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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31603

FusionGeneSummary for RNF4_RGS12

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF4_RGS12
Fusion gene ID: 31603
HgeneTgene
Gene symbol

RNF4

RGS12

Gene ID

6047

6002

Gene namering finger protein 4regulator of G protein signaling 12
SynonymsRES4-26|SLX5|SNURF-
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF4E3 ubiquitin ligase RNF4RING-type E3 ubiquitin transferase RNF4small nuclear RING finger proteinregulator of G-protein signaling 12regulator of G-protein signalling 12
Modification date2018052320180519
UniProtAcc

P78317

O14924

Ensembl transtripts involved in fusion geneENST00000314289, ENST00000541204, 
ENST00000509258, ENST00000511843, 
ENST00000511859, ENST00000506706, 
ENST00000511600, 
ENST00000543385, 
ENST00000336727, ENST00000344733, 
ENST00000382788, ENST00000306648, 
ENST00000338806, ENST00000508158, 
ENST00000538395, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 5 X 3=60
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNF4 [Title/Abstract] AND RGS12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF4

GO:0045944

positive regulation of transcription by RNA polymerase II

12885770

HgeneRNF4

GO:0046685

response to arsenic-containing substance

20943951


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-V1-A9ZR-01ARNF4chr4

2502465

+RGS12chr4

3379897

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000314289ENST00000543385RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000314289ENST00000336727RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000314289ENST00000344733RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000314289ENST00000382788RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000314289ENST00000306648RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000314289ENST00000338806RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000314289ENST00000508158RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000314289ENST00000538395RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000541204ENST00000543385RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000541204ENST00000336727RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000541204ENST00000344733RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000541204ENST00000382788RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000541204ENST00000306648RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000541204ENST00000338806RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000541204ENST00000508158RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000541204ENST00000538395RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000509258ENST00000543385RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000509258ENST00000336727RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000509258ENST00000344733RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000509258ENST00000382788RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000509258ENST00000306648RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000509258ENST00000338806RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000509258ENST00000508158RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000509258ENST00000538395RNF4chr4

2502465

+RGS12chr4

3379897

+
3UTR-intronENST00000511843ENST00000543385RNF4chr4

2502465

+RGS12chr4

3379897

+
3UTR-intronENST00000511843ENST00000336727RNF4chr4

2502465

+RGS12chr4

3379897

+
3UTR-intronENST00000511843ENST00000344733RNF4chr4

2502465

+RGS12chr4

3379897

+
3UTR-intronENST00000511843ENST00000382788RNF4chr4

2502465

+RGS12chr4

3379897

+
3UTR-intronENST00000511843ENST00000306648RNF4chr4

2502465

+RGS12chr4

3379897

+
3UTR-intronENST00000511843ENST00000338806RNF4chr4

2502465

+RGS12chr4

3379897

+
3UTR-intronENST00000511843ENST00000508158RNF4chr4

2502465

+RGS12chr4

3379897

+
3UTR-intronENST00000511843ENST00000538395RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511859ENST00000543385RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511859ENST00000336727RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511859ENST00000344733RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511859ENST00000382788RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511859ENST00000306648RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511859ENST00000338806RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511859ENST00000508158RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511859ENST00000538395RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000506706ENST00000543385RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000506706ENST00000336727RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000506706ENST00000344733RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000506706ENST00000382788RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000506706ENST00000306648RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000506706ENST00000338806RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000506706ENST00000508158RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000506706ENST00000538395RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511600ENST00000543385RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511600ENST00000336727RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511600ENST00000344733RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511600ENST00000382788RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511600ENST00000306648RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511600ENST00000338806RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511600ENST00000508158RNF4chr4

2502465

+RGS12chr4

3379897

+
5CDS-intronENST00000511600ENST00000538395RNF4chr4

2502465

+RGS12chr4

3379897

+

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FusionProtFeatures for RNF4_RGS12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF4

P78317

RGS12

O14924

E3 ubiquitin-protein ligase which binds polysumoylatedchains covalently attached to proteins and mediates 'Lys-6'-,'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination ofthose substrates and their subsequent targeting to the proteasomefor degradation. Regulates the degradation of several proteinsincluding PML and the transcriptional activator PEA3. Involved inchromosome alignment and spindle assembly, it regulates thekinetochore CENPH-CENPI-CENPK complex by targeting polysumoylatedCENPI to proteasomal degradation. Regulates the cellular responsesto hypoxia and heat shock through degradation of respectivelyEPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomesand have a more direct role in the regulation of transcription forinstance enhancing basal transcription and steroid receptor-mediated transcriptional activation. {ECO:0000269|PubMed:12885770,ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308,ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:20212317,ECO:0000269|PubMed:20943951}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF4_RGS12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF4_RGS12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF4AR, PATZ1, TCF20, ESR1, PGR, TBP, SP1, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2L6, UBE2T, UBE2W, UEVLD, UBE2E1, UBE2E3, UBE2H, UBE2I, UBE2K, UBE2E2, IKBKG, RNF4, SUMO2, TRIM28, PML, SART1, UHRF1, MDC1, RPA1, SUMO1, TDG, APEX1, TRPS1, SKIL, NFE2L2, TRAIP, HNF4A, SRPK2, UBC, HIST2H3C, ATXN1, TARDBP, MECP2, NCOA1, TERF2, FANCA, UBE2N, MAP3K7, TAB2, TAB3, USP11, MYC, CTNNB1, TRIM25, MIS18BP1, UBE2A, UBE2BRGS12GNAI1, GNAI3, GNAI2, CUL4A, EEF1A1, ARL4C, MTNR1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF4_RGS12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF4_RGS12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRGS12C0036341Schizophrenia1CTD_human