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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 31660

FusionGeneSummary for ROBO1_MED12L

check button Fusion gene summary
Fusion gene informationFusion gene name: ROBO1_MED12L
Fusion gene ID: 31660
HgeneTgene
Gene symbol

ROBO1

MED12L

Gene ID

6091

116931

Gene nameroundabout guidance receptor 1mediator complex subunit 12 like
SynonymsDUTT1|SAX3NOPAR|TNRC11L|TRALP|TRALPUSH
Cytomap

3p12.3

3q25.1

Type of geneprotein-codingprotein-coding
Descriptionroundabout homolog 1deleted in U twenty twentyroundabout, axon guidance receptor, homolog 1mediator of RNA polymerase II transcription subunit 12-like proteinmediator of RNA polymerase II transcription, subunit 12 homolog-likeno opposite paired repeat proteinthyroid hormone receptor-associated-like proteintrinucleotide repeat-containing gen
Modification date2018051920180523
UniProtAcc

Q9Y6N7

Q86YW9

Ensembl transtripts involved in fusion geneENST00000464233, ENST00000436010, 
ENST00000495273, ENST00000467549, 
ENST00000466906, 		ENST00000474524, 
ENST00000273432, ENST00000491549, 
ENST00000422248, ENST00000309237, 
Fusion gene scores* DoF score11 X 11 X 5=6054 X 4 X 3=48
# samples 114
** MAII scorelog2(11/605*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROBO1 [Title/Abstract] AND MED12L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROBO1

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

HgeneROBO1

GO:0021836

chemorepulsion involved in postnatal olfactory bulb interneuron migration

15207848

HgeneROBO1

GO:0050772

positive regulation of axonogenesis

12504588

HgeneROBO1

GO:0050925

negative regulation of negative chemotaxis

11748139


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2781-01AROBO1chr3

78987751

-MED12Lchr3

150911277

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000464233ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
In-frameENST00000464233ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000464233ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000464233ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000464233ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000436010ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000436010ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000436010ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000436010ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000436010ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000495273ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000495273ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000495273ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000495273ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000495273ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000467549ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000467549ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000467549ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000467549ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000467549ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-3CDSENST00000466906ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-3CDSENST00000466906ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-intronENST00000466906ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-intronENST00000466906ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-intronENST00000466906ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+

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FusionProtFeatures for ROBO1_MED12L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROBO1

Q9Y6N7

MED12L

Q86YW9

Receptor for SLIT1 and SLIT2 that mediates cellularresponses to molecular guidance cues in cellular migration,including axonal navigation at the ventral midline of the neuraltube and projection of axons to different regions during neuronaldevelopment (PubMed:10102268, PubMed:24560577). Interaction withthe intracellular domain of FLRT3 mediates axon attraction towardscells expressing NTN1 (PubMed:24560577). In axon growth cones, thesilencing of the attractive effect of NTN1 by SLIT2 may requirethe formation of a ROBO1-DCC complex (By similarity). Plays a rolein the regulation of cell migration via its interaction withMYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPaseactivity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development(By similarity). {ECO:0000250|UniProtKB:O89026,ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577,ECO:0000269|PubMed:26529257, ECO:0000305}. May be a component of the Mediator complex, acoactivator involved in the regulated transcription of nearly allRNA polymerase II-dependent genes. Mediator functions as a bridgeto convey information from gene-specific regulatory proteins tothe basal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-43168_1641661652DomainNote=Ig-like C2-type 1
TgeneMED12Lchr3:78987751chr3:150911277ENST00000309237+13151877_2134691757Compositional biasNote=Gln-rich
TgeneMED12Lchr3:78987751chr3:150911277ENST00000422248+12141877_2134656722Compositional biasNote=Gln-rich
TgeneMED12Lchr3:78987751chr3:150911277ENST00000474524+12431877_21346562146Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229170_2571271613DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229262_3461271613DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229351_4461271613DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229455_5411271613DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229563_6571271613DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229676_7731271613DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-22968_1641271613DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229778_8741271613DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431170_2571661652DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431262_3461661652DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431351_4461661652DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431455_5411661652DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431563_6571661652DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431676_7731661652DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431778_8741661652DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229170_2571271552DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229262_3461271552DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229351_4461271552DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229455_5411271552DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229563_6571271552DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229676_7731271552DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-22968_1641271552DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229778_8741271552DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229170_2571271607DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229262_3461271607DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229351_4461271607DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229455_5411271607DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229563_6571271607DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229676_7731271607DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-22968_1641271607DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229778_8741271607DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-22926_8971271613Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229919_16511271613Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-43126_8971661652Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431919_16511661652Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-22926_8971271552Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229919_16511271552Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-22926_8971271607Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229919_16511271607Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229898_9181271613TransmembraneHelical
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431898_9181661652TransmembraneHelical
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229898_9181271552TransmembraneHelical
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229898_9181271607TransmembraneHelical


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FusionGeneSequence for ROBO1_MED12L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ROBO1_ENST00000464233_chr3_78987751_-_MED12L_ENST00000474524_chr3_150911277_+_1656aa
MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK
AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANFFSYAWRILXECQ
HFVGQKNVSXLXEVGEEGKAKGINFSIXLXPPSPLTVCNTFSYTSGXIFKSXMXPAHNPSLWSRQRAXXSKASAEEDYQRYPENSKXEEH
HRDRGWGRRTKSQEEQTGDISNTGDCVHXTPAPFIFXSTSSDISDFXQCARTNHKLCVRNILSSPFGSPHSAHLXSHGASTEHQRTNXLR
NTVTKXTECCGSXTAPKILQPGRKLYNRTVCLHRGCSQALSQLSNLESXSDSPGVXRVVWCGQACRKPLRMFFPXKMHFSLPLXSLCVMX
PPQKXIWRPLQXCLFKSKANHIXXRDACKFELAMGSRLHDGFYXESLSPQHQLLNAGQDPQXQCGQSLQLCLQYTHECMYGPSGCWQDXR
HSQFLLXAYGLLHCSXFRMAGGSEGSLLFFKSRVGVXXCTLHCRCEXPFIPXFISYFHCYSDSTTVFFPGGRRAACRTSLSSSSSLWGCG
RRAWGENDMPTLASSLPSSPGLLLTSSNGQTFPWNKIILXXTPLSRCSQQHXSGSRVCCLKSNYDAWRCQNWQXQCQLFKEXXLHHERFA
MXWECXXYLDCLTKSKILWEKHFHRNCQFKRIRXICTEDYLSTGMGRRALLKRTXKIMYRQRTYIGPCAFKYASTEITAAYLLSSWHXRM
YRGGQSAKTAHXAYSSESXAVDTEAILVRTPANDQTVLEGPWLWFCGRNEQLTGQYCKGNNRGIPAVCRPKXFFXFWHEPLQPKQYWKCX
YKXHETEWNKDIPKFLRTQGCMVGGPPHRQVANFCARKSAESRWGRAGEGTALGFFFQKGKGQTETEKYVSFESTTLPLTGTYLPXGTRX
TKGRPPNISPESSXPDFKXLERRTIPRXHKSAADDARSIATPPKFGRRNVXHGAEEHPVDYRLGPATPSDHYFRNCXHAHXQXIIHNSSX
HAGCFNQWNVSLXPIKCIPWGIXREQACIHEFSKETEKRARRQAIRKYXQSSTVTTFAETDMXCHHLXTYGFLDXHKRKQNCWIXLYRXK
TGSPGLYEAEGVPVGLVXGSEEPSSFVLGLVWDSPSGPKSDQVRGAASPPAVSHTPHAQAPQLLPPATAPASXGGRGRAHISSFSGTRKE
VRXAVRSGKNHNRXRKENKRKEAQDEIXLKSXXISTEQHIPSASXLLAYLLPNDAPSTVHLVGLQPRGPAPAARLFPSEPISYSRWLQIG
PCRLLCPNQHQTSSVKHATAALRRHDAAAFSSCNHIAAAVDTDEASAAAAATATSQASPDSAFPTGPAGGPGCSLCCASTALPSAPSVSR
AAASTDHATGLYNVWDTDAFAADIAAAGWQCGPVSQLXLQSLSGRTFQPRANGKTQTDSAAAEWLCSAAGLAVPAAPDWLSETEPSGSTA
EPSGGRGNXCCADFCTSKPSLRAPASGSHETQTAASSTAAETPPDAAAPAAPAPAASPAPAVLAVPESDPWSPSNAAPAALVSQARLAAD

>In-frame_ROBO1_ENST00000464233_chr3_78987751_-_MED12L_ENST00000273432_chr3_150911277_+_1460aa
MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK
AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANFFSYAWRILXECQ
HFVGQKNVSXLXEVGEEGKAKGINFSIXLXPPSPLTVCNTFSYTSGXIFKSXMXPAHNPSLWSRQRAXXSKASAEEDYQRYPENSKXEEH
HRDRGWGRRTKSQEEQTGDISNTGDCVHXTPAPFIFXSTSSDISDFXQCARTNHKLCVRNILSSPFGSPHSAHLXSHGASTEHQRTNXLR
NTVTKXTECCGSXTAPKILQPGRKLYNRTVCLHRGCSQALSQLSNLESXSDSPGVXRVVWCGQACRKPLRMFFPXKMHFSLPLXSLCVMX
PPQKXIWRPLQXCLFKSKANHIXXRDACKFELAMGSRLHDGFYXESLSPQHQLLNAGQDPQXQCGQSLQLCLQYTHECMYGPSGCWQDXR
HSQFLLXAYGLLHCSXFRMAGGSEGSLLFFKSRVGVXXCTLHCRCEXPFIPXFISYFHCYSDSTTVFFPGGRRAACRTSLSSSSSLWGCG
RRAWGENDMPTLASSLPSSPGLLLTSSNGQTFPWNKIILXXTPLSRCSQQHXSGSRVCCLKSNYDAWRCQNWQXQCQLFKEXXLHHERFA
MXWECXXYLDCLTKSKILWEKHFHRNCQFKRIRXICTEDYLSTGMGRRALLKRTXKIMYRQRTYIGPCAFKYASTEITAAYLLSSWHXRM
YRGGQSAKTAHXAYSSESXAVDTEAILVRTPANDQTVLEGPWLWFCGRNEQLTGQYCKGNNRGIPAVCRPKXFFXFWHEPLQPKQYWKCX
YKXHETEWNKDIPKFLRTQGCMVGGPPHRQVANFCARKSAESRWGRAGEGTALGFFFQKGKGQTETEKYVSFESTTLPLTGTYLPXGTRX
TKGRPPNISPESSXPDFKXLERRTIPRXHKSAADDARSIATPPKFGRRNVXHGAEEHPVDYRLGPATPSDHYFRNCXHAHXQXIIHNSSX
HAGCFNQWNVSLXPIKCIPWGIXREQACIHEFSKETEKRARRQAIRKYXQSSTVTTFAETDMXCHHLXTYGFLDXHKRKQNCWIXLYRXK
TGSPGLYEAEGVPVGLVXGSEEPSSFVLGLVWDSPSGPKSDQVRGAASPPAVSHTPHAQAPQLLPPATAPASXGGRGRAHISSFSGTRKE
VRXAVRSGKNHNRXRKENKRKEAQDEIXLKSXXISTEQHIPSASXLLAYLLPNDAPSTVHLVGLQPRGPAPAARLFPSEPISYSRWLQIG
PCRLLCPNQHQTSSVKHATAALRRHDAAAFSSCNHIAAAVDTDEASAAAAATATSQASPDSAFPTVSQARLAADPAAAADGRLGAAAPEA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ROBO1_ENST00000464233_chr3_78987751_-_MED12L_ENST00000474524_chr3_150911277_+_4969nt
ATGAAATGGAAACATGTTCCTTTTTTGGTCATGATATCACTCCTCAGCTTATCCCCAAATCACCTGTTTCTGGCCCAGCTTATTCCAGAC
CCTGAAGATGTAGAGAGGGGGAACGACCACGGGACGCCAATCCCCACCTCTGATAACGATGACAATTCGCTGGGCTATACAGGCTCCCGT
CTTCGTCAGGAAGATTTTCCACCTCGCATTGTTGAACACCCTTCAGACCTGATTGTCTCAAAAGGAGAACCTGCAACTTTGAACTGCAAA
GCTGAAGGCCGCCCCACACCCACTATTGAATGGTACAAAGGGGGAGAGAGAGTGGAGACAGACAAAGATGACCCTCGCTCACACCGAATG
TTGCTGCCGAGTGGATCTTTATTTTTCTTACGTATAGTACATGGACGGAAAAGTAGACCTGATGAAGGAGTCTATGTCTGTGTAGCAAGG
AATTACCTTGGAGAGGCTGTGAGCCACAATGCATCGCTGGAAGTAGCCAATTTTTTCTCCTATGCCTGGAGAATCCTGTGAGAATGCCAA
CACTTCGTTGGGCAGAAGAATGTCAGTTAATTGTGAGAAGTTGGTGAAGAGGGAAAAGCCAAGGGAATTAATTTTTCCATCTAATTATGA
CCTCCTTCGCCACTTACAGTATGCAACACATTTTCCTATACCTCTGGATGAATCTTCAAGTCATGAATGTAACCAGCGCACAATCCTTCT
CTATGGAGTCGGCAAAGAGCGTGATGAAGCAAGGCATCAGCTGAAGAAGATTACCAAAGATATCCTGAAAATTCTAAATAAGAAGAGCAC
CACAGAGACAGGGGTTGGGGACGAAGGACAAAAAGCCAGGAAGAACAAACAGGAGACATTTCCAACACTGGAGACTGTGTTCACTAAACT
CCAGCTCCTTTCATATTTTGATCAACATCAAGTGACATCTCAGATTTCTAACAATGTGCTAGAACAAATCACAAGCTTTGCGTCAGGAAC
ATCCTATCATCTCCCTTTGGCTCACCACATTCAGCTCATCTTTGATCTCATGGAGCCAGCACTGAACATCAACGGACTAATTGACTTCGC
AATACAGTTACTAAATGAACTGAGTGTTGTGGAAGCTGAACTGCTCCTAAAATCCTCCAGCCTGGCAGGAAGTTATACAACAGGACTGTG
TGTCTGCATCGTGGCTGTTCTCAGGCGCTATCACAGTTGTCTAATCTTGAATCCTGATCAGACAGCCCAGGTGTTTGAAGGGTTGTGTGG
TGTGGTCAAGCATGTCGTAAACCCCTCAGAATGTTCTTCCCCTGAAAGATGCATTTTAGCCTACCTCTATGATCTCTATGTGTCATGTAG
CCACCTCAGAAGTAAATTTGGAGACCTCTTCAGTAGTGCCTGTTCAAAAGTAAAGCAAACCATATATAATAACGTGATGCCTGCAAATTC
GAACTTGCGATGGGATCCAGACTTCATGATGGATTTTATTGAGAATCCCTCAGCCCGCAGCATCAACTACTCAATGCTGGGCAAGATCCT
CAGTGACAATGCGGCCAATCGCTACAGCTTTGTCTGCAATACACTCATGAATGTATGTATGGGCCATCAGGATGCTGGCAGGATTAACGA
CATAGCCAATTTCTCCTCTGAGCTTACGGCTTGCTGCACTGTTCTTAGTTCAGAATGGCTGGGGGTTCTGAAGGCTCTTTGTTGTTCTTC
AAATCACGTGTGGGGGTTTAATGATGTACTTTGCACTGTAGATGTGAGTGACCTTTCATTCCATGATTCATTAGCTACTTTCATTGCTAT
TCTGATAGCACGACAGTGTTTTTCCCTGGAGGACGTCGTGCAGCATGTCGCACTTCCCTCTCTTCTAGCAGCAGCTTGTGGGGATGCGGA
CGCCGAGCCTGGGGCGAGAATGACATGCCGACTCTTGCTTCATCTCTTCCGAGCTCCCCAGGCCTGCTTCTTACCTCAAGCAACGGGCAA
ACCTTTCCCTGGAATAAGATCATCTTGTGATAGACACCTCTTAGCCGCTGCTCACAACAGCATTGAAGTGGGAGCCGTGTTTGCTGTCTT
AAAAGCAATTATGATGCTTGGAGATGCCAAAATTGGCAATAACAGTGTCAGCTCTTTAAAGAATGATGACTTCACCATGAGAGGTTTGCG
ATGTGATGGGAATGCTGATGATATCTGGACTGCCTCACAAAATCCAAAATCCTGTGGGAAAAGCATTTCCATAGAAACTGCCAATTTAAG
AGAATACGCTAGATATGTACTGAGGACTATCTGTCAACAGGAATGGGTAGGAGAGCATTGCTTAAAAGAACCTGAAAGATTATGTACAGA
CAAAGAACTTATATTGGACCCTGTGCTTTCAAATATGCAAGCACAGAAATTACTGCAGCTTATCTGTTATCCTCATGGCATTAAAGAATG
TACCGAGGGGGACAATCTGCAAAGACAGCACATTAAGCGTATTCTTCAGAATCTTGAGCAGTGGACACTGAGGCAATCCTGGTTAGAACT
CCAGCTAATGATCAAACAGTGCTTGAAGGACCCTGGCTCTGGTTCTGTGGCCGAAATGAACAACTTACTGGACAATATTGCAAAGGCAAC
AATAGAGGTATTCCAGCAGTCTGCAGACCTAAATAATTCTTCTAATTCTGGCATGAGCCTCTTCAACCCAAACAGTATTGGAAGTGCTGA
TACAAGTAGCACGAGACAGAATGGAATAAAGACATTCCTAAGTTCCTCCGAACGCAGGGGTGTATGGTTGGTGGCCCCCCTCATCGCCAG
GTTGCCAACTTCTGTGCAAGGAAGAGTGCTGAAAGCCGCTGGGGAAGAGCTGGAGAAGGGACAGCACTTGGGTTCTTCTTCCAAAAAGGA
AAGGGACAGACAGAAACAGAAAAGTATGTCTCTTTTGAGTCAACAACCCTTCCTCTCACTGGTACTTACCTGCCTTAAGGGACAAGATGA
ACAAAGGGAAGGCCTCCTAACATCTCTCCAGAATCAAGTTAACCAGATTTTAAGTAACTGGAGAGAAGAACGATACCAAGATGACATAAA
AGCGCGGCAGATGATGCACGAAGCATTGCAACTCCGCCTAAATTTGGTAGGAGGAATGTTTGACACGGTGCAGAGGAGCACCCAGTGGAC
TACAGACTGGGCCCTGCTACTCCTTCAGATCATTACTTCAGGAACTGTTGACATGCACACTAACAATGAATTATTCACAACAGTTCTTGA
CATGCTGGGTGTTTTAATCAATGGAACGTTAGCCTCTGACCTATCAAATGCATCCCCTGGGGGATCTGAAGAGAACAAGCGTGCATACAT
GAATTTAGTAAAGAAACTGAAAAAAGAGCTAGGAGACAAGCGATCAGAAAGTATTGACAAAGTTCGACAGTTACTACCTTTGCCGAAACA
GACATGTGATGTCATCACTTGTGAACCTATGGGTTCCTTGATTGACACAAAAGGAAACAAAATTGCTGGATTTGACTCTATAGATAAAAA
ACAGGGTCTCCAGGTCTCTACGAAGCAGAAGGTGTCCCCGTGGGACTTGTTTGAGGGTCAGAAGAACCCAGCTCCTTTGTCCTGGGCCTG
GTTTGGGACAGTCCGAGTGGACCGAAGAGTGATCAAGTACGAGGAGCAGCATCACCTCCTGCTGTATCACACACACCCCATGCCCAAGCC
CCGCAGTTACTACCTCCAGCCACTGCCCCTGCCTCCTGAGGAGGAAGAGGAAGAGCCCACATCTCCAGTTTCTCAGGAACCAGAAAGGAA
GTCCGCTGAGCTGTCAGATCAGGGAAAAACCACAACAGATGAAGAAAAGAAAACAAAAGGAAGGAAGCGCAAGACGAAATCTAGCTCAAG
AGTTGATGAATATCCACAGAGCAACATATACCGAGTGCCTCCTAATTACTCGCCTATCTCCTCCCAAATGATGCACCATCCACAGTCCAC
CTTGTGGGGTTACAACCTCGTGGGCCAGCCCCAGCAGCCCGGCTTTTTCCTTCAGAACCAATCTCTTACTCCAGGTGGCTCCAGATTGGA
CCCTGCAGGCTCCTTTGTCCCAACCAACACCAAACAAGCTCTGTCAAACATGCTACAGCGGCGCTCAGGCGCCATGATGCAGCCGCCTTC
TCTTCATGCAATCACATCGCAGCAGCAGTTGATACAGATGAAGCTTCTGCAGCAGCAGCAGCAACAGCGACTTCTCAGGCAAGCCCAGAC
TCGGCCTTTCCAACAGGGCCAGCCGGGGGACCAGGCTGCTCTCTTTGCTGCGCAAGCACGGCCCTCCCCTCAGCTCCCTCAGTATCCAGG
GCTGCAGCAAGCACAGACCATGCCACAGGGCTATACAATGTATGGGACACAGATGCCTTTGCAGCAGACATCGCAGCAGCAGGCTGGCAG
TGTGGTCCTGTCTCCCAGCTATAACTCCAGAGCCTATCCGGCCGCACATTCCAACCCCGTGCTAATGGAAAGACTCAGACAGATTCAGCA
GCAGCCGAGTGGCTATGTTCAGCAGCAGGCCTCGCCGTACCTGCAGCCCCTGACTGGCTCTCAGAGACTGAACCATCAGGCTCTACAGCA
GAGCCCTCTGGTGGGCGGGGGAATTGATGCTGTGCTGACTTCTGCACATCCAAACCTTCCCTCCGTGCCCCTGCCTCAGGATCCCATGAG
ACCCAGACAGCCGCAAGTTCGACAGCAGCAGAGACTCCTCCAGATGCAGCAGCCCCAGCAGCCCCAGCCCCAGCAGCCTCCCCAGCCCCA
GCAGTCCTCGCAGTCCCAGAGTCAGACCCTTGGTCTCCAAGCAATGCAGCCCCAGCAGCCCTTGTTTCCCAGGCAAGGCTTGCAGCAGAC
CCAGCAGCAGCAGCAGACGGCCGCCTTGGTGCGGCAGCTCCAGAAGCAGCTTTCCAGCAACCAGCCACAGCAAGGAGTGACTCCGTATGG

>In-frame_ROBO1_ENST00000464233_chr3_78987751_-_MED12L_ENST00000273432_chr3_150911277_+_4381nt
ATGAAATGGAAACATGTTCCTTTTTTGGTCATGATATCACTCCTCAGCTTATCCCCAAATCACCTGTTTCTGGCCCAGCTTATTCCAGAC
CCTGAAGATGTAGAGAGGGGGAACGACCACGGGACGCCAATCCCCACCTCTGATAACGATGACAATTCGCTGGGCTATACAGGCTCCCGT
CTTCGTCAGGAAGATTTTCCACCTCGCATTGTTGAACACCCTTCAGACCTGATTGTCTCAAAAGGAGAACCTGCAACTTTGAACTGCAAA
GCTGAAGGCCGCCCCACACCCACTATTGAATGGTACAAAGGGGGAGAGAGAGTGGAGACAGACAAAGATGACCCTCGCTCACACCGAATG
TTGCTGCCGAGTGGATCTTTATTTTTCTTACGTATAGTACATGGACGGAAAAGTAGACCTGATGAAGGAGTCTATGTCTGTGTAGCAAGG
AATTACCTTGGAGAGGCTGTGAGCCACAATGCATCGCTGGAAGTAGCCAATTTTTTCTCCTATGCCTGGAGAATCCTGTGAGAATGCCAA
CACTTCGTTGGGCAGAAGAATGTCAGTTAATTGTGAGAAGTTGGTGAAGAGGGAAAAGCCAAGGGAATTAATTTTTCCATCTAATTATGA
CCTCCTTCGCCACTTACAGTATGCAACACATTTTCCTATACCTCTGGATGAATCTTCAAGTCATGAATGTAACCAGCGCACAATCCTTCT
CTATGGAGTCGGCAAAGAGCGTGATGAAGCAAGGCATCAGCTGAAGAAGATTACCAAAGATATCCTGAAAATTCTAAATAAGAAGAGCAC
CACAGAGACAGGGGTTGGGGACGAAGGACAAAAAGCCAGGAAGAACAAACAGGAGACATTTCCAACACTGGAGACTGTGTTCACTAAACT
CCAGCTCCTTTCATATTTTGATCAACATCAAGTGACATCTCAGATTTCTAACAATGTGCTAGAACAAATCACAAGCTTTGCGTCAGGAAC
ATCCTATCATCTCCCTTTGGCTCACCACATTCAGCTCATCTTTGATCTCATGGAGCCAGCACTGAACATCAACGGACTAATTGACTTCGC
AATACAGTTACTAAATGAACTGAGTGTTGTGGAAGCTGAACTGCTCCTAAAATCCTCCAGCCTGGCAGGAAGTTATACAACAGGACTGTG
TGTCTGCATCGTGGCTGTTCTCAGGCGCTATCACAGTTGTCTAATCTTGAATCCTGATCAGACAGCCCAGGTGTTTGAAGGGTTGTGTGG
TGTGGTCAAGCATGTCGTAAACCCCTCAGAATGTTCTTCCCCTGAAAGATGCATTTTAGCCTACCTCTATGATCTCTATGTGTCATGTAG
CCACCTCAGAAGTAAATTTGGAGACCTCTTCAGTAGTGCCTGTTCAAAAGTAAAGCAAACCATATATAATAACGTGATGCCTGCAAATTC
GAACTTGCGATGGGATCCAGACTTCATGATGGATTTTATTGAGAATCCCTCAGCCCGCAGCATCAACTACTCAATGCTGGGCAAGATCCT
CAGTGACAATGCGGCCAATCGCTACAGCTTTGTCTGCAATACACTCATGAATGTATGTATGGGCCATCAGGATGCTGGCAGGATTAACGA
CATAGCCAATTTCTCCTCTGAGCTTACGGCTTGCTGCACTGTTCTTAGTTCAGAATGGCTGGGGGTTCTGAAGGCTCTTTGTTGTTCTTC
AAATCACGTGTGGGGGTTTAATGATGTACTTTGCACTGTAGATGTGAGTGACCTTTCATTCCATGATTCATTAGCTACTTTCATTGCTAT
TCTGATAGCACGACAGTGTTTTTCCCTGGAGGACGTCGTGCAGCATGTCGCACTTCCCTCTCTTCTAGCAGCAGCTTGTGGGGATGCGGA
CGCCGAGCCTGGGGCGAGAATGACATGCCGACTCTTGCTTCATCTCTTCCGAGCTCCCCAGGCCTGCTTCTTACCTCAAGCAACGGGCAA
ACCTTTCCCTGGAATAAGATCATCTTGTGATAGACACCTCTTAGCCGCTGCTCACAACAGCATTGAAGTGGGAGCCGTGTTTGCTGTCTT
AAAAGCAATTATGATGCTTGGAGATGCCAAAATTGGCAATAACAGTGTCAGCTCTTTAAAGAATGATGACTTCACCATGAGAGGTTTGCG
ATGTGATGGGAATGCTGATGATATCTGGACTGCCTCACAAAATCCAAAATCCTGTGGGAAAAGCATTTCCATAGAAACTGCCAATTTAAG
AGAATACGCTAGATATGTACTGAGGACTATCTGTCAACAGGAATGGGTAGGAGAGCATTGCTTAAAAGAACCTGAAAGATTATGTACAGA
CAAAGAACTTATATTGGACCCTGTGCTTTCAAATATGCAAGCACAGAAATTACTGCAGCTTATCTGTTATCCTCATGGCATTAAAGAATG
TACCGAGGGGGACAATCTGCAAAGACAGCACATTAAGCGTATTCTTCAGAATCTTGAGCAGTGGACACTGAGGCAATCCTGGTTAGAACT
CCAGCTAATGATCAAACAGTGCTTGAAGGACCCTGGCTCTGGTTCTGTGGCCGAAATGAACAACTTACTGGACAATATTGCAAAGGCAAC
AATAGAGGTATTCCAGCAGTCTGCAGACCTAAATAATTCTTCTAATTCTGGCATGAGCCTCTTCAACCCAAACAGTATTGGAAGTGCTGA
TACAAGTAGCACGAGACAGAATGGAATAAAGACATTCCTAAGTTCCTCCGAACGCAGGGGTGTATGGTTGGTGGCCCCCCTCATCGCCAG
GTTGCCAACTTCTGTGCAAGGAAGAGTGCTGAAAGCCGCTGGGGAAGAGCTGGAGAAGGGACAGCACTTGGGTTCTTCTTCCAAAAAGGA
AAGGGACAGACAGAAACAGAAAAGTATGTCTCTTTTGAGTCAACAACCCTTCCTCTCACTGGTACTTACCTGCCTTAAGGGACAAGATGA
ACAAAGGGAAGGCCTCCTAACATCTCTCCAGAATCAAGTTAACCAGATTTTAAGTAACTGGAGAGAAGAACGATACCAAGATGACATAAA
AGCGCGGCAGATGATGCACGAAGCATTGCAACTCCGCCTAAATTTGGTAGGAGGAATGTTTGACACGGTGCAGAGGAGCACCCAGTGGAC
TACAGACTGGGCCCTGCTACTCCTTCAGATCATTACTTCAGGAACTGTTGACATGCACACTAACAATGAATTATTCACAACAGTTCTTGA
CATGCTGGGTGTTTTAATCAATGGAACGTTAGCCTCTGACCTATCAAATGCATCCCCTGGGGGATCTGAAGAGAACAAGCGTGCATACAT
GAATTTAGTAAAGAAACTGAAAAAAGAGCTAGGAGACAAGCGATCAGAAAGTATTGACAAAGTTCGACAGTTACTACCTTTGCCGAAACA
GACATGTGATGTCATCACTTGTGAACCTATGGGTTCCTTGATTGACACAAAAGGAAACAAAATTGCTGGATTTGACTCTATAGATAAAAA
ACAGGGTCTCCAGGTCTCTACGAAGCAGAAGGTGTCCCCGTGGGACTTGTTTGAGGGTCAGAAGAACCCAGCTCCTTTGTCCTGGGCCTG
GTTTGGGACAGTCCGAGTGGACCGAAGAGTGATCAAGTACGAGGAGCAGCATCACCTCCTGCTGTATCACACACACCCCATGCCCAAGCC
CCGCAGTTACTACCTCCAGCCACTGCCCCTGCCTCCTGAGGAGGAAGAGGAAGAGCCCACATCTCCAGTTTCTCAGGAACCAGAAAGGAA
GTCCGCTGAGCTGTCAGATCAGGGAAAAACCACAACAGATGAAGAAAAGAAAACAAAAGGAAGGAAGCGCAAGACGAAATCTAGCTCAAG
AGTTGATGAATATCCACAGAGCAACATATACCGAGTGCCTCCTAATTACTCGCCTATCTCCTCCCAAATGATGCACCATCCACAGTCCAC
CTTGTGGGGTTACAACCTCGTGGGCCAGCCCCAGCAGCCCGGCTTTTTCCTTCAGAACCAATCTCTTACTCCAGGTGGCTCCAGATTGGA
CCCTGCAGGCTCCTTTGTCCCAACCAACACCAAACAAGCTCTGTCAAACATGCTACAGCGGCGCTCAGGCGCCATGATGCAGCCGCCTTC
TCTTCATGCAATCACATCGCAGCAGCAGTTGATACAGATGAAGCTTCTGCAGCAGCAGCAGCAACAGCGACTTCTCAGGCAAGCCCAGAC
TCGGCCTTTCCAACAGTTTCCCAGGCAAGGCTTGCAGCAGACCCAGCAGCAGCAGCAGACGGCCGCCTTGGTGCGGCAGCTCCAGAAGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ROBO1_ENST00000464233_chr3_78987751_-_MED12L_ENST00000474524_chr3_150911277_+_9351nt
AAAGTTGCAGGGCTGCGTCTGCACTACGGAGCCTCTAGATTGCTGAAAACAGTCTTATGGAAGGATAACACATTGTCTGTCACTGGCTGG
TTGTAATGCAAGGAAGGGACAAAGATGAAATGGAAACATGTTCCTTTTTTGGTCATGATATCACTCCTCAGCTTATCCCCAAATCACCTG
TTTCTGGCCCAGCTTATTCCAGACCCTGAAGATGTAGAGAGGGGGAACGACCACGGGACGCCAATCCCCACCTCTGATAACGATGACAAT
TCGCTGGGCTATACAGGCTCCCGTCTTCGTCAGGAAGATTTTCCACCTCGCATTGTTGAACACCCTTCAGACCTGATTGTCTCAAAAGGA
GAACCTGCAACTTTGAACTGCAAAGCTGAAGGCCGCCCCACACCCACTATTGAATGGTACAAAGGGGGAGAGAGAGTGGAGACAGACAAA
GATGACCCTCGCTCACACCGAATGTTGCTGCCGAGTGGATCTTTATTTTTCTTACGTATAGTACATGGACGGAAAAGTAGACCTGATGAA
GGAGTCTATGTCTGTGTAGCAAGGAATTACCTTGGAGAGGCTGTGAGCCACAATGCATCGCTGGAAGTAGCCAATTTTTTCTCCTATGCC
TGGAGAATCCTGTGAGAATGCCAACACTTCGTTGGGCAGAAGAATGTCAGTTAATTGTGAGAAGTTGGTGAAGAGGGAAAAGCCAAGGGA
ATTAATTTTTCCATCTAATTATGACCTCCTTCGCCACTTACAGTATGCAACACATTTTCCTATACCTCTGGATGAATCTTCAAGTCATGA
ATGTAACCAGCGCACAATCCTTCTCTATGGAGTCGGCAAAGAGCGTGATGAAGCAAGGCATCAGCTGAAGAAGATTACCAAAGATATCCT
GAAAATTCTAAATAAGAAGAGCACCACAGAGACAGGGGTTGGGGACGAAGGACAAAAAGCCAGGAAGAACAAACAGGAGACATTTCCAAC
ACTGGAGACTGTGTTCACTAAACTCCAGCTCCTTTCATATTTTGATCAACATCAAGTGACATCTCAGATTTCTAACAATGTGCTAGAACA
AATCACAAGCTTTGCGTCAGGAACATCCTATCATCTCCCTTTGGCTCACCACATTCAGCTCATCTTTGATCTCATGGAGCCAGCACTGAA
CATCAACGGACTAATTGACTTCGCAATACAGTTACTAAATGAACTGAGTGTTGTGGAAGCTGAACTGCTCCTAAAATCCTCCAGCCTGGC
AGGAAGTTATACAACAGGACTGTGTGTCTGCATCGTGGCTGTTCTCAGGCGCTATCACAGTTGTCTAATCTTGAATCCTGATCAGACAGC
CCAGGTGTTTGAAGGGTTGTGTGGTGTGGTCAAGCATGTCGTAAACCCCTCAGAATGTTCTTCCCCTGAAAGATGCATTTTAGCCTACCT
CTATGATCTCTATGTGTCATGTAGCCACCTCAGAAGTAAATTTGGAGACCTCTTCAGTAGTGCCTGTTCAAAAGTAAAGCAAACCATATA
TAATAACGTGATGCCTGCAAATTCGAACTTGCGATGGGATCCAGACTTCATGATGGATTTTATTGAGAATCCCTCAGCCCGCAGCATCAA
CTACTCAATGCTGGGCAAGATCCTCAGTGACAATGCGGCCAATCGCTACAGCTTTGTCTGCAATACACTCATGAATGTATGTATGGGCCA
TCAGGATGCTGGCAGGATTAACGACATAGCCAATTTCTCCTCTGAGCTTACGGCTTGCTGCACTGTTCTTAGTTCAGAATGGCTGGGGGT
TCTGAAGGCTCTTTGTTGTTCTTCAAATCACGTGTGGGGGTTTAATGATGTACTTTGCACTGTAGATGTGAGTGACCTTTCATTCCATGA
TTCATTAGCTACTTTCATTGCTATTCTGATAGCACGACAGTGTTTTTCCCTGGAGGACGTCGTGCAGCATGTCGCACTTCCCTCTCTTCT
AGCAGCAGCTTGTGGGGATGCGGACGCCGAGCCTGGGGCGAGAATGACATGCCGACTCTTGCTTCATCTCTTCCGAGCTCCCCAGGCCTG
CTTCTTACCTCAAGCAACGGGCAAACCTTTCCCTGGAATAAGATCATCTTGTGATAGACACCTCTTAGCCGCTGCTCACAACAGCATTGA
AGTGGGAGCCGTGTTTGCTGTCTTAAAAGCAATTATGATGCTTGGAGATGCCAAAATTGGCAATAACAGTGTCAGCTCTTTAAAGAATGA
TGACTTCACCATGAGAGGTTTGCGATGTGATGGGAATGCTGATGATATCTGGACTGCCTCACAAAATCCAAAATCCTGTGGGAAAAGCAT
TTCCATAGAAACTGCCAATTTAAGAGAATACGCTAGATATGTACTGAGGACTATCTGTCAACAGGAATGGGTAGGAGAGCATTGCTTAAA
AGAACCTGAAAGATTATGTACAGACAAAGAACTTATATTGGACCCTGTGCTTTCAAATATGCAAGCACAGAAATTACTGCAGCTTATCTG
TTATCCTCATGGCATTAAAGAATGTACCGAGGGGGACAATCTGCAAAGACAGCACATTAAGCGTATTCTTCAGAATCTTGAGCAGTGGAC
ACTGAGGCAATCCTGGTTAGAACTCCAGCTAATGATCAAACAGTGCTTGAAGGACCCTGGCTCTGGTTCTGTGGCCGAAATGAACAACTT
ACTGGACAATATTGCAAAGGCAACAATAGAGGTATTCCAGCAGTCTGCAGACCTAAATAATTCTTCTAATTCTGGCATGAGCCTCTTCAA
CCCAAACAGTATTGGAAGTGCTGATACAAGTAGCACGAGACAGAATGGAATAAAGACATTCCTAAGTTCCTCCGAACGCAGGGGTGTATG
GTTGGTGGCCCCCCTCATCGCCAGGTTGCCAACTTCTGTGCAAGGAAGAGTGCTGAAAGCCGCTGGGGAAGAGCTGGAGAAGGGACAGCA
CTTGGGTTCTTCTTCCAAAAAGGAAAGGGACAGACAGAAACAGAAAAGTATGTCTCTTTTGAGTCAACAACCCTTCCTCTCACTGGTACT
TACCTGCCTTAAGGGACAAGATGAACAAAGGGAAGGCCTCCTAACATCTCTCCAGAATCAAGTTAACCAGATTTTAAGTAACTGGAGAGA
AGAACGATACCAAGATGACATAAAAGCGCGGCAGATGATGCACGAAGCATTGCAACTCCGCCTAAATTTGGTAGGAGGAATGTTTGACAC
GGTGCAGAGGAGCACCCAGTGGACTACAGACTGGGCCCTGCTACTCCTTCAGATCATTACTTCAGGAACTGTTGACATGCACACTAACAA
TGAATTATTCACAACAGTTCTTGACATGCTGGGTGTTTTAATCAATGGAACGTTAGCCTCTGACCTATCAAATGCATCCCCTGGGGGATC
TGAAGAGAACAAGCGTGCATACATGAATTTAGTAAAGAAACTGAAAAAAGAGCTAGGAGACAAGCGATCAGAAAGTATTGACAAAGTTCG
ACAGTTACTACCTTTGCCGAAACAGACATGTGATGTCATCACTTGTGAACCTATGGGTTCCTTGATTGACACAAAAGGAAACAAAATTGC
TGGATTTGACTCTATAGATAAAAAACAGGGTCTCCAGGTCTCTACGAAGCAGAAGGTGTCCCCGTGGGACTTGTTTGAGGGTCAGAAGAA
CCCAGCTCCTTTGTCCTGGGCCTGGTTTGGGACAGTCCGAGTGGACCGAAGAGTGATCAAGTACGAGGAGCAGCATCACCTCCTGCTGTA
TCACACACACCCCATGCCCAAGCCCCGCAGTTACTACCTCCAGCCACTGCCCCTGCCTCCTGAGGAGGAAGAGGAAGAGCCCACATCTCC
AGTTTCTCAGGAACCAGAAAGGAAGTCCGCTGAGCTGTCAGATCAGGGAAAAACCACAACAGATGAAGAAAAGAAAACAAAAGGAAGGAA
GCGCAAGACGAAATCTAGCTCAAGAGTTGATGAATATCCACAGAGCAACATATACCGAGTGCCTCCTAATTACTCGCCTATCTCCTCCCA
AATGATGCACCATCCACAGTCCACCTTGTGGGGTTACAACCTCGTGGGCCAGCCCCAGCAGCCCGGCTTTTTCCTTCAGAACCAATCTCT
TACTCCAGGTGGCTCCAGATTGGACCCTGCAGGCTCCTTTGTCCCAACCAACACCAAACAAGCTCTGTCAAACATGCTACAGCGGCGCTC
AGGCGCCATGATGCAGCCGCCTTCTCTTCATGCAATCACATCGCAGCAGCAGTTGATACAGATGAAGCTTCTGCAGCAGCAGCAGCAACA
GCGACTTCTCAGGCAAGCCCAGACTCGGCCTTTCCAACAGGGCCAGCCGGGGGACCAGGCTGCTCTCTTTGCTGCGCAAGCACGGCCCTC
CCCTCAGCTCCCTCAGTATCCAGGGCTGCAGCAAGCACAGACCATGCCACAGGGCTATACAATGTATGGGACACAGATGCCTTTGCAGCA
GACATCGCAGCAGCAGGCTGGCAGTGTGGTCCTGTCTCCCAGCTATAACTCCAGAGCCTATCCGGCCGCACATTCCAACCCCGTGCTAAT
GGAAAGACTCAGACAGATTCAGCAGCAGCCGAGTGGCTATGTTCAGCAGCAGGCCTCGCCGTACCTGCAGCCCCTGACTGGCTCTCAGAG
ACTGAACCATCAGGCTCTACAGCAGAGCCCTCTGGTGGGCGGGGGAATTGATGCTGTGCTGACTTCTGCACATCCAAACCTTCCCTCCGT
GCCCCTGCCTCAGGATCCCATGAGACCCAGACAGCCGCAAGTTCGACAGCAGCAGAGACTCCTCCAGATGCAGCAGCCCCAGCAGCCCCA
GCCCCAGCAGCCTCCCCAGCCCCAGCAGTCCTCGCAGTCCCAGAGTCAGACCCTTGGTCTCCAAGCAATGCAGCCCCAGCAGCCCTTGTT
TCCCAGGCAAGGCTTGCAGCAGACCCAGCAGCAGCAGCAGACGGCCGCCTTGGTGCGGCAGCTCCAGAAGCAGCTTTCCAGCAACCAGCC
ACAGCAAGGAGTGACTCCGTATGGGCATCCTTCACACTTCTGAATCTGCAAGAGGAGAAGACATGACGTTTTATGTTTGCACTGAAAAAC
AGAAAATCAAATTTAATGCATTAGTCATCTTAAAAATGTCCCTTTTTTTCATTTCTTTGACATTTTACTATATTTTATGCTACATCTCAC
AAAAAAAAAAAAAGGTGTTTAAACAAAAAGCCAAGGAGAAGTTGTGGTTTGATTTTGTTGAATTCACCTTTAAAGTAGGTTTACAAATGT
GAATCATGCAGGCAGGCCTACTCCCGGAAGAGTGTGCTAGCAGACCTTTTGAAATTGGTGCTTTTTTTGAATCTCACATTTCTAGAAAGA
ATGGATTATGATGGATCTAAGGTATTTATGTATTTCATTCATTAATGATGACGTTGTTTTTTTTTTTTTAATTTTATTTTCCAAACTGTG
CTGGACCAAACTACTGATTTGAAAGGCATGTCAGATCTTGACAGAAACATGGCCTGTTTATTCTGCATTCACCTGTGATGGTGAAACGGA
CATTTATTTGCATCGCTCTAATTTGAAATGTTTGTAATCTCATAAGCACTTTATAAACTTTGTTCTTATTTATGTAGGACTCTTCTTTGC
TTTTGTTGTGGTCAAAAGGTGCTGAAACAGATTGTTGCTTCGTACTTAAACTTCTTAAACCAAGAACCTAAACCAAGGTTTCTTTGAGAG
CCGCCCTAAGATGTGCGGAAACCTGTTAGAAGTAGCTGTACTCAAATTTGTTTTGAGGCAAGATCATTGATGAGAGTCATTGTGAAGGTA
CAACATGTAAATCCTAAAGGCCTGAAAGAACTGCAGTGGAATCGTCCAACTATTTATTGCCAGTTTTGGTTCTCCTGAACCTTATGCCAC
CTTAAGGGGAAAAAAAAATCCAGTAGCTGGCTTGAGATTCCAGTGCTCACACTTGACATGGTTTCCAGAGAATCTGGCCCCAAAGTCCAG
AAGGCTCTGGTTTTCATAAAAGGTGTATTTGCTGTTTATTTTGTATGGTAAGTATTTGCTCTTTTGAATTTAATTATTACTGTCAGTGTC
AGTCTTGGTTGTGTATTGCATATACTGTATTTATAAATTGGTGCAAAAAGCACAAGTAAATTATACATCAAATTTATTATAAAGAAATAG
TAACTATTTTAACTTTGTTCAAGTATGTGGTAATTTGCTCCTATTAGAGTAAAAAAGAAACCAGTAAATTATCAGTTTGTGTAACTTAAG
AGTATTCTATATAATATTTTTTTAGATTTAGATGCATAAAATTTTGAATGTGAAAATTGCAGGGCATTTTAAAACATATGTGGGGGATAT
TTTCCCATGTTCTCTGTTATTTCATTTTCTTTTGCCATATGATTTTACATATAATATAGTCAAGCATACTGTGAATAGACTTGTCTATAA
TGAGCAGACCATGTAAATCTACTTTTTTTAAAATGTAGCTAGTACAACTTTAGTAGACATTTTCTTTTGCAAATCATTATCTATAAATAA
TTTATATCTTCCTGGGTGAGTTACTCATTGCAAAGTTTGACTCATGCAAATGACCTCAAATACATGTCAGCTTACTTTGCTGTGGCAACA
TCCATGTGAACTGCTTTGTACACTGTGAAAATATTTCACTCCAGCCTGCCCATTTTGTGTTTACTCTGGGCTGGAAAAGACTTTGCCAAA
ACATTAAAAACTATTCTTTTCACTAAATTAATAGTCTATCTGCTTTCAGAAGATGTATCATCTATCTGTACACATTTTTGCTGGTTTTGT
ATATCAGATTTTTTCCTCTCAAGAAACATACTTAGATAAGCTAATGAAGTTGTTTTCTTCAAAGTAATATATCTATATAATGACTGCATT
GGCAAATCAACCGAAATGTGAATGTTGTGCCTAGTGAGTGAGTCATGTTCCATCATTATTTCTTTCCAAATTTCTTTGCCAGTTCAGTTT
GAACCATATATTTTGTAGCTCAGCATTGCAAACAACAGTAATACTGTTTTAAGAATGAGTGTTATAATTGCATAGCATTTGTATGCACTT
TATACTTTGCAGAGGTGAGTTAAATTATTAATCATTTTGCACATGAAAGCTGTGGGGCATATCTTTTTTCTTTTTTTAGGTGAGGAAGTT
ATGCTACGACTCTAATTAATTCCACGATTCTATTGAAAGTTGAGGAATGCTGTTTTACCCCTGCGCATTATAAAGAAAATAACTAGAATT
ACTTTAGTCTTCAGATTTTCTCCCTGTTAATTCTGTATCTTGAGAGGTTTCTTTTTTTTTTTTTTTTTTTTCTTTTCTTGCAAATGCATT
CTTTTGCATTAAGATGGTCACAAGGTAAAGCCCTGTGGCAGAACCTGGTACTTTACCTTACCAGAGGAAATTACCTTAGAATAAGATGGA
GCGAGACCCCAGCTCCCCTTAAAGACAAGACCTTGAAATCAAATGGAGTCAGCTATACCTATCAATCAATCACAGTTCTTGGATATAAGA
AGCCCATAGACTCTCTTGTTTACACTGTAGGCTTTTTCTTAATAGGGTTGCATTTGTCAGTCATTGCATTTACCCTTCTTGGCCTGGAAG
TAGAGGAGATCAATGCGTAGCTTTGACCACTTCCAGCCACAGGGTACTAACATCAGACATAAGTTGCAACCAGGTCACATTTTAGGCTGA
GATGGGGCTAACTGAAAGTCAGTGTGATGAAAACCCAAGGGCGCTATTCCACATGTCTCAAATGATTGGCAGGGGCTAACTTATTAGTAA
TTCTCGGTTTTGTGCACTGAGATATCTAAGACCTATGGCATTTTTTTCCCATTTATAAAGCTCCTATAATTCTTAAGTAAGTACTAGGTG
AATGTTTGAATAGATGCTGGAGAAATTACACTGGAAAACCCCACCCCTAGATTTAGATAAGATCAATCATTTAATATTCCCCAAATTAAT
TCAGGTTGAATTAAGCATGTAATATAAATTCAGTGAATTACAAAAACACATTTTGTGTAGGATTGATCAGATTTTAAATACAGTGAAACT
TCATTATATATAATAGACCTAGACCCTCCCAAGCATTTTCCCATCCCATAAAGAATTAATGAAATGAAATGCTTATAGAGCAACGATTCC
TGCTCAGAAAAATTTCCTTATAAACAGCTCCAAACCAGGGGTGCCTGAGCTAGATTTTAAAGTTATAAAGAAGTTTCATTGTATTTTTAA
AACCTTTTTAATGGGTGTATTTGGACAAAAATAACCCCCTTTTCACATTTTATGATGTGCAGGTATTACATTGCTTTTTACATGTGGAAA
AGTGAGCCTGCATTTATTTTTAAATGCAGTTATTAAAACATTTTTGTATTCCCCATCAATGAAAATTTTCAGTGTGAACAAATGGTGAAT
CATAAGACAGTTCAGTGCTTATTTTCTGTAGGTTTTAGCAAAAAAATTTATAAACCACAAAATATTTATACATCAGGATGGTAAATTTAC
ATCATAAAGATTGCAGATTTAATATTTTCCATTGTCTCTGTTCTGAGTGCCATGCTTGTAACATTGATAGGAGGTGGACACTAGGCAACT
GGTATTAGAAGTTCATTTTTTTACTGAAAAATTCAGGTACATTAGCCATTTGTTATTTTATAGTGAACCGTTTCAATGTTTGTTTATTGT
TATTTGTTGGCAAAATAAAAGTGCCTTAAGTTAAAAGTTTGTTTTGAGATCCATTAAATAAATCAGTATCATCAGTTCATAATGCATTTA
TTTACAAGTCCTTTTATTTTGCATGTTCATTGTAAATTTAATACTGTAAATGTATTCAAATTCATTTACATGCCTATGGCTGCCTTTGAT
TAAACTTCTTCCAAAAAATAAATTCTGCCCAGATGTTGTTGACTTTATTATTTCATGTCAGATTACTTGAATATACGTTGCTGCATAATC
ACTACCAAGTGGGTTCTTTGCTGTGCATTTGTATATCCCAGAATCGGAGGTTTGGGGATTCTGAATGACTAGGGTACCTTGTAAGTGAAG
CTGCTCACTTCCATGTGTCCTCTCTTTACTTGCCGTTGAGAGAAGGGAGTGGTCAGGCATCTCCCATGTGATTTCTGGCTTGGGAACTCC
CAAGGCCACACAGTGGAGCTGAAAGGCTGCCCCTGTCCTGGTGACAATACTCCTGGGTGGACGATTTGTAATTCGGGGAGGGTAGGCTAC

>In-frame_ROBO1_ENST00000464233_chr3_78987751_-_MED12L_ENST00000273432_chr3_150911277_+_5433nt
AAAGTTGCAGGGCTGCGTCTGCACTACGGAGCCTCTAGATTGCTGAAAACAGTCTTATGGAAGGATAACACATTGTCTGTCACTGGCTGG
TTGTAATGCAAGGAAGGGACAAAGATGAAATGGAAACATGTTCCTTTTTTGGTCATGATATCACTCCTCAGCTTATCCCCAAATCACCTG
TTTCTGGCCCAGCTTATTCCAGACCCTGAAGATGTAGAGAGGGGGAACGACCACGGGACGCCAATCCCCACCTCTGATAACGATGACAAT
TCGCTGGGCTATACAGGCTCCCGTCTTCGTCAGGAAGATTTTCCACCTCGCATTGTTGAACACCCTTCAGACCTGATTGTCTCAAAAGGA
GAACCTGCAACTTTGAACTGCAAAGCTGAAGGCCGCCCCACACCCACTATTGAATGGTACAAAGGGGGAGAGAGAGTGGAGACAGACAAA
GATGACCCTCGCTCACACCGAATGTTGCTGCCGAGTGGATCTTTATTTTTCTTACGTATAGTACATGGACGGAAAAGTAGACCTGATGAA
GGAGTCTATGTCTGTGTAGCAAGGAATTACCTTGGAGAGGCTGTGAGCCACAATGCATCGCTGGAAGTAGCCAATTTTTTCTCCTATGCC
TGGAGAATCCTGTGAGAATGCCAACACTTCGTTGGGCAGAAGAATGTCAGTTAATTGTGAGAAGTTGGTGAAGAGGGAAAAGCCAAGGGA
ATTAATTTTTCCATCTAATTATGACCTCCTTCGCCACTTACAGTATGCAACACATTTTCCTATACCTCTGGATGAATCTTCAAGTCATGA
ATGTAACCAGCGCACAATCCTTCTCTATGGAGTCGGCAAAGAGCGTGATGAAGCAAGGCATCAGCTGAAGAAGATTACCAAAGATATCCT
GAAAATTCTAAATAAGAAGAGCACCACAGAGACAGGGGTTGGGGACGAAGGACAAAAAGCCAGGAAGAACAAACAGGAGACATTTCCAAC
ACTGGAGACTGTGTTCACTAAACTCCAGCTCCTTTCATATTTTGATCAACATCAAGTGACATCTCAGATTTCTAACAATGTGCTAGAACA
AATCACAAGCTTTGCGTCAGGAACATCCTATCATCTCCCTTTGGCTCACCACATTCAGCTCATCTTTGATCTCATGGAGCCAGCACTGAA
CATCAACGGACTAATTGACTTCGCAATACAGTTACTAAATGAACTGAGTGTTGTGGAAGCTGAACTGCTCCTAAAATCCTCCAGCCTGGC
AGGAAGTTATACAACAGGACTGTGTGTCTGCATCGTGGCTGTTCTCAGGCGCTATCACAGTTGTCTAATCTTGAATCCTGATCAGACAGC
CCAGGTGTTTGAAGGGTTGTGTGGTGTGGTCAAGCATGTCGTAAACCCCTCAGAATGTTCTTCCCCTGAAAGATGCATTTTAGCCTACCT
CTATGATCTCTATGTGTCATGTAGCCACCTCAGAAGTAAATTTGGAGACCTCTTCAGTAGTGCCTGTTCAAAAGTAAAGCAAACCATATA
TAATAACGTGATGCCTGCAAATTCGAACTTGCGATGGGATCCAGACTTCATGATGGATTTTATTGAGAATCCCTCAGCCCGCAGCATCAA
CTACTCAATGCTGGGCAAGATCCTCAGTGACAATGCGGCCAATCGCTACAGCTTTGTCTGCAATACACTCATGAATGTATGTATGGGCCA
TCAGGATGCTGGCAGGATTAACGACATAGCCAATTTCTCCTCTGAGCTTACGGCTTGCTGCACTGTTCTTAGTTCAGAATGGCTGGGGGT
TCTGAAGGCTCTTTGTTGTTCTTCAAATCACGTGTGGGGGTTTAATGATGTACTTTGCACTGTAGATGTGAGTGACCTTTCATTCCATGA
TTCATTAGCTACTTTCATTGCTATTCTGATAGCACGACAGTGTTTTTCCCTGGAGGACGTCGTGCAGCATGTCGCACTTCCCTCTCTTCT
AGCAGCAGCTTGTGGGGATGCGGACGCCGAGCCTGGGGCGAGAATGACATGCCGACTCTTGCTTCATCTCTTCCGAGCTCCCCAGGCCTG
CTTCTTACCTCAAGCAACGGGCAAACCTTTCCCTGGAATAAGATCATCTTGTGATAGACACCTCTTAGCCGCTGCTCACAACAGCATTGA
AGTGGGAGCCGTGTTTGCTGTCTTAAAAGCAATTATGATGCTTGGAGATGCCAAAATTGGCAATAACAGTGTCAGCTCTTTAAAGAATGA
TGACTTCACCATGAGAGGTTTGCGATGTGATGGGAATGCTGATGATATCTGGACTGCCTCACAAAATCCAAAATCCTGTGGGAAAAGCAT
TTCCATAGAAACTGCCAATTTAAGAGAATACGCTAGATATGTACTGAGGACTATCTGTCAACAGGAATGGGTAGGAGAGCATTGCTTAAA
AGAACCTGAAAGATTATGTACAGACAAAGAACTTATATTGGACCCTGTGCTTTCAAATATGCAAGCACAGAAATTACTGCAGCTTATCTG
TTATCCTCATGGCATTAAAGAATGTACCGAGGGGGACAATCTGCAAAGACAGCACATTAAGCGTATTCTTCAGAATCTTGAGCAGTGGAC
ACTGAGGCAATCCTGGTTAGAACTCCAGCTAATGATCAAACAGTGCTTGAAGGACCCTGGCTCTGGTTCTGTGGCCGAAATGAACAACTT
ACTGGACAATATTGCAAAGGCAACAATAGAGGTATTCCAGCAGTCTGCAGACCTAAATAATTCTTCTAATTCTGGCATGAGCCTCTTCAA
CCCAAACAGTATTGGAAGTGCTGATACAAGTAGCACGAGACAGAATGGAATAAAGACATTCCTAAGTTCCTCCGAACGCAGGGGTGTATG
GTTGGTGGCCCCCCTCATCGCCAGGTTGCCAACTTCTGTGCAAGGAAGAGTGCTGAAAGCCGCTGGGGAAGAGCTGGAGAAGGGACAGCA
CTTGGGTTCTTCTTCCAAAAAGGAAAGGGACAGACAGAAACAGAAAAGTATGTCTCTTTTGAGTCAACAACCCTTCCTCTCACTGGTACT
TACCTGCCTTAAGGGACAAGATGAACAAAGGGAAGGCCTCCTAACATCTCTCCAGAATCAAGTTAACCAGATTTTAAGTAACTGGAGAGA
AGAACGATACCAAGATGACATAAAAGCGCGGCAGATGATGCACGAAGCATTGCAACTCCGCCTAAATTTGGTAGGAGGAATGTTTGACAC
GGTGCAGAGGAGCACCCAGTGGACTACAGACTGGGCCCTGCTACTCCTTCAGATCATTACTTCAGGAACTGTTGACATGCACACTAACAA
TGAATTATTCACAACAGTTCTTGACATGCTGGGTGTTTTAATCAATGGAACGTTAGCCTCTGACCTATCAAATGCATCCCCTGGGGGATC
TGAAGAGAACAAGCGTGCATACATGAATTTAGTAAAGAAACTGAAAAAAGAGCTAGGAGACAAGCGATCAGAAAGTATTGACAAAGTTCG
ACAGTTACTACCTTTGCCGAAACAGACATGTGATGTCATCACTTGTGAACCTATGGGTTCCTTGATTGACACAAAAGGAAACAAAATTGC
TGGATTTGACTCTATAGATAAAAAACAGGGTCTCCAGGTCTCTACGAAGCAGAAGGTGTCCCCGTGGGACTTGTTTGAGGGTCAGAAGAA
CCCAGCTCCTTTGTCCTGGGCCTGGTTTGGGACAGTCCGAGTGGACCGAAGAGTGATCAAGTACGAGGAGCAGCATCACCTCCTGCTGTA
TCACACACACCCCATGCCCAAGCCCCGCAGTTACTACCTCCAGCCACTGCCCCTGCCTCCTGAGGAGGAAGAGGAAGAGCCCACATCTCC
AGTTTCTCAGGAACCAGAAAGGAAGTCCGCTGAGCTGTCAGATCAGGGAAAAACCACAACAGATGAAGAAAAGAAAACAAAAGGAAGGAA
GCGCAAGACGAAATCTAGCTCAAGAGTTGATGAATATCCACAGAGCAACATATACCGAGTGCCTCCTAATTACTCGCCTATCTCCTCCCA
AATGATGCACCATCCACAGTCCACCTTGTGGGGTTACAACCTCGTGGGCCAGCCCCAGCAGCCCGGCTTTTTCCTTCAGAACCAATCTCT
TACTCCAGGTGGCTCCAGATTGGACCCTGCAGGCTCCTTTGTCCCAACCAACACCAAACAAGCTCTGTCAAACATGCTACAGCGGCGCTC
AGGCGCCATGATGCAGCCGCCTTCTCTTCATGCAATCACATCGCAGCAGCAGTTGATACAGATGAAGCTTCTGCAGCAGCAGCAGCAACA
GCGACTTCTCAGGCAAGCCCAGACTCGGCCTTTCCAACAGTTTCCCAGGCAAGGCTTGCAGCAGACCCAGCAGCAGCAGCAGACGGCCGC
CTTGGTGCGGCAGCTCCAGAAGCAGCTTTCCAGCAACCAGCCACAGCAAGGAGTGACTCCGTATGGGCATCCTTCACACTTCTGAATCTG
CAAGAGGAGAAGACATGACGTTTTATGTTTGCACTGAAAAACAGAAAATCAAATTTAATGCATTAGTCATCTTAAAAATGTCCCTTTTTT
TCATTTCTTTGACATTTTACTATATTTTATGCTACATCTCACAAAAAAAAAAAAAGGTGTTTAAACAAAAAGCCAAGGAGAAGTTGTGGT
TTGATTTTGTTGAATTCACCTTTAAAGTAGGTTTACAAATGTGAATCATGCAGGCAGGCCTACTCCCGGAAGAGTGTGCTAGCAGACCTT
TTGAAATTGGTGCTTTTTTTGAATCTCACATTTCTAGAAAGAATGGATTATGATGGATCTAAGGTATTTATGTATTTCATTCATTAATGA
TGACGTTGTTTTTTTTTTTTTAATTTTATTTTCCAAACTGTGCTGGACCAAACTACTGATTTGAAAGGCATGTCAGATCTTGACAGAAAC
ATGGCCTGTTTATTCTGCATTCACCTGTGATGGTGAAACGGACATTTATTTGCATCGCTCTAATTTGAAATGTTTGTAATCTCATAAGCA
CTTTATAAACTTTGTTCTTATTTATGTAGGACTCTTCTTTGCTTTTGTTGTGGTCAAAAGGTGCTGAAACAGATTGTTGCTTCGTACTTA
AACTTCTTAAACCAAGAACCTAAACCAAGGTTTCTTTGAGAGCCGCCCTAAGATGTGCGGAAACCTGTTAGAAGTAGCTGTACTCAAATT
TGTTTTGAGGCAAGATCATTGATGAGAGTCATTGTGAAGGTACAACATGTAAATCCTAAAGGCCTGAAAGAACTGCAGTGGAATCGTCCA
ACTATTTATTGCCAGTTTTGGTTCTCCTGAACCTTATGCCACCTTAAGGGGAAAAAAAAATCCAGTAGCTGGCTTGAGATTCCAGTGCTC


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FusionGenePPI for ROBO1_MED12L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ROBO1TUBB3, MAPK14, USP33, MAPK12, ARPP19, CDK2, PARD6B, CTDSPL, GDPD5, TRIM25MED12LAR, MED7, CCNC, MED19, CDK8, CDK19, NCAPD2, CDC5L, MED21, MED18, MED1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ROBO1_MED12L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ROBO1_MED12L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneROBO1C0001418Adenocarcinoma1CTD_human
HgeneROBO1C0004352Autistic Disorder1CTD_human
HgeneROBO1C0024121Lung Neoplasms1CTD_human