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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31551

FusionGeneSummary for RNF217_MRPS27

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF217_MRPS27
Fusion gene ID: 31551
HgeneTgene
Gene symbol

RNF217

MRPS27

Gene ID

154214

23107

Gene namering finger protein 217mitochondrial ribosomal protein S27
SynonymsC6orf172|IBRDC1|OSTL|dJ84N20.1MRP-S27|S27mt
Cytomap

6q22.31

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase RNF217IBR domain containing 1opposite STL28S ribosomal protein S27, mitochondrialmitochondrial 28S ribosomal protein S27mitochondrial small ribosomal subunit protein mS27
Modification date2018052320180519
UniProtAcc

Q8TC41

Q92552

Ensembl transtripts involved in fusion geneENST00000521654, ENST00000560949, 
ENST00000454842, ENST00000368414, 
ENST00000359704, ENST00000275184, 
ENST00000261413, ENST00000457646, 
ENST00000513900, ENST00000515404, 
ENST00000522562, ENST00000522095, 
Fusion gene scores* DoF score7 X 4 X 7=1963 X 3 X 2=18
# samples 104
** MAII scorelog2(10/196*10)=-0.970853654340483
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNF217 [Title/Abstract] AND MRPS27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB085590RNF217chr6

125330430

+MRPS27chr5

71533957

-
ChiTaRS3.1AK310474RNF217chr6

125330430

+MRPS27chr5

71533957

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000521654ENST00000261413RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000521654ENST00000457646RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000521654ENST00000513900RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000521654ENST00000515404RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000521654ENST00000522562RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-intronENST00000521654ENST00000522095RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000560949ENST00000261413RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000560949ENST00000457646RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000560949ENST00000513900RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000560949ENST00000515404RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000560949ENST00000522562RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-intronENST00000560949ENST00000522095RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000454842ENST00000261413RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000454842ENST00000457646RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000454842ENST00000513900RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000454842ENST00000515404RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000454842ENST00000522562RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-intronENST00000454842ENST00000522095RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000368414ENST00000261413RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000368414ENST00000457646RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000368414ENST00000513900RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000368414ENST00000515404RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000368414ENST00000522562RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-intronENST00000368414ENST00000522095RNF217chr6

125330430

+MRPS27chr5

71533957

-
Frame-shiftENST00000359704ENST00000261413RNF217chr6

125330430

+MRPS27chr5

71533957

-
Frame-shiftENST00000359704ENST00000457646RNF217chr6

125330430

+MRPS27chr5

71533957

-
Frame-shiftENST00000359704ENST00000513900RNF217chr6

125330430

+MRPS27chr5

71533957

-
Frame-shiftENST00000359704ENST00000515404RNF217chr6

125330430

+MRPS27chr5

71533957

-
In-frameENST00000359704ENST00000522562RNF217chr6

125330430

+MRPS27chr5

71533957

-
5CDS-intronENST00000359704ENST00000522095RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000275184ENST00000261413RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000275184ENST00000457646RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000275184ENST00000513900RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000275184ENST00000515404RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-3CDSENST00000275184ENST00000522562RNF217chr6

125330430

+MRPS27chr5

71533957

-
intron-intronENST00000275184ENST00000522095RNF217chr6

125330430

+MRPS27chr5

71533957

-

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FusionProtFeatures for RNF217_MRPS27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF217

Q8TC41

MRPS27

Q92552

E3 ubiquitin-protein ligase which accepts ubiquitin fromE2 ubiquitin-conjugating enzymes in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.{ECO:0000250}. RNA-binding component of the mitochondrial smallribosomal subunit (mt-SSU) that plays a role in mitochondrialprotein synthesis (PubMed:22841715). Stimulates mitochondrial mRNAtranslation of subunit components of the mitochondrial electrontransport chain (PubMed:22841715). Binds to the mitochondrial 12SrRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved alsoin positive regulation of cell proliferation and tumor cell growth(PubMed:28714366). {ECO:0000269|PubMed:22841715,ECO:0000269|PubMed:28714366}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF217_MRPS27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RNF217_ENST00000359704_chr6_125330430_+_MRPS27_ENST00000522562_chr5_71533957_-_2aa

>In-frame_RNF217_ENST00000359704_chr6_125330430_+_MRPS27_ENST00000522562_chr5_71533957_-_2aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RNF217_ENST00000359704_chr6_125330430_+_MRPS27_ENST00000522562_chr5_71533957_-_6nt

>In-frame_RNF217_ENST00000359704_chr6_125330430_+_MRPS27_ENST00000522562_chr5_71533957_-_6nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_RNF217_ENST00000359704_chr6_125330430_+_MRPS27_ENST00000522562_chr5_71533957_-_1176nt
AGTATACAGAGGAGGACACAAACATGAGAAGATTAAGGTAGAGAGTGAAATATGGTCAGGACAAATGTGAATTTAGAGCCTGAGTGATGG
TTTAGTGGATTTATGTCCTCACTTGTCACTAATGAAAAGGACCTTACAGGTTATATAATTAAAGCTCTGTTGACATTGGCTCTTGAAGGC
AAACTTCATAATGAGGGGAAGAGTCAAGTTTTGTGTAACCTGAAGCATATACAGTGTCCATTGCCAGCACTTGAGTAAAGATAAAGAGTA
GGAGAATCAAAGCTGTTGTATAATTAGTTCTCTTCTCATCCACACCCATAAACCAGTTCAAGAAAGGGATGAAGAGGTTTCGACACAGCC
CCAACTGCTGGTACCTGAGAAACTGGACTATCCACACCTGGATTAGGCAGTGTCTAAAATATGATGCACAAGACAAAGCCCTATATACCC
TTGTAAATAAGGTTCAATATGGAATTTTTCCAGATAACTTTACATTCAATTTACTGATGGATTCTTTCATAAAGAAAGAAAATTACAAAG
ATGCTTTATCTGTGGTTTTTGAGGTCATGATGCAAGAAGCCTTTGAAGTGCCTTCCACCCAACTTCTCTCCCTCTATGTTTTATTTCATT
GCCTGGCAAAGAAGACAGACTTCAGTTGGGAAGAGGAGAGGAACTTTGGTGCATCCCTTTTGCTTCCAGGCCTAAAACAAAAGAACTCAG
TGGGTTTCAGTTCCCAGTTGTATGGCTATGCACTTCTTGATCAGCATTCAGGACTGTCATACAGCCTGAATTGGTCAGAAGTGACAGGGC
AAAGAATATGTACTTTGTTGTGGTTTGTGAGCAGAGGCCCTGGTTCTTTGTGATAGCAGCCATCAGATCAGAAGCTCTTTGCTCTCATTG
TGTCATTTGCCGTGCAGCCTCACTCAGCCCTGATGGAAGCAGCTGCCCAGAATGTAACTGCAGTCCAGCCCCAAGCACCTTAAAGGGAAG
GTGGAGTTGCAGCAAGGGCTACGGGCTGTGTACCACAACATGCCTCTGATATGGAAACCAGGCTACCTTGACAGAGCCCTTCAAGTGATG
GAGAAAGTGGCTGCCTCCCCAGAAGACATAAAGCTGTGTAGAGAAGCGCTCGATGTGCTGGGTGCAGTGCTGAAGGCTCTGACTTCAGCT

>In-frame_RNF217_ENST00000359704_chr6_125330430_+_MRPS27_ENST00000522562_chr5_71533957_-_1176nt
AGTATACAGAGGAGGACACAAACATGAGAAGATTAAGGTAGAGAGTGAAATATGGTCAGGACAAATGTGAATTTAGAGCCTGAGTGATGG
TTTAGTGGATTTATGTCCTCACTTGTCACTAATGAAAAGGACCTTACAGGTTATATAATTAAAGCTCTGTTGACATTGGCTCTTGAAGGC
AAACTTCATAATGAGGGGAAGAGTCAAGTTTTGTGTAACCTGAAGCATATACAGTGTCCATTGCCAGCACTTGAGTAAAGATAAAGAGTA
GGAGAATCAAAGCTGTTGTATAATTAGTTCTCTTCTCATCCACACCCATAAACCAGTTCAAGAAAGGGATGAAGAGGTTTCGACACAGCC
CCAACTGCTGGTACCTGAGAAACTGGACTATCCACACCTGGATTAGGCAGTGTCTAAAATATGATGCACAAGACAAAGCCCTATATACCC
TTGTAAATAAGGTTCAATATGGAATTTTTCCAGATAACTTTACATTCAATTTACTGATGGATTCTTTCATAAAGAAAGAAAATTACAAAG
ATGCTTTATCTGTGGTTTTTGAGGTCATGATGCAAGAAGCCTTTGAAGTGCCTTCCACCCAACTTCTCTCCCTCTATGTTTTATTTCATT
GCCTGGCAAAGAAGACAGACTTCAGTTGGGAAGAGGAGAGGAACTTTGGTGCATCCCTTTTGCTTCCAGGCCTAAAACAAAAGAACTCAG
TGGGTTTCAGTTCCCAGTTGTATGGCTATGCACTTCTTGATCAGCATTCAGGACTGTCATACAGCCTGAATTGGTCAGAAGTGACAGGGC
AAAGAATATGTACTTTGTTGTGGTTTGTGAGCAGAGGCCCTGGTTCTTTGTGATAGCAGCCATCAGATCAGAAGCTCTTTGCTCTCATTG
TGTCATTTGCCGTGCAGCCTCACTCAGCCCTGATGGAAGCAGCTGCCCAGAATGTAACTGCAGTCCAGCCCCAAGCACCTTAAAGGGAAG
GTGGAGTTGCAGCAAGGGCTACGGGCTGTGTACCACAACATGCCTCTGATATGGAAACCAGGCTACCTTGACAGAGCCCTTCAAGTGATG
GAGAAAGTGGCTGCCTCCCCAGAAGACATAAAGCTGTGTAGAGAAGCGCTCGATGTGCTGGGTGCAGTGCTGAAGGCTCTGACTTCAGCT


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FusionGenePPI for RNF217_MRPS27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF217KIAA0368, HAX1, POTEKP, ACTBL2, H1FNT, ACTA2MRPS27HNRNPA1, KHDRBS2, CDK9, ICT1, HDGF, ELAVL1, CUL3, CUL1, COPS5, CAND1, GRK5, MRPS23, DAP3, ILF3, SMURF1, ESR2, C1QBP, YWHAQ, MRPL3, MRPL12, TARDBP, PARK2, RIOK2, GRSF1, AURKB, HAUS2, CEP76, TP53, NECAB2, MOV10, NXF1, BTRC, FBXW11, NOL12, RPL13, TRA2A, RPL6, RPS8, DNAJC1, LRRC15, TRMT10B, ZNF707, LUC7L, MRPS31, MRPS5, MRPS22, MRPS28, NTRK1, CENPA, HNRNPU, RPL10, TSNAX, THOC5, PHF8, THOC2, MYH7B, FBXO31, FERMT3, ZSCAN26, ERBB3, ZNF746, C8orf82, NOA1, MRPS34, MRPS9, MRPS33, MRPS7, MRPS11, MRPS26, PTCD3, MRPS35, MRPS24, MRPS21, STRBP, MRPS15, MRPS10, MRPS14, MRPS18C, MRPS2, MRPS25, MRPS16, MRPS18B, METTL17, AURKAIP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF217_MRPS27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF217_MRPS27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource