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Fusion gene ID: 31607 |
FusionGeneSummary for RNF6_USP18 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF6_USP18 | Fusion gene ID: 31607 | Hgene | Tgene | Gene symbol | RNF6 | USP18 | Gene ID | 6049 | 11274 |
| Gene name | ring finger protein 6 | ubiquitin specific peptidase 18 | |
| Synonyms | - | ISG43|PTORCH2|UBP43 | |
| Cytomap | 13q12.13 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase RNF6RING-H2 protein RNF-6RING-type E3 ubiquitin transferase RNF6ring finger protein (C3H2C3 type) 6 | ubl carboxyl-terminal hydrolase 1843 kDa ISG15-specific proteaseISG15-specific-processing proteasehUBP43ubiquitin specific protease 18ubl thioesterase 18ubl thiolesterase 18 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y252 | Q9UMW8 | |
| Ensembl transtripts involved in fusion gene | ENST00000468480, ENST00000346166, ENST00000381588, ENST00000381570, ENST00000399762, | ENST00000215794, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 2 X 4=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RNF6 [Title/Abstract] AND USP18 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RNF6 | GO:0044314 | protein K27-linked ubiquitination | 19345326 |
| Hgene | RNF6 | GO:0085020 | protein K6-linked ubiquitination | 19345326 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-DB-A75O-01A | RNF6 | chr13 | 26792649 | - | USP18 | chr22 | 18659538 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000468480 | ENST00000215794 | RNF6 | chr13 | 26792649 | - | USP18 | chr22 | 18659538 | + |
| Frame-shift | ENST00000346166 | ENST00000215794 | RNF6 | chr13 | 26792649 | - | USP18 | chr22 | 18659538 | + |
| In-frame | ENST00000381588 | ENST00000215794 | RNF6 | chr13 | 26792649 | - | USP18 | chr22 | 18659538 | + |
| In-frame | ENST00000381570 | ENST00000215794 | RNF6 | chr13 | 26792649 | - | USP18 | chr22 | 18659538 | + |
| 5UTR-3CDS | ENST00000399762 | ENST00000215794 | RNF6 | chr13 | 26792649 | - | USP18 | chr22 | 18659538 | + |
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FusionProtFeatures for RNF6_USP18 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF6 | USP18 |
| E3 ubiquitin-protein ligase mediating 'Lys-48'-linkedpolyubiquitination of LIMK1 and its subsequent targeting to theproteasome for degradation. Negatively regulates axonal outgrowththrough regulation of the LIMK1 turnover. Mediates 'Lys-6' and'Lys-27'-linked polyubiquitination of AR/androgen receptor therebymodulating its transcriptional activity. May also bind DNA andfunction as a transcriptional regulator.{ECO:0000269|PubMed:19345326}. | Involved in the regulation of inflammatory response tointerferon type 1 (PubMed:27325888). Can efficiently cleave onlyISG15 fusions including native ISG15 conjugates linked viaisopeptide bonds. Necessary to maintain a critical cellularbalance of ISG15-conjugated proteins in both healthy and stressedorganisms. {ECO:0000269|PubMed:27325888}. Isoform 2: Has enzymatic activity similar to isoform 1and interferes with type I interferon signaling. MajordeISGylation enzyme for nuclear proteins (PubMed:22170061).{ECO:0000269|PubMed:22170061}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF6_USP18 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RNF6_ENST00000381588_chr13_26792649_-_USP18_ENST00000215794_chr22_18659538_+_15aa >In-frame_RNF6_ENST00000381570_chr13_26792649_-_USP18_ENST00000215794_chr22_18659538_+_15aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RNF6_ENST00000381588_chr13_26792649_-_USP18_ENST00000215794_chr22_18659538_+_46nt >In-frame_RNF6_ENST00000381570_chr13_26792649_-_USP18_ENST00000215794_chr22_18659538_+_46nt |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RNF6_ENST00000381588_chr13_26792649_-_USP18_ENST00000215794_chr22_18659538_+_1668nt GACAGACTTCAGAATTTATTAGGGTTTGTAATTTCCAGGTTCCAAAGCACAGCAAGGGAAAGGGCCTGGCTGGGTAGTACGTTACACCCG GAAGTAAAGAGACGCATACACCGTTGGGTGCACTTTATAGTCTGGCTGGCAAACGAGCGACACCGACGCGCAGAGTTAAGTGCTGGGACT TCCCAAGCCTGGAAAGCAGACCGTGTCTCTGCAACTACGCGGCTGCCACGAGCGCTGAGCGGCCGGGCATTTGGCCTCGAGGAGGAGGCA CTGTAAGGGCGGCGCAAGAGGGCGGAACGCGGGACGCCAGGCACCCTAGCTCCCGACGGACGCAGTTTTCAGTTGCACGGGCGAGCTCCG GGCCGGCTGCGGAGCGACTCCCCGCCGCCAAGTGGGCGGCGTGGCTGTCGGGAAAGAAGGGCTGGGGCCTGCCGTTCTTCCTCCCGAGTA TCCCCTCCAGCTGGACGACCCCACGCTGCAGCACGGGCTTCCGGCTTCTCTCCTCAGTGGCCAATTCGAGGGCACAGCGGGCTCCGGAGG CGCGGCGGCAAGCCTATCCCGCCTCCCAACCACAGCCTCCAGCACCCGAGAGAACGGCCGCCCACAGCACACGTTCTCCGGACAGGAGGG CGAAGGCCCAAGACCTGGAGAGATGGGCAGCTCTCAAAAAAGGCACAAACAATTGAAGGATGGATACCATGGCATATGTTAAAAGCGTGT TGAAAGGAAAATAAGAAAGCCAGGAATCTCAGGATGAATCAGTCTAGATCGAGATCAGATGGTGGCAGTGAAGAAACCTTACCTCAAGAC CATAATCATCATGAAAATGAGAGAAGATGGCAGCAAGAGCGTCTCCACAGAGAAGAGGCCTATTATCAGTTTATTAATGAACTCAATGAT GAAGATTATCGGCTTATGAGAGACCATAATCTTTTAGGCACCCCTGGAGAAATAACATCAGAAGAACTGCAACAGCGGTTAGATGGCGTC AAGGAACAACTAGCATCTCAGCCTGACTTGAGAGATGGAACGAATTACAGAGGCAGGAAACTGCATATCTTCTGGTTTACATGAAGATGG AGTGCTAATGGAAATGCCCAAAACCTTCAGAGATTGACACGCTGTCATTTTCCATTTCCGTTCCTGGATCTACGGAGTCTTCTAAGAGAT TTTGCAATGAGGAGAAGCATTGTTTTCAAACTATATAACTGAGCCTTATTTATAATTAGGGATATTATCAAAATATGTAACCATGAGGCC CCTCAGGTCCTGATCAGTCAGAATGGATGCTTTCACCAGCAGACCCGGCCATGTGGCTGCTCGGTCCTGGGTGCTCGCTGCTGTGCAAGA CATTAGCCCTTTAGTTATGAGCCTGTGGGAACTTCAGGGGTTCCCAGTGGGGAGAGCAGTGGCAGTGGGAGGCATCTGGGGGCCAAAGGT CAGTGGCAGGGGGTATTTCAGTATTATACAACTGCTGTGACCAGACTTGTATACTGGCTGAATATCAGTGCTGTTTGTAATTTTTCACTT TGAGAACCAACATTAATTCCATATGAATCAAGTGTTTTGTAACTGCTATTCATTTATTCAGCAAATATTTATTGATCATCTCTTCTCCAT >In-frame_RNF6_ENST00000381570_chr13_26792649_-_USP18_ENST00000215794_chr22_18659538_+_1206nt GGGAAAGAAACCAGTAGCGGGACGGAGGGCGGGGGTGGCAAGAAAGTCAAGGTTTAGAAGTAAGCCGGAGACGCCTAACCCTGGTAACAT CCGAATGGGAACGGGATAGGAAGGAAGGCCTTTGAGAGAGGAGGCGTAAACCCAGGAACAGTGACAGTGTAGGACGAAAGGCCTAAGTTT GTTGCGGAAGATGGGCAGCTCTCAAAAAAGGCACAAACAATTGAAGGATGGATACCATGGCATATGTTAAAAGCGTGTTGAAAGGAAAAT AAGAAAGCCAGGAATCTCAGGATGAATCAGTCTAGATCGAGATCAGATGGTGGCAGTGAAGAAACCTTACCTCAAGACCATAATCATCAT GAAAATGAGAGAAGATGGCAGCAAGAGCGTCTCCACAGAGAAGAGGCCTATTATCAGTTTATTAATGAACTCAATGATGAAGATTATCGG CTTATGAGAGACCATAATCTTTTAGGCACCCCTGGAGAAATAACATCAGAAGAACTGCAACAGCGGTTAGATGGCGTCAAGGAACAACTA GCATCTCAGCCTGACTTGAGAGATGGAACGAATTACAGAGGCAGGAAACTGCATATCTTCTGGTTTACATGAAGATGGAGTGCTAATGGA AATGCCCAAAACCTTCAGAGATTGACACGCTGTCATTTTCCATTTCCGTTCCTGGATCTACGGAGTCTTCTAAGAGATTTTGCAATGAGG AGAAGCATTGTTTTCAAACTATATAACTGAGCCTTATTTATAATTAGGGATATTATCAAAATATGTAACCATGAGGCCCCTCAGGTCCTG ATCAGTCAGAATGGATGCTTTCACCAGCAGACCCGGCCATGTGGCTGCTCGGTCCTGGGTGCTCGCTGCTGTGCAAGACATTAGCCCTTT AGTTATGAGCCTGTGGGAACTTCAGGGGTTCCCAGTGGGGAGAGCAGTGGCAGTGGGAGGCATCTGGGGGCCAAAGGTCAGTGGCAGGGG GTATTTCAGTATTATACAACTGCTGTGACCAGACTTGTATACTGGCTGAATATCAGTGCTGTTTGTAATTTTTCACTTTGAGAACCAACA TTAATTCCATATGAATCAAGTGTTTTGTAACTGCTATTCATTTATTCAGCAAATATTTATTGATCATCTCTTCTCCATAAGATAGTGTGA |
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FusionGenePPI for RNF6_USP18 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RNF6 | UBE2H, AR, LDB1, UBE2D1, ALOX5, VASN, ASAH1 | USP18 | ISG15, MYL6, NME1, KDM3B, USP41, SKP2, IFNAR2, TRIM54, PCNA, MOV10, NXF1, ZDHHC17, HERC1, BECN1, ATG14, PIK3C3, UVRAG, TMEM14A, TAB1, MAP3K7, CHUK, IKBKB, IKBKG, CARD11, TAB2, TMEM173 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF6_USP18 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF6_USP18 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | USP18 | C0023269 | leiomyosarcoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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