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Fusion gene ID: 31482 |
FusionGeneSummary for RNF180_CWC27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF180_CWC27 | Fusion gene ID: 31482 | Hgene | Tgene | Gene symbol | RNF180 | CWC27 | Gene ID | 285671 | 10283 |
| Gene name | ring finger protein 180 | CWC27 spliceosome associated protein homolog | |
| Synonyms | RINES | NY-CO-10|RPSKA|SDCCAG-10|SDCCAG10 | |
| Cytomap | 5q12.3 | 5q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase RNF180RING-type E3 ubiquitin transferase RNF180 | peptidyl-prolyl cis-trans isomerase CWC27 homologPPIase CWC27PPIase SDCCAG10antigen NY-CO-10peptidyl-prolyl cis-trans isomerase SDCCAG10serologically defined colon cancer antigen 10 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86T96 | Q6UX04 | |
| Ensembl transtripts involved in fusion gene | ENST00000389100, ENST00000296615, ENST00000381081, | ENST00000381070, ENST00000508024, ENST00000545000, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 4 X 3 X 3=36 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RNF180 [Title/Abstract] AND CWC27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-KP-A3VZ-01A | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000389100 | ENST00000381070 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| 5CDS-intron | ENST00000389100 | ENST00000508024 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| 5CDS-3UTR | ENST00000389100 | ENST00000545000 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| intron-3CDS | ENST00000296615 | ENST00000381070 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| intron-intron | ENST00000296615 | ENST00000508024 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| intron-3UTR | ENST00000296615 | ENST00000545000 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| intron-3CDS | ENST00000381081 | ENST00000381070 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| intron-intron | ENST00000381081 | ENST00000508024 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
| intron-3UTR | ENST00000381081 | ENST00000545000 | RNF180 | chr5 | 63626233 | + | CWC27 | chr5 | 64267530 | + |
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FusionProtFeatures for RNF180_CWC27 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF180 | CWC27 |
| E3 ubiquitin-protein ligase which promotespolyubiquitination and degradation by the proteasome pathway ofZIC2. {ECO:0000250|UniProtKB:Q3U827}. | As part of the spliceosome, plays a role in pre-mRNAsplicing (PubMed:29360106). Probable inactive PPIase with nopeptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).{ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 432_474 | 526 | 593 | Zinc finger | RING-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 1_564 | -37 | 417 | Topological domain | Cytoplasmic |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 586_592 | -37 | 417 | Topological domain | Extracellular |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 1_564 | -37 | 97 | Topological domain | Cytoplasmic |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 586_592 | -37 | 97 | Topological domain | Extracellular |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 1_564 | 526 | 593 | Topological domain | Cytoplasmic |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 586_592 | 526 | 593 | Topological domain | Extracellular |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 565_585 | -37 | 417 | Transmembrane | Helical |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 565_585 | -37 | 97 | Transmembrane | Helical |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 565_585 | 526 | 593 | Transmembrane | Helical |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 432_474 | -37 | 417 | Zinc finger | RING-type |
| Hgene | >RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 432_474 | -37 | 97 | Zinc finger | RING-type |
| Tgene | CWC27 | chr5:63626233 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 206_230 | 347 | 473 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CWC27 | chr5:63626233 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 306_377 | 347 | 473 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CWC27 | chr5:63626233 | chr5:64267530 | ENST00000381070 | + | 10 | 14 | 11_166 | 347 | 473 | Domain | PPIase cyclophilin-type |
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FusionGeneSequence for RNF180_CWC27 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RNF180_ENST00000389100_chr5_63626233_+_CWC27_ENST00000381070_chr5_64267530_+_652aa MKRSKELITKNHSQEETSILRCWKCRKCIASSGCFMEYLENQVIKDKDDSVDAQNICHVWHMNVEALPEWISCLIQKAQWTVGKLNCPFC GARLGGFNFVSTPKCSCGQLAAVHLSKSRTDYQPTQAGRLMRPSVKYLSHPRVQSGCDKEALLTGGGSENRNHRLLNMARNNNDPGRLTE ALCLEVRPTYFEMKNEKLLSKASEPKYQLFVPQLVTGRCATRAFHRKSHSLDLNISEKLTLLPTLYEIHSKTTAYSRLNETQPIDLSGLP LQSSKNSYSFQNPSSFDPSMLLQRFSVAPHETQTQRGGEFQCGLEAASVYSDHTNTNNLTFLMDLPSAGRSMPEASDQEEHLSPLDFLHS ANFSLGSINQRLNKRERSKLKNLRRKQRRRERWLQKQGKYSGVGLLDHMTLNNEMSTDEDNEYAEEKDSYICAVCLDVYFNPYMCYPCHH IFCEPCLRTLAKDNPSSTPCPLCRTIISRVFFQTELNNATKTFFTKEYLKIKQSFQKSNSAKWPLPSCRKAFHLFGEEEAPPDGAVAEYR REKQKYEALRKQQSKKGTSREDQTLALLNQFKSKLTQAIAETPENDIPETEVEDDEGWMSHVLQFEDKSRKVKDASMQDSDTFEIYDPRN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RNF180_ENST00000389100_chr5_63626233_+_CWC27_ENST00000381070_chr5_64267530_+_1956nt ATGAAAAGAAGCAAAGAATTGATAACTAAAAATCATAGTCAAGAGGAAACAAGTATTCTTCGTTGTTGGAAATGTAGAAAATGTATAGCA AGCTCTGGTTGTTTTATGGAGTATCTTGAGAATCAAGTGATTAAGGATAAAGATGATTCAGTTGATGCTCAAAATATTTGTCATGTGTGG CACATGAATGTAGAAGCCCTTCCAGAATGGATAAGCTGCCTAATCCAAAAAGCCCAGTGGACAGTTGGAAAACTGAATTGTCCTTTCTGT GGGGCCCGTTTAGGGGGCTTTAATTTTGTCAGCACTCCAAAATGTTCCTGTGGCCAGCTTGCAGCTGTACATCTCTCCAAGAGCCGGACT GATTATCAGCCAACACAGGCAGGCAGACTAATGAGACCATCAGTGAAATACTTGTCACATCCTAGAGTTCAGTCAGGTTGTGACAAGGAA GCTCTGCTGACAGGTGGTGGCTCTGAAAACAGAAATCACAGGCTTTTAAACATGGCCCGAAATAATAATGACCCTGGAAGATTAACAGAA GCACTCTGCCTGGAGGTGCGACCAACATATTTTGAGATGAAGAACGAAAAACTGCTGTCCAAAGCATCAGAACCAAAATACCAGCTTTTT GTTCCCCAGCTTGTGACTGGCAGATGCGCTACAAGAGCTTTTCATAGAAAATCACATAGTTTGGATCTGAACATCAGTGAGAAACTGACT TTATTACCCACTTTATATGAAATACATAGTAAGACTACTGCCTATTCCAGACTAAATGAAACACAGCCTATTGACCTTTCAGGCTTGCCT TTACAATCTAGTAAAAATAGCTATTCCTTTCAGAATCCATCCAGTTTTGATCCTAGTATGCTGCTGCAAAGATTTTCAGTGGCCCCCCAT GAGACCCAGACACAAAGAGGAGGAGAATTTCAGTGTGGTCTAGAAGCTGCTTCAGTGTATTCTGACCATACTAATACTAACAATCTGACT TTCCTGATGGACCTGCCCTCAGCTGGCAGGAGCATGCCGGAGGCCTCAGACCAGGAAGAGCACCTCTCCCCTCTGGACTTCCTGCACTCA GCCAATTTTTCATTGGGCAGCATTAATCAGAGGCTTAATAAGAGAGAAAGGAGCAAGTTGAAGAATCTAAGAAGGAAACAACGAAGGCGT GAAAGATGGCTACAGAAGCAGGGTAAATACTCAGGAGTGGGATTGCTGGATCATATGACTTTGAATAATGAGATGAGTACAGATGAAGAC AATGAATATGCAGAAGAAAAGGATAGCTACATCTGTGCAGTGTGTCTGGACGTTTATTTCAACCCTTATATGTGTTACCCTTGCCATCAC ATCTTCTGTGAGCCCTGCTTACGGACTCTGGCCAAAGACAATCCTTCAAGCACTCCATGCCCATTGTGTCGGACAATTATTTCTAGAGTC TTTTTCCAAACAGAATTGAACAATGCCACAAAAACTTTCTTTACTAAAGAATATTTGAAAATAAAACAAAGCTTTCAGAAATCCAACTCT GCAAAATGGCCCCTACCAAGCTGCAGAAAAGCATTTCATCTTTTTGGAGAGGAAGAAGCCCCTCCAGATGGTGCTGTTGCCGAATACAGA AGAGAAAAGCAAAAGTATGAAGCTTTGAGGAAGCAACAGTCAAAGAAGGGAACTTCCCGGGAAGATCAGACCCTTGCACTGCTGAACCAG TTTAAATCTAAACTCACTCAAGCAATTGCTGAAACGCCTGAAAATGACATTCCTGAAACAGAAGTAGAAGATGATGAAGGATGGATGTCA CATGTACTTCAGTTTGAGGATAAAAGCAGAAAAGTGAAAGATGCAAGCATGCAAGACTCAGATACATTTGAAATCTATGATCCTCGGAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RNF180_ENST00000389100_chr5_63626233_+_CWC27_ENST00000381070_chr5_64267530_+_2470nt AGAGCCTGGCTGCTGGCGGCCGGGAGCGCCGGGACGGGGCGCGAAGCCGGAGGCTCCGGGACGTGGATACAGATGAAAAGAAGCAAAGAA TTGATAACTAAAAATCATAGTCAAGAGGAAACAAGTATTCTTCGTTGTTGGAAATGTAGAAAATGTATAGCAAGCTCTGGTTGTTTTATG GAGTATCTTGAGAATCAAGTGATTAAGGATAAAGATGATTCAGTTGATGCTCAAAATATTTGTCATGTGTGGCACATGAATGTAGAAGCC CTTCCAGAATGGATAAGCTGCCTAATCCAAAAAGCCCAGTGGACAGTTGGAAAACTGAATTGTCCTTTCTGTGGGGCCCGTTTAGGGGGC TTTAATTTTGTCAGCACTCCAAAATGTTCCTGTGGCCAGCTTGCAGCTGTACATCTCTCCAAGAGCCGGACTGATTATCAGCCAACACAG GCAGGCAGACTAATGAGACCATCAGTGAAATACTTGTCACATCCTAGAGTTCAGTCAGGTTGTGACAAGGAAGCTCTGCTGACAGGTGGT GGCTCTGAAAACAGAAATCACAGGCTTTTAAACATGGCCCGAAATAATAATGACCCTGGAAGATTAACAGAAGCACTCTGCCTGGAGGTG CGACCAACATATTTTGAGATGAAGAACGAAAAACTGCTGTCCAAAGCATCAGAACCAAAATACCAGCTTTTTGTTCCCCAGCTTGTGACT GGCAGATGCGCTACAAGAGCTTTTCATAGAAAATCACATAGTTTGGATCTGAACATCAGTGAGAAACTGACTTTATTACCCACTTTATAT GAAATACATAGTAAGACTACTGCCTATTCCAGACTAAATGAAACACAGCCTATTGACCTTTCAGGCTTGCCTTTACAATCTAGTAAAAAT AGCTATTCCTTTCAGAATCCATCCAGTTTTGATCCTAGTATGCTGCTGCAAAGATTTTCAGTGGCCCCCCATGAGACCCAGACACAAAGA GGAGGAGAATTTCAGTGTGGTCTAGAAGCTGCTTCAGTGTATTCTGACCATACTAATACTAACAATCTGACTTTCCTGATGGACCTGCCC TCAGCTGGCAGGAGCATGCCGGAGGCCTCAGACCAGGAAGAGCACCTCTCCCCTCTGGACTTCCTGCACTCAGCCAATTTTTCATTGGGC AGCATTAATCAGAGGCTTAATAAGAGAGAAAGGAGCAAGTTGAAGAATCTAAGAAGGAAACAACGAAGGCGTGAAAGATGGCTACAGAAG CAGGGTAAATACTCAGGAGTGGGATTGCTGGATCATATGACTTTGAATAATGAGATGAGTACAGATGAAGACAATGAATATGCAGAAGAA AAGGATAGCTACATCTGTGCAGTGTGTCTGGACGTTTATTTCAACCCTTATATGTGTTACCCTTGCCATCACATCTTCTGTGAGCCCTGC TTACGGACTCTGGCCAAAGACAATCCTTCAAGCACTCCATGCCCATTGTGTCGGACAATTATTTCTAGAGTCTTTTTCCAAACAGAATTG AACAATGCCACAAAAACTTTCTTTACTAAAGAATATTTGAAAATAAAACAAAGCTTTCAGAAATCCAACTCTGCAAAATGGCCCCTACCA AGCTGCAGAAAAGCATTTCATCTTTTTGGAGAGGAAGAAGCCCCTCCAGATGGTGCTGTTGCCGAATACAGAAGAGAAAAGCAAAAGTAT GAAGCTTTGAGGAAGCAACAGTCAAAGAAGGGAACTTCCCGGGAAGATCAGACCCTTGCACTGCTGAACCAGTTTAAATCTAAACTCACT CAAGCAATTGCTGAAACGCCTGAAAATGACATTCCTGAAACAGAAGTAGAAGATGATGAAGGATGGATGTCACATGTACTTCAGTTTGAG GATAAAAGCAGAAAAGTGAAAGATGCAAGCATGCAAGACTCAGATACATTTGAAATCTATGATCCTCGGAATCCAGTGAATAAAAGAAGG AGGGAAGAAAGCAAAAAGCTGATGAGAGAGAAAAAAGAAAGAAGATAAAATGAGAATAATGATAACCAGAACTTGCTGGAAATGTGCCTA CAATGGCCTTGTAACAGCCATTGTTCCCAACAGCATCACTTAGGGGTGTGAAAAGAAGTATTTTTGAACCTGTTGTCTGGTTTTGAAAAA CAATTATCTTGTTTTGCAAATTGTGGAATGATGTAAGCAAATGCTTTTGGTTACTGGTACATGTGTTTTTTCCTAGCTGACCTTTTATAT TGCTAAATCTGAAATAAAATAACTTTCCTTCCACATTACATGTTAACCATTGCAGACTGCAAGCCTGTTTGTGTCCTTTTACCCTAAAAT ATATGAAGGCTTCCTTTTCAAGATTTTTTTATAAGAAGTTCCTACAGAAAGAATATTTGTGGGAAACCTCCCTTTCACTAACTTCAGAAT |
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FusionGenePPI for RNF180_CWC27 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RNF180 | ZIC2, LYN | CWC27 | SNW1, SKIV2L2, DHX38, PRKDC, XRCC4, SCYL1, HOXC10, SIPA1L1, FRA10AC1, HMGA1, VTI1B, EDA, EPB41L3, LSM2, LSM6, CLK1, YWHAZ, IGSF6, EPB41L5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | RNF180 | chr5:63626233 | chr5:64267530 | ENST00000389100 | + | 7 | 8 | 281_489 | 526 | 593 | ZIC2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RNF180 | chr5:63626233 | chr5:64267530 | ENST00000296615 | + | 1 | 5 | 281_489 | -37 | 417 | ZIC2 |
| Hgene | RNF180 | chr5:63626233 | chr5:64267530 | ENST00000381081 | + | 1 | 4 | 281_489 | -37 | 97 | ZIC2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF180_CWC27 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF180_CWC27 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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