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Fusion gene ID: 31481 |
FusionGeneSummary for RNF180_CASC2 |
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Fusion gene information | Fusion gene name: RNF180_CASC2 | Fusion gene ID: 31481 | Hgene | Tgene | Gene symbol | RNF180 | CASC2 | Gene ID | 285671 | 255082 |
Gene name | ring finger protein 180 | cancer susceptibility 2 | |
Synonyms | RINES | C10orf5 | |
Cytomap | 5q12.3 | 10q26.11 | |
Type of gene | protein-coding | ncRNA | |
Description | E3 ubiquitin-protein ligase RNF180RING-type E3 ubiquitin transferase RNF180 | cancer susceptibility 2 (non-protein coding)cancer susceptibility candidate 2 (non-protein coding) | |
Modification date | 20180523 | 20180520 | |
UniProtAcc | Q86T96 | ||
Ensembl transtripts involved in fusion gene | ENST00000389100, ENST00000296615, ENST00000381081, | ENST00000414722, ENST00000435944, ENST00000454857, ENST00000439517, ENST00000426021, ENST00000454781, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 3 X 3 X 3=27 |
# samples | 4 | 3 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RNF180 [Title/Abstract] AND CASC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CASC2 | GO:0002357 | defense response to tumor cell | 28621238 |
Tgene | CASC2 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 28621238 |
Tgene | CASC2 | GO:0043409 | negative regulation of MAPK cascade | 28621238 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM718923 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000389100 | ENST00000414722 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
5CDS-3UTR | ENST00000389100 | ENST00000435944 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
5CDS-intron | ENST00000389100 | ENST00000454857 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
5CDS-3UTR | ENST00000389100 | ENST00000439517 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
5CDS-intron | ENST00000389100 | ENST00000426021 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
5CDS-intron | ENST00000389100 | ENST00000454781 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-intron | ENST00000296615 | ENST00000414722 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-3UTR | ENST00000296615 | ENST00000435944 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-intron | ENST00000296615 | ENST00000454857 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-3UTR | ENST00000296615 | ENST00000439517 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-intron | ENST00000296615 | ENST00000426021 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-intron | ENST00000296615 | ENST00000454781 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-intron | ENST00000381081 | ENST00000414722 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-3UTR | ENST00000381081 | ENST00000435944 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-intron | ENST00000381081 | ENST00000454857 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-3UTR | ENST00000381081 | ENST00000439517 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-intron | ENST00000381081 | ENST00000426021 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
intron-intron | ENST00000381081 | ENST00000454781 | RNF180 | chr5 | 63621048 | + | CASC2 | chr10 | 119967000 | + |
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FusionProtFeatures for RNF180_CASC2 |
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Hgene | Tgene |
RNF180 | CASC2 |
E3 ubiquitin-protein ligase which promotespolyubiquitination and degradation by the proteasome pathway ofZIC2. {ECO:0000250|UniProtKB:Q3U827}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF180_CASC2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNF180_CASC2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF180_CASC2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF180_CASC2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |