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Fusion gene ID: 31654 |
FusionGeneSummary for RNU6ATAC_DDX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNU6ATAC_DDX1 | Fusion gene ID: 31654 | Hgene | Tgene | Gene symbol | RNU6ATAC | DDX1 | Gene ID | 100151684 | 1653 |
| Gene name | RNA, U6atac small nuclear (U12-dependent splicing) | DEAD-box helicase 1 | |
| Synonyms | RNU6ATAC1|U6ATAC | DBP-RB|UKVH5d | |
| Cytomap | 9q34.2 | 2p24.3 | |
| Type of gene | snRNA | protein-coding | |
| Description | RNA, U6atac small nuclear 1 | ATP-dependent RNA helicase DDX1DEAD (Asp-Glu-Ala-Asp) box helicase 1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1DEAD box polypeptide 1DEAD box protein 1DEAD box protein retinoblastomaDEAD box-1DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1DEAD/H-box h | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q92499 | ||
| Ensembl transtripts involved in fusion gene | ENST00000408749, | ENST00000381341, ENST00000233084, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNU6ATAC [Title/Abstract] AND DDX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DDX1 | GO:0006302 | double-strand break repair | 18710941 |
| Tgene | DDX1 | GO:0032508 | DNA duplex unwinding | 18710941 |
| Tgene | DDX1 | GO:0090305 | nucleic acid phosphodiester bond hydrolysis | 18710941 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA765942 | RNU6ATAC | chr9 | 137029560 | - | DDX1 | chr2 | 15731992 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000408749 | ENST00000381341 | RNU6ATAC | chr9 | 137029560 | - | DDX1 | chr2 | 15731992 | + |
| 5CDS-5UTR | ENST00000408749 | ENST00000233084 | RNU6ATAC | chr9 | 137029560 | - | DDX1 | chr2 | 15731992 | + |
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FusionProtFeatures for RNU6ATAC_DDX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNU6ATAC | DDX1 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Acts as an ATP-dependent RNA helicase, able to unwindboth RNA-RNA and RNA-DNA duplexes. Possesses 5' single-strandedRNA overhang nuclease activity. Possesses ATPase activity onvarious RNA, but not DNA polynucleotides. May play a role in RNAclearance at DNA double-strand breaks (DSBs), thereby facilitatingthe template-guided repair of transcriptionally active regions ofthe genome. Together with RELA, acts as a coactivator to enhanceNF-kappa-B-mediated transcriptional activation. Acts as a positivetranscriptional regulator of cyclin CCND2 expression. Binds to thecyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds topoly(A) RNA. May be involved in 3'-end cleavage andpolyadenylation of pre-mRNAs. Component of the tRNA-splicingligase complex required to facilitate the enzymatic turnover ofcatalytic subunit RTCB: together with archease (ZBTB8OS), acts byfacilitating the guanylylation of RTCB, a key intermediate step intRNA ligation (PubMed:24870230). {ECO:0000269|PubMed:12183465,ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541,ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827,ECO:0000269|PubMed:24870230}. (Microbial infection) Required for HIV-1 Rev function aswell as for HIV-1 and coronavirus IBV replication. Binds to theRRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}. (Microbial infection) Required for Coronavirus IBVreplication. {ECO:0000269|PubMed:20573827}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNU6ATAC_DDX1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNU6ATAC_DDX1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNU6ATAC_DDX1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNU6ATAC_DDX1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DDX1 | C0014173 | Endometrial Hyperplasia | 1 | CTD_human |
| Tgene | DDX1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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