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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31480

FusionGeneSummary for RNF170_SFRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF170_SFRP1
Fusion gene ID: 31480
HgeneTgene
Gene symbol

RNF170

SFRP1

Gene ID

81790

6422

Gene namering finger protein 170secreted frizzled related protein 1
SynonymsADSA|SNAX1FRP|FRP-1|FRP1|FrzA|SARP2
Cytomap

8p11.21

8p11.21

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF170RING-type E3 ubiquitin transferase RNF170putative LAG1-interacting proteinsecreted frizzled-related protein 1SARP-2frizzled-related proteinsFRP-1secreted apoptosis-related protein 2
Modification date2018051920180523
UniProtAcc

Q96K19

Q8N474

Ensembl transtripts involved in fusion geneENST00000319104, ENST00000319073, 
ENST00000534961, ENST00000527424, 
ENST00000526349, 		ENST00000220772, 
ENST00000379845, 
Fusion gene scores* DoF score6 X 3 X 4=723 X 3 X 3=27
# samples 63
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNF170 [Title/Abstract] AND SFRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSFRP1

GO:0002244

hematopoietic progenitor cell differentiation

19778523

TgeneSFRP1

GO:0008284

positive regulation of cell proliferation

10980594

TgeneSFRP1

GO:0008285

negative regulation of cell proliferation

10347172|17443492|17994217|19277043|20208569

TgeneSFRP1

GO:0009950

dorsal/ventral axis specification

9192640

TgeneSFRP1

GO:0010629

negative regulation of gene expression

10980594

TgeneSFRP1

GO:0010719

negative regulation of epithelial to mesenchymal transition

19095296

TgeneSFRP1

GO:0014070

response to organic cyclic compound

20208569

TgeneSFRP1

GO:0030177

positive regulation of Wnt signaling pathway

10660608

TgeneSFRP1

GO:0030178

negative regulation of Wnt signaling pathway

9192640|10660608|17500071|20208569

TgeneSFRP1

GO:0030279

negative regulation of ossification

15677765

TgeneSFRP1

GO:0030307

positive regulation of cell growth

10980594|16288033

TgeneSFRP1

GO:0030308

negative regulation of cell growth

19569235|20208569

TgeneSFRP1

GO:0030336

negative regulation of cell migration

10980594

TgeneSFRP1

GO:0042493

response to drug

19072540|19254787

TgeneSFRP1

GO:0043065

positive regulation of apoptotic process

9391078|15677765

TgeneSFRP1

GO:0044344

cellular response to fibroblast growth factor stimulus

17500071

TgeneSFRP1

GO:0045600

positive regulation of fat cell differentiation

12055200|15886250

TgeneSFRP1

GO:0045892

negative regulation of transcription, DNA-templated

10660608|19095296|19277043|20234818

TgeneSFRP1

GO:0045893

positive regulation of transcription, DNA-templated

10660608|15886250|19569235

TgeneSFRP1

GO:0046676

negative regulation of insulin secretion

17994217

TgeneSFRP1

GO:0048147

negative regulation of fibroblast proliferation

19734317

TgeneSFRP1

GO:0050680

negative regulation of epithelial cell proliferation

19095296

TgeneSFRP1

GO:0050732

negative regulation of peptidyl-tyrosine phosphorylation

10980594

TgeneSFRP1

GO:0060070

canonical Wnt signaling pathway

18787224

TgeneSFRP1

GO:0060218

hematopoietic stem cell differentiation

19778523

TgeneSFRP1

GO:0060766

negative regulation of androgen receptor signaling pathway

19277043

TgeneSFRP1

GO:0071356

cellular response to tumor necrosis factor

9391078

TgeneSFRP1

GO:0071363

cellular response to growth factor stimulus

17500071

TgeneSFRP1

GO:0071391

cellular response to estrogen stimulus

18941195

TgeneSFRP1

GO:0071504

cellular response to heparin

17500071

TgeneSFRP1

GO:0090090

negative regulation of canonical Wnt signaling pathway

9391078|10347172|16149051|16288033|17443492|17471511|19095296|19277043|19569235

TgeneSFRP1

GO:0090263

positive regulation of canonical Wnt signaling pathway

18941195

TgeneSFRP1

GO:1902043

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

9391078

TgeneSFRP1

GO:2000052

positive regulation of non-canonical Wnt signaling pathway

19569235

TgeneSFRP1

GO:2000054

negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

9192640

TgeneSFRP1

GO:2000080

negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

17994217

TgeneSFRP1

GO:2000270

negative regulation of fibroblast apoptotic process

14581477

TgeneSFRP1

GO:2000271

positive regulation of fibroblast apoptotic process

14581477


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-50-6673-01ARNF170chr8

42742871

-SFRP1chr8

41123008

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000319104ENST00000220772RNF170chr8

42742871

-SFRP1chr8

41123008

-
Frame-shiftENST00000319104ENST00000379845RNF170chr8

42742871

-SFRP1chr8

41123008

-
5UTR-3CDSENST00000319073ENST00000220772RNF170chr8

42742871

-SFRP1chr8

41123008

-
5UTR-3CDSENST00000319073ENST00000379845RNF170chr8

42742871

-SFRP1chr8

41123008

-
Frame-shiftENST00000534961ENST00000220772RNF170chr8

42742871

-SFRP1chr8

41123008

-
In-frameENST00000534961ENST00000379845RNF170chr8

42742871

-SFRP1chr8

41123008

-
In-frameENST00000527424ENST00000220772RNF170chr8

42742871

-SFRP1chr8

41123008

-
Frame-shiftENST00000527424ENST00000379845RNF170chr8

42742871

-SFRP1chr8

41123008

-
intron-3CDSENST00000526349ENST00000220772RNF170chr8

42742871

-SFRP1chr8

41123008

-
intron-3CDSENST00000526349ENST00000379845RNF170chr8

42742871

-SFRP1chr8

41123008

-

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FusionProtFeatures for RNF170_SFRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF170

Q96K19

SFRP1

Q8N474

Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP1 decreases intracellular beta-cateninlevels (By similarity). Has antiproliferative effects on vascularcells, in vitro and in vivo, and can induce, in vivo, anangiogenic response. In vascular cell cycle, delays the G1 phaseand entry into the S phase (By similarity). In kidney development,inhibits tubule formation and bud growth in metanephroi (Bysimilarity). Inhibits WNT1/WNT4-mediated TCF-dependenttranscription. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF170chr8:42742871chr8:41123008ENST00000319104-261_2445201Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000527424-271_2445259Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000534961-271_2445259Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000319104-2625_4545201TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000527424-2725_4545259TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000534961-2725_4545259TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF170chr8:42742871chr8:41123008ENST00000319073-261_24-26163Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000319073-26223_223-26163Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000319073-26245_258-26163Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000319073-2646_201-26163Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000319104-26223_22345201Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000319104-26245_25845201Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000319104-2646_20145201Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000526349-171_24-121175Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000526349-17223_223-121175Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000526349-17245_258-121175Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000526349-1746_201-121175Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000527424-27223_22345259Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000527424-27245_25845259Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000527424-2746_20145259Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000534961-27223_22345259Topological domainLumenal
HgeneRNF170chr8:42742871chr8:41123008ENST00000534961-27245_25845259Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000534961-2746_20145259Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:41123008ENST00000319073-26202_222-26163TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000319073-26224_244-26163TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000319073-2625_45-26163TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000319104-26202_22245201TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000319104-26224_24445201TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000526349-17202_222-121175TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000526349-17224_244-121175TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000526349-1725_45-121175TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000527424-27202_22245259TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000527424-27224_24445259TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000534961-27202_22245259TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000534961-27224_24445259TransmembraneHelical
HgeneRNF170chr8:42742871chr8:41123008ENST00000319073-2687_130-26163Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:41123008ENST00000319104-2687_13045201Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:41123008ENST00000526349-1787_130-121175Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:41123008ENST00000527424-2787_13045259Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:41123008ENST00000534961-2787_13045259Zinc fingerRING-type
TgeneSFRP1chr8:42742871chr8:41123008ENST00000220772-13186_306207315DomainNTR
TgeneSFRP1chr8:42742871chr8:41123008ENST00000220772-1353_169207315DomainFZ


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FusionGeneSequence for RNF170_SFRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RNF170_ENST00000319104_chr8_42742871_-_SFRP1_ENST00000220772_chr8_41123008_-_153aa
MAKYQGEVQSLKLDDDSVIEGVSDQVLVAVVVSFALIATLVYALFSTEDENKRSEKRKWRQEDCPQEEEAPEVGAHQEEGPEEACAVPEE

>In-frame_RNF170_ENST00000534961_chr8_42742871_-_SFRP1_ENST00000379845_chr8_41123008_-_153aa
MAKYQGEVQSLKLDDDSVIEGVSDQVLVAVVVSFALIATLVYALFSTEDENKRSEKRKWRQEDCPQEEEAPEVGAHQEEGPEEACAVPEE

>In-frame_RNF170_ENST00000527424_chr8_42742871_-_SFRP1_ENST00000220772_chr8_41123008_-_153aa
MAKYQGEVQSLKLDDDSVIEGVSDQVLVAVVVSFALIATLVYALFSTEDENKRSEKRKWRQEDCPQEEEAPEVGAHQEEGPEEACAVPEE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RNF170_ENST00000319104_chr8_42742871_-_SFRP1_ENST00000220772_chr8_41123008_-_460nt
ATGGCCAAATATCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGACCAAGTACTTGTGGCAGTT
GTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGCACTGAGGATGAAAATAAAAGAAGTGAAAAAAGAAAATGGCGA
CAAGAAGATTGTCCCCAAGAAGAAGAAGCCCCTGAAGTTGGGGCCCATCAAGAAGAAGGACCTGAAGAAGCTTGTGCTGTACCTGAAGAA
TGGGGCTGACTGTCCCTGCCACCAGCTGGACAACCTCAGCCACCACTTCCTCATCATGGGCCGCAAGGTGAAGAGCCAGTACTTGCTGAC
GGCCATCCACAAGTGGGACAAGAAAAACAAGGAGTTCAAAAACTTCATGAAGAAAATGAAAAACCATGAGTGCCCCACCTTTCAGTCCGT

>In-frame_RNF170_ENST00000534961_chr8_42742871_-_SFRP1_ENST00000379845_chr8_41123008_-_460nt
ATGGCCAAATATCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGACCAAGTACTTGTGGCAGTT
GTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGCACTGAGGATGAAAATAAAAGAAGTGAAAAAAGAAAATGGCGA
CAAGAAGATTGTCCCCAAGAAGAAGAAGCCCCTGAAGTTGGGGCCCATCAAGAAGAAGGACCTGAAGAAGCTTGTGCTGTACCTGAAGAA
TGGGGCTGACTGTCCCTGCCACCAGCTGGACAACCTCAGCCACCACTTCCTCATCATGGGCCGCAAGGTGAAGAGCCAGTACTTGCTGAC
GGCCATCCACAAGTGGGACAAGAAAAACAAGGAGTTCAAAAACTTCATGAAGAAAATGAAAAACCATGAGTGCCCCACCTTTCAGTCCGT

>In-frame_RNF170_ENST00000527424_chr8_42742871_-_SFRP1_ENST00000220772_chr8_41123008_-_460nt
ATGGCCAAATATCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGACCAAGTACTTGTGGCAGTT
GTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGCACTGAGGATGAAAATAAAAGAAGTGAAAAAAGAAAATGGCGA
CAAGAAGATTGTCCCCAAGAAGAAGAAGCCCCTGAAGTTGGGGCCCATCAAGAAGAAGGACCTGAAGAAGCTTGTGCTGTACCTGAAGAA
TGGGGCTGACTGTCCCTGCCACCAGCTGGACAACCTCAGCCACCACTTCCTCATCATGGGCCGCAAGGTGAAGAGCCAGTACTTGCTGAC
GGCCATCCACAAGTGGGACAAGAAAAACAAGGAGTTCAAAAACTTCATGAAGAAAATGAAAAACCATGAGTGCCCCACCTTTCAGTCCGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_RNF170_ENST00000319104_chr8_42742871_-_SFRP1_ENST00000220772_chr8_41123008_-_3774nt
GACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTGGAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTT
CGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGA
CCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGCACTGAGGATGAAAATAAAAGAAG
TGAAAAAAGAAAATGGCGACAAGAAGATTGTCCCCAAGAAGAAGAAGCCCCTGAAGTTGGGGCCCATCAAGAAGAAGGACCTGAAGAAGC
TTGTGCTGTACCTGAAGAATGGGGCTGACTGTCCCTGCCACCAGCTGGACAACCTCAGCCACCACTTCCTCATCATGGGCCGCAAGGTGA
AGAGCCAGTACTTGCTGACGGCCATCCACAAGTGGGACAAGAAAAACAAGGAGTTCAAAAACTTCATGAAGAAAATGAAAAACCATGAGT
GCCCCACCTTTCAGTCCGTGTTTAAGTGATTCTCCCGGGGGCAGGGTGGGGAGGGAGCCTCGGGTGGGGTGGGAGCGGGGGGGACAGTGC
CCCGGGAACCCGGTGGGTCACACACACGCACTGCGCCTGTCAGTAGTGGACATTGTAATCCAGTCGGCTTGTTCTTGCAGCATTCCCGCT
CCCTTCCCTCCATAGCCACGCTCCAAACCCCAGGGTAGCCATGGCCGGGTAAAGCAAGGGCCATTTAGATTAGGAAGGTTTTTAAGATCC
GCAATGTGGAGCAGCAGCCACTGCACAGGAGGAGGTGACAAACCATTTCCAACAGCAACACAGCCACTAAAACACAAAAAGGGGGATTGG
GCGGAAAGTGAGAGCCAGCAGCAAAAACTACATTTTGCAACTTGTTGGTGTGGATCTATTGGCTGATCTATGCCTTTCAACTAGAAAATT
CTAATGATTGGCAAGTCACGTTGTTTTCAGGTCCAGAGTAGTTTCTTTCTGTCTGCTTTAAATGGAAACAGACTCATACCACACTTACAA
TTAAGGTCAAGCCCAGAAAGTGATAAGTGCAGGGAGGAAAAGTGCAAGTCCATTATGTAATAGTGACAGCAAAGGGACCAGGGGAGAGGC
ATTGCCTTCTCTGCCCACAGTCTTTCCGTGTGATTGTCTTTGAATCTGAATCAGCCAGTCTCAGATGCCCCAAAGTTTCGGTTCCTATGA
GCCCGGGGCATGATCTGATCCCCAAGACATGTGGAGGGGCAGCCTGTGCCTGCCTTTGTGTCAGAAAAAGGAAACCACAGTGAGCCTGAG
AGAGACGGCGATTTTCGGGCTGAGAAGGCAGTAGTTTTCAAAACACATAGTTAAAAAAGAAACAAATGAAAAAAATTTTAGAACAGTCCA
GCAAATTGCTAGTCAGGGTGAATTGTGAAATTGGGTGAAGAGCTTAGGATTCTAATCTCATGTTTTTTCCTTTTCACATTTTTAAAAGAA
CAATGACAAACACCCACTTATTTTTCAAGGTTTTAAAACAGTCTACATTGAGCATTTGAAAGGTGTGCTAGAACAAGGTCTCCTGATCCG
TCCGAGGCTGCTTCCCAGAGGAGCAGCTCTCCCCAGGCATTTGCCAAGGGAGGCGGATTTCCCTGGTAGTGTAGCTGTGTGGCTTTCCTT
CCTGAAGAGTCCGTGGTTGCCCTAGAACCTAACACCCCCTAGCAAAACTCACAGAGCTTTCCGTTTTTTTCTTTCCTGTAAAGAAACATT
TCCTTTGAACTTGATTGCCTATGGATCAAAGAAATTCAGAACAGCCTGCCTGTCCCCCCGCACTTTTTACATATATTTGTTTCATTTCTG
CAGATGGAAAGTTGACATGGGTGGGGTGTCCCCATCCAGCGAGAGAGTTTCAAAAGCAAAACATCTCTGCAGTTTTTCCCAAGTACCCTG
AGATACTTCCCAAAGCCCTTATGTTTAATCAGCGATGTATATAAGCCAGTTCACTTAGACAACTTTACCCTTCTTGTCCAATGTACAGGA
AGTAGTTCTAAAAAAAATGCATATTAATTTCTTCCCCCAAAGCCGGATTCTTAATTCTCTGCAACACTTTGAGGACATTTATGATTGTCC
CTCTGGGCCAATGCTTATACCCAGTGAGGATGCTGCAGTGAGGCTGTAAAGTGGCCCCCTGCGGCCCTAGCCTGACCCGGAGGAAAGGAT
GGTAGATTCTGTTAACTCTTGAAGACTCCAGTATGAAAATCAGCATGCCCGCCTAGTTACCTACCGGAGAGTTATCCTGATAAATTAACC
TCTCACAGTTAGTGATCCTGTCCTTTTAACACCTTTTTTGTGGGGTTCTCTCTGACCTTTCATCGTAAAGTGCTGGGGACCTTAAGTGAT
TTGCCTGTAATTTTGGATGATTAAAAAATGTGTATATATATTAGCTAATTAGAAATATTCTACTTCTCTGTTGTCAAACTGAAATTCAGA
GCAAGTTCCTGAGTGCGTGGATCTGGGTCTTAGTTCTGGTTGATTCACTCAAGAGTTCAGTGCTCATACGTATCTGCTCATTTTGACAAA
GTGCCTCATGCAACCGGGCCCTCTCTCTGCGGCAGAGTCCTTAGTGGAGGGGTTTACCTGGAACATTAGTAGTTACCACAGAATACGGAA
GAGCAGGTGACTGTGCTGTGCAGCTCTCTAAATGGGAATTCTCAGGTAGGAAGCAACAGCTTCAGAAAGAGCTCAAAATAAATTGGAAAT
GTGAATCGCAGCTGTGGGTTTTACCACCGTCTGTCTCAGAGTCCCAGGACCTTGAGTGTCATTAGTTACTTTATTGAAGGTTTTAGACCC
ATAGCAGCTTTGTCTCTGTCACATCAGCAATTTCAGAACCAAAAGGGAGGCTCTCTGTAGGCACAGAGCTGCACTATCACGAGCCTTTGT
TTTTCTCCACAAAGTATCTAACAAAACCAATGTGCAGACTGATTGGCCTGGTCATTGGTCTCCGAGAGAGGAGGTTTGCCTGTGATTTCC
TAATTATCGCTAGGGCCAAGGTGGGATTTGTAAAGCTTTACAATAATCATTCTGGATAGAGTCCTGGGAGGTCCTTGGCAGAACTCAGTT
AAATCTTTGAAGAATATTTGTAGTTATCTTAGAAGATAGCATGGGAGGTGAGGATTCCAAAAACATTTTATTTTTAAAATATCCTGTGTA
ACACTTGGCTCTTGGTACCTGTGGGTTAGCATCAAGTTCTCCCCAGGGTAGAATTCAATCAGAGCTCCAGTTTGCATTTGGATGTGTAAA
TTACAGTAATCCCATTTCCCAAACCTAAAATCTGTTTTTCTCATCAGACTCTGAGTAACTGGTTGCTGTGTCATAACTTCATAGATGCAG
GAGGCTCAGGTGATCTGTTTGAGGAGAGCACCCTAGGCAGCCTGCAGGGAATAACATACTGGCCGTTCTGACCTGTTGCCAGCAGATACA
CAGGACATGGATGAAATTCCCGTTTCCTCTAGTTTCTTCCTGTAGTACTCCTCTTTTAGATCCTAAGTCTCTTACAAAAGCTTTGAATAC
TGTGAAAATGTTTTACATTCCATTTCATTTGTGTTGTTTTTTTAACTGCATTTTACCAGATGTTTTGATGTTATCGCTTATGTTAATAGT

>In-frame_RNF170_ENST00000534961_chr8_42742871_-_SFRP1_ENST00000379845_chr8_41123008_-_4140nt
AGTTCGCTGCGTGTCGAGGCGAGCACGCGCTCCGCCCTGGAGGCTGCGGCGACGGGTCCTCCTCCGCCGTCCGGTCGCGCCCTCGCGGAA
GCTCGGCAGTGCGCGTGCGCCCGCACCCGCACTCCAAATTAGAAAGGGGACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCC
TGGAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTTCGCGGTGGAGAGGTACGTCCGGCGCGCGGCGGCCACGCCCAC
CCTATCGGGGCCCGCGGAGCCGCGGACGGCGGGGTCTGGCCTTCTTGGGGTAGCTCTGGCCGCCGAGGCTCTGCGGGGCGGCGGGAGTCG
CCGCCTCCTTCCCCCCGGGCCCCTCCCTCGTCTGGAAGCCCCAGAATCGCCCCGCGGCTGTCCGGAGTCGCCGGCGACGGTGGAGGGGCC
GACGCGGAGAGCGGCTCTAGACCTGGAATGGCCAAATATCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGA
GTAAGCGACCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGCACTGAGGATGAAAAT
AAAAGAAGTGAAAAAAGAAAATGGCGACAAGAAGATTGTCCCCAAGAAGAAGAAGCCCCTGAAGTTGGGGCCCATCAAGAAGAAGGACCT
GAAGAAGCTTGTGCTGTACCTGAAGAATGGGGCTGACTGTCCCTGCCACCAGCTGGACAACCTCAGCCACCACTTCCTCATCATGGGCCG
CAAGGTGAAGAGCCAGTACTTGCTGACGGCCATCCACAAGTGGGACAAGAAAAACAAGGAGTTCAAAAACTTCATGAAGAAAATGAAAAA
CCATGAGTGCCCCACCTTTCAGTCCGTGTTTAAGTGATTCTCCCGGGGGCAGGGTGGGGAGGGAGCCTCGGGTGGGGTGGGAGCGGGGGG
GACAGTGCCCCGGGAACCCGGTGGGTCACACACACGCACTGCGCCTGTCAGTAGTGGACATTGTAATCCAGTCGGCTTGTTCTTGCAGCA
TTCCCGCTCCCTTCCCTCCATAGCCACGCTCCAAACCCCAGGGTAGCCATGGCCGGGTAAAGCAAGGGCCATTTAGATTAGGAAGGTTTT
TAAGATCCGCAATGTGGAGCAGCAGCCACTGCACAGGAGGAGGTGACAAACCATTTCCAACAGCAACACAGCCACTAAAACACAAAAAGG
GGGATTGGGCGGAAAGTGAGAGCCAGCAGCAAAAACTACATTTTGCAACTTGTTGGTGTGGATCTATTGGCTGATCTATGCCTTTCAACT
AGAAAATTCTAATGATTGGCAAGTCACGTTGTTTTCAGGTCCAGAGTAGTTTCTTTCTGTCTGCTTTAAATGGAAACAGACTCATACCAC
ACTTACAATTAAGGTCAAGCCCAGAAAGTGATAAGTGCAGGGAGGAAAAGTGCAAGTCCATTATGTAATAGTGACAGCAAAGGGACCAGG
GGAGAGGCATTGCCTTCTCTGCCCACAGTCTTTCCGTGTGATTGTCTTTGAATCTGAATCAGCCAGTCTCAGATGCCCCAAAGTTTCGGT
TCCTATGAGCCCGGGGCATGATCTGATCCCCAAGACATGTGGAGGGGCAGCCTGTGCCTGCCTTTGTGTCAGAAAAAGGAAACCACAGTG
AGCCTGAGAGAGACGGCGATTTTCGGGCTGAGAAGGCAGTAGTTTTCAAAACACATAGTTAAAAAAGAAACAAATGAAAAAAATTTTAGA
ACAGTCCAGCAAATTGCTAGTCAGGGTGAATTGTGAAATTGGGTGAAGAGCTTAGGATTCTAATCTCATGTTTTTTCCTTTTCACATTTT
TAAAAGAACAATGACAAACACCCACTTATTTTTCAAGGTTTTAAAACAGTCTACATTGAGCATTTGAAAGGTGTGCTAGAACAAGGTCTC
CTGATCCGTCCGAGGCTGCTTCCCAGAGGAGCAGCTCTCCCCAGGCATTTGCCAAGGGAGGCGGATTTCCCTGGTAGTGTAGCTGTGTGG
CTTTCCTTCCTGAAGAGTCCGTGGTTGCCCTAGAACCTAACACCCCCTAGCAAAACTCACAGAGCTTTCCGTTTTTTTCTTTCCTGTAAA
GAAACATTTCCTTTGAACTTGATTGCCTATGGATCAAAGAAATTCAGAACAGCCTGCCTGTCCCCCCGCACTTTTTACATATATTTGTTT
CATTTCTGCAGATGGAAAGTTGACATGGGTGGGGTGTCCCCATCCAGCGAGAGAGTTTCAAAAGCAAAACATCTCTGCAGTTTTTCCCAA
GTACCCTGAGATACTTCCCAAAGCCCTTATGTTTAATCAGCGATGTATATAAGCCAGTTCACTTAGACAACTTTACCCTTCTTGTCCAAT
GTACAGGAAGTAGTTCTAAAAAAAATGCATATTAATTTCTTCCCCCAAAGCCGGATTCTTAATTCTCTGCAACACTTTGAGGACATTTAT
GATTGTCCCTCTGGGCCAATGCTTATACCCAGTGAGGATGCTGCAGTGAGGCTGTAAAGTGGCCCCCTGCGGCCCTAGCCTGACCCGGAG
GAAAGGATGGTAGATTCTGTTAACTCTTGAAGACTCCAGTATGAAAATCAGCATGCCCGCCTAGTTACCTACCGGAGAGTTATCCTGATA
AATTAACCTCTCACAGTTAGTGATCCTGTCCTTTTAACACCTTTTTTGTGGGGTTCTCTCTGACCTTTCATCGTAAAGTGCTGGGGACCT
TAAGTGATTTGCCTGTAATTTTGGATGATTAAAAAATGTGTATATATATTAGCTAATTAGAAATATTCTACTTCTCTGTTGTCAAACTGA
AATTCAGAGCAAGTTCCTGAGTGCGTGGATCTGGGTCTTAGTTCTGGTTGATTCACTCAAGAGTTCAGTGCTCATACGTATCTGCTCATT
TTGACAAAGTGCCTCATGCAACCGGGCCCTCTCTCTGCGGCAGAGTCCTTAGTGGAGGGGTTTACCTGGAACATTAGTAGTTACCACAGA
ATACGGAAGAGCAGGTGACTGTGCTGTGCAGCTCTCTAAATGGGAATTCTCAGGTAGGAAGCAACAGCTTCAGAAAGAGCTCAAAATAAA
TTGGAAATGTGAATCGCAGCTGTGGGTTTTACCACCGTCTGTCTCAGAGTCCCAGGACCTTGAGTGTCATTAGTTACTTTATTGAAGGTT
TTAGACCCATAGCAGCTTTGTCTCTGTCACATCAGCAATTTCAGAACCAAAAGGGAGGCTCTCTGTAGGCACAGAGCTGCACTATCACGA
GCCTTTGTTTTTCTCCACAAAGTATCTAACAAAACCAATGTGCAGACTGATTGGCCTGGTCATTGGTCTCCGAGAGAGGAGGTTTGCCTG
TGATTTCCTAATTATCGCTAGGGCCAAGGTGGGATTTGTAAAGCTTTACAATAATCATTCTGGATAGAGTCCTGGGAGGTCCTTGGCAGA
ACTCAGTTAAATCTTTGAAGAATATTTGTAGTTATCTTAGAAGATAGCATGGGAGGTGAGGATTCCAAAAACATTTTATTTTTAAAATAT
CCTGTGTAACACTTGGCTCTTGGTACCTGTGGGTTAGCATCAAGTTCTCCCCAGGGTAGAATTCAATCAGAGCTCCAGTTTGCATTTGGA
TGTGTAAATTACAGTAATCCCATTTCCCAAACCTAAAATCTGTTTTTCTCATCAGACTCTGAGTAACTGGTTGCTGTGTCATAACTTCAT
AGATGCAGGAGGCTCAGGTGATCTGTTTGAGGAGAGCACCCTAGGCAGCCTGCAGGGAATAACATACTGGCCGTTCTGACCTGTTGCCAG
CAGATACACAGGACATGGATGAAATTCCCGTTTCCTCTAGTTTCTTCCTGTAGTACTCCTCTTTTAGATCCTAAGTCTCTTACAAAAGCT
TTGAATACTGTGAAAATGTTTTACATTCCATTTCATTTGTGTTGTTTTTTTAACTGCATTTTACCAGATGTTTTGATGTTATCGCTTATG
TTAATAGTAATTCCCGTACGTGTTCATTTTATTTTCATGCTTTTTCAGCCATGTATCAATATTCACTTGACTAAAATCACTCAATTAATC

>In-frame_RNF170_ENST00000527424_chr8_42742871_-_SFRP1_ENST00000220772_chr8_41123008_-_3910nt
TTCGCTGCGTGTCGAGGCGAGCACGCGCTCCGCCCTGGAGGCTGCGGCGACGGGTCCTCCTCCGCCGTCCGGTCGCGCCCTCGCGGAAGC
TCGGCAGTGCGCGTGCGCCCGCACCCGCACTCCAAATTAGAAAGGGGACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTG
GAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTTCGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTGAAGTTC
AAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGACCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTA
CCCTGGTATATGCACTTTTCAGCACTGAGGATGAAAATAAAAGAAGTGAAAAAAGAAAATGGCGACAAGAAGATTGTCCCCAAGAAGAAG
AAGCCCCTGAAGTTGGGGCCCATCAAGAAGAAGGACCTGAAGAAGCTTGTGCTGTACCTGAAGAATGGGGCTGACTGTCCCTGCCACCAG
CTGGACAACCTCAGCCACCACTTCCTCATCATGGGCCGCAAGGTGAAGAGCCAGTACTTGCTGACGGCCATCCACAAGTGGGACAAGAAA
AACAAGGAGTTCAAAAACTTCATGAAGAAAATGAAAAACCATGAGTGCCCCACCTTTCAGTCCGTGTTTAAGTGATTCTCCCGGGGGCAG
GGTGGGGAGGGAGCCTCGGGTGGGGTGGGAGCGGGGGGGACAGTGCCCCGGGAACCCGGTGGGTCACACACACGCACTGCGCCTGTCAGT
AGTGGACATTGTAATCCAGTCGGCTTGTTCTTGCAGCATTCCCGCTCCCTTCCCTCCATAGCCACGCTCCAAACCCCAGGGTAGCCATGG
CCGGGTAAAGCAAGGGCCATTTAGATTAGGAAGGTTTTTAAGATCCGCAATGTGGAGCAGCAGCCACTGCACAGGAGGAGGTGACAAACC
ATTTCCAACAGCAACACAGCCACTAAAACACAAAAAGGGGGATTGGGCGGAAAGTGAGAGCCAGCAGCAAAAACTACATTTTGCAACTTG
TTGGTGTGGATCTATTGGCTGATCTATGCCTTTCAACTAGAAAATTCTAATGATTGGCAAGTCACGTTGTTTTCAGGTCCAGAGTAGTTT
CTTTCTGTCTGCTTTAAATGGAAACAGACTCATACCACACTTACAATTAAGGTCAAGCCCAGAAAGTGATAAGTGCAGGGAGGAAAAGTG
CAAGTCCATTATGTAATAGTGACAGCAAAGGGACCAGGGGAGAGGCATTGCCTTCTCTGCCCACAGTCTTTCCGTGTGATTGTCTTTGAA
TCTGAATCAGCCAGTCTCAGATGCCCCAAAGTTTCGGTTCCTATGAGCCCGGGGCATGATCTGATCCCCAAGACATGTGGAGGGGCAGCC
TGTGCCTGCCTTTGTGTCAGAAAAAGGAAACCACAGTGAGCCTGAGAGAGACGGCGATTTTCGGGCTGAGAAGGCAGTAGTTTTCAAAAC
ACATAGTTAAAAAAGAAACAAATGAAAAAAATTTTAGAACAGTCCAGCAAATTGCTAGTCAGGGTGAATTGTGAAATTGGGTGAAGAGCT
TAGGATTCTAATCTCATGTTTTTTCCTTTTCACATTTTTAAAAGAACAATGACAAACACCCACTTATTTTTCAAGGTTTTAAAACAGTCT
ACATTGAGCATTTGAAAGGTGTGCTAGAACAAGGTCTCCTGATCCGTCCGAGGCTGCTTCCCAGAGGAGCAGCTCTCCCCAGGCATTTGC
CAAGGGAGGCGGATTTCCCTGGTAGTGTAGCTGTGTGGCTTTCCTTCCTGAAGAGTCCGTGGTTGCCCTAGAACCTAACACCCCCTAGCA
AAACTCACAGAGCTTTCCGTTTTTTTCTTTCCTGTAAAGAAACATTTCCTTTGAACTTGATTGCCTATGGATCAAAGAAATTCAGAACAG
CCTGCCTGTCCCCCCGCACTTTTTACATATATTTGTTTCATTTCTGCAGATGGAAAGTTGACATGGGTGGGGTGTCCCCATCCAGCGAGA
GAGTTTCAAAAGCAAAACATCTCTGCAGTTTTTCCCAAGTACCCTGAGATACTTCCCAAAGCCCTTATGTTTAATCAGCGATGTATATAA
GCCAGTTCACTTAGACAACTTTACCCTTCTTGTCCAATGTACAGGAAGTAGTTCTAAAAAAAATGCATATTAATTTCTTCCCCCAAAGCC
GGATTCTTAATTCTCTGCAACACTTTGAGGACATTTATGATTGTCCCTCTGGGCCAATGCTTATACCCAGTGAGGATGCTGCAGTGAGGC
TGTAAAGTGGCCCCCTGCGGCCCTAGCCTGACCCGGAGGAAAGGATGGTAGATTCTGTTAACTCTTGAAGACTCCAGTATGAAAATCAGC
ATGCCCGCCTAGTTACCTACCGGAGAGTTATCCTGATAAATTAACCTCTCACAGTTAGTGATCCTGTCCTTTTAACACCTTTTTTGTGGG
GTTCTCTCTGACCTTTCATCGTAAAGTGCTGGGGACCTTAAGTGATTTGCCTGTAATTTTGGATGATTAAAAAATGTGTATATATATTAG
CTAATTAGAAATATTCTACTTCTCTGTTGTCAAACTGAAATTCAGAGCAAGTTCCTGAGTGCGTGGATCTGGGTCTTAGTTCTGGTTGAT
TCACTCAAGAGTTCAGTGCTCATACGTATCTGCTCATTTTGACAAAGTGCCTCATGCAACCGGGCCCTCTCTCTGCGGCAGAGTCCTTAG
TGGAGGGGTTTACCTGGAACATTAGTAGTTACCACAGAATACGGAAGAGCAGGTGACTGTGCTGTGCAGCTCTCTAAATGGGAATTCTCA
GGTAGGAAGCAACAGCTTCAGAAAGAGCTCAAAATAAATTGGAAATGTGAATCGCAGCTGTGGGTTTTACCACCGTCTGTCTCAGAGTCC
CAGGACCTTGAGTGTCATTAGTTACTTTATTGAAGGTTTTAGACCCATAGCAGCTTTGTCTCTGTCACATCAGCAATTTCAGAACCAAAA
GGGAGGCTCTCTGTAGGCACAGAGCTGCACTATCACGAGCCTTTGTTTTTCTCCACAAAGTATCTAACAAAACCAATGTGCAGACTGATT
GGCCTGGTCATTGGTCTCCGAGAGAGGAGGTTTGCCTGTGATTTCCTAATTATCGCTAGGGCCAAGGTGGGATTTGTAAAGCTTTACAAT
AATCATTCTGGATAGAGTCCTGGGAGGTCCTTGGCAGAACTCAGTTAAATCTTTGAAGAATATTTGTAGTTATCTTAGAAGATAGCATGG
GAGGTGAGGATTCCAAAAACATTTTATTTTTAAAATATCCTGTGTAACACTTGGCTCTTGGTACCTGTGGGTTAGCATCAAGTTCTCCCC
AGGGTAGAATTCAATCAGAGCTCCAGTTTGCATTTGGATGTGTAAATTACAGTAATCCCATTTCCCAAACCTAAAATCTGTTTTTCTCAT
CAGACTCTGAGTAACTGGTTGCTGTGTCATAACTTCATAGATGCAGGAGGCTCAGGTGATCTGTTTGAGGAGAGCACCCTAGGCAGCCTG
CAGGGAATAACATACTGGCCGTTCTGACCTGTTGCCAGCAGATACACAGGACATGGATGAAATTCCCGTTTCCTCTAGTTTCTTCCTGTA
GTACTCCTCTTTTAGATCCTAAGTCTCTTACAAAAGCTTTGAATACTGTGAAAATGTTTTACATTCCATTTCATTTGTGTTGTTTTTTTA
ACTGCATTTTACCAGATGTTTTGATGTTATCGCTTATGTTAATAGTAATTCCCGTACGTGTTCATTTTATTTTCATGCTTTTTCAGCCAT


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FusionGenePPI for RNF170_SFRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF170UBE2U, PSMA6, RNF170, P2RY12, LPAR1, FAM134C, PON2, PRICKLE3, MYH9, TM9SF4, RAB4B, PARD6B, CHMP4B, UBE2D2, ERLIN2, ITPR1, RDH14, ERLIN1, ST7L, ABCB10, TYW1, ASPHD2, ATP13A2, PDE3B, TMBIM6SFRP1WNT1, WNT2, FZD6, WNT4, PPP1CC, PPP1CA, KIAA1522, PPP1CB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF170_SFRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF170_SFRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRNF170C1837015ATAXIA, SENSORY, AUTOSOMAL DOMINANT1UNIPROT
TgeneSFRP1C0009404Colorectal Neoplasms2CTD_human
TgeneSFRP1C0005586Bipolar Disorder1PSYGENET
TgeneSFRP1C0011570Mental Depression1PSYGENET
TgeneSFRP1C0011581Depressive disorder1PSYGENET
TgeneSFRP1C0021390Inflammatory Bowel Diseases1CTD_human
TgeneSFRP1C0023267Fibroid Tumor1CTD_human
TgeneSFRP1C1458155Mammary Neoplasms1CTD_human