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Fusion gene ID: 31688 |
FusionGeneSummary for ROCK1_LRIG3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROCK1_LRIG3 | Fusion gene ID: 31688 | Hgene | Tgene | Gene symbol | ROCK1 | LRIG3 | Gene ID | 6093 | 121227 |
| Gene name | Rho associated coiled-coil containing protein kinase 1 | leucine rich repeats and immunoglobulin like domains 3 | |
| Synonyms | P160ROCK|ROCK-I | LIG3 | |
| Cytomap | 18q11.1 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35 | leucine-rich repeats and immunoglobulin-like domains protein 3LIG-3 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q13464 | Q6UXM1 | |
| Ensembl transtripts involved in fusion gene | ENST00000399799, | ENST00000379141, ENST00000320743, | |
| Fusion gene scores | * DoF score | 21 X 11 X 11=2541 | 3 X 2 X 2=12 |
| # samples | 23 | 3 | |
| ** MAII score | log2(23/2541*10)=-3.46569060910898 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ROCK1 [Title/Abstract] AND LRIG3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROCK1 | GO:0007159 | leukocyte cell-cell adhesion | 12082081 |
| Hgene | ROCK1 | GO:0022614 | membrane to membrane docking | 12082081 |
| Hgene | ROCK1 | GO:0032091 | negative regulation of protein binding | 18573880 |
| Hgene | ROCK1 | GO:0032956 | regulation of actin cytoskeleton organization | 25911094 |
| Hgene | ROCK1 | GO:0050900 | leukocyte migration | 12082081 |
| Hgene | ROCK1 | GO:0050901 | leukocyte tethering or rolling | 12082081 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A091-01A | ROCK1 | chr18 | 18625253 | - | LRIG3 | chr12 | 59308117 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000399799 | ENST00000379141 | ROCK1 | chr18 | 18625253 | - | LRIG3 | chr12 | 59308117 | - |
| In-frame | ENST00000399799 | ENST00000320743 | ROCK1 | chr18 | 18625253 | - | LRIG3 | chr12 | 59308117 | - |
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FusionProtFeatures for ROCK1_LRIG3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROCK1 | LRIG3 |
| Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2,MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and actssynergistically with it to promote SRC-dependent non-apoptoticplasma membrane blebbing. Phosphorylates JIP3 and regulates therecruitment of JNK to JIP3 upon UVB-induced stress. Acts as asuppressor of inflammatory cell migration by regulating PTENphosphorylation and stability. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Required forcentrosome positioning and centrosome-dependent exit from mitosis.Plays a role in terminal erythroid differentiation. May regulateclosure of the eyelids and ventral body wall by inducing theassembly of actomyosin bundles. Promotes keratinocyte terminaldifferentiation. Involved in osteoblast compaction through thefibronectin fibrillogenesis cell-mediated matrix assembly process,essential for osteoblast mineralization.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353,ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607,ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880,ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714,ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057,ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. | May play a role in craniofacial and inner earmorphogenesis during embryonic development. May act within theotic vesicle epithelium to control formation of the lateralsemicircular canal in the inner ear, possibly by restricting theexpression of NTN1 (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 82_90 | 196 | 1355 | Nucleotide binding | ATP |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 444_495 | 78 | 1120 | Domain | Note=LRRCT |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 499_598 | 78 | 1120 | Domain | Note=Ig-like C2-type 1 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 603_692 | 78 | 1120 | Domain | Note=Ig-like C2-type 2 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 697_783 | 78 | 1120 | Domain | Note=Ig-like C2-type 3 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 38_74 | 18 | 1060 | Domain | Note=LRRNT |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 444_495 | 18 | 1060 | Domain | Note=LRRCT |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 499_598 | 18 | 1060 | Domain | Note=Ig-like C2-type 1 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 603_692 | 18 | 1060 | Domain | Note=Ig-like C2-type 2 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 697_783 | 18 | 1060 | Domain | Note=Ig-like C2-type 3 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 122_142 | 78 | 1120 | Repeat | Note=LRR 3 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 146_167 | 78 | 1120 | Repeat | Note=LRR 4 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 168_189 | 78 | 1120 | Repeat | Note=LRR 5 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 193_214 | 78 | 1120 | Repeat | Note=LRR 6 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 216_237 | 78 | 1120 | Repeat | Note=LRR 7 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 240_261 | 78 | 1120 | Repeat | Note=LRR 8 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 264_285 | 78 | 1120 | Repeat | Note=LRR 9 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 288_309 | 78 | 1120 | Repeat | Note=LRR 10 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 312_333 | 78 | 1120 | Repeat | Note=LRR 11 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 336_357 | 78 | 1120 | Repeat | Note=LRR 12 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 360_382 | 78 | 1120 | Repeat | Note=LRR 13 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 387_408 | 78 | 1120 | Repeat | Note=LRR 14 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 411_432 | 78 | 1120 | Repeat | Note=LRR 15 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 75_96 | 78 | 1120 | Repeat | Note=LRR 1 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 99_120 | 78 | 1120 | Repeat | Note=LRR 2 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 122_142 | 18 | 1060 | Repeat | Note=LRR 3 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 146_167 | 18 | 1060 | Repeat | Note=LRR 4 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 168_189 | 18 | 1060 | Repeat | Note=LRR 5 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 193_214 | 18 | 1060 | Repeat | Note=LRR 6 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 216_237 | 18 | 1060 | Repeat | Note=LRR 7 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 240_261 | 18 | 1060 | Repeat | Note=LRR 8 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 264_285 | 18 | 1060 | Repeat | Note=LRR 9 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 288_309 | 18 | 1060 | Repeat | Note=LRR 10 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 312_333 | 18 | 1060 | Repeat | Note=LRR 11 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 336_357 | 18 | 1060 | Repeat | Note=LRR 12 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 360_382 | 18 | 1060 | Repeat | Note=LRR 13 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 387_408 | 18 | 1060 | Repeat | Note=LRR 14 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 411_432 | 18 | 1060 | Repeat | Note=LRR 15 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 75_96 | 18 | 1060 | Repeat | Note=LRR 1 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 99_120 | 18 | 1060 | Repeat | Note=LRR 2 |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 810_830 | 78 | 1120 | Transmembrane | Helical |
| Tgene | >LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000379141 | - | 0 | 19 | 810_830 | 18 | 1060 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 1011_1102 | 196 | 1355 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 422_692 | 196 | 1355 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 636_980 | 196 | 1355 | Compositional bias | Note=Glu-rich |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 1118_1317 | 196 | 1355 | Domain | PH |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 341_409 | 196 | 1355 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 479_556 | 196 | 1355 | Domain | REM-1 |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 76_338 | 196 | 1355 | Domain | Protein kinase |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 949_1015 | 196 | 1355 | Domain | RhoBD |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 1115_1354 | 196 | 1355 | Region | Note=Auto-inhibitory |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 998_1010 | 196 | 1355 | Region | Note=RHOA binding |
| Hgene | >ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 1228_1281 | 196 | 1355 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | LRIG3 | chr18:18625253 | chr12:59308117 | ENST00000320743 | - | 0 | 19 | 38_74 | 78 | 1120 | Domain | Note=LRRNT |
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FusionGeneSequence for ROCK1_LRIG3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ROCK1_ENST00000399799_chr18_18625253_-_LRIG3_ENST00000379141_chr12_59308117_-_1238aa MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVTDLDFPALRKNKNIDNFLSRTKDTINKIRDLRMKAEDTEVVKVIGRGAFGEV QLVRHKSTRKVTAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFTAFQDDRTLYMVMEYMPGGDLVNLMSNTDVPEKWARFTTA EVVLALDAIHSMGFIHRDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDL SSNNISELQTAFPALQLKTLTLNSNRVTSMEPGTFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALK SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFL GLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAI MSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIK GSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENTAHLRAQGGEVMETTTILRLREVEFASEGKTQCVISNHFGSSYSVKAKLTVNML PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLT VLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRL SVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSTLSSQGTLADRQDGYV SSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATDLFLCPFLGSTGPMTLKGNVTGSDPFETTHTGCSPDPRTVLMDHTEP SYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNSFMGTFGKALRRPHLDA >In-frame_ROCK1_ENST00000399799_chr18_18625253_-_LRIG3_ENST00000320743_chr12_59308117_-_1238aa MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVTDLDFPALRKNKNIDNFLSRTKDTINKIRDLRMKAEDTEVVKVIGRGAFGEV QLVRHKSTRKVTAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFTAFQDDRTLYMVMEYMPGGDLVNLMSNTDVPEKWARFTTA EVVLALDAIHSMGFIHRDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDL SSNNISELQTAFPALQLKTLTLNSNRVTSMEPGTFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALK SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFL GLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAI MSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIK GSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENTAHLRAQGGEVMETTTILRLREVEFASEGKTQCVISNHFGSSYSVKAKLTVNML PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLT VLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRL SVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSTLSSQGTLADRQDGYV SSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATDLFLCPFLGSTGPMTLKGNVTGSDPFETTHTGCSPDPRTVLMDHTEP SYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNSFMGTFGKALRRPHLDA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ROCK1_ENST00000399799_chr18_18625253_-_LRIG3_ENST00000379141_chr12_59308117_-_3714nt ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG CTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAAGAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAA GACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATGAAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTT CAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTCTCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTT TTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTGTTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTAC ATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCAACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCA GAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACAGGGACTTAAGTCACAACAGATTATCTTTCATCAAGGCAAGT TCCATGAGCCACCTTCAAAGCCTTCGAGAAGTGAAACTGAACAACAATGAATTGGAGACCATTCCAAATCTGGGACCAGTCTCGGCAAAT ATTACACTTCTCTCCTTGGCTGGAAACAGGATTGTTGAAATACTCCCTGAACATCTGAAAGAGTTTCAGTCCCTTGAAACTTTGGACCTT AGCAGCAACAATATTTCAGAGCTCCAAACTGCATTTCCAGCCCTACAGCTCAAATATCTGTATCTCAACAGCAACCGAGTCACATCAATG GAACCTGGGTATTTTGACAATTTGGCCAACACACTCCTTGTGTTAAAGCTGAACAGGAACCGAATCTCAGCTATCCCACCCAAGATGTTT AAACTGCCCCAACTGCAACATCTCGAATTGAACCGAAACAAGATTAAAAATGTAGATGGACTGACATTCCAAGGCCTTGGTGCTCTGAAG TCTCTGAAAATGCAAAGAAATGGAGTAACGAAACTTATGGATGGAGCTTTTTGGGGGCTGAGCAACATGGAAATTTTGCAGCTGGACCAT AACAACCTAACAGAGATTACCAAAGGCTGGCTTTACGGCTTGCTGATGCTGCAGGAACTTCATCTCAGCCAAAATGCCATCAACAGGATC AGCCCTGATGCCTGGGAGTTCTGCCAGAAGCTCAGTGAGCTGGACCTAACTTTCAATCACTTATCAAGGTTAGATGATTCAAGCTTCCTT GGCCTAAGCTTACTAAATACACTGCACATTGGGAACAACAGAGTCAGCTACATTGCTGATTGTGCCTTCCGGGGGCTTTCCAGTTTAAAG ACTTTGGATCTGAAGAACAATGAAATTTCCTGGACTATTGAAGACATGAATGGTGCTTTCTCTGGGCTTGACAAACTGAGGCGACTGATA CTCCAAGGAAATCGGATCCGTTCTATTACTAAAAAAGCCTTCACTGGTTTGGATGCATTGGAGCATCTAGACCTGAGTGACAACGCAATC ATGTCTTTACAAGGCAATGCATTTTCACAAATGAAGAAACTGCAACAATTGCATTTAAATACATCAAGCCTTTTGTGCGATTGCCAGCTA AAATGGCTCCCACAGTGGGTGGCGGAAAACAACTTTCAGAGCTTTGTAAATGCCAGTTGTGCCCATCCTCAGCTGCTAAAAGGAAGAAGC ATTTTTGCTGTTAGCCCAGATGGCTTTGTGTGTGATGATTTTCCCAAACCCCAGATCACGGTTCAGCCAGAAACACAGTCGGCAATAAAA GGTTCCAATTTGAGTTTCATCTGCTCAGCTGCCAGCAGCAGTGATTCCCCAATGACTTTTGCTTGGAAAAAAGACAATGAACTACTGCAT GATGCTGAAATGGAAAATTATGCACACCTCCGGGCCCAAGGTGGCGAGGTGATGGAGTATACCACCATCCTTCGGCTGCGCGAGGTGGAA TTTGCCAGTGAGGGGAAATATCAGTGTGTCATCTCCAATCACTTTGGTTCATCCTACTCTGTCAAAGCCAAGCTTACAGTAAATATGCTT CCCTCATTCACCAAGACCCCCATGGATCTCACCATCCGAGCTGGGGCCATGGCACGCTTGGAGTGTGCTGCTGTGGGGCACCCAGCCCCC CAGATAGCCTGGCAGAAGGATGGGGGCACAGACTTCCCAGCTGCACGGGAGAGACGCATGCATGTGATGCCCGAGGATGACGTGTTCTTT ATCGTGGATGTGAAGATAGAGGACATTGGGGTATACAGCTGCACAGCTCAGAACAGTGCAGGAAGTATTTCAGCAAATGCAACTCTGACT GTCCTAGAAACACCATCATTTTTGCGGCCACTGTTGGACCGAACTGTAACCAAGGGAGAAACAGCCGTCCTACAGTGCATTGCTGGAGGA AGCCCTCCCCCTAAACTGAACTGGACCAAAGATGATAGCCCATTGGTGGTAACCGAGAGGCACTTTTTTGCAGCAGGCAATCAGCTTCTG ATTATTGTGGACTCAGATGTCAGTGATGCTGGGAAATACACATGTGAGATGTCTAACACCCTTGGCACTGAGAGAGGAAACGTGCGCCTC AGTGTGATCCCCACTCCAACCTGCGACTCCCCTCAGATGACAGCCCCATCGTTAGACGATGACGGATGGGCCACTGTGGGTGTCGTGATC ATAGCCGTGGTTTGCTGTGTGGTGGGCACGTCACTCGTGTGGGTGGTCATCATATACCACACAAGGCGGAGGAATGAAGATTGCAGCATT ACCAACACAGATGAGACCAACTTGCCAGCAGATATTCCTAGTTATTTGTCATCTCAGGGAACGTTAGCTGACAGGCAGGATGGGTACGTG TCTTCAGAAAGTGGAAGCCACCACCAGTTTGTCACATCTTCAGGTGCTGGATTTTTCTTACCACAACATGACAGTAGTGGGACCTGCCAT ATTGACAATAGCAGTGAAGCTGATGTGGAAGCTGCCACAGATCTGTTCCTTTGTCCGTTTTTGGGATCCACAGGCCCTATGTATTTGAAG GGAAATGTGTATGGCTCAGATCCTTTTGAAACATATCATACAGGTTGCAGTCCTGACCCAAGAACAGTTTTAATGGACCACTATGAGCCC AGTTACATAAAGAAAAAGGAGTGCTACCCATGTTCTCATCCTTCAGAAGAATCCTGCGAACGGAGCTTCAGTAATATATCGTGGCCTTCA CATGTGAGGAAGCTACTTAACACTAGTTACTCTCACAATGAAGGACCTGGAATGAAAAATCTGTGTCTAAACAAGTCCTCTTTAGATTTT AGTGCAAATCCAGAGCCAGCGTCGGTTGCCTCGAGTAATTCTTTCATGGGTACCTTTGGAAAAGCTCTCAGGAGACCTCACCTAGATGCC TATTCAAGCTTTGGACAGCCATCAGATTGTCAGCCAAGAGCCTTTTATTTGAAAGCTCATTCTTCCCCAGACTTGGACTCTGGGTCAGAG GAAGATGGGAAAGAAAGGACAGATTTTCAGGAAGAAAATCACATTTGTACCTTTAAACAGACTTTAGAAAACTACAGGACTCCAAATTTT >In-frame_ROCK1_ENST00000399799_chr18_18625253_-_LRIG3_ENST00000320743_chr12_59308117_-_3714nt ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG CTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAAGAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAA GACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATGAAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTT CAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTCTCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTT TTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTGTTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTAC ATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCAACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCA GAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACAGGGACTTAAGTCACAACAGATTATCTTTCATCAAGGCAAGT TCCATGAGCCACCTTCAAAGCCTTCGAGAAGTGAAACTGAACAACAATGAATTGGAGACCATTCCAAATCTGGGACCAGTCTCGGCAAAT ATTACACTTCTCTCCTTGGCTGGAAACAGGATTGTTGAAATACTCCCTGAACATCTGAAAGAGTTTCAGTCCCTTGAAACTTTGGACCTT AGCAGCAACAATATTTCAGAGCTCCAAACTGCATTTCCAGCCCTACAGCTCAAATATCTGTATCTCAACAGCAACCGAGTCACATCAATG GAACCTGGGTATTTTGACAATTTGGCCAACACACTCCTTGTGTTAAAGCTGAACAGGAACCGAATCTCAGCTATCCCACCCAAGATGTTT AAACTGCCCCAACTGCAACATCTCGAATTGAACCGAAACAAGATTAAAAATGTAGATGGACTGACATTCCAAGGCCTTGGTGCTCTGAAG TCTCTGAAAATGCAAAGAAATGGAGTAACGAAACTTATGGATGGAGCTTTTTGGGGGCTGAGCAACATGGAAATTTTGCAGCTGGACCAT AACAACCTAACAGAGATTACCAAAGGCTGGCTTTACGGCTTGCTGATGCTGCAGGAACTTCATCTCAGCCAAAATGCCATCAACAGGATC AGCCCTGATGCCTGGGAGTTCTGCCAGAAGCTCAGTGAGCTGGACCTAACTTTCAATCACTTATCAAGGTTAGATGATTCAAGCTTCCTT GGCCTAAGCTTACTAAATACACTGCACATTGGGAACAACAGAGTCAGCTACATTGCTGATTGTGCCTTCCGGGGGCTTTCCAGTTTAAAG ACTTTGGATCTGAAGAACAATGAAATTTCCTGGACTATTGAAGACATGAATGGTGCTTTCTCTGGGCTTGACAAACTGAGGCGACTGATA CTCCAAGGAAATCGGATCCGTTCTATTACTAAAAAAGCCTTCACTGGTTTGGATGCATTGGAGCATCTAGACCTGAGTGACAACGCAATC ATGTCTTTACAAGGCAATGCATTTTCACAAATGAAGAAACTGCAACAATTGCATTTAAATACATCAAGCCTTTTGTGCGATTGCCAGCTA AAATGGCTCCCACAGTGGGTGGCGGAAAACAACTTTCAGAGCTTTGTAAATGCCAGTTGTGCCCATCCTCAGCTGCTAAAAGGAAGAAGC ATTTTTGCTGTTAGCCCAGATGGCTTTGTGTGTGATGATTTTCCCAAACCCCAGATCACGGTTCAGCCAGAAACACAGTCGGCAATAAAA GGTTCCAATTTGAGTTTCATCTGCTCAGCTGCCAGCAGCAGTGATTCCCCAATGACTTTTGCTTGGAAAAAAGACAATGAACTACTGCAT GATGCTGAAATGGAAAATTATGCACACCTCCGGGCCCAAGGTGGCGAGGTGATGGAGTATACCACCATCCTTCGGCTGCGCGAGGTGGAA TTTGCCAGTGAGGGGAAATATCAGTGTGTCATCTCCAATCACTTTGGTTCATCCTACTCTGTCAAAGCCAAGCTTACAGTAAATATGCTT CCCTCATTCACCAAGACCCCCATGGATCTCACCATCCGAGCTGGGGCCATGGCACGCTTGGAGTGTGCTGCTGTGGGGCACCCAGCCCCC CAGATAGCCTGGCAGAAGGATGGGGGCACAGACTTCCCAGCTGCACGGGAGAGACGCATGCATGTGATGCCCGAGGATGACGTGTTCTTT ATCGTGGATGTGAAGATAGAGGACATTGGGGTATACAGCTGCACAGCTCAGAACAGTGCAGGAAGTATTTCAGCAAATGCAACTCTGACT GTCCTAGAAACACCATCATTTTTGCGGCCACTGTTGGACCGAACTGTAACCAAGGGAGAAACAGCCGTCCTACAGTGCATTGCTGGAGGA AGCCCTCCCCCTAAACTGAACTGGACCAAAGATGATAGCCCATTGGTGGTAACCGAGAGGCACTTTTTTGCAGCAGGCAATCAGCTTCTG ATTATTGTGGACTCAGATGTCAGTGATGCTGGGAAATACACATGTGAGATGTCTAACACCCTTGGCACTGAGAGAGGAAACGTGCGCCTC AGTGTGATCCCCACTCCAACCTGCGACTCCCCTCAGATGACAGCCCCATCGTTAGACGATGACGGATGGGCCACTGTGGGTGTCGTGATC ATAGCCGTGGTTTGCTGTGTGGTGGGCACGTCACTCGTGTGGGTGGTCATCATATACCACACAAGGCGGAGGAATGAAGATTGCAGCATT ACCAACACAGATGAGACCAACTTGCCAGCAGATATTCCTAGTTATTTGTCATCTCAGGGAACGTTAGCTGACAGGCAGGATGGGTACGTG TCTTCAGAAAGTGGAAGCCACCACCAGTTTGTCACATCTTCAGGTGCTGGATTTTTCTTACCACAACATGACAGTAGTGGGACCTGCCAT ATTGACAATAGCAGTGAAGCTGATGTGGAAGCTGCCACAGATCTGTTCCTTTGTCCGTTTTTGGGATCCACAGGCCCTATGTATTTGAAG GGAAATGTGTATGGCTCAGATCCTTTTGAAACATATCATACAGGTTGCAGTCCTGACCCAAGAACAGTTTTAATGGACCACTATGAGCCC AGTTACATAAAGAAAAAGGAGTGCTACCCATGTTCTCATCCTTCAGAAGAATCCTGCGAACGGAGCTTCAGTAATATATCGTGGCCTTCA CATGTGAGGAAGCTACTTAACACTAGTTACTCTCACAATGAAGGACCTGGAATGAAAAATCTGTGTCTAAACAAGTCCTCTTTAGATTTT AGTGCAAATCCAGAGCCAGCGTCGGTTGCCTCGAGTAATTCTTTCATGGGTACCTTTGGAAAAGCTCTCAGGAGACCTCACCTAGATGCC TATTCAAGCTTTGGACAGCCATCAGATTGTCAGCCAAGAGCCTTTTATTTGAAAGCTCATTCTTCCCCAGACTTGGACTCTGGGTCAGAG GAAGATGGGAAAGAAAGGACAGATTTTCAGGAAGAAAATCACATTTGTACCTTTAAACAGACTTTAGAAAACTACAGGACTCCAAATTTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ROCK1_ENST00000399799_chr18_18625253_-_LRIG3_ENST00000379141_chr12_59308117_-_5078nt GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAA GAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAAGACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATG AAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTC TCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTTTTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTG TTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCA ACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCAGAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACA GGGACTTAAGTCACAACAGATTATCTTTCATCAAGGCAAGTTCCATGAGCCACCTTCAAAGCCTTCGAGAAGTGAAACTGAACAACAATG AATTGGAGACCATTCCAAATCTGGGACCAGTCTCGGCAAATATTACACTTCTCTCCTTGGCTGGAAACAGGATTGTTGAAATACTCCCTG AACATCTGAAAGAGTTTCAGTCCCTTGAAACTTTGGACCTTAGCAGCAACAATATTTCAGAGCTCCAAACTGCATTTCCAGCCCTACAGC TCAAATATCTGTATCTCAACAGCAACCGAGTCACATCAATGGAACCTGGGTATTTTGACAATTTGGCCAACACACTCCTTGTGTTAAAGC TGAACAGGAACCGAATCTCAGCTATCCCACCCAAGATGTTTAAACTGCCCCAACTGCAACATCTCGAATTGAACCGAAACAAGATTAAAA ATGTAGATGGACTGACATTCCAAGGCCTTGGTGCTCTGAAGTCTCTGAAAATGCAAAGAAATGGAGTAACGAAACTTATGGATGGAGCTT TTTGGGGGCTGAGCAACATGGAAATTTTGCAGCTGGACCATAACAACCTAACAGAGATTACCAAAGGCTGGCTTTACGGCTTGCTGATGC TGCAGGAACTTCATCTCAGCCAAAATGCCATCAACAGGATCAGCCCTGATGCCTGGGAGTTCTGCCAGAAGCTCAGTGAGCTGGACCTAA CTTTCAATCACTTATCAAGGTTAGATGATTCAAGCTTCCTTGGCCTAAGCTTACTAAATACACTGCACATTGGGAACAACAGAGTCAGCT ACATTGCTGATTGTGCCTTCCGGGGGCTTTCCAGTTTAAAGACTTTGGATCTGAAGAACAATGAAATTTCCTGGACTATTGAAGACATGA ATGGTGCTTTCTCTGGGCTTGACAAACTGAGGCGACTGATACTCCAAGGAAATCGGATCCGTTCTATTACTAAAAAAGCCTTCACTGGTT TGGATGCATTGGAGCATCTAGACCTGAGTGACAACGCAATCATGTCTTTACAAGGCAATGCATTTTCACAAATGAAGAAACTGCAACAAT TGCATTTAAATACATCAAGCCTTTTGTGCGATTGCCAGCTAAAATGGCTCCCACAGTGGGTGGCGGAAAACAACTTTCAGAGCTTTGTAA ATGCCAGTTGTGCCCATCCTCAGCTGCTAAAAGGAAGAAGCATTTTTGCTGTTAGCCCAGATGGCTTTGTGTGTGATGATTTTCCCAAAC CCCAGATCACGGTTCAGCCAGAAACACAGTCGGCAATAAAAGGTTCCAATTTGAGTTTCATCTGCTCAGCTGCCAGCAGCAGTGATTCCC CAATGACTTTTGCTTGGAAAAAAGACAATGAACTACTGCATGATGCTGAAATGGAAAATTATGCACACCTCCGGGCCCAAGGTGGCGAGG TGATGGAGTATACCACCATCCTTCGGCTGCGCGAGGTGGAATTTGCCAGTGAGGGGAAATATCAGTGTGTCATCTCCAATCACTTTGGTT CATCCTACTCTGTCAAAGCCAAGCTTACAGTAAATATGCTTCCCTCATTCACCAAGACCCCCATGGATCTCACCATCCGAGCTGGGGCCA TGGCACGCTTGGAGTGTGCTGCTGTGGGGCACCCAGCCCCCCAGATAGCCTGGCAGAAGGATGGGGGCACAGACTTCCCAGCTGCACGGG AGAGACGCATGCATGTGATGCCCGAGGATGACGTGTTCTTTATCGTGGATGTGAAGATAGAGGACATTGGGGTATACAGCTGCACAGCTC AGAACAGTGCAGGAAGTATTTCAGCAAATGCAACTCTGACTGTCCTAGAAACACCATCATTTTTGCGGCCACTGTTGGACCGAACTGTAA CCAAGGGAGAAACAGCCGTCCTACAGTGCATTGCTGGAGGAAGCCCTCCCCCTAAACTGAACTGGACCAAAGATGATAGCCCATTGGTGG TAACCGAGAGGCACTTTTTTGCAGCAGGCAATCAGCTTCTGATTATTGTGGACTCAGATGTCAGTGATGCTGGGAAATACACATGTGAGA TGTCTAACACCCTTGGCACTGAGAGAGGAAACGTGCGCCTCAGTGTGATCCCCACTCCAACCTGCGACTCCCCTCAGATGACAGCCCCAT CGTTAGACGATGACGGATGGGCCACTGTGGGTGTCGTGATCATAGCCGTGGTTTGCTGTGTGGTGGGCACGTCACTCGTGTGGGTGGTCA TCATATACCACACAAGGCGGAGGAATGAAGATTGCAGCATTACCAACACAGATGAGACCAACTTGCCAGCAGATATTCCTAGTTATTTGT CATCTCAGGGAACGTTAGCTGACAGGCAGGATGGGTACGTGTCTTCAGAAAGTGGAAGCCACCACCAGTTTGTCACATCTTCAGGTGCTG GATTTTTCTTACCACAACATGACAGTAGTGGGACCTGCCATATTGACAATAGCAGTGAAGCTGATGTGGAAGCTGCCACAGATCTGTTCC TTTGTCCGTTTTTGGGATCCACAGGCCCTATGTATTTGAAGGGAAATGTGTATGGCTCAGATCCTTTTGAAACATATCATACAGGTTGCA GTCCTGACCCAAGAACAGTTTTAATGGACCACTATGAGCCCAGTTACATAAAGAAAAAGGAGTGCTACCCATGTTCTCATCCTTCAGAAG AATCCTGCGAACGGAGCTTCAGTAATATATCGTGGCCTTCACATGTGAGGAAGCTACTTAACACTAGTTACTCTCACAATGAAGGACCTG GAATGAAAAATCTGTGTCTAAACAAGTCCTCTTTAGATTTTAGTGCAAATCCAGAGCCAGCGTCGGTTGCCTCGAGTAATTCTTTCATGG GTACCTTTGGAAAAGCTCTCAGGAGACCTCACCTAGATGCCTATTCAAGCTTTGGACAGCCATCAGATTGTCAGCCAAGAGCCTTTTATT TGAAAGCTCATTCTTCCCCAGACTTGGACTCTGGGTCAGAGGAAGATGGGAAAGAAAGGACAGATTTTCAGGAAGAAAATCACATTTGTA CCTTTAAACAGACTTTAGAAAACTACAGGACTCCAAATTTTCAGTCTTATGACTTGGACACATAGACTGAATGAGACCAAAGGAAAAGCT TAACATACTACCTCAAGTGAACTTTTATTTAAAAGAGAGAGAATCTTATGTTTTTTAAATGGAGTTATGAATTTTAAAAGGATAAAAATG CTTTATTTATACAGATGAACCAAAATTACAAAAAGTTATGAAAATTTTTATACTGGGAATGATGCTCATATAAGAATACCTTTTTAAACT ATTTTTTAACTTTGTTTTATGCAAAAAAGTATCTTACGTAAATTAATGATATAAATCATGATTATTTTATGTATTTTTATAATGCCAGAT TTCTTTTTATGGAAAATGAGTTACTAAAGCATTTTAAATAATACCTGCCTTGTACCATTTTTTAAATAGAAGTTACTTCATTATATTTTG >In-frame_ROCK1_ENST00000399799_chr18_18625253_-_LRIG3_ENST00000320743_chr12_59308117_-_5078nt GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAA GAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAAGACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATG AAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTC TCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTTTTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTG TTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCA ACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCAGAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACA GGGACTTAAGTCACAACAGATTATCTTTCATCAAGGCAAGTTCCATGAGCCACCTTCAAAGCCTTCGAGAAGTGAAACTGAACAACAATG AATTGGAGACCATTCCAAATCTGGGACCAGTCTCGGCAAATATTACACTTCTCTCCTTGGCTGGAAACAGGATTGTTGAAATACTCCCTG AACATCTGAAAGAGTTTCAGTCCCTTGAAACTTTGGACCTTAGCAGCAACAATATTTCAGAGCTCCAAACTGCATTTCCAGCCCTACAGC TCAAATATCTGTATCTCAACAGCAACCGAGTCACATCAATGGAACCTGGGTATTTTGACAATTTGGCCAACACACTCCTTGTGTTAAAGC TGAACAGGAACCGAATCTCAGCTATCCCACCCAAGATGTTTAAACTGCCCCAACTGCAACATCTCGAATTGAACCGAAACAAGATTAAAA ATGTAGATGGACTGACATTCCAAGGCCTTGGTGCTCTGAAGTCTCTGAAAATGCAAAGAAATGGAGTAACGAAACTTATGGATGGAGCTT TTTGGGGGCTGAGCAACATGGAAATTTTGCAGCTGGACCATAACAACCTAACAGAGATTACCAAAGGCTGGCTTTACGGCTTGCTGATGC TGCAGGAACTTCATCTCAGCCAAAATGCCATCAACAGGATCAGCCCTGATGCCTGGGAGTTCTGCCAGAAGCTCAGTGAGCTGGACCTAA CTTTCAATCACTTATCAAGGTTAGATGATTCAAGCTTCCTTGGCCTAAGCTTACTAAATACACTGCACATTGGGAACAACAGAGTCAGCT ACATTGCTGATTGTGCCTTCCGGGGGCTTTCCAGTTTAAAGACTTTGGATCTGAAGAACAATGAAATTTCCTGGACTATTGAAGACATGA ATGGTGCTTTCTCTGGGCTTGACAAACTGAGGCGACTGATACTCCAAGGAAATCGGATCCGTTCTATTACTAAAAAAGCCTTCACTGGTT TGGATGCATTGGAGCATCTAGACCTGAGTGACAACGCAATCATGTCTTTACAAGGCAATGCATTTTCACAAATGAAGAAACTGCAACAAT TGCATTTAAATACATCAAGCCTTTTGTGCGATTGCCAGCTAAAATGGCTCCCACAGTGGGTGGCGGAAAACAACTTTCAGAGCTTTGTAA ATGCCAGTTGTGCCCATCCTCAGCTGCTAAAAGGAAGAAGCATTTTTGCTGTTAGCCCAGATGGCTTTGTGTGTGATGATTTTCCCAAAC CCCAGATCACGGTTCAGCCAGAAACACAGTCGGCAATAAAAGGTTCCAATTTGAGTTTCATCTGCTCAGCTGCCAGCAGCAGTGATTCCC CAATGACTTTTGCTTGGAAAAAAGACAATGAACTACTGCATGATGCTGAAATGGAAAATTATGCACACCTCCGGGCCCAAGGTGGCGAGG TGATGGAGTATACCACCATCCTTCGGCTGCGCGAGGTGGAATTTGCCAGTGAGGGGAAATATCAGTGTGTCATCTCCAATCACTTTGGTT CATCCTACTCTGTCAAAGCCAAGCTTACAGTAAATATGCTTCCCTCATTCACCAAGACCCCCATGGATCTCACCATCCGAGCTGGGGCCA TGGCACGCTTGGAGTGTGCTGCTGTGGGGCACCCAGCCCCCCAGATAGCCTGGCAGAAGGATGGGGGCACAGACTTCCCAGCTGCACGGG AGAGACGCATGCATGTGATGCCCGAGGATGACGTGTTCTTTATCGTGGATGTGAAGATAGAGGACATTGGGGTATACAGCTGCACAGCTC AGAACAGTGCAGGAAGTATTTCAGCAAATGCAACTCTGACTGTCCTAGAAACACCATCATTTTTGCGGCCACTGTTGGACCGAACTGTAA CCAAGGGAGAAACAGCCGTCCTACAGTGCATTGCTGGAGGAAGCCCTCCCCCTAAACTGAACTGGACCAAAGATGATAGCCCATTGGTGG TAACCGAGAGGCACTTTTTTGCAGCAGGCAATCAGCTTCTGATTATTGTGGACTCAGATGTCAGTGATGCTGGGAAATACACATGTGAGA TGTCTAACACCCTTGGCACTGAGAGAGGAAACGTGCGCCTCAGTGTGATCCCCACTCCAACCTGCGACTCCCCTCAGATGACAGCCCCAT CGTTAGACGATGACGGATGGGCCACTGTGGGTGTCGTGATCATAGCCGTGGTTTGCTGTGTGGTGGGCACGTCACTCGTGTGGGTGGTCA TCATATACCACACAAGGCGGAGGAATGAAGATTGCAGCATTACCAACACAGATGAGACCAACTTGCCAGCAGATATTCCTAGTTATTTGT CATCTCAGGGAACGTTAGCTGACAGGCAGGATGGGTACGTGTCTTCAGAAAGTGGAAGCCACCACCAGTTTGTCACATCTTCAGGTGCTG GATTTTTCTTACCACAACATGACAGTAGTGGGACCTGCCATATTGACAATAGCAGTGAAGCTGATGTGGAAGCTGCCACAGATCTGTTCC TTTGTCCGTTTTTGGGATCCACAGGCCCTATGTATTTGAAGGGAAATGTGTATGGCTCAGATCCTTTTGAAACATATCATACAGGTTGCA GTCCTGACCCAAGAACAGTTTTAATGGACCACTATGAGCCCAGTTACATAAAGAAAAAGGAGTGCTACCCATGTTCTCATCCTTCAGAAG AATCCTGCGAACGGAGCTTCAGTAATATATCGTGGCCTTCACATGTGAGGAAGCTACTTAACACTAGTTACTCTCACAATGAAGGACCTG GAATGAAAAATCTGTGTCTAAACAAGTCCTCTTTAGATTTTAGTGCAAATCCAGAGCCAGCGTCGGTTGCCTCGAGTAATTCTTTCATGG GTACCTTTGGAAAAGCTCTCAGGAGACCTCACCTAGATGCCTATTCAAGCTTTGGACAGCCATCAGATTGTCAGCCAAGAGCCTTTTATT TGAAAGCTCATTCTTCCCCAGACTTGGACTCTGGGTCAGAGGAAGATGGGAAAGAAAGGACAGATTTTCAGGAAGAAAATCACATTTGTA CCTTTAAACAGACTTTAGAAAACTACAGGACTCCAAATTTTCAGTCTTATGACTTGGACACATAGACTGAATGAGACCAAAGGAAAAGCT TAACATACTACCTCAAGTGAACTTTTATTTAAAAGAGAGAGAATCTTATGTTTTTTAAATGGAGTTATGAATTTTAAAAGGATAAAAATG CTTTATTTATACAGATGAACCAAAATTACAAAAAGTTATGAAAATTTTTATACTGGGAATGATGCTCATATAAGAATACCTTTTTAAACT ATTTTTTAACTTTGTTTTATGCAAAAAAGTATCTTACGTAAATTAATGATATAAATCATGATTATTTTATGTATTTTTATAATGCCAGAT TTCTTTTTATGGAAAATGAGTTACTAAAGCATTTTAAATAATACCTGCCTTGTACCATTTTTTAAATAGAAGTTACTTCATTATATTTTG |
Top |
FusionGenePPI for ROCK1_LRIG3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ROCK1 | CDC25A, PFN2, RHOA, RND3, GAB1, CFL1, LIMK2, HNRNPA1, ITSN2, ARRB1, TSG101, NOTCH1, SMURF1, SMAD2, CASP3, CASP7, CDK15, ANKFY1, MON2, FAM21A, KIAA1033, IKBKB, LMO2, MAGEB4, POLR3C, C6orf165, FAM124A, NXF1, NTRK1, MED23, XRCC5, NEIL3, TRIM15, HGS, SLC9A1, UBE2T, CDKN3, TENC1, ROCK2, ADD2, IL20RA, CYLD | LRIG3 | CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ROCK1 | chr18:18625253 | chr12:59308117 | ENST00000399799 | - | 5 | 33 | 368_727 | 196 | 1355 | FHOD1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ROCK1_LRIG3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ROCK1_LRIG3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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