FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31675

FusionGeneSummary for ROCK1_ANKRD29

check button Fusion gene summary
Fusion gene informationFusion gene name: ROCK1_ANKRD29
Fusion gene ID: 31675
HgeneTgene
Gene symbol

ROCK1

ANKRD29

Gene ID

6093

147463

Gene nameRho associated coiled-coil containing protein kinase 1ankyrin repeat domain 29
SynonymsP160ROCK|ROCK-I-
Cytomap

18q11.1

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionrho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35ankyrin repeat domain-containing protein 29
Modification date2018052720180519
UniProtAcc

Q13464

Q8N6D5

Ensembl transtripts involved in fusion geneENST00000399799, ENST00000592179, 
ENST00000322980, ENST00000585908, 
ENST00000284207, ENST00000586511, 
Fusion gene scores* DoF score21 X 11 X 11=25416 X 4 X 6=144
# samples 238
** MAII scorelog2(23/2541*10)=-3.46569060910898
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROCK1 [Title/Abstract] AND ANKRD29 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROCK1

GO:0007159

leukocyte cell-cell adhesion

12082081

HgeneROCK1

GO:0022614

membrane to membrane docking

12082081

HgeneROCK1

GO:0032091

negative regulation of protein binding

18573880

HgeneROCK1

GO:0032956

regulation of actin cytoskeleton organization

25911094

HgeneROCK1

GO:0050900

leukocyte migration

12082081

HgeneROCK1

GO:0050901

leukocyte tethering or rolling

12082081


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-IB-A7M4-01AROCK1chr18

18595392

-ANKRD29chr18

21181273

-
TCGARVSTADTCGA-BR-8677-01AROCK1chr18

18690779

-ANKRD29chr18

21229157

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000399799ENST00000592179ROCK1chr18

18595392

-ANKRD29chr18

21181273

-
In-frameENST00000399799ENST00000322980ROCK1chr18

18595392

-ANKRD29chr18

21181273

-
5CDS-intronENST00000399799ENST00000585908ROCK1chr18

18595392

-ANKRD29chr18

21181273

-
5CDS-intronENST00000399799ENST00000284207ROCK1chr18

18595392

-ANKRD29chr18

21181273

-
5CDS-intronENST00000399799ENST00000586511ROCK1chr18

18595392

-ANKRD29chr18

21181273

-
In-frameENST00000399799ENST00000592179ROCK1chr18

18690779

-ANKRD29chr18

21229157

-
In-frameENST00000399799ENST00000322980ROCK1chr18

18690779

-ANKRD29chr18

21229157

-
Frame-shitENST00000399799ENST00000585908ROCK1chr18

18690779

-ANKRD29chr18

21229157

-
In-frameENST00000399799ENST00000284207ROCK1chr18

18690779

-ANKRD29chr18

21229157

-
5CDS-intronENST00000399799ENST00000586511ROCK1chr18

18690779

-ANKRD29chr18

21229157

-

Top

FusionProtFeatures for ROCK1_ANKRD29


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROCK1

Q13464

ANKRD29

Q8N6D5

Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2,MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and actssynergistically with it to promote SRC-dependent non-apoptoticplasma membrane blebbing. Phosphorylates JIP3 and regulates therecruitment of JNK to JIP3 upon UVB-induced stress. Acts as asuppressor of inflammatory cell migration by regulating PTENphosphorylation and stability. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Required forcentrosome positioning and centrosome-dependent exit from mitosis.Plays a role in terminal erythroid differentiation. May regulateclosure of the eyelids and ventral body wall by inducing theassembly of actomyosin bundles. Promotes keratinocyte terminaldifferentiation. Involved in osteoblast compaction through thefibronectin fibrillogenesis cell-mediated matrix assembly process,essential for osteoblast mineralization.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353,ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607,ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880,ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714,ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057,ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKRD29chr18:18690779chr18:21229157ENST00000322980-09111_1407269RepeatNote=ANK 4
TgeneANKRD29chr18:18690779chr18:21229157ENST00000322980-0911_417269RepeatNote=ANK 1
TgeneANKRD29chr18:18690779chr18:21229157ENST00000322980-09144_1737269RepeatNote=ANK 5
TgeneANKRD29chr18:18690779chr18:21229157ENST00000322980-09177_2067269RepeatNote=ANK 6
TgeneANKRD29chr18:18690779chr18:21229157ENST00000322980-09210_2397269RepeatNote=ANK 7
TgeneANKRD29chr18:18690779chr18:21229157ENST00000322980-09242_2717269RepeatNote=ANK 8
TgeneANKRD29chr18:18690779chr18:21229157ENST00000322980-0945_747269RepeatNote=ANK 2
TgeneANKRD29chr18:18690779chr18:21229157ENST00000322980-0978_1077269RepeatNote=ANK 3
TgeneANKRD29chr18:18690779chr18:21229157ENST00000592179-010111_1407302RepeatNote=ANK 4
TgeneANKRD29chr18:18690779chr18:21229157ENST00000592179-01011_417302RepeatNote=ANK 1
TgeneANKRD29chr18:18690779chr18:21229157ENST00000592179-010144_1737302RepeatNote=ANK 5
TgeneANKRD29chr18:18690779chr18:21229157ENST00000592179-010177_2067302RepeatNote=ANK 6
TgeneANKRD29chr18:18690779chr18:21229157ENST00000592179-010210_2397302RepeatNote=ANK 7
TgeneANKRD29chr18:18690779chr18:21229157ENST00000592179-010242_2717302RepeatNote=ANK 8
TgeneANKRD29chr18:18690779chr18:21229157ENST00000592179-01045_747302RepeatNote=ANK 2
TgeneANKRD29chr18:18690779chr18:21229157ENST00000592179-01078_1077302RepeatNote=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-1331011_1102311355Coiled coilOntology_term=ECO:0000255
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-133422_692311355Coiled coilOntology_term=ECO:0000255
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-133636_980311355Compositional biasNote=Glu-rich
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-1331118_1317311355DomainPH
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-133341_409311355DomainNote=AGC-kinase C-terminal
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-133479_556311355DomainREM-1
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-13376_338311355DomainProtein kinase
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-133949_1015311355DomainRhoBD
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-13382_90311355Nucleotide bindingATP
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-1331115_1354311355RegionNote=Auto-inhibitory
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-133998_1010311355RegionNote=RHOA binding
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-1331228_1281311355Zinc fingerPhorbol-ester/DAG-type


Top

FusionGeneSequence for ROCK1_ANKRD29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ROCK1_ENST00000399799_chr18_18595392_-_ANKRD29_ENST00000322980_chr18_21181273_-_498aa
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVTDLDFPALRKNKNIDNFLSRTKDTINKIRDLRMKAEDTEVVKVIGRGAFGEV
QLVRHKSTRKVTAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFTAFQDDRTLYMVMEYMPGGDLVNLMSNTDVPEKWARFTTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDTISPEVLKSQGGDGTTGRECDWWSVGVFLYE
MLVGDTPFTADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTTTSNRRYLSSANPNDNRTSSNADKSLQESLQKTITKLEEQLHNEMQLKDEME

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000592179_chr18_21229157_-_326aa
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV
LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLTDGATALFLAAQGG
YLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGTNDVIKELLKFSPTLGILKNGTSA

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000322980_chr18_21229157_-_293aa
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV
LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLTDGATALFLAAQGG
YLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGTNDVIKELLKFSPTLGILKANELP

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000284207_chr18_21229157_-_293aa
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV
LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLTDGATALFLAAQGG
YLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGTNDVIKELLKFSPTLGILKANELP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ROCK1_ENST00000399799_chr18_18595392_-_ANKRD29_ENST00000322980_chr18_21181273_-_1494nt
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG
CTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAAGAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAA
GACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATGAAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTT
CAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTCTCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTT
TTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTGTTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTAC
ATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCAACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCA
GAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACAGAGATGTGAAGCCTGATAACATGCTGCTGGATAAATCTGGA
CATTTGAAGTTAGCAGATTTTGGTACTTGTATGAAGATGAATAAGGAAGGCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTAT
ATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAAGAGAATGTGACTGGTGGTCGGTTGGGGTATTTTTATACGAA
ATGCTTGTAGGTGATACACCTTTTTATGCAGATTCTTTGGTTGGAACTTACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCT
GATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCCTTACTGACAGGGAAGTGAGGTTAGGGCGAAATGGTGTAGAA
GAAATCAAACGACATCTCTTCTTCAAAAATGACCAGTGGGCTTGGGAAACGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGT
AGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAGAGGAAGAAACATTCCCTATTCCTAAAGCTTTCGTTGGCAAT
CAACTACCTTTTGTAGGATTTACATATTATAGCAATCGTAGATACTTATCTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCA
GATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAGAACAGCTGCATAATGAAATGCAGTTAAAAGATGAAATGGAG
CAGAAGTGCAGAACCTCAAACATAAAACTAGACAAGATAATGAAAGAATTGGATGAAGAGGCCAATGAACTTCCGGCAGAACTAACCAAA

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000592179_chr18_21229157_-_978nt
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG
CTGAAGGAAACTCCACTTGCCAATGCTGCATTCTGGGCAGCCAGGAGAGGAAACCTGGCGCTGCTGAAGCTGCTGTTGAACAGCGGCCGG
GTGGACGTGGACTGCAGAGACAGCCATGGCACCACACTCCTGATGGTTGCTGCCTACGCTGGCCACATAGACTGTGTGAGGGAACTGGTT
CTGCAAGGAGCAGACATCAATCTCCAGAGAGAGTCAGGTACAACTGCCCTATTCTTTGCCGCCCAGCAAGGCCATAATGATGTCGTGAGA
TTTCTCTTTGGATTTGGAGCATCCACTGAATTTAGGACCAAAGACGGGGGCACCGCCCTGTTGGCTGCCAGTCAGTACGGGCACATGCAG
GTGGTGGAGACCTTGCTGAAGCACGGAGCAAACATCCATGACCAACTTTATGATGGAGCCACTGCCCTCTTCCTAGCTGCCCAAGGTGGT
TACTTGGATGTTATTCGATTACTGCTGGCTTCAGGAGCAAAAGTCAACCAGCCAAGGCAGGACGGGACAGCGCCCCTGTGGATCGCGTCC
CAGATGGGCCACAGCGAGGTGGTGCGGGTGATGCTGCTGCGCGGAGCCGACCGCGACGCTGCGCGGAACGATGGCACAACAGCATTATTG
AAAGCAGCCAACAAAGGGTATAATGATGTCATAAAAGAGTTGCTTAAATTCTCACCCACTCTTGGTATTTTGAAGAATGGGACATCAGCG
CTCCATGCAGCAGTGCTCAGTGGAAACATTAAAACAGTTGCGCTGCTCCTAGAAGCAGGGGCAGACCCATCCCTGAGAAACAAGGCCAAT

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000322980_chr18_21229157_-_879nt
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG
CTGAAGGAAACTCCACTTGCCAATGCTGCATTCTGGGCAGCCAGGAGAGGAAACCTGGCGCTGCTGAAGCTGCTGTTGAACAGCGGCCGG
GTGGACGTGGACTGCAGAGACAGCCATGGCACCACACTCCTGATGGTTGCTGCCTACGCTGGCCACATAGACTGTGTGAGGGAACTGGTT
CTGCAAGGAGCAGACATCAATCTCCAGAGAGAGTCAGGTACAACTGCCCTATTCTTTGCCGCCCAGCAAGGCCATAATGATGTCGTGAGA
TTTCTCTTTGGATTTGGAGCATCCACTGAATTTAGGACCAAAGACGGGGGCACCGCCCTGTTGGCTGCCAGTCAGTACGGGCACATGCAG
GTGGTGGAGACCTTGCTGAAGCACGGAGCAAACATCCATGACCAACTTTATGATGGAGCCACTGCCCTCTTCCTAGCTGCCCAAGGTGGT
TACTTGGATGTTATTCGATTACTGCTGGCTTCAGGAGCAAAAGTCAACCAGCCAAGGCAGGACGGGACAGCGCCCCTGTGGATCGCGTCC
CAGATGGGCCACAGCGAGGTGGTGCGGGTGATGCTGCTGCGCGGAGCCGACCGCGACGCTGCGCGGAACGATGGCACAACAGCATTATTG
AAAGCAGCCAACAAAGGGTATAATGATGTCATAAAAGAGTTGCTTAAATTCTCACCCACTCTTGGTATTTTGAAGGCCAATGAACTTCCG

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000284207_chr18_21229157_-_879nt
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG
CTGAAGGAAACTCCACTTGCCAATGCTGCATTCTGGGCAGCCAGGAGAGGAAACCTGGCGCTGCTGAAGCTGCTGTTGAACAGCGGCCGG
GTGGACGTGGACTGCAGAGACAGCCATGGCACCACACTCCTGATGGTTGCTGCCTACGCTGGCCACATAGACTGTGTGAGGGAACTGGTT
CTGCAAGGAGCAGACATCAATCTCCAGAGAGAGTCAGGTACAACTGCCCTATTCTTTGCCGCCCAGCAAGGCCATAATGATGTCGTGAGA
TTTCTCTTTGGATTTGGAGCATCCACTGAATTTAGGACCAAAGACGGGGGCACCGCCCTGTTGGCTGCCAGTCAGTACGGGCACATGCAG
GTGGTGGAGACCTTGCTGAAGCACGGAGCAAACATCCATGACCAACTTTATGATGGAGCCACTGCCCTCTTCCTAGCTGCCCAAGGTGGT
TACTTGGATGTTATTCGATTACTGCTGGCTTCAGGAGCAAAAGTCAACCAGCCAAGGCAGGACGGGACAGCGCCCCTGTGGATCGCGTCC
CAGATGGGCCACAGCGAGGTGGTGCGGGTGATGCTGCTGCGCGGAGCCGACCGCGACGCTGCGCGGAACGATGGCACAACAGCATTATTG
AAAGCAGCCAACAAAGGGTATAATGATGTCATAAAAGAGTTGCTTAAATTCTCACCCACTCTTGGTATTTTGAAGGCCAATGAACTTCCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ROCK1_ENST00000399799_chr18_18595392_-_ANKRD29_ENST00000322980_chr18_21181273_-_3201nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAA
GAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAAGACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATG
AAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTC
TCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTTTTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTG
TTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCA
ACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCAGAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACA
GAGATGTGAAGCCTGATAACATGCTGCTGGATAAATCTGGACATTTGAAGTTAGCAGATTTTGGTACTTGTATGAAGATGAATAAGGAAG
GCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTATATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAA
GAGAATGTGACTGGTGGTCGGTTGGGGTATTTTTATACGAAATGCTTGTAGGTGATACACCTTTTTATGCAGATTCTTTGGTTGGAACTT
ACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCTGATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCC
TTACTGACAGGGAAGTGAGGTTAGGGCGAAATGGTGTAGAAGAAATCAAACGACATCTCTTCTTCAAAAATGACCAGTGGGCTTGGGAAA
CGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGTAGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAG
AGGAAGAAACATTCCCTATTCCTAAAGCTTTCGTTGGCAATCAACTACCTTTTGTAGGATTTACATATTATAGCAATCGTAGATACTTAT
CTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCAGATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAG
AACAGCTGCATAATGAAATGCAGTTAAAAGATGAAATGGAGCAGAAGTGCAGAACCTCAAACATAAAACTAGACAAGATAATGAAAGAAT
TGGATGAAGAGGCCAATGAACTTCCGGCAGAACTAACCAAAAATGAACGTATATTGCGTCTCCTGAGAAGTAAAGAAGGTCCCAGAAAGA
GCTAACTTAGCTCCATATTTGACAGAAAGATAGAAAGCTTAACCACATTGTCCAAAAAGAAATTGCATTTCAAGCAGTGTTGGAAATTCT
TTTATGAAAAAAAAAGATGCCCAGAATGCCCATCCTGTGGGTCCCTGACAAAGAAGAGCTACGCTCTGTGCACGAAGTCAAGAACCAAAC
AGCTCAGGGACCCTCTTGCCCCTTCACCATGGACTTCTCATGGTGTCCTGTAACTCATCTCCCGGGGGGCCTGGCATGTTCACAGATTCC
ACAGAAACTCATTTTCAACAATGCTAACTTGGACCTGTCAGTTAAACTCTAAGGTGGACAGGGTTCTCAGTACTAAGCAAGGAGACAGAA
TGCTTTGTTCCTTTAAAAGACTGAAAAGCTGACCTTCAATGGATTGAGGCACTTTTGCTTTTGTGTTAAATGTAGATGTGCTAAAATATA
TAGATCTATCATATTTTACCTACATATGTATGTCATTCCAGTATAAAACATTCTCCTCTACCCAAGAACCATAGCCATGATTGTTATAAA
TCAATGAAGTGTAAACATACATTATTAAAAAACCACTTCTGACATTCCATTATGTGCTATTCAAAGATGGACTATTGAACTATAGAAAAG
ACAGACTGTGCATTTGTTCGTTGATCCTCATCTTATTCCTGACATGTAAAAATCAATTTTACGTAGAGTCAACATTGTAGGTAGGTTAAA

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000592179_chr18_21229157_-_4219nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAGGAAACTCCACTTGCCAATGCTGCATTCTGGGCAGCCAGGAGAG
GAAACCTGGCGCTGCTGAAGCTGCTGTTGAACAGCGGCCGGGTGGACGTGGACTGCAGAGACAGCCATGGCACCACACTCCTGATGGTTG
CTGCCTACGCTGGCCACATAGACTGTGTGAGGGAACTGGTTCTGCAAGGAGCAGACATCAATCTCCAGAGAGAGTCAGGTACAACTGCCC
TATTCTTTGCCGCCCAGCAAGGCCATAATGATGTCGTGAGATTTCTCTTTGGATTTGGAGCATCCACTGAATTTAGGACCAAAGACGGGG
GCACCGCCCTGTTGGCTGCCAGTCAGTACGGGCACATGCAGGTGGTGGAGACCTTGCTGAAGCACGGAGCAAACATCCATGACCAACTTT
ATGATGGAGCCACTGCCCTCTTCCTAGCTGCCCAAGGTGGTTACTTGGATGTTATTCGATTACTGCTGGCTTCAGGAGCAAAAGTCAACC
AGCCAAGGCAGGACGGGACAGCGCCCCTGTGGATCGCGTCCCAGATGGGCCACAGCGAGGTGGTGCGGGTGATGCTGCTGCGCGGAGCCG
ACCGCGACGCTGCGCGGAACGATGGCACAACAGCATTATTGAAAGCAGCCAACAAAGGGTATAATGATGTCATAAAAGAGTTGCTTAAAT
TCTCACCCACTCTTGGTATTTTGAAGAATGGGACATCAGCGCTCCATGCAGCAGTGCTCAGTGGAAACATTAAAACAGTTGCGCTGCTCC
TAGAAGCAGGGGCAGACCCATCCCTGAGAAACAAGGCCAATGAACTTCCGGCAGAACTAACCAAAAATGAACGTATATTGCGTCTCCTGA
GAAGTAAAGAAGGTCCCAGAAAGAGCTAACTTAGCTCCATATTTGACAGAAAGATAGAAAGCTTAACCACATTGTCCAAAAAGAAATTGC
ATTTCAAGCAGTGTTGGAAATTCTTTTATGAAAAAAAAAGATGCCCAGAATGCCCATCCTGTGGGTCCCTGACAAAGAAGAGCTACGCTC
TGTGCACGAAGTCAAGAACCAAACAGCTCAGGGACCCTCTTGCCCCTTCACCATGGACTTCTCATGGTGTCCTGTAACTCATCTCCCGGG
GGGCCTGGCATGTTCACAGATTCCACAGAAACTCATTTTCAACAATGCTAACTTGGACCTGTCAGTTAAACTCTAAGGTGGACAGGGTTC
TCAGTACTAAGCAAGGAGACAGAATGCTTTGTTCCTTTAAAAGACTGAAAAGCTGACCTTCAATGGATTGAGGCACTTTTGCTTTTGTGT
TAAATGTAGATGTGCTAAAATATATAGATCTATCATATTTTACCTACATATGTATGTCATTCCAGTATAAAACATTCTCCTCTACCCAAG
AACCATAGCCATGATTGTTATAAATCAATGAAGTGTAAACATACATTATTAAAAAACCACTTCTGACATTCCATTATGTGCTATTCAAAG
ATGGACTATTGAACTATAGAAAAGACAGACTGTGCATTTGTTCGTTGATCCTCATCTTATTCCTGACATGTAAAAATCAATTTTACGTAG
AGTCAACATTGTAGGTAGGTTAAAATACCAGTGGCAAATTTGGAAATTCAGAAACTTATAAACCACGAGAAATATATAGGCTTGTCTCTT
TGGTCTTTTATTTTGGCTCTATTGTTGGGAATCTATTTCCTATTCTATAAGTAAGTATACCTAACATGCTGTGGAATCTTGAGTTTCCAA
CACCGTGCTGCTTGATAGAATGACTTTGAGGTCCTTGGATAAAATGTGATATATGCAAGTACAGTATGTTGCTATTACTATTGCAGGAAT
ATAAATAATAAAAGACTGTTATTAGCACTTAGTAAGTCTTCATCTATGCATGTTTTTGAGTTGACTGATTCCAAGAATGAAATATGAGGT
TTATTGAATTATTCCTTTGAAAGGGATCAAAACTTATATTCAATGCACTTTATAATTAATGGTGTCTAAATGCCTCAGTCAGTGCCTAAC
TGCACATACAAAAATAAAACCTTCTTTCTGTAATCTACCAAAATAAACGCAATGGTATTTCTGCTATTTAAACACATCTTTAGCTTATTT
CTTCATGTTCTGCTCTGGTTTTCAGTCAGTGTCTATGTAAAGACACTTTTAGAGGAAAATGTTGTAATCCCAAAAGAATTTTTGTTTAAC
CAACTTTCAGAGTTACTAAAAGGATTATCTTTAATTCAGTAAATAATAGAATATAATCTTCAAAATTAGAAGATATTCTCTTAAAATTTA
TAACAATTAATGCAACAAAAATCAGCATATTTTGATAAATGTCTCAAGCAAATGAGCAACTCACAGGCCCCACAGGTGCCTACAGCCTGA
CCAGCTATACAAAAAGCCTGCAACCTGATTCTAGGATAAAATATTAGAAAGCTCTCTGTTGCTAAAACATCCAGATATAAACATTTTGGT
GGCTAAAATCAATGCCATTTCCTCATTGACATTCTTTTATTCAGCAAATTTGTACAAATATACATTTTCTCCTGTGCGAATTTCAAAAAG
CTATATTCATTTTGAAGAGGAAAATAATATGGCATTAAATGCTTTGTATTTTCCCCTTAGTTAGCCCTTATGGCAAAAATAGTTGCTAAT
CACTGATACAAAGCAAAACGTTATGGGTACTGATAACAAAGTTCCAAAAGCCAAAATGGGATGAATCACAAACTTACTGTTTTTCACTAA
AACATGTAATTGGCCTATTACATCAATAGTTTTAAGTGGGTAATGTTCTTGAACAATATTAGAGCCATAAAATTGAAGCCAGTAGCTTGA
ACAATATGGAGGCCTTCTTACTGTAGGGAAGAGGTGTCTAGCTTAGAAGGATCACATTTGATCTAGATGAGATTACCCATAGCAGGGAAA
ATGAATCATCACCTACCAAAGACTGTACGGAAAGGTGTGTTATTTTCAAAATTGCATTTTAGTTTGCACACATGTAAATGATTATTCTAT
GTTAATCTAATTGACAATTCAGTTAGCTCCGCATCCTAAGACTTAAAACTAGCAATTCCTATGCAAATCATCTGCTTAACTGAACTACAA

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000322980_chr18_21229157_-_2586nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAGGAAACTCCACTTGCCAATGCTGCATTCTGGGCAGCCAGGAGAG
GAAACCTGGCGCTGCTGAAGCTGCTGTTGAACAGCGGCCGGGTGGACGTGGACTGCAGAGACAGCCATGGCACCACACTCCTGATGGTTG
CTGCCTACGCTGGCCACATAGACTGTGTGAGGGAACTGGTTCTGCAAGGAGCAGACATCAATCTCCAGAGAGAGTCAGGTACAACTGCCC
TATTCTTTGCCGCCCAGCAAGGCCATAATGATGTCGTGAGATTTCTCTTTGGATTTGGAGCATCCACTGAATTTAGGACCAAAGACGGGG
GCACCGCCCTGTTGGCTGCCAGTCAGTACGGGCACATGCAGGTGGTGGAGACCTTGCTGAAGCACGGAGCAAACATCCATGACCAACTTT
ATGATGGAGCCACTGCCCTCTTCCTAGCTGCCCAAGGTGGTTACTTGGATGTTATTCGATTACTGCTGGCTTCAGGAGCAAAAGTCAACC
AGCCAAGGCAGGACGGGACAGCGCCCCTGTGGATCGCGTCCCAGATGGGCCACAGCGAGGTGGTGCGGGTGATGCTGCTGCGCGGAGCCG
ACCGCGACGCTGCGCGGAACGATGGCACAACAGCATTATTGAAAGCAGCCAACAAAGGGTATAATGATGTCATAAAAGAGTTGCTTAAAT
TCTCACCCACTCTTGGTATTTTGAAGGCCAATGAACTTCCGGCAGAACTAACCAAAAATGAACGTATATTGCGTCTCCTGAGAAGTAAAG
AAGGTCCCAGAAAGAGCTAACTTAGCTCCATATTTGACAGAAAGATAGAAAGCTTAACCACATTGTCCAAAAAGAAATTGCATTTCAAGC
AGTGTTGGAAATTCTTTTATGAAAAAAAAAGATGCCCAGAATGCCCATCCTGTGGGTCCCTGACAAAGAAGAGCTACGCTCTGTGCACGA
AGTCAAGAACCAAACAGCTCAGGGACCCTCTTGCCCCTTCACCATGGACTTCTCATGGTGTCCTGTAACTCATCTCCCGGGGGGCCTGGC
ATGTTCACAGATTCCACAGAAACTCATTTTCAACAATGCTAACTTGGACCTGTCAGTTAAACTCTAAGGTGGACAGGGTTCTCAGTACTA
AGCAAGGAGACAGAATGCTTTGTTCCTTTAAAAGACTGAAAAGCTGACCTTCAATGGATTGAGGCACTTTTGCTTTTGTGTTAAATGTAG
ATGTGCTAAAATATATAGATCTATCATATTTTACCTACATATGTATGTCATTCCAGTATAAAACATTCTCCTCTACCCAAGAACCATAGC
CATGATTGTTATAAATCAATGAAGTGTAAACATACATTATTAAAAAACCACTTCTGACATTCCATTATGTGCTATTCAAAGATGGACTAT
TGAACTATAGAAAAGACAGACTGTGCATTTGTTCGTTGATCCTCATCTTATTCCTGACATGTAAAAATCAATTTTACGTAGAGTCAACAT

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ANKRD29_ENST00000284207_chr18_21229157_-_3030nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAGGAAACTCCACTTGCCAATGCTGCATTCTGGGCAGCCAGGAGAG
GAAACCTGGCGCTGCTGAAGCTGCTGTTGAACAGCGGCCGGGTGGACGTGGACTGCAGAGACAGCCATGGCACCACACTCCTGATGGTTG
CTGCCTACGCTGGCCACATAGACTGTGTGAGGGAACTGGTTCTGCAAGGAGCAGACATCAATCTCCAGAGAGAGTCAGGTACAACTGCCC
TATTCTTTGCCGCCCAGCAAGGCCATAATGATGTCGTGAGATTTCTCTTTGGATTTGGAGCATCCACTGAATTTAGGACCAAAGACGGGG
GCACCGCCCTGTTGGCTGCCAGTCAGTACGGGCACATGCAGGTGGTGGAGACCTTGCTGAAGCACGGAGCAAACATCCATGACCAACTTT
ATGATGGAGCCACTGCCCTCTTCCTAGCTGCCCAAGGTGGTTACTTGGATGTTATTCGATTACTGCTGGCTTCAGGAGCAAAAGTCAACC
AGCCAAGGCAGGACGGGACAGCGCCCCTGTGGATCGCGTCCCAGATGGGCCACAGCGAGGTGGTGCGGGTGATGCTGCTGCGCGGAGCCG
ACCGCGACGCTGCGCGGAACGATGGCACAACAGCATTATTGAAAGCAGCCAACAAAGGGTATAATGATGTCATAAAAGAGTTGCTTAAAT
TCTCACCCACTCTTGGTATTTTGAAGGCCAATGAACTTCCGGCAGAACTAACCAAAAATGAACGTATATTGCGTCTCCTGAGAAGTAAAG
AAGGTCCCAGAAAGAGCTAACTTAGCTCCATATTTGACAGAAAGATAGAAAGCTTAACCACATTGTCCAAAAAGAAATTGCATTTCAAGC
AGTGTTGGAAATTCTTTTATGAAAAAAAAAGATGCCCAGAATGCCCATCCTGTGGGTCCCTGACAAAGAAGAGCTACGCTCTGTGCACGA
AGTCAAGAACCAAACAGCTCAGGGACCCTCTTGCCCCTTCACCATGGACTTCTCATGGTGTCCTGTAACTCATCTCCCGGGGGGCCTGGC
ATGTTCACAGATTCCACAGAAACTCATTTTCAACAATGCTAACTTGGACCTGTCAGTTAAACTCTAAGGTGGACAGGGTTCTCAGTACTA
AGCAAGGAGACAGAATGCTTTGTTCCTTTAAAAGACTGAAAAGCTGACCTTCAATGGATTGAGGCACTTTTGCTTTTGTGTTAAATGTAG
ATGTGCTAAAATATATAGATCTATCATATTTTACCTACATATGTATGTCATTCCAGTATAAAACATTCTCCTCTACCCAAGAACCATAGC
CATGATTGTTATAAATCAATGAAGTGTAAACATACATTATTAAAAAACCACTTCTGACATTCCATTATGTGCTATTCAAAGATGGACTAT
TGAACTATAGAAAAGACAGACTGTGCATTTGTTCGTTGATCCTCATCTTATTCCTGACATGTAAAAATCAATTTTACGTAGAGTCAACAT
TGTAGGTAGGTTAAAATACCAGTGGCAAATTTGGAAATTCAGAAACTTATAAACCACGAGAAATATATAGGCTTGTCTCTTTGGTCTTTT
ATTTTGGCTCTATTGTTGGGAATCTATTTCCTATTCTATAAGTAAGTATACCTAACATGCTGTGGAATCTTGAGTTTCCAACACCGTGCT
GCTTGATAGAATGACTTTGAGGTCCTTGGATAAAATGTGATATATGCAAGTACAGTATGTTGCTATTACTATTGCAGGAATATAAATAAT
AAAAGACTGTTATTAGCACTTAGTAAGTCTTCATCTATGCATGTTTTTGAGTTGACTGATTCCAAGAATGAAATATGAGGTTTATTGAAT
TATTCCTTTGAAAGGGATCAAAACTTATATTCAATGCACTTTATAATTAATGGTGTCTAAATGCCTCAGTCAGTGCCTAACTGCACATAC


Top

FusionGenePPI for ROCK1_ANKRD29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ROCK1CDC25A, PFN2, RHOA, RND3, GAB1, CFL1, LIMK2, HNRNPA1, ITSN2, ARRB1, TSG101, NOTCH1, SMURF1, SMAD2, CASP3, CASP7, CDK15, ANKFY1, MON2, FAM21A, KIAA1033, IKBKB, LMO2, MAGEB4, POLR3C, C6orf165, FAM124A, NXF1, NTRK1, MED23, XRCC5, NEIL3, TRIM15, HGS, SLC9A1, UBE2T, CDKN3, TENC1, ROCK2, ADD2, IL20RA, CYLDANKRD29YTHDF1, ADD2, ADD1, FAM122B, UBP1, TFCP2, ADD3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneROCK1chr18:18690779chr18:21229157ENST00000399799-133368_727311355FHOD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ROCK1_ANKRD29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ROCK1_ANKRD29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource