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Fusion gene ID: 31653 |
FusionGeneSummary for RNU6-42P_ATR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNU6-42P_ATR | Fusion gene ID: 31653 | Hgene | Tgene | Gene symbol | RNU6-42P | ATR | Gene ID | 100302742 | 84168 |
| Gene name | RNA, U6 small nuclear 42, pseudogene | ANTXR cell adhesion molecule 1 | |
| Synonyms | RNU6-42 | ATR|GAPO|TEM8 | |
| Cytomap | 3q29 | 2p13.3 | |
| Type of gene | pseudo | protein-coding | |
| Description | - | anthrax toxin receptor 12310008J16Rik2810405N18Riktumor endothelial marker 8 | |
| Modification date | 20180406 | 20180523 | |
| UniProtAcc | Q13535 | ||
| Ensembl transtripts involved in fusion gene | ENST00000384165, | ENST00000350721, ENST00000383101, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 4=80 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNU6-42P [Title/Abstract] AND ATR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATR | GO:0031532 | actin cytoskeleton reorganization | 16762926 |
| Tgene | ATR | GO:0034446 | substrate adhesion-dependent cell spreading | 16762926 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DW440900 | RNU6-42P | chr3 | 180949632 | + | ATR | chr3 | 142224037 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000384165 | ENST00000350721 | RNU6-42P | chr3 | 180949632 | + | ATR | chr3 | 142224037 | - |
| intron-3CDS | ENST00000384165 | ENST00000383101 | RNU6-42P | chr3 | 180949632 | + | ATR | chr3 | 142224037 | - |
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FusionProtFeatures for RNU6-42P_ATR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNU6-42P | ATR |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Serine/threonine protein kinase which activatescheckpoint signaling upon genotoxic stresses such as ionizingradiation (IR), ultraviolet light (UV), or DNA replicationstalling, thereby acting as a DNA damage sensor. Recognizes thesubstrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1,MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibitDNA replication and mitosis and promote DNA repair, recombinationand apoptosis. Phosphorylates 'Ser-139' of histone variantH2AX/H2AFX at sites of DNA damage, thereby regulating DNA damageresponse mechanism. Required for FANCD2 ubiquitination. Criticalfor maintenance of fragile site stability and efficient regulationof centrosome duplication. {ECO:0000269|PubMed:10597277,ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164,ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864,ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054,ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805,ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551,ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973,ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935,ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423,ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835,ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720,ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169,ECO:0000269|PubMed:9925639}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNU6-42P_ATR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNU6-42P_ATR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNU6-42P_ATR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNU6-42P_ATR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ATR | C0032273 | Pneumoconiosis | 1 | CTD_human |
| Tgene | ATR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | ATR | C0042076 | Urologic Neoplasms | 1 | CTD_human |
| Tgene | ATR | C3281203 | CUTANEOUS TELANGIECTASIA AND CANCER SYNDROME, FAMILIAL | 1 | ORPHANET;UNIPROT |
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