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Fusion gene ID: 31419 |
FusionGeneSummary for RNF128_THSD4 |
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Fusion gene information | Fusion gene name: RNF128_THSD4 | Fusion gene ID: 31419 | Hgene | Tgene | Gene symbol | RNF128 | THSD4 | Gene ID | 79589 | 79875 |
Gene name | ring finger protein 128, E3 ubiquitin protein ligase | thrombospondin type 1 domain containing 4 | |
Synonyms | GRAIL | ADAMTSL-6|ADAMTSL6|FVSY9334|PRO34005 | |
Cytomap | Xq22.3 | 15q23 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase RNF128RING-type E3 ubiquitin transferase RNF128gene related to anergy in lymphocytes protein | thrombospondin type-1 domain-containing protein 4A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6ADAMTS-like protein 6thrombospondin, type I, domain containing 4 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8TEB7 | Q6ZMP0 | |
Ensembl transtripts involved in fusion gene | ENST00000324342, ENST00000255499, | ENST00000355327, ENST00000261862, ENST00000357769, ENST00000567838, | |
Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 22 X 7 X 13=2002 |
# samples | 3 | 22 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(22/2002*10)=-3.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RNF128 [Title/Abstract] AND THSD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW379188 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000324342 | ENST00000355327 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
intron-intron | ENST00000324342 | ENST00000261862 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
intron-intron | ENST00000324342 | ENST00000357769 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
intron-intron | ENST00000324342 | ENST00000567838 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
intron-intron | ENST00000255499 | ENST00000355327 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
intron-intron | ENST00000255499 | ENST00000261862 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
intron-intron | ENST00000255499 | ENST00000357769 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
intron-intron | ENST00000255499 | ENST00000567838 | RNF128 | chrX | 106019471 | - | THSD4 | chr15 | 71556023 | + |
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FusionProtFeatures for RNF128_THSD4 |
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Hgene | Tgene |
RNF128 | THSD4 |
E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and'Lys-63'-linked polyubiquitin chains formation. Functions as aninhibitor of cytokine gene transcription. Inhibits IL2 and IL4transcription, thereby playing an important role in the inductionof the anergic phenotype, a long-term stable state of T-lymphocyteunresponsiveness to antigenic stimulation associated with theblockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to theirdegradation, down-regulation of these cytosleletal componentsresults in impaired lamellipodium formation and reducedaccumulation of F-actin at the immunological synapse. Functions inthe patterning of the dorsal ectoderm; sensitizes ectoderm torespond to neural-inducing signals. {ECO:0000269|PubMed:12705856,ECO:0000269|PubMed:22016387}. | Promotes FBN1 matrix assembly. Attenuates TGFBsignaling, possibly by accelerating the sequestration of largelatent complexes of TGFB or active TGFB by FBN1 microfibrilassembly, thereby negatively regulating the expression of TGFBregulatory targets, such as POSTN (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF128_THSD4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNF128_THSD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF128_THSD4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF128_THSD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | THSD4 | C0236969 | Substance-Related Disorders | 1 | CTD_human |