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Fusion gene ID: 31681 |
FusionGeneSummary for ROCK1_CIDEA |
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Fusion gene information | Fusion gene name: ROCK1_CIDEA | Fusion gene ID: 31681 | Hgene | Tgene | Gene symbol | ROCK1 | CIDEA | Gene ID | 6093 | 1149 |
Gene name | Rho associated coiled-coil containing protein kinase 1 | cell death-inducing DFFA-like effector a | |
Synonyms | P160ROCK|ROCK-I | CIDE-A | |
Cytomap | 18q11.1 | 18p11.21|18 | |
Type of gene | protein-coding | protein-coding | |
Description | rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35 | cell death activator CIDE-A | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q13464 | O60543 | |
Ensembl transtripts involved in fusion gene | ENST00000399799, | ENST00000320477, ENST00000521296, | |
Fusion gene scores | * DoF score | 21 X 11 X 11=2541 | 2 X 2 X 2=8 |
# samples | 23 | 2 | |
** MAII score | log2(23/2541*10)=-3.46569060910898 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ROCK1 [Title/Abstract] AND CIDEA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ROCK1 | GO:0007159 | leukocyte cell-cell adhesion | 12082081 |
Hgene | ROCK1 | GO:0022614 | membrane to membrane docking | 12082081 |
Hgene | ROCK1 | GO:0032091 | negative regulation of protein binding | 18573880 |
Hgene | ROCK1 | GO:0032956 | regulation of actin cytoskeleton organization | 25911094 |
Hgene | ROCK1 | GO:0050900 | leukocyte migration | 12082081 |
Hgene | ROCK1 | GO:0050901 | leukocyte tethering or rolling | 12082081 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-L5-A8NE-01A | ROCK1 | chr18 | 18691436 | - | CIDEA | chr18 | 12262824 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000399799 | ENST00000320477 | ROCK1 | chr18 | 18691436 | - | CIDEA | chr18 | 12262824 | + |
intron-3UTR | ENST00000399799 | ENST00000521296 | ROCK1 | chr18 | 18691436 | - | CIDEA | chr18 | 12262824 | + |
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FusionProtFeatures for ROCK1_CIDEA |
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Hgene | Tgene |
ROCK1 | CIDEA |
Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2,MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and actssynergistically with it to promote SRC-dependent non-apoptoticplasma membrane blebbing. Phosphorylates JIP3 and regulates therecruitment of JNK to JIP3 upon UVB-induced stress. Acts as asuppressor of inflammatory cell migration by regulating PTENphosphorylation and stability. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Required forcentrosome positioning and centrosome-dependent exit from mitosis.Plays a role in terminal erythroid differentiation. May regulateclosure of the eyelids and ventral body wall by inducing theassembly of actomyosin bundles. Promotes keratinocyte terminaldifferentiation. Involved in osteoblast compaction through thefibronectin fibrillogenesis cell-mediated matrix assembly process,essential for osteoblast mineralization.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353,ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607,ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880,ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714,ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057,ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. | Acts as a CEBPB coactivator in mammary epithelial cellsto control the expression of a subset of CEBPB downstream targetgenes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but notcasein. By interacting with CEBPB, strengthens the association ofCEBPB with the XDH promoter, increases histone acetylation anddissociates HDAC1 from the promoter (By similarity). Binds tolipid droplets and regulates their enlargement, therebyrestricting lipolysis and favoring storage. At focal contact sitesbetween lipid droplets, promotes directional net neutral lipidtransfer from the smaller to larger lipid droplets. The transferdirection may be driven by the internal pressure differencebetween the contacting lipid droplet pair and occurs at a lowerrate than that promoted by CIDEC. When overexpressed, inducesapoptosis. The physiological significance of its role in apoptosisis unclear. {ECO:0000250, ECO:0000269|PubMed:19843876}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ROCK1_CIDEA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ROCK1_CIDEA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ROCK1 | CDC25A, PFN2, RHOA, RND3, GAB1, CFL1, LIMK2, HNRNPA1, ITSN2, ARRB1, TSG101, NOTCH1, SMURF1, SMAD2, CASP3, CASP7, CDK15, ANKFY1, MON2, FAM21A, KIAA1033, IKBKB, LMO2, MAGEB4, POLR3C, C6orf165, FAM124A, NXF1, NTRK1, MED23, XRCC5, NEIL3, TRIM15, HGS, SLC9A1, UBE2T, CDKN3, TENC1, ROCK2, ADD2, IL20RA, CYLD | CIDEA | ZBTB16, CIDEB, PRKAB1, IGHG2, PKP1, S100A14, SERPINA12, PKP3, CIDEC, ICAM1, KPRP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ROCK1_CIDEA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ROCK1_CIDEA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CIDEA | C0018801 | Heart failure | 1 | CTD_human |
Tgene | CIDEA | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CIDEA | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | CIDEA | C0028754 | Obesity | 1 | CTD_human |