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Fusion gene ID: 31601 |
FusionGeneSummary for RNF4_DCTD |
Fusion gene summary |
Fusion gene information | Fusion gene name: RNF4_DCTD | Fusion gene ID: 31601 | Hgene | Tgene | Gene symbol | RNF4 | DCTD | Gene ID | 6047 | 1635 |
Gene name | ring finger protein 4 | dCMP deaminase | |
Synonyms | RES4-26|SLX5|SNURF | - | |
Cytomap | 4p16.3 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase RNF4E3 ubiquitin ligase RNF4RING-type E3 ubiquitin transferase RNF4small nuclear RING finger protein | deoxycytidylate deaminase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P78317 | P32321 | |
Ensembl transtripts involved in fusion gene | ENST00000314289, ENST00000541204, ENST00000509258, ENST00000511843, ENST00000511859, ENST00000506706, ENST00000511600, | ENST00000357067, ENST00000438320, ENST00000510370, ENST00000513383, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 3 X 2=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RNF4 [Title/Abstract] AND DCTD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RNF4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12885770 |
Hgene | RNF4 | GO:0046685 | response to arsenic-containing substance | 20943951 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM554139 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000314289 | ENST00000357067 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-5UTR | ENST00000314289 | ENST00000438320 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-5UTR | ENST00000314289 | ENST00000510370 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-intron | ENST00000314289 | ENST00000513383 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-3CDS | ENST00000541204 | ENST00000357067 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-5UTR | ENST00000541204 | ENST00000438320 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-5UTR | ENST00000541204 | ENST00000510370 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-intron | ENST00000541204 | ENST00000513383 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-3CDS | ENST00000509258 | ENST00000357067 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-5UTR | ENST00000509258 | ENST00000438320 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-5UTR | ENST00000509258 | ENST00000510370 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-intron | ENST00000509258 | ENST00000513383 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
3UTR-3CDS | ENST00000511843 | ENST00000357067 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
3UTR-5UTR | ENST00000511843 | ENST00000438320 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
3UTR-5UTR | ENST00000511843 | ENST00000510370 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
3UTR-intron | ENST00000511843 | ENST00000513383 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-3CDS | ENST00000511859 | ENST00000357067 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-5UTR | ENST00000511859 | ENST00000438320 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-5UTR | ENST00000511859 | ENST00000510370 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
5UTR-intron | ENST00000511859 | ENST00000513383 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
intron-3CDS | ENST00000506706 | ENST00000357067 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
intron-5UTR | ENST00000506706 | ENST00000438320 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
intron-5UTR | ENST00000506706 | ENST00000510370 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
intron-intron | ENST00000506706 | ENST00000513383 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
intron-3CDS | ENST00000511600 | ENST00000357067 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
intron-5UTR | ENST00000511600 | ENST00000438320 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
intron-5UTR | ENST00000511600 | ENST00000510370 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
intron-intron | ENST00000511600 | ENST00000513383 | RNF4 | chr4 | 2470985 | + | DCTD | chr4 | 183836729 | - |
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FusionProtFeatures for RNF4_DCTD |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
RNF4 | DCTD |
E3 ubiquitin-protein ligase which binds polysumoylatedchains covalently attached to proteins and mediates 'Lys-6'-,'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination ofthose substrates and their subsequent targeting to the proteasomefor degradation. Regulates the degradation of several proteinsincluding PML and the transcriptional activator PEA3. Involved inchromosome alignment and spindle assembly, it regulates thekinetochore CENPH-CENPI-CENPK complex by targeting polysumoylatedCENPI to proteasomal degradation. Regulates the cellular responsesto hypoxia and heat shock through degradation of respectivelyEPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomesand have a more direct role in the regulation of transcription forinstance enhancing basal transcription and steroid receptor-mediated transcriptional activation. {ECO:0000269|PubMed:12885770,ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308,ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:20212317,ECO:0000269|PubMed:20943951}. | Supplies the nucleotide substrate for thymidylatesynthetase. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF4_DCTD |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNF4_DCTD |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RNF4 | AR, PATZ1, TCF20, ESR1, PGR, TBP, SP1, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2L6, UBE2T, UBE2W, UEVLD, UBE2E1, UBE2E3, UBE2H, UBE2I, UBE2K, UBE2E2, IKBKG, RNF4, SUMO2, TRIM28, PML, SART1, UHRF1, MDC1, RPA1, SUMO1, TDG, APEX1, TRPS1, SKIL, NFE2L2, TRAIP, HNF4A, SRPK2, UBC, HIST2H3C, ATXN1, TARDBP, MECP2, NCOA1, TERF2, FANCA, UBE2N, MAP3K7, TAB2, TAB3, USP11, MYC, CTNNB1, TRIM25, MIS18BP1, UBE2A, UBE2B | DCTD | LNX1, CEP76, NUDT18, NIF3L1, DCTD, ELAVL1, FGF12, SDCBP, TXN2, GORASP2, MALSU1, NGRN |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF4_DCTD |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF4_DCTD |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |