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Fusion gene ID: 31484 |
FusionGeneSummary for RNF180_IPO11 |
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Fusion gene information | Fusion gene name: RNF180_IPO11 | Fusion gene ID: 31484 | Hgene | Tgene | Gene symbol | RNF180 | IPO11 | Gene ID | 285671 | 51194 |
Gene name | ring finger protein 180 | importin 11 | |
Synonyms | RINES | RanBP11 | |
Cytomap | 5q12.3 | 5q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase RNF180RING-type E3 ubiquitin transferase RNF180 | importin-11Ran binding protein 11imp11ran-binding protein 11 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q86T96 | Q9UI26 | |
Ensembl transtripts involved in fusion gene | ENST00000389100, ENST00000296615, ENST00000381081, | ENST00000325324, ENST00000409296, ENST00000409534, ENST00000512177, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: RNF180 [Title/Abstract] AND IPO11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRP | TCGA-B9-A5W9-01A | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000389100 | ENST00000325324 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
Frame-shift | ENST00000389100 | ENST00000409296 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
5CDS-5UTR | ENST00000389100 | ENST00000409534 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
5CDS-intron | ENST00000389100 | ENST00000512177 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
Frame-shift | ENST00000296615 | ENST00000325324 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
Frame-shift | ENST00000296615 | ENST00000409296 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
5CDS-5UTR | ENST00000296615 | ENST00000409534 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
5CDS-intron | ENST00000296615 | ENST00000512177 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
Frame-shift | ENST00000381081 | ENST00000325324 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
Frame-shift | ENST00000381081 | ENST00000409296 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
5CDS-5UTR | ENST00000381081 | ENST00000409534 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
5CDS-intron | ENST00000381081 | ENST00000512177 | RNF180 | chr5 | 63513223 | + | IPO11 | chr5 | 61887404 | + |
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FusionProtFeatures for RNF180_IPO11 |
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Hgene | Tgene |
RNF180 | IPO11 |
E3 ubiquitin-protein ligase which promotespolyubiquitination and degradation by the proteasome pathway ofZIC2. {ECO:0000250|UniProtKB:Q3U827}. | Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of UBE2E3,and of RPL12 (By similarity). {ECO:0000250,ECO:0000269|PubMed:11032817}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF180_IPO11 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNF180_IPO11 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RNF180 | ZIC2, LYN | IPO11 | TRAF2, PLCD4, C20orf24, RPL12, DDX5, KEAP1, RAN, UBE2E1, UBE2E3, UBE2E2, NXF1, SH3GL2, CFTR, PHB, EGFR, FBXO6, MOB1A, MOB1B, AARS, CACYBP, DR1, EIF4A3, HNRNPD, HNRNPH1, AGFG1, ARPC1B, CALU, HSF1, LPP, METTL1, TPD52L2, TTLL12, UBE3A, PDLIM5, PKM, PLIN3, PRDX2, RANGAP1, SRP9, TPRKB, EIF4A2, C1orf94, ADORA3, COMTD1, BSG, TNFSF13B, PNKD, LPAR6, P2RY12, PTGER3, ARL13B, SCN2B, XPO1, NTRK1, CEP128, SIGLECL1, IL13RA2, HTR2C, FZD10, CHRM4, TMEM206, OPRM1, CD70, SLC15A1, APLNR, STOM, AAR2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF180_IPO11 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF180_IPO11 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IPO11 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | IPO11 | C0043094 | Weight Gain | 1 | CTD_human |