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Fusion gene ID: 31470 |
FusionGeneSummary for RNF169_ANAPC15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF169_ANAPC15 | Fusion gene ID: 31470 | Hgene | Tgene | Gene symbol | RNF169 | ANAPC15 | Gene ID | 254225 | 25906 |
| Gene name | ring finger protein 169 | anaphase promoting complex subunit 15 | |
| Synonyms | - | APC15|C11orf51|HSPC020 | |
| Cytomap | 11q13.4 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase RNF169RING-type E3 ubiquitin transferase RNF169 | anaphase-promoting complex subunit 15 | |
| Modification date | 20180520 | 20180523 | |
| UniProtAcc | Q8NCN4 | P60006 | |
| Ensembl transtripts involved in fusion gene | ENST00000299563, | ENST00000502597, ENST00000543050, ENST00000543587, ENST00000543015, ENST00000545680, ENST00000227618, ENST00000542531, ENST00000535234, ENST00000545944, ENST00000538393, ENST00000535503, ENST00000538919, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RNF169 [Title/Abstract] AND ANAPC15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RNF169 | GO:0006974 | cellular response to DNA damage stimulus | 22733822 |
| Hgene | RNF169 | GO:2000780 | negative regulation of double-strand break repair | 22742833 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A423-01A | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000299563 | ENST00000502597 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-intron | ENST00000299563 | ENST00000543050 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-5UTR | ENST00000299563 | ENST00000543587 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-intron | ENST00000299563 | ENST00000543015 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-5UTR | ENST00000299563 | ENST00000545680 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-5UTR | ENST00000299563 | ENST00000227618 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-5UTR | ENST00000299563 | ENST00000542531 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-5UTR | ENST00000299563 | ENST00000535234 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-intron | ENST00000299563 | ENST00000545944 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-5UTR | ENST00000299563 | ENST00000538393 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-5UTR | ENST00000299563 | ENST00000535503 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
| 5CDS-5UTR | ENST00000299563 | ENST00000538919 | RNF169 | chr11 | 74500744 | + | ANAPC15 | chr11 | 71822542 | - |
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FusionProtFeatures for RNF169_ANAPC15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF169 | ANAPC15 |
| Probable E3 ubiquitin-protein ligase that acts as anegative regulator of double-strand breaks (DSBs) repair followingDNA damage. Recruited to DSB repair sites by recognizing andbinding ubiquitin catalyzed by RNF168 and competes with TP53BP1and BRCA1 for association with RNF168-modified chromatin, therebyacting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBsrepair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822,ECO:0000269|PubMed:22742833}. | Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle. Inthe complex, plays a role in the release of the mitotic checkpointcomplex (MCC) from the APC/C: not required for APC/C activityitself, but promotes the turnover of CDC20 and MCC on the APC/C,thereby participating in the responsiveness of the spindleassembly checkpoint. Also required for degradation of CDC20.{ECO:0000269|PubMed:21926987}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF169_ANAPC15 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNF169_ANAPC15 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RNF169 | UBC, HIST2H2AC, HIST2H2BE, UBE2E1, DYRK1B, DYRK1A, BRCA1, HIST1H2BG, HIST1H3A, USP7, CDC14B, DCAF7, KLHDC2, IL16, CAPZB, CAPZA1, TUBB4B, RPS3, DDB1, C1QBP, HNRNPU | ANAPC15 | ANAPC4, CDC27, ANAPC1, ANAPC2, ANAPC5, CDC16, ANAPC7, CDC23, ANAPC10, CDC26, CDC20, NEK2, PRDX1, RRM2, RTKN, PRDX2, TK2, VBP1, USP6NL, SORBS3, DHRS2, INADL, PROSC, ECD, PACS2, PRDX5, ANAPC13, FBXO5, FZR1, SIRT6, PPP1R9A, ZNF512B, CFAP97, DENND1A, MRPL11, GNPTAB, GNPTG, MRRF, C1QTNF6, ANAPC16, BRINP1, USP37, ABL1, CDKN2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF169_ANAPC15 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF169_ANAPC15 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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