![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 31482 |
FusionGeneSummary for RNF180_CWC27 |
![]() |
Fusion gene information | Fusion gene name: RNF180_CWC27 | Fusion gene ID: 31482 | Hgene | Tgene | Gene symbol | RNF180 | CWC27 | Gene ID | 285671 | 10283 |
Gene name | ring finger protein 180 | CWC27 spliceosome associated protein homolog | |
Synonyms | RINES | NY-CO-10|RPSKA|SDCCAG-10|SDCCAG10 | |
Cytomap | 5q12.3 | 5q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase RNF180RING-type E3 ubiquitin transferase RNF180 | peptidyl-prolyl cis-trans isomerase CWC27 homologPPIase CWC27PPIase SDCCAG10antigen NY-CO-10peptidyl-prolyl cis-trans isomerase SDCCAG10serologically defined colon cancer antigen 10 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q86T96 | Q6UX04 | |
Ensembl transtripts involved in fusion gene | ENST00000389100, ENST00000296615, ENST00000381081, | ENST00000381070, ENST00000508024, ENST00000545000, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 4 X 3 X 3=36 |
# samples | 4 | 4 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RNF180 [Title/Abstract] AND CWC27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-KP-A3VZ-01A | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000389100 | ENST00000381070 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
5CDS-intron | ENST00000389100 | ENST00000508024 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
5CDS-3UTR | ENST00000389100 | ENST00000545000 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
intron-3CDS | ENST00000296615 | ENST00000381070 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
intron-intron | ENST00000296615 | ENST00000508024 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
intron-3UTR | ENST00000296615 | ENST00000545000 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
intron-3CDS | ENST00000381081 | ENST00000381070 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
intron-intron | ENST00000381081 | ENST00000508024 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
intron-3UTR | ENST00000381081 | ENST00000545000 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
Top |
FusionProtFeatures for RNF180_CWC27 |
![]() |
Hgene | Tgene |
RNF180 | CWC27 |
E3 ubiquitin-protein ligase which promotespolyubiquitination and degradation by the proteasome pathway ofZIC2. {ECO:0000250|UniProtKB:Q3U827}. | As part of the spliceosome, plays a role in pre-mRNAsplicing (PubMed:29360106). Probable inactive PPIase with nopeptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).{ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 432_474 | 526 | 593 | Zinc finger | RING-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 1_564 | -37 | 417 | Topological domain | Cytoplasmic |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 586_592 | -37 | 417 | Topological domain | Extracellular |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 1_564 | -37 | 97 | Topological domain | Cytoplasmic |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 586_592 | -37 | 97 | Topological domain | Extracellular |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 1_564 | 526 | 593 | Topological domain | Cytoplasmic |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 586_592 | 526 | 593 | Topological domain | Extracellular |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 565_585 | -37 | 417 | Transmembrane | Helical |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 565_585 | -37 | 97 | Transmembrane | Helical |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 565_585 | 526 | 593 | Transmembrane | Helical |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 432_474 | -37 | 417 | Zinc finger | RING-type |
Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 432_474 | -37 | 97 | Zinc finger | RING-type |
Tgene | CWC27 | chr5:63626233 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 206_230 | 347 | 473 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CWC27 | chr5:63626233 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 306_377 | 347 | 473 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CWC27 | chr5:63626233 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 11_166 | 347 | 473 | Domain | PPIase cyclophilin-type |
Top |
FusionGeneSequence for RNF180_CWC27 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_RNF180_ENST00000389100_chr5_63626233_+_CWC27_ENST00000381070_chr5_64267530_+_652aa MKRSKELITKNHSQEETSILRCWKCRKCIASSGCFMEYLENQVIKDKDDSVDAQNICHVWHMNVEALPEWISCLIQKAQWTVGKLNCPFC GARLGGFNFVSTPKCSCGQLAAVHLSKSRTDYQPTQAGRLMRPSVKYLSHPRVQSGCDKEALLTGGGSENRNHRLLNMARNNNDPGRLTE ALCLEVRPTYFEMKNEKLLSKASEPKYQLFVPQLVTGRCATRAFHRKSHSLDLNISEKLTLLPTLYEIHSKTTAYSRLNETQPIDLSGLP LQSSKNSYSFQNPSSFDPSMLLQRFSVAPHETQTQRGGEFQCGLEAASVYSDHTNTNNLTFLMDLPSAGRSMPEASDQEEHLSPLDFLHS ANFSLGSINQRLNKRERSKLKNLRRKQRRRERWLQKQGKYSGVGLLDHMTLNNEMSTDEDNEYAEEKDSYICAVCLDVYFNPYMCYPCHH IFCEPCLRTLAKDNPSSTPCPLCRTIISRVFFQTELNNATKTFFTKEYLKIKQSFQKSNSAKWPLPSCRKAFHLFGEEEAPPDGAVAEYR REKQKYEALRKQQSKKGTSREDQTLALLNQFKSKLTQAIAETPENDIPETEVEDDEGWMSHVLQFEDKSRKVKDASMQDSDTFEIYDPRN |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_RNF180_ENST00000389100_chr5_63626233_+_CWC27_ENST00000381070_chr5_64267530_+_1956nt ATGAAAAGAAGCAAAGAATTGATAACTAAAAATCATAGTCAAGAGGAAACAAGTATTCTTCGTTGTTGGAAATGTAGAAAATGTATAGCA AGCTCTGGTTGTTTTATGGAGTATCTTGAGAATCAAGTGATTAAGGATAAAGATGATTCAGTTGATGCTCAAAATATTTGTCATGTGTGG CACATGAATGTAGAAGCCCTTCCAGAATGGATAAGCTGCCTAATCCAAAAAGCCCAGTGGACAGTTGGAAAACTGAATTGTCCTTTCTGT GGGGCCCGTTTAGGGGGCTTTAATTTTGTCAGCACTCCAAAATGTTCCTGTGGCCAGCTTGCAGCTGTACATCTCTCCAAGAGCCGGACT GATTATCAGCCAACACAGGCAGGCAGACTAATGAGACCATCAGTGAAATACTTGTCACATCCTAGAGTTCAGTCAGGTTGTGACAAGGAA GCTCTGCTGACAGGTGGTGGCTCTGAAAACAGAAATCACAGGCTTTTAAACATGGCCCGAAATAATAATGACCCTGGAAGATTAACAGAA GCACTCTGCCTGGAGGTGCGACCAACATATTTTGAGATGAAGAACGAAAAACTGCTGTCCAAAGCATCAGAACCAAAATACCAGCTTTTT GTTCCCCAGCTTGTGACTGGCAGATGCGCTACAAGAGCTTTTCATAGAAAATCACATAGTTTGGATCTGAACATCAGTGAGAAACTGACT TTATTACCCACTTTATATGAAATACATAGTAAGACTACTGCCTATTCCAGACTAAATGAAACACAGCCTATTGACCTTTCAGGCTTGCCT TTACAATCTAGTAAAAATAGCTATTCCTTTCAGAATCCATCCAGTTTTGATCCTAGTATGCTGCTGCAAAGATTTTCAGTGGCCCCCCAT GAGACCCAGACACAAAGAGGAGGAGAATTTCAGTGTGGTCTAGAAGCTGCTTCAGTGTATTCTGACCATACTAATACTAACAATCTGACT TTCCTGATGGACCTGCCCTCAGCTGGCAGGAGCATGCCGGAGGCCTCAGACCAGGAAGAGCACCTCTCCCCTCTGGACTTCCTGCACTCA GCCAATTTTTCATTGGGCAGCATTAATCAGAGGCTTAATAAGAGAGAAAGGAGCAAGTTGAAGAATCTAAGAAGGAAACAACGAAGGCGT GAAAGATGGCTACAGAAGCAGGGTAAATACTCAGGAGTGGGATTGCTGGATCATATGACTTTGAATAATGAGATGAGTACAGATGAAGAC AATGAATATGCAGAAGAAAAGGATAGCTACATCTGTGCAGTGTGTCTGGACGTTTATTTCAACCCTTATATGTGTTACCCTTGCCATCAC ATCTTCTGTGAGCCCTGCTTACGGACTCTGGCCAAAGACAATCCTTCAAGCACTCCATGCCCATTGTGTCGGACAATTATTTCTAGAGTC TTTTTCCAAACAGAATTGAACAATGCCACAAAAACTTTCTTTACTAAAGAATATTTGAAAATAAAACAAAGCTTTCAGAAATCCAACTCT GCAAAATGGCCCCTACCAAGCTGCAGAAAAGCATTTCATCTTTTTGGAGAGGAAGAAGCCCCTCCAGATGGTGCTGTTGCCGAATACAGA AGAGAAAAGCAAAAGTATGAAGCTTTGAGGAAGCAACAGTCAAAGAAGGGAACTTCCCGGGAAGATCAGACCCTTGCACTGCTGAACCAG TTTAAATCTAAACTCACTCAAGCAATTGCTGAAACGCCTGAAAATGACATTCCTGAAACAGAAGTAGAAGATGATGAAGGATGGATGTCA CATGTACTTCAGTTTGAGGATAAAAGCAGAAAAGTGAAAGATGCAAGCATGCAAGACTCAGATACATTTGAAATCTATGATCCTCGGAAT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RNF180_ENST00000389100_chr5_63626233_+_CWC27_ENST00000381070_chr5_64267530_+_2470nt AGAGCCTGGCTGCTGGCGGCCGGGAGCGCCGGGACGGGGCGCGAAGCCGGAGGCTCCGGGACGTGGATACAGATGAAAAGAAGCAAAGAA TTGATAACTAAAAATCATAGTCAAGAGGAAACAAGTATTCTTCGTTGTTGGAAATGTAGAAAATGTATAGCAAGCTCTGGTTGTTTTATG GAGTATCTTGAGAATCAAGTGATTAAGGATAAAGATGATTCAGTTGATGCTCAAAATATTTGTCATGTGTGGCACATGAATGTAGAAGCC CTTCCAGAATGGATAAGCTGCCTAATCCAAAAAGCCCAGTGGACAGTTGGAAAACTGAATTGTCCTTTCTGTGGGGCCCGTTTAGGGGGC TTTAATTTTGTCAGCACTCCAAAATGTTCCTGTGGCCAGCTTGCAGCTGTACATCTCTCCAAGAGCCGGACTGATTATCAGCCAACACAG GCAGGCAGACTAATGAGACCATCAGTGAAATACTTGTCACATCCTAGAGTTCAGTCAGGTTGTGACAAGGAAGCTCTGCTGACAGGTGGT GGCTCTGAAAACAGAAATCACAGGCTTTTAAACATGGCCCGAAATAATAATGACCCTGGAAGATTAACAGAAGCACTCTGCCTGGAGGTG CGACCAACATATTTTGAGATGAAGAACGAAAAACTGCTGTCCAAAGCATCAGAACCAAAATACCAGCTTTTTGTTCCCCAGCTTGTGACT GGCAGATGCGCTACAAGAGCTTTTCATAGAAAATCACATAGTTTGGATCTGAACATCAGTGAGAAACTGACTTTATTACCCACTTTATAT GAAATACATAGTAAGACTACTGCCTATTCCAGACTAAATGAAACACAGCCTATTGACCTTTCAGGCTTGCCTTTACAATCTAGTAAAAAT AGCTATTCCTTTCAGAATCCATCCAGTTTTGATCCTAGTATGCTGCTGCAAAGATTTTCAGTGGCCCCCCATGAGACCCAGACACAAAGA GGAGGAGAATTTCAGTGTGGTCTAGAAGCTGCTTCAGTGTATTCTGACCATACTAATACTAACAATCTGACTTTCCTGATGGACCTGCCC TCAGCTGGCAGGAGCATGCCGGAGGCCTCAGACCAGGAAGAGCACCTCTCCCCTCTGGACTTCCTGCACTCAGCCAATTTTTCATTGGGC AGCATTAATCAGAGGCTTAATAAGAGAGAAAGGAGCAAGTTGAAGAATCTAAGAAGGAAACAACGAAGGCGTGAAAGATGGCTACAGAAG CAGGGTAAATACTCAGGAGTGGGATTGCTGGATCATATGACTTTGAATAATGAGATGAGTACAGATGAAGACAATGAATATGCAGAAGAA AAGGATAGCTACATCTGTGCAGTGTGTCTGGACGTTTATTTCAACCCTTATATGTGTTACCCTTGCCATCACATCTTCTGTGAGCCCTGC TTACGGACTCTGGCCAAAGACAATCCTTCAAGCACTCCATGCCCATTGTGTCGGACAATTATTTCTAGAGTCTTTTTCCAAACAGAATTG AACAATGCCACAAAAACTTTCTTTACTAAAGAATATTTGAAAATAAAACAAAGCTTTCAGAAATCCAACTCTGCAAAATGGCCCCTACCA AGCTGCAGAAAAGCATTTCATCTTTTTGGAGAGGAAGAAGCCCCTCCAGATGGTGCTGTTGCCGAATACAGAAGAGAAAAGCAAAAGTAT GAAGCTTTGAGGAAGCAACAGTCAAAGAAGGGAACTTCCCGGGAAGATCAGACCCTTGCACTGCTGAACCAGTTTAAATCTAAACTCACT CAAGCAATTGCTGAAACGCCTGAAAATGACATTCCTGAAACAGAAGTAGAAGATGATGAAGGATGGATGTCACATGTACTTCAGTTTGAG GATAAAAGCAGAAAAGTGAAAGATGCAAGCATGCAAGACTCAGATACATTTGAAATCTATGATCCTCGGAATCCAGTGAATAAAAGAAGG AGGGAAGAAAGCAAAAAGCTGATGAGAGAGAAAAAAGAAAGAAGATAAAATGAGAATAATGATAACCAGAACTTGCTGGAAATGTGCCTA CAATGGCCTTGTAACAGCCATTGTTCCCAACAGCATCACTTAGGGGTGTGAAAAGAAGTATTTTTGAACCTGTTGTCTGGTTTTGAAAAA CAATTATCTTGTTTTGCAAATTGTGGAATGATGTAAGCAAATGCTTTTGGTTACTGGTACATGTGTTTTTTCCTAGCTGACCTTTTATAT TGCTAAATCTGAAATAAAATAACTTTCCTTCCACATTACATGTTAACCATTGCAGACTGCAAGCCTGTTTGTGTCCTTTTACCCTAAAAT ATATGAAGGCTTCCTTTTCAAGATTTTTTTATAAGAAGTTCCTACAGAAAGAATATTTGTGGGAAACCTCCCTTTCACTAACTTCAGAAT |
Top |
FusionGenePPI for RNF180_CWC27 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RNF180 | ZIC2, LYN | CWC27 | SNW1, SKIV2L2, DHX38, PRKDC, XRCC4, SCYL1, HOXC10, SIPA1L1, FRA10AC1, HMGA1, VTI1B, EDA, EPB41L3, LSM2, LSM6, CLK1, YWHAZ, IGSF6, EPB41L5 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 281_489 | 526 | 593 | ZIC2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 281_489 | -37 | 417 | ZIC2 |
Hgene | RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 281_489 | -37 | 97 | ZIC2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RNF180_CWC27 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RNF180_CWC27 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |