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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31489

FusionGeneSummary for RNF185_ESRRG

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF185_ESRRG
Fusion gene ID: 31489
HgeneTgene
Gene symbol

RNF185

ESRRG

Gene ID

91445

2104

Gene namering finger protein 185estrogen related receptor gamma
Synonyms-ERR-gamma|ERR3|ERRg|ERRgamma|NR3B3
Cytomap

22q12.2

1q41

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF185BSK65-MONO1BSK65-MONO2BSK65-PANC1BSK65-PANC2BSK65-TEST1BSK65-TEST2BSK65-TEST3RING-type E3 ubiquitin transferase RNF185estrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3
Modification date2018052320180519
UniProtAcc

Q96GF1

P62508

Ensembl transtripts involved in fusion geneENST00000426256, ENST00000326132, 
ENST00000266252, 		ENST00000361525, 
ENST00000366940, ENST00000361395, 
ENST00000366938, ENST00000359162, 
ENST00000493603, ENST00000463665, 
ENST00000487276, ENST00000493748, 
ENST00000471371, ENST00000391890, 
ENST00000366937, ENST00000408911, 
ENST00000360012, 
Fusion gene scores* DoF score10 X 6 X 7=4205 X 4 X 4=80
# samples 125
** MAII scorelog2(12/420*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF185 [Title/Abstract] AND ESRRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF185

GO:0051865

protein autoubiquitination

24019521

TgeneESRRG

GO:0006355

regulation of transcription, DNA-templated

23836911


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG333167RNF185chr22

31597528

+ESRRGchr1

217047131

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000426256ENST00000361525RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000366940RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000361395RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000366938RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000359162RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000493603RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000463665RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000487276RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000493748RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000471371RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000391890RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000366937RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000408911RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000426256ENST00000360012RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000361525RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000366940RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000361395RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000366938RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000359162RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000493603RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000463665RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000487276RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000493748RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000471371RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000391890RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000366937RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000408911RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000326132ENST00000360012RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000361525RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000366940RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000361395RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000366938RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000359162RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000493603RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000463665RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000487276RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000493748RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000471371RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000391890RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000366937RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000408911RNF185chr22

31597528

+ESRRGchr1

217047131

-
5CDS-intronENST00000266252ENST00000360012RNF185chr22

31597528

+ESRRGchr1

217047131

-

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FusionProtFeatures for RNF185_ESRRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF185

Q96GF1

ESRRG

P62508

E3 ubiquitin-protein ligase that regulates selectivemitochondrial autophagy by mediating 'Lys-63'-linkedpolyubiquitination of BNIP1 (PubMed:21931693). Acts in theendoplasmic reticulum (ER)-associated degradation (ERAD) pathway,which targets misfolded proteins that accumulate in theendoplasmic reticulum (ER) for ubiquitination and subsequentproteasome-mediated degradation (PubMed:27485036). Protects cellsfrom ER stress-induced apoptosis (PubMed:27485036). Responsiblefor the cotranslational ubiquitination and degradation of CFTR inthe ERAD pathway (PubMed:24019521). Preferentially associates withthe E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521).{ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521,ECO:0000269|PubMed:27485036}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF185_ESRRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF185_ESRRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF185_ESRRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneESRRGP62508DB00675TamoxifenEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB02659Cholic AcidEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB00255DiethylstilbestrolEstrogen-related receptor gammasmall moleculeapproved|investigational
TgeneESRRGP62508DB00783EstradiolEstrogen-related receptor gammasmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for RNF185_ESRRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource