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Fusion gene ID: 3157 |
FusionGeneSummary for ATG10_EMC7 |
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Fusion gene information | Fusion gene name: ATG10_EMC7 | Fusion gene ID: 3157 | Hgene | Tgene | Gene symbol | ATG10 | EMC7 | Gene ID | 83734 | 56851 |
Gene name | autophagy related 10 | ER membrane protein complex subunit 7 | |
Synonyms | APG10|APG10L|pp12616 | C11orf3|C15orf24|HT022|ORF1-FL1 | |
Cytomap | 5q14.1-q14.2 | 15q14 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin-like-conjugating enzyme ATG10APG10 autophagy 10-likeATG10 autophagy related 10 homologautophagy-related protein 10 | ER membrane protein complex subunit 7UPF0480 protein C15orf24chromosome 15 hypothetical ATG/GTP binding protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H0Y0 | Q9NPA0 | |
Ensembl transtripts involved in fusion gene | ENST00000355178, ENST00000282185, ENST00000458350, ENST00000513443, ENST00000513634, ENST00000514253, | ENST00000256545, ENST00000532113, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 2 X 4=32 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ATG10 [Title/Abstract] AND EMC7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ATG10 | GO:0032446 | protein modification by small protein conjugation | 16963840 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-BF-A5EQ-01A | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000355178 | ENST00000256545 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-intron | ENST00000355178 | ENST00000532113 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-3CDS | ENST00000282185 | ENST00000256545 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-intron | ENST00000282185 | ENST00000532113 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
5UTR-3CDS | ENST00000458350 | ENST00000256545 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
5UTR-intron | ENST00000458350 | ENST00000532113 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-3CDS | ENST00000513443 | ENST00000256545 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-intron | ENST00000513443 | ENST00000532113 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-3CDS | ENST00000513634 | ENST00000256545 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-intron | ENST00000513634 | ENST00000532113 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-3CDS | ENST00000514253 | ENST00000256545 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
intron-intron | ENST00000514253 | ENST00000532113 | ATG10 | chr5 | 81272146 | + | EMC7 | chr15 | 34388215 | - |
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FusionProtFeatures for ATG10_EMC7 |
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Hgene | Tgene |
ATG10 | EMC7 |
E2-like enzyme involved in autophagy. Acts as an E2-likeenzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12conjugation to ATG5 is required for autophagy. Likely serves as anATG5-recognition molecule. Not involved in ATG12 conjugation toATG3 (By similarity). Plays a role in adenovirus-mediated celllysis. {ECO:0000250, ECO:0000269|PubMed:21367888}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATG10_EMC7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATG10_EMC7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ATG10 | ATG12, ATG7, KRT85, MAP1B, USP11, ATG4B, ATG3, USP7, HAT1, RBBP7, ADSS | EMC7 | ATP13A2, FBXO6, EMC9, UBQLN2, EMC8, EMC2, EMC3, EMC10, CLPTM1L, EMC6, MMGT1, EMC1, EMC4, TMED10, SDF2L1, ATP1B3, SLC8A3, OR2S2, SLC18A1, P2RX4, ENPP6, CD164L2, TCTN2, TCTN3, TMEM17, TMEM216, TRDN, SLC4A8, PDIA4, KLHL22, IFNA21, KLK6, GPR6, MTNR1A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATG10_EMC7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATG10_EMC7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |