAAGAATGCTGCCAATGCCTCTGCATCCAAGTCGGCCAAGACCGCCACTGCAGGA CCAGGAACTACCAAGACGACCAAGTCATCTGCTGTGCCCCCAGGCCTCCCTGTGTATTTGGACCTGTGCTACATTCCTAACCACAGCAAT AGTAAGAATGTTGATGTGGAATTTTTCAAGAGAGTGCGGTCTTCCTACTACGTGGTGAGTGGGAATGACCCTGCTGCTGAGGAGCCCAGC CGGGCTGTCCTGGACGCTTTGTTGGAAGGAAAGGCTCAGTGGGGCAGCAACATGCAGGTGACACTGATCCCAACTCATGACTCAGAAGTG ATGAGGGAATGGTACCAGGAGACCCATGAGAAACAGCAAGATCTCAACATCATGGTTTTAGCAAGCAGCAGCACAGTGGTTATGCAAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ROCK1_ENST00000399799_chr18_18546878_-_MAP1B_ENST00000296755_chr5_71479570_+_15743nt GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAA GAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAAGACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATG AAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTC TCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTTTTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTG TTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCA ACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCAGAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACA GAGATGTGAAGCCTGATAACATGCTGCTGGATAAATCTGGACATTTGAAGTTAGCAGATTTTGGTACTTGTATGAAGATGAATAAGGAAG GCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTATATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAA GAGAATGTGACTGGTGGTCGGTTGGGGTATTTTTATACGAAATGCTTGTAGGTGATACACCTTTTTATGCAGATTCTTTGGTTGGAACTT ACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCTGATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCC TTACTGACAGGGAAGTGAGGTTAGGGCGAAATGGTGTAGAAGAAATCAAACGACATCTCTTCTTCAAAAATGACCAGTGGGCTTGGGAAA CGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGTAGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAG AGGAAGAAACATTCCCTATTCCTAAAGCTTTCGTTGGCAATCAACTACCTTTTGTAGGATTTACATATTATAGCAATCGTAGATACTTAT CTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCAGATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAG AACAGCTGCATAATGAAATGCAGTTAAAAGATGAAATGGAGCAGAAGTGCAGAACCTCAAACATAAAACTAGACAAGATAATGAAAGAAT TGGATGAAGAGGGAAATCAAAGAAGAAATCTAGAATCTACAGTGTCTCAGATTGAGAAGGAGAAAATGTTGCTACAGCATAGAATTAATG AGTACCAAAGAAAAGCTGAACAGGAAAATGAGAAGAGAAGAAATGTAGAAAATGAAGTTTCTACATTAAAGGATCAGTTGGAAGACTTAA AGAAAGTCAGTCAGAATTCACAGCTTGCTAATGAGAAGCTGTCCCAGTTACAAAAGCAGCTAGAAGAAGCCAATGACTTACTTAGGACAG AATCGGACACAGCTGTAAGATTGAGGAAGAGTCACACAGAGATGAGCAAGTCAATTAGTCAGTTAGAGTCCCTGAACAGAGAGTTGCAAG AGAGAAATCGAATTTTAGAGAATTCTAAGTCACAAACAGACAAAGATTATTACCAGCTGCAAGCTATATTAGAAGCTGAACGAAGAGACA GAGGTCATGATTCTGAGATGATTGGAGACCTTCAAGCTCGAATTACATCTTTACAAGAGGAGGTGAAGCATCTCAAACATAATCTCGAAA AAGTGGAAGGAGAAAGAAAAGAGGCTCAAGACATGCTTAATCACTCAGAAAAGGAAAAGAATAATTTAGAGATAGATTTAAACTACAAAC TTAAATCATTACAACAACGGTTAGAACAAGAGGTAAATGAACACAAAGTAACCAAAGCTCGTTTAACTGACAAACATCAATCTATTGAAG AGGCAAAGTCTGTGGCAATGTGTGAGATGGAAAAAAAGCTGAAAGAAGAAAGAGAAGCTCGAGAGAAGGCTGAAAATCGGGTTGTTCAGA TTGAGAAACAGTGTTCCATGCTAGACGTTGATCTGAAGCAATCTCAGCAGAAACTAGAACATTTGACTGGAAATAAAGAAAGGATGGAGG ATGAAGTTAAGAATCTAACCCTGCAACTGGAGCAGGAATCAAATAAGCGGCTGTTGTTACAAAATGAATTGAAGACTCAAGCATTTGAGG CAGACAATTTAAAAGGTTTAGAAAAGCAGATGAAACAGGAAATAAATACTTTATTGGAAGCAAAGAGATTATTAGAATTTGAGTTAGCTC AGCTTACGAAACAGTATAGAGGAAATGAAGGACAGATGCGGGAGCTACAAGATCAGCTTGAAGCTGAGCAATATTTCTCGACACTTTATA AAACCCAGGTAAAGGAACTTAAAGAAGAAATTGAAGAAAAAAACAGAGAAAATTTAAAGAAAATACAGGAACTACAAAATGAAAAAGAAA CTCTTGCTACTCAGTTGGATCTAGCAGAAACAAAAGCTGAGTCTGAGCAGTTGGCGCGAGGCCTTCTGGAAGAACAGTATTTTGAATTGA CGCAAGAAAGCAAGAAAGCTGCTTCAAGAAATAGACAAGAGATTACAGATAAAGATCACACTGTTAGTCGGCTTGAAGAAGCAAACAGCA TGCTAACCAAAGATATTGAAATATTAAGAAGAGAGAATGAAGAGCTAACAGAGAAAATGAAGAAGGCAGAGGAAGAATATAAACTGGAGA AGGAGGAGGAGATCAGTAATCTTAAGGCTGCCTTTGAAAAGAATATCAACACTGAACGAACCCTTAAAACACAGGCTGTTAACAAATTGG CAGAAATAATGAATCGAAAAGATTTTAAAATTGATAGAAAGAAAGCTAATACACAAGATTTGAGAAAGAAAGAAAAGGAAAATCGAAAGC TGCAACTGGAACTCAACCAAGAAAGAGAGAAATTCAACCAGATGGTAGTGAAACATCAGAAGGAACTGAATGACATGCAAGCGCAATTGG TAGAAGAATGTGCACATAGGAATGAGCTTCAGATGCAGTTGGCCAGCAAAGAGAGTGATATTGAGCAATTGCGTGCTAAACTTTTGGACC TCTCGGATTCTACAAGTGTTGCTAGTTTTCCTAGTGCTGATGAAACTGATGGTAACCTCCCAGGACAAAAGATCCTTCATCACCGAAGTG ACGTTTTAGAAACAGTGGTCCTGATCAACCCTTCTGATGAAGCAGTCAGCACCGAGGTGCGCTTAATGATCACTGATGCTGCCCGACACA AGCTGCTCGTGCTGACCGGGCAGTGCTTTGAAAATACCGGAGAGCTCATTCTCCAGTCCGGCTCTTTCTCCTTCCAGAACTTCATAGAGA TTTTCACCGATCAAGAGATCGGGGAGTTACTAAGCACCACCCATCCTGCCAACAAAGCCAGCTTAACCCTGTTCTGTCCTGAAGAAGGGG ACTGGAAGAACTCCAATCTTGACAGACACAATCTCCAAGACTTCATCAATATTAAACTCAATTCAGCTTCTATCTTGCCAGAAATGGAAG GACTTTCTGAGTTTACCGAGTATCTCTCAGAATCAGTGGAAGTCCCATCTCCCTTTGACATCTTGGAACCTCCCACATCGGGTGGATTTC TGAAGCTCTCCAAGCCCTGCTGTTATATTTTTCCAGGAGGGAGGGGCGATTCTGCCTTGTTTGCAGTGAATGGTTTCAATATGCTCATCA ATGGCGGATCAGAGAGAAAATCCTGCTTCTGGAAGCTCATCCGACACTTAGACCGAGTGGACTCCATCCTGCTCACCCACATTGGGGATG ACAATTTGCCTGGAATAAACAGCATGTTACAGCGGAAAATTGCAGAGCTCGAGGAAGAACAGTCCCAGGGCTCCACCACAAATAGTGACT GGATGAAAAACCTCATCTCCCCTGACTTAGGAGTTGTATTTCTCAATGTACCTGAAAATCTCAAAAATCCAGAGCCAAACATCAAGATGA AGAGAAGCATAGAAGAAGCCTGCTTCACTCTCCAGTACCTAAACAAATTGTCCATGAAACCAGAACCTCTGTTTAGAAGTGTAGGCAATA CTATTGATCCTGTCATTCTTTTCCAAAAAATGGGAGTAGGTAAACTTGAGATGTATGTGCTTAATCCAGTCAAGAGCAGCAAGGAAATGC AGTATTTTATGCAGCAGTGGACTGGTACCAACAAAGACAAGGCTGAATTCATTCTGCCTAATGGTCAAGAAGTAGATCTCCCGATTTCCT ACTTAACTTCAGTCTCATCTTTGATTGTGTGGCATCCAGCAAACCCTGCGGAGAAAATCATCCGAGTCCTGTTTCCTGGGAACAGCACCC AGTACAACATCCTGGAAGGGTTGGAAAAGCTCAAACATCTAGACTTTCTGAAGCAGCCACTGGCCACCCAAAAGGATCTCACTGGCCAGG TGCCCACTCCTGTGGTGAAACAAACAAAACTGAAACAGAGGGCTGATAGCCGAGAAAGTCTGAAGCCAGCCGCAAAACCACTTCCTAGCA AATCCGTGCGCAAGGAGTCAAAAGAAGAAACCCCTGAGGTCACAAAAGTGAATCACGTGGAAAAGCCACCCAAAGTTGAAAGCAAAGAAA AGGTAATGGTGAAAAAAGACAAGCCAATAAAAACAGAGACCAAACCTTCAGTGACTGAAAAGGAGGTTCCCAGCAAAGAAGAGCCATCTC CAGTGAAAGCCGAGGTGGCTGAGAAGCAAGCCACAGATGTCAAACCCAAAGCTGCCAAGGAGAAGACGGTGAAAAAGGAAACAAAGGTAA AGCCTGAAGACAAGAAAGAGGAGAAAGAAAAGCCAAAGAAAGAAGTGGCTAAAAAGGAGGACAAAACACCTATCAAGAAGGAGGAAAAAC CAAAAAAGGAAGAGGTGAAAAAAGAAGTCAAAAAAGAGATCAAGAAAGAAGAGAAAAAAGAACCCAAGAAAGAGGTTAAGAAAGAAACAC CGCCAAAGGAAGTCAAGAAGGAAGTTAAGAAGGAAGAGAAGAAGGAAGTGAAAAAGGAAGAAAAGGAACCCAAAAAAGAAATTAAGAAGC TCCCTAAAGACGCAAAGAAATCATCTACTCCTCTGTCTGAAGCAAAAAAACCAGCTGCTTTAAAACCAAAAGTACCCAAGAAGGAAGAGT CTGTCAAGAAAGATTCTGTTGCTGCCGGAAAGCCAAAGGAGAAGGGGAAAATAAAAGTCATTAAGAAGGAAGGCAAGGCCGCAGAGGCTG TCGCTGCAGCTGTCGGCACTGGAGCCACCACAGCAGCTGTCATGGCGGCAGCTGGAATAGCAGCCATTGGCCCTGCCAAAGAACTCGAAG CTGAGAGGTCCCTTATGTCATCTCCTGAGGATCTAACCAAGGACTTTGAAGAGTTAAAGGCTGAAGAGGTCGATGTAACAAAGGACATCA AGCCTCAGCTGGAGCTAATCGAAGACGAAGAGAAACTGAAGGAAACTGAGCCAGTCGAAGCCTACGTCATCCAGAAGGAGAGAGAAGTCA CCAAAGGTCCTGCCGAGTCCCCTGATGAGGGAATCACTACCACTGAAGGGGAGGGCGAATGTGAACAGACACCTGAGGAGCTGGAGCCCG TCGAGAAGCAGGGAGTAGACGACATTGAAAAATTTGAAGATGAAGGAGCCGGTTTTGAAGAATCTTCAGAGACTGGAGACTATGAAGAGA AGGCAGAAACTGAGGAGGCTGAGGAGCCAGAAGAGGATGGGGAGGAACACGTATGTGTGAGCGCCTCCAAGCACAGCCCCACTGAGGATG AGGAAAGTGCCAAGGCGGAGGCTGATGCATACATCAGGGAGAAGAGGGAGTCTGTGGCCAGTGGGGATGACCGAGCCGAAGAAGACATGG ATGAGGCCATTGAGAAAGGAGAGGCTGAACAATCTGAAGAGGAGGCTGATGAGGAGGACAAAGCTGAAGATGCCAGAGAGGAGGAATATG AGCCGGAAAAAATGGAAGCTGAAGACTATGTGATGGCTGTGGTCGACAAGGCTGCAGAGGCTGGTGGTGCCGAGGAGCAGTATGGATTCC TCACCACACCAACCAAGCAACTAGGAGCCCAGTCTCCTGGCCGAGAACCTGCATCTTCAATTCATGATGAGACTTTACCTGGAGGCTCAG AGAGCGAGGCCACCGCTTCTGATGAGGAGAATCGAGAAGACCAGCCTGAGGAATTCACTGCCACCTCTGGCTACACTCAGTCTACTATTG AGATATCCAGTGAGCCCACCCCCATGGATGAGATGTCTACCCCTCGAGACGTGATGAGTGATGAGACCAACAATGAAGAGACGGAGTCCC CTTCTCAGGAATTCGTAAATATCACCAAATATGAATCTTCATTGTATTCTCAGGAATACTCTAAACCTGCTGATGTTACACCGCTCAACG GATTTTCTGAAGGATCAAAAACAGATGCCACTGATGGCAAGGATTACAATGCTTCAGCCTCTACCATATCACCACCCTCTTCCATGGAGG AAGACAAATTCAGCAGATCTGCTTTACGTGATGCTTACTGCTCTGAAGTGAAAGCCAGCACCACTTTGGACATCAAAGATAGCATCTCAG CTGTTTCAAGTGAAAAGGTCAGCCCATCGAAGAGCCCGTCCCTGAGTCCATCTCCACCATCACCCTTAGAAAAGACCCCCCTGGGTGAAC GTAGTGTGAACTTCTCTCTGACGCCCAATGAGATTAAAGTCTCTGCAGAGGCAGAAGTAGCCCCGGTGTCTCCTGAGGTGACCCAAGAAG TAGTTGAAGAACATTGTGCTAGTCCTGAGGACAAGACTCTGGAAGTGGTGTCACCATCTCAGTCCGTGACTGGCAGTGCTGGTCACACAC CTTACTATCAATCTCCTACTGACGAGAAATCCAGTCATCTCCCTACAGAAGTCATTGAAAAACCACCAGCAGTTCCAGTGAGTTTTGAAT TCAGTGATGCCAAAGATGAGAATGAAAGGGCTTCAGTAAGCCCCATGGATGAGCCCGTGCCTGACTCAGAGTCTCCTATTGAAAAAGTTT TGTCTCCTTTACGCAGCCCGCCCCTCATTGGATCCGAGTCTGCTTATGAAAGTTTTCTAAGTGCTGATGACAAGGCTTCTGGCAGAGGTG CCGAAAGTCCTTTTGAAGAAAAGAGTGGAAAACAAGGCTCTCCAGACCAAGTAAGTCCAGTTTCTGAAATGACTTCTACTAGTCTTTACC AAGACAAACAGGAAGGGAAAAGCACAGACTTTGCACCAATAAAAGAAGACTTTGGCCAAGAAAAGAAAACTGATGATGTTGAAGCCATGA GTTCTCAACCAGCACTGGCTCTGGATGAAAGGAAATTAGGAGATGTTTCTCCCACACAAATAGATGTCAGTCAGTTTGGATCTTTTAAAG AAGACACTAAGATGTCCATTTCTGAAGGTACTGTCTCAGACAAGTCAGCTACTCCTGTTGATGAGGGCGTAGCAGAAGACACGTACTCTC ATATGGAGGGTGTGGCCTCAGTGTCCACAGCCTCAGTGGCTACGAGCTCATTTCCAGAGCCAACAACAGATGATGTGTCTCCATCTCTGC ATGCTGAGGTTGGCTCCCCACATTCCACAGAAGTAGATGACTCCCTTTCAGTGTCTGTTGTGCAAACACCTACCACATTCCAGGAAACAG AAATGTCTCCATCTAAAGAAGAATGCCCAAGACCGATGTCAATTTCTCCACCAGATTTCTCCCCTAAAACTGCAAAGTCCAGGACACCCG TTCAAGATCACAGATCTGAACAGTCCTCAATGTCTATTGAATTTGGCCAAGAATCTCCTGAGCAATCCCTTGCTATGGACTTCAGTCGAC AGTCTCCAGATCACCCTACAGTGGGTGCAGGCGTGCTTCACATCACTGAAAATGGGCCAACTGAAGTGGACTACAGTCCTTCTGACATGC AGGACTCCAGTTTATCACATAAGATACCACCTATGGAGGAGCCGTCCTACACCCAAGATAATGATCTTTCTGAGCTCATCTCAGTATCTC AGGTAGAGGCCTCCCCGTCCACCTCTTCTGCTCATACCCCTTCTCAGATCGCTTCTCCTCTCCAAGAAGATACTCTATCCGATGTTGCTC CTCCCAGAGATATGTCCTTATATGCCTCACTCACCTCTGAAAAAGTGCAAAGTCTGGAAGGAGAGAAGCTCTCTCCAAAATCTGATATCT CTCCACTCACCCCACGAGAGTCCTCTCCTTTATATTCACCTACTTTTTCAGATTCTACCTCTGCAGTCAAAGAGAAAACAGCAACTTGCC ACAGTTCCTCTTCTCCACCAATAGATGCAGCATCCGCAGAGCCCTATGGCTTCCGTGCCTCAGTGTTATTCGATACAATGCAACACCATC TAGCCTTGAATAGAGATTTGTCCACACCTGGCCTGGAGAAGGACAGTGGAGGGAAGACACCTGGTGACTTTAGCTATGCCTATCAAAAGC CTGAGGAAACAACCAGGTCCCCAGATGAAGAAGATTATGACTATGAGTCTTATGAGAAGACCACCCGGACCTCAGATGTGGGTGGCTATT ACTATGAGAAGATAGAGAGAACCACAAAATCTCCAAGTGACAGTGGCTACTCCTATGAGACCATTGGGAAAACTACCAAGACCCCTGAAG ATGGTGACTATTCCTATGAAATTATTGAGAAGACCACACGGACCCCTGAAGAGGGTGGGTACTCATATGACATAAGTGAAAAGACCACCA GCCCCCCCGAAGTGAGTGGTTACAGCTATGAAAAGACTGAGAGGTCTAGAAGGCTTCTGGATGACATCAGCAATGGCTATGATGACTCTG AGGATGGTGGCCACACACTTGGGGACCCCAGCTACTCTTATGAAACCACTGAGAAAATTACCAGTTTCCCTGAGTCTGAAGGTTATTCCT ATGAGACATCTACAAAGACAACACGAACCCCTGATACTTCCACATACTGTTACGAGACTGCAGAGAAAATCACTAGAACCCCTCAGGCAT CCACATATTCCTACGAGACTTCAGACCTATGCTACACTGCAGAAAAGAAGTCCCCCTCAGAAGCCCGTCAGGATGTCGATTTATGCCTCG TGTCCTCTTGTGAATACAAGCACCCCAAGACAGAGCTTTCACCCTCTTTCATTAATCCCAATCCTCTTGAGTGGTTTGCCAGTGAAGAAC CCACTGAAGAATCTGAAAAGCCCCTCACTCAATCAGGGGGAGCCCCACCGCCTCCAGGAGGAAAGCAACAGGGCCGACAGTGTGATGAAA CCCCTCCCACCTCAGTCAGCGAGTCAGCCCCATCCCAGACCGACTCTGATGTTCCCCCGGAGACTGAAGAGTGCCCCTCCATCACGGCCG ATGCCAATATCGACTCTGAAGACGAGTCGGAAACCATCCCCACAGACAAAACTGTCACGTACAAACACATGGACCCACCTCCAGCTCCCG TGCAAGACCGCAGCCCTTCGCCACGCCACCCTGATGTGTCCATGGTGGACCCAGAGGCCTTGGCCATTGAGCAGAACCTGGGCAAAGCTC TAAAGAAAGATCTGAAAGAGAAGACCAAAACCAAAAAGCCAGGTACAAAGACCAAGTCATCTTCACCTGTCAAAAAGAGTGATGGGAAGT CTAAGCCCTTGGCAGCTTCACCAAAACCAGCGGGCTTGAAAGAATCCTCGGATAAAGTGTCCAGGGTGGCTTCTCCTAAGAAGAAAGAAT CTGTGGAAAAGGCAGCAAAACCCACCACCACTCCTGAGGTCAAAGCTGCACGTGGGGAAGAGAAAGACAAGGAGACCAAGAATGCTGCCA ATGCCTCTGCATCCAAGTCGGCCAAGACCGCCACTGCAGGACCAGGAACTACCAAGACGACCAAGTCATCTGCTGTGCCCCCAGGCCTCC CTGTGTATTTGGACCTGTGCTACATTCCTAACCACAGCAATAGTAAGAATGTTGATGTGGAATTTTTCAAGAGAGTGCGGTCTTCCTACT ACGTGGTGAGTGGGAATGACCCTGCTGCTGAGGAGCCCAGCCGGGCTGTCCTGGACGCTTTGTTGGAAGGAAAGGCTCAGTGGGGCAGCA ACATGCAGGTGACACTGATCCCAACTCATGACTCAGAAGTGATGAGGGAATGGTACCAGGAGACCCATGAGAAACAGCAAGATCTCAACA TCATGGTTTTAGCAAGCAGCAGCACAGTGGTTATGCAAGATGAATCCTTCCCTGCATGCAAGATTGAACTGTAAAAACCAAGGCCAGCCA CACCACAGGATCTGAACTTTGTTTCCAGAAATTCTTCAATTTGAAATCACCTTTTCTAAAAAGTCAATTCATCTAGTTAAGTCGCTGAAC AATTACCTGCCAAATGCTATACTGTGTCATGGTGATGCAAGTCACTAAATTTCTCAGTTTTTGCTGATTGCTAAGGGAAATAACAGTATT TCCACAATAGGGTTCAAATTCCTGCAAAATTACCTACCCCAGTTCATCTCTGCTGAACATTTGGAAACCATGCACTAGCCAACCCAACTG ACTTCTGCTAGGTAGAGGCATTTGTCTTAGAGAGAGAGAGAGCGCGGGAGAGAGTGAGAGAGAGTGAGAGCACAAAGATAACGCAGGAGA GAGAGAGAGAAAGAATGAGAAAGAAAAGGAATGCAAGAGAAGGAGATGTAATGACAGAGAGTTCTGGTGAGATACCCAGAGAGAAAAAGA GAGAGCAGGGTGGGGTAAGGAGGAGAAAATAAACCAACAATTAGGTCTGCATTTTCTCAGGCAGTAGGCATTCTTTAGTCTACATAGGCA AAGTTTTCCATTTTTGTCAGTCTGAGTCATCAAAAAGAGTCTTAATTTTCTAAAACAAGTTGGCTAGAAGAAAGTAAAAAGAACAACACT TGTTATGAGGGCATGTGATATTTTCACATCTTAATTAAGCTCCTTCAGTTTGAAGGCTGCACACTGACATAATGTAGTGAGTGTAGACTG GCCATGCAAGTGGTTTGGGCCCCATTCAGAACTCTCAGACTCTAAACACACAAGTAGATTGATCTAAGGCATGCTCCCAGCATTTGTCCA CCCACTTAGTCCACTCTGAGTCGATTAACCTGCATGCAGCAACACCCAAGTCCACCCCAATTAACTGAAGCAAATACCAAAGCAGTTGGG AGTACATATGGTAGACAATTTGCCTTAGGAAGTGACTTGAATGTACAAAGATACTTGATGCACTTATTTTTTAATGTGAGACAGCAAGTT TATAAAACATCCATATAGGATTATAGATACTTAAAGGAACACGTGGGTGAGCGTGTGTGGGGGTACTAGAAGCTGATCTGATTGGTCCAA CAGTTTGATGCTGAGTCATGCGTGTTGAATCCCACTTCAGTGCACCTGTGGCCTCTCAGTCAAACAAGTTGTGCCTTTCACAGCTTCTTT ACTACTGCAAGTTCAAGACTGAAATGGCTTCTATGATCAGAACTGGGAAAACAGTGAATCTTATGGTGGAAGAGGTTCTCAGCAAGTGTA CAGTATTTACCTTCCTTTGTCTTACATTGGCTTTTTAAATTTTCCATTAATTTCAACATAATTATGGGAACAAGTGTACAGAAGAATTTT TTTTTTAAGATATGTGAGAACTTTTCATAGATGAACTTTTTAACAAATGTTTTCATTTACAGGAAATTGCAAAGAAAATTCTCAAGTGAT AGTCTTTTTTTTTAAGTGTTTCGTAAGACAAAAATTGAATAATGTTTTTTGAAGTTCTGGCAAGATTGAAGTCTGATATTGCAGTAATGA TATTTATTAAAAACCCATAACTACCAGGAATAATGATACCTCCCACCCCTTGATTCCCATAACATAAAAGTGCTACTTGAGAGTGGGGGA GAATGGCATGGTAGGCTACTTTTCAGGGCCTTGACAAGTACATCACCCAGTGGTATCCTACATACTTCTTTCAAGATCTTCAACCATGAG GTAAAAGAGCCAAGTTCAAAGAACCCTAGCACAAATTTGCTTTGGGATTTTCTTTTCTGGAAAAAAAAAATAAAAGAAATAGTACATTGA AAACAAATGAATTCTCAACTCCTACGGTTCATGTAGAGTTTAGAGAAAATTTCCATCATTGTCATCATTGAACTGTGAACCTGGGAAGCC AGATCATGATTAACACTGACATCAAGTTTCAAGTTGCAGATCAATGCACCCAGTGTTCAGATGAGGCAAACTTCTCCGTGACAACTGTGC TGTGCTCTGTCACATTACATTTCCTGCAGACTCTAAGATCTACGGAGTAGAGAACAATGACCTCATTTTATTTTCTATGTTAGTTATTTA TTTCAAAATTAACATTTTAGTTGATTTTTGTCTGATAAGTCTATGTTTTGCACTGCTAACTATGATGAGGGTTTAAAAAAATGCTTCTTC AGGGTCCTTTCACTGAGGACCTATGCAGTCTACTTAATGCTGTGAATTACATTTTTCAAATGTTTAATTTTTTAAAGAAAATTAATATTC TATTTTTGTTAGGCTTCTCTAGAAATGCAGCTTTTATTTATTACCCCATTTCTTTCAAGTCCTTGGAAAATAACATATTAAGGGTACAAG AAATTAACACATGATGGAAAAGTCATTGTGACGCCAATGAATTTCATTGAGTATAAACTCATCTACTTCAAATTTATTTTATAACACAAC CTAAGATACTCAAGATAATTATTTAATGGTTAGCTCTTAAGTTGAATTGGTCTACATAATGCGTGGGAAGAAAACCAGATTTTTAGCCTT CTTGCCAAATCCAGACCTCTGGTTGATTTTTCTTTGACAGAAGATGCAAGTTATTTTCCAATTTCACAATTAAATGTATTTAACCTGAAC ATTATTTTGCTTTAAAAACTATAAACATTGTAGGAGAATTATAGCCAGTCTTCAGTTATAACCACTCCACCCTCCTCACTTTCTCTCTCT CTCTCTCTTTTTTTTTTTTTTTTTTTTTGCTATGGGATTTAATGGGAAAAATATGTAAAAACTGTCACTAGTCAGCTGGCTCTTTTTCCT ATGAAATCTATCAGTACCTTTCTCCATCCGTTGTTCTCAATATGACCACAGAGCCTGAGTATACCAAGAAAACCAATATTCGCATTACAG GTTGCTCCTGTCCTTCCAGACACCTTTCCTGCCTGTGTGACTAACCTAATTTTGCTAGTTCCATAAATACACGATTAGTTTAGTAACAGC CATCACAATGTACCATGTACATTCATGGTGAGAGCTAAAGATCGACACAGACTTCTAGGAGCTTTGTTCATACTGATTACTTAATCCAAT TGTATAGATTGAATATTTGAGTGGAAGGAATTTACACTCTGTTTAAATGATGGGATTCTATCGAGATAGCACTCATGATCATGACCTTTT TGGTAGTATTCTTAAACAAAATTCTACAGAGACTAAATGTTAGCGATGATCCTCCATTTTCAATTTTAACCAATTCTGTCCCCTTTCTCA AAACCCTGAGCCCTGTGCATGCTTTCTCAGTCTTGTGGTGGGACTGGATACAATGACTAACTTCCCCTCCTCCCCTCTTTAAACACCATT TTCCATGGAGTTCAAAAAAATTTTTTTTCTTAACGTTACATATCATAGTGAATGGTTTCCCCAGTGTATATGAATGTTTTAAGTGTCTCC AATAGCTTATGCAGTCTAGGAGCTTTCCAATACTCATTTAATTAAGATTTAATCATTTGCTAATGGAAATCTTACCACCTTTCATTTTCC CTCTGTTACCAAATTTCAGCTCTTAGGAGCTGCTCTACAATTCTGAATTTGCTTTTCTTGCCTCTCTTTAGTCACCTGTCACAGGAGGTT CCTGCTCAGTAATGATATTGTGAGTTAGGATAATAACTTTTTTTTTTTGTGCTTCAGATTTAGAAGAAAAGATCCTGTTTCCATTTGAAA GGAACTGTAAGCTTTTATCTTTTAACCAACTGAACAATACACCAAAAGCAGCCTAGGGATGAGCATTTCTTTGAAAGCAATTAGGTTATT CACCTGGTATTAAAACTATTTACTGTTAAAAAATCTGTGACTTCATGAAGTTGATTTTTAAAGGCAGCATCAAAAACTGAAAAGGAAGGG AAAAAATAGGCAGCTTCTCTGCACTTGTTTGGAGCTCCCCAAAACAGGAGCCATGGAGAAGTGGCATCAAGACCGGGCTGCCCTTTCGAG AACACCCTGTGGCAGTTCAGAGACACGCTTTTCCTACACTGCATGCAGCCCCTCTTTCCAGCACTGGAAAGAAGTGGTCTTGAGCCCAGC TGAGAAGCACTTCACACTCCTCTCTCTTGTTCTGAATGGTGTTTGTGTCAGTCTGCAGCTGTGTATGGTATTATGTCTTATAATCCTGCA TCACTTCTATCCTATCCAGTCATATCTAATGTAGAAAATTAGTTTCCAGTGAAAGTAATATGTAGTGCTTTTATGATATTTGTGTGCAAT 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FusionGenePPI for ROCK1_MAP1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ROCK1 | CDC25A, PFN2, RHOA, RND3, GAB1, CFL1, LIMK2, HNRNPA1, ITSN2, ARRB1, TSG101, NOTCH1, SMURF1, SMAD2, CASP3, CASP7, CDK15, ANKFY1, MON2, FAM21A, KIAA1033, IKBKB, LMO2, MAGEB4, POLR3C, C6orf165, FAM124A, NXF1, NTRK1, MED23, XRCC5, NEIL3, TRIM15, HGS, SLC9A1, UBE2T, CDKN3, TENC1, ROCK2, ADD2, IL20RA, CYLD | MAP1B | ANP32A, RASSF1, GAN, SNCA, MAG, RAE1, AMBRA1, ATG10, ATG12, ATG3, MAP1LC3A, MAP1LC3B, PRKAG2, RASSF5, STK4, HDAC5, ARRB1, ARRB2, SIRT7, SPP1, PINK1, MARCH5, CUL3, ACTN1, LRRK2, PARK7, EIF4A3, MAGOH, SMURF1, IQCB1, PAN2, NPM1, EEF1D, FOS, STK3, CUL7, CCDC8, EED, PPT1, ABCE1, FBXW11, MLF1, DBF4B, CRYAB, HSPB6, MAP1S, RASSF3, WHSC1, SFN, NTRK1, MED4, CACNA1B, CACNA1A, FOXK2, ALKBH3, ATOH1, CYLD, RUVBL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | ROCK1 | chr18:18546878 | chr5:71479570 | ENST00000399799 | - | 27 | 33 | 368_727 | 1117 | 1355 | FHOD1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ROCK1_MAP1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ROCK1_MAP1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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