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Fusion gene ID: 31406 |
FusionGeneSummary for RNF121_VPS37C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF121_VPS37C | Fusion gene ID: 31406 | Hgene | Tgene | Gene symbol | RNF121 | VPS37C | Gene ID | 55298 | 55048 |
| Gene name | ring finger protein 121 | VPS37C, ESCRT-I subunit | |
| Synonyms | - | - | |
| Cytomap | 11q13.4 | 11q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RING finger protein 121 | vacuolar protein sorting-associated protein 37CESCRT-I complex subunit VPS37ChVps37Cvacuolar protein sorting 37 homolog Cvacuolar protein sorting 37C | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9H920 | A5D8V6 | |
| Ensembl transtripts involved in fusion gene | ENST00000361756, ENST00000533380, ENST00000393713, ENST00000490867, ENST00000545854, ENST00000530137, | ENST00000301765, | |
| Fusion gene scores | * DoF score | 14 X 4 X 7=392 | 5 X 3 X 4=60 |
| # samples | 15 | 5 | |
| ** MAII score | log2(15/392*10)=-1.38589115361933 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF121 [Title/Abstract] AND VPS37C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A1G4-01A | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361756 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| In-frame | ENST00000533380 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| In-frame | ENST00000393713 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| 3UTR-3CDS | ENST00000490867 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| 5UTR-3CDS | ENST00000545854 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| In-frame | ENST00000530137 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
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FusionProtFeatures for RNF121_VPS37C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF121 | VPS37C |
| Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May beinvolved in cell growth and differentiation.{ECO:0000269|PubMed:15509564}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RNF121 | chr11:71671937 | chr11:60901679 | ENST00000361756 | + | 3 | 9 | 50_70 | 81 | 328 | Transmembrane | Helical |
| Tgene | >VPS37C | chr11:71671937 | chr11:60901679 | ENST00000301765 | - | 1 | 5 | 171_353 | 31 | 356 | Compositional bias | Note=Pro-rich |
| Tgene | >VPS37C | chr11:71671937 | chr11:60901679 | ENST00000301765 | - | 1 | 5 | 78_167 | 31 | 356 | Domain | VPS37 C-terminal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RNF121 | chr11:71671937 | chr11:60901679 | ENST00000361756 | + | 3 | 9 | 100_120 | 81 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71671937 | chr11:60901679 | ENST00000361756 | + | 3 | 9 | 148_168 | 81 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71671937 | chr11:60901679 | ENST00000361756 | + | 3 | 9 | 172_192 | 81 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71671937 | chr11:60901679 | ENST00000361756 | + | 3 | 9 | 306_326 | 81 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71671937 | chr11:60901679 | ENST00000361756 | + | 3 | 9 | 79_99 | 81 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71671937 | chr11:60901679 | ENST00000361756 | + | 3 | 9 | 226_276 | 81 | 328 | Zinc finger | RING-type%3B atypical |
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FusionGeneSequence for RNF121_VPS37C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RNF121_ENST00000361756_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_406aa MAAVVEVEVGGGAAGERELDEVDMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNVQDLQLERE MALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLE TFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAH GALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPP >In-frame_RNF121_ENST00000533380_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_374aa MRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQ ELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRA SQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGP RGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPY >In-frame_RNF121_ENST00000393713_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_374aa MRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQ ELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRA SQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGP RGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPY >In-frame_RNF121_ENST00000530137_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_374aa MRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQ ELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRA SQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGP RGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RNF121_ENST00000361756_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_1218nt ATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGTTGATATGTCAGATCTCTCTCCAGAA GAGCAATGGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCA ACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATGTCCAGGACCTACAGCTGGAACGGGAG ATGGCACTGGCCACCAACCGGAGCCTGGCAGAGCGGAACTTGGAGTTCCAGGGTCCCCTGGAGATCAGCCGCTCAAACCTCTCGGATAGA TACCAGGAGCTCCGGAAGCTCGTGGAGCGGTGCCAGGAGCAGAAGGCAAAGCTGGAGAAATTTTCTTCAGCACTGCAGCCAGGGACCTTG TTAGACCTTCTGCAGGTGGAAGGCATGAAGATCGAAGAAGAGTCCGAGGCCATGGCTGAGAAGTTCCTGGAGGGCGAGGTGCCCCTGGAA ACGTTCCTGGAGAATTTTTCCTCCATGAGGATGCTGTCCCACCTGCGCCGGGTTCGCGTGGAAAAGCTCCAGGAAGTGGTGAGGAAGCCC AGGGCTTCCCAGGAGCTGGCCGGCGATGCCCCTCCACCCCGTCCACCACCCCCGGTGCGCCCAGTCCCCCAGGGAACACCCCCTGTGGTT GAAGAGCAGCCGCAGCCACCATTAGCCATGCCTCCCTACCCTTTGCCCTACAGCCCATCCCCCAGCCTGCCTGTGGGCCCCACTGCCCAT GGAGCCCTGCCACCGGCCCCTTTCCCAGTAGTGTCCCAGCCCTCCTTCTACAGCGGGCCTCTGGGCCCCACTTACCCGGCAGCCCAGCTT GGACCCAGGGGTGCTGCGGGTTACTCCTGGTCCCCACAGAGGAGCATGCCACCCCGGCCGGGCTATCCTGGGACCCCAATGGGTGCCTCT GGGCCTGGGTACCCCTTGCGGGGAGGCAGGGCCCCCAGTCCTGGTTATCCTCAACAGTCCCCATACCCCGCAACAGGAGGAAAACCTCCC TACCCAATACAGCCTCAGCTCCCCAGCTTTCCAGGCCAGCCCCAGCCCTCAGTGCCCCTGCAGCCCCCTTATCCCCCCGGGCCCGCCCCT >In-frame_RNF121_ENST00000533380_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_1122nt ATGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTG GTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATGTCCAGGACCTACAGCTGGAACGGGAGATGGCA CTGGCCACCAACCGGAGCCTGGCAGAGCGGAACTTGGAGTTCCAGGGTCCCCTGGAGATCAGCCGCTCAAACCTCTCGGATAGATACCAG GAGCTCCGGAAGCTCGTGGAGCGGTGCCAGGAGCAGAAGGCAAAGCTGGAGAAATTTTCTTCAGCACTGCAGCCAGGGACCTTGTTAGAC CTTCTGCAGGTGGAAGGCATGAAGATCGAAGAAGAGTCCGAGGCCATGGCTGAGAAGTTCCTGGAGGGCGAGGTGCCCCTGGAAACGTTC CTGGAGAATTTTTCCTCCATGAGGATGCTGTCCCACCTGCGCCGGGTTCGCGTGGAAAAGCTCCAGGAAGTGGTGAGGAAGCCCAGGGCT TCCCAGGAGCTGGCCGGCGATGCCCCTCCACCCCGTCCACCACCCCCGGTGCGCCCAGTCCCCCAGGGAACACCCCCTGTGGTTGAAGAG CAGCCGCAGCCACCATTAGCCATGCCTCCCTACCCTTTGCCCTACAGCCCATCCCCCAGCCTGCCTGTGGGCCCCACTGCCCATGGAGCC CTGCCACCGGCCCCTTTCCCAGTAGTGTCCCAGCCCTCCTTCTACAGCGGGCCTCTGGGCCCCACTTACCCGGCAGCCCAGCTTGGACCC AGGGGTGCTGCGGGTTACTCCTGGTCCCCACAGAGGAGCATGCCACCCCGGCCGGGCTATCCTGGGACCCCAATGGGTGCCTCTGGGCCT GGGTACCCCTTGCGGGGAGGCAGGGCCCCCAGTCCTGGTTATCCTCAACAGTCCCCATACCCCGCAACAGGAGGAAAACCTCCCTACCCA ATACAGCCTCAGCTCCCCAGCTTTCCAGGCCAGCCCCAGCCCTCAGTGCCCCTGCAGCCCCCTTATCCCCCCGGGCCCGCCCCTCCCTAT >In-frame_RNF121_ENST00000393713_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_1122nt ATGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTG GTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATGTCCAGGACCTACAGCTGGAACGGGAGATGGCA CTGGCCACCAACCGGAGCCTGGCAGAGCGGAACTTGGAGTTCCAGGGTCCCCTGGAGATCAGCCGCTCAAACCTCTCGGATAGATACCAG GAGCTCCGGAAGCTCGTGGAGCGGTGCCAGGAGCAGAAGGCAAAGCTGGAGAAATTTTCTTCAGCACTGCAGCCAGGGACCTTGTTAGAC CTTCTGCAGGTGGAAGGCATGAAGATCGAAGAAGAGTCCGAGGCCATGGCTGAGAAGTTCCTGGAGGGCGAGGTGCCCCTGGAAACGTTC CTGGAGAATTTTTCCTCCATGAGGATGCTGTCCCACCTGCGCCGGGTTCGCGTGGAAAAGCTCCAGGAAGTGGTGAGGAAGCCCAGGGCT TCCCAGGAGCTGGCCGGCGATGCCCCTCCACCCCGTCCACCACCCCCGGTGCGCCCAGTCCCCCAGGGAACACCCCCTGTGGTTGAAGAG CAGCCGCAGCCACCATTAGCCATGCCTCCCTACCCTTTGCCCTACAGCCCATCCCCCAGCCTGCCTGTGGGCCCCACTGCCCATGGAGCC CTGCCACCGGCCCCTTTCCCAGTAGTGTCCCAGCCCTCCTTCTACAGCGGGCCTCTGGGCCCCACTTACCCGGCAGCCCAGCTTGGACCC AGGGGTGCTGCGGGTTACTCCTGGTCCCCACAGAGGAGCATGCCACCCCGGCCGGGCTATCCTGGGACCCCAATGGGTGCCTCTGGGCCT GGGTACCCCTTGCGGGGAGGCAGGGCCCCCAGTCCTGGTTATCCTCAACAGTCCCCATACCCCGCAACAGGAGGAAAACCTCCCTACCCA ATACAGCCTCAGCTCCCCAGCTTTCCAGGCCAGCCCCAGCCCTCAGTGCCCCTGCAGCCCCCTTATCCCCCCGGGCCCGCCCCTCCCTAT >In-frame_RNF121_ENST00000530137_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_1122nt ATGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTG GTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATGTCCAGGACCTACAGCTGGAACGGGAGATGGCA CTGGCCACCAACCGGAGCCTGGCAGAGCGGAACTTGGAGTTCCAGGGTCCCCTGGAGATCAGCCGCTCAAACCTCTCGGATAGATACCAG GAGCTCCGGAAGCTCGTGGAGCGGTGCCAGGAGCAGAAGGCAAAGCTGGAGAAATTTTCTTCAGCACTGCAGCCAGGGACCTTGTTAGAC CTTCTGCAGGTGGAAGGCATGAAGATCGAAGAAGAGTCCGAGGCCATGGCTGAGAAGTTCCTGGAGGGCGAGGTGCCCCTGGAAACGTTC CTGGAGAATTTTTCCTCCATGAGGATGCTGTCCCACCTGCGCCGGGTTCGCGTGGAAAAGCTCCAGGAAGTGGTGAGGAAGCCCAGGGCT TCCCAGGAGCTGGCCGGCGATGCCCCTCCACCCCGTCCACCACCCCCGGTGCGCCCAGTCCCCCAGGGAACACCCCCTGTGGTTGAAGAG CAGCCGCAGCCACCATTAGCCATGCCTCCCTACCCTTTGCCCTACAGCCCATCCCCCAGCCTGCCTGTGGGCCCCACTGCCCATGGAGCC CTGCCACCGGCCCCTTTCCCAGTAGTGTCCCAGCCCTCCTTCTACAGCGGGCCTCTGGGCCCCACTTACCCGGCAGCCCAGCTTGGACCC AGGGGTGCTGCGGGTTACTCCTGGTCCCCACAGAGGAGCATGCCACCCCGGCCGGGCTATCCTGGGACCCCAATGGGTGCCTCTGGGCCT GGGTACCCCTTGCGGGGAGGCAGGGCCCCCAGTCCTGGTTATCCTCAACAGTCCCCATACCCCGCAACAGGAGGAAAACCTCCCTACCCA ATACAGCCTCAGCTCCCCAGCTTTCCAGGCCAGCCCCAGCCCTCAGTGCCCCTGCAGCCCCCTTATCCCCCCGGGCCCGCCCCTCCCTAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RNF121_ENST00000361756_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_3143nt ACGTCTCGCTCCTTGGAGCCCAGACTGAGGGAGCGTCGCGAAAGTTGCCCGTTTTGGAACGCTCCCATTTGGCTCTCCAAAGGGAAGAAT TGGTTAAATAGTTGCACTGAAAATAATGCGATTCAAATTTCTCATTTTCCAAGAACGCTCCCTTGCTGAAGCTTGCAAGGGCACGGTACT CCCCTCTCCTTGACCCTGAAACGTGCAGCAAGTAGATAACCTCCTGATCCCTGACAGTCTCCGCCTGTGTTGATGCCCCGCCCCCTCTGC TGGAGTCCGAGCCGCCGATTGGCTAGGAGCACTTGAGCAGCGGAAGCAGCTGGCTCGCGCGGGGACTGCGGTGAGGGGGCGAGCCGTGAA GATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGTTGATATGTCAGATCTCTCTCCAGA AGAGCAATGGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGC AACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATGTCCAGGACCTACAGCTGGAACGGGA GATGGCACTGGCCACCAACCGGAGCCTGGCAGAGCGGAACTTGGAGTTCCAGGGTCCCCTGGAGATCAGCCGCTCAAACCTCTCGGATAG ATACCAGGAGCTCCGGAAGCTCGTGGAGCGGTGCCAGGAGCAGAAGGCAAAGCTGGAGAAATTTTCTTCAGCACTGCAGCCAGGGACCTT GTTAGACCTTCTGCAGGTGGAAGGCATGAAGATCGAAGAAGAGTCCGAGGCCATGGCTGAGAAGTTCCTGGAGGGCGAGGTGCCCCTGGA AACGTTCCTGGAGAATTTTTCCTCCATGAGGATGCTGTCCCACCTGCGCCGGGTTCGCGTGGAAAAGCTCCAGGAAGTGGTGAGGAAGCC CAGGGCTTCCCAGGAGCTGGCCGGCGATGCCCCTCCACCCCGTCCACCACCCCCGGTGCGCCCAGTCCCCCAGGGAACACCCCCTGTGGT TGAAGAGCAGCCGCAGCCACCATTAGCCATGCCTCCCTACCCTTTGCCCTACAGCCCATCCCCCAGCCTGCCTGTGGGCCCCACTGCCCA TGGAGCCCTGCCACCGGCCCCTTTCCCAGTAGTGTCCCAGCCCTCCTTCTACAGCGGGCCTCTGGGCCCCACTTACCCGGCAGCCCAGCT TGGACCCAGGGGTGCTGCGGGTTACTCCTGGTCCCCACAGAGGAGCATGCCACCCCGGCCGGGCTATCCTGGGACCCCAATGGGTGCCTC TGGGCCTGGGTACCCCTTGCGGGGAGGCAGGGCCCCCAGTCCTGGTTATCCTCAACAGTCCCCATACCCCGCAACAGGAGGAAAACCTCC CTACCCAATACAGCCTCAGCTCCCCAGCTTTCCAGGCCAGCCCCAGCCCTCAGTGCCCCTGCAGCCCCCTTATCCCCCCGGGCCCGCCCC TCCCTATGGGTTCCCACCACCGCCGGGGCCTGCCTGGCCTGGGTATTAGACACACTCCTGGCCCTCGGCCCCTCCCTAGTCCCACCCACG CTCAACCTTTGGCCCAGCCATCGCCGAGATTCGAGGGTCAACTGGAAGTGGCGTTGGTGCTCCCTGTGGACTTGCGTCGGCACCCAGAGG CCTTGGAGGGACAAGGCACTGGGCGGTGTGACTGGTCATGGCACTTGCTGGCCTTCTGGCCAGAGGTCCTCCTGGAAGCCCCTCCTTTCA GTGCCTGGCTGCAGCGGTGCTAGCCAGGCTGGAGTCCAGCACCTCTCGCCGGTGTCTGTGTGAGTGAGCGCATGTGCGCATTTATGAGCA TCTACTTGCGGCTGCACTCAGGGCCATTTGAACCCAGTGCAGAGTTATCTCTATGAGGAGGCCCCGGGTCTCCAGCCCCCTCCATCTCCC CTGGGGTTTGGCATATTTGACATGGAGCCCCATGCCAAGGGATGCAGCTGTTGGTGTCTGTCCAGTCCATTCAAGGCTAGCCTGCCCATG CACTGTGGCAGGGGTTGGATTGGAGGGAGAGAACAGAGTTGGGAAAAACAACAGGTTTGAGTCCTATAAAGCCATAATTTAACTCCAGTA GCTGATGTCAGACAAGCTTGTCCTATGTCCTATTTGAGTGGCAGCAGCGCCAGCCCAGCAAGAAGGCTGGGGGTTGTCAAGGTTGTCCCC AGACCTTGCTTGCAGTGGTTGGAGAACCCAGGGGGCTGCCTTGGGCCCTCTGGCCAGAGGGAAGCGGGCAGCTCTAGCCCTGGAGATTGT GGTCACATTGGGGCTTGTTTAGGATTGGAGGGCCAGGTCACCTCCCCAGCCACCCTCCCTTCTCTCCTCTGGGGTCCCCACTTTAGGGCG ACTTTGCCCGAGGCCCACGCATCCATCCACTCCTTTAGTGCCTTGAATCTCATTCACAAGCAGCCCCCTCCCTTCCCCTCCCCTTCTCAC TCTGTTGATGTAATCCTCCCACCCCCAGTGTCCATCCTAAGACAGGCATCAAAAGAGGCCCTAACTTTACTTCCCAAATGGTGCTTTTTA AAAAACACCATCACTACATTAGGGGCAATTTTTTCACACCTCCCTGTCTTCAGAATGTAAAGGGTGGGGATTATGTCTCTGTTTAATATG CAGCCCCCTGCACTGTGGGGTTTGGGGCATGTTCAGTAATAAGAATGAATACAATAGACAAAGGGGGTGTGATGAGTGTTAACTTGGTTG TTCCAGAGGTAAACCAGGTCTCAGGGAAGAGCCTGGAGCTGCTATTGCTTAGGAAGTTGTACGTGCCTTGAAATGTCCACTACCTGAGGA CGCAGCATCTGGTGGGCCCGGGGCTGCTGGGGCCAAGGAGGGACCTTGACCTTCTGGTGCCTGCCCCTCCCCGGCCTATGTGCCATCCGC GTGACGCTAGGTCAGCGCTGCCGGTTCTTTACCAAATGTGCTTGCTTCTCCTAAGTTATTTATAAAGAGAAATCACTAATGGACTCTACT >In-frame_RNF121_ENST00000533380_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_2774nt GGGACTGCGGTGAGGGGGCGAGCCGTGAAGATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGAT GAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGT GGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATGTCCAGGACCTACAGCTGGAACGGGAGATGGCACT GGCCACCAACCGGAGCCTGGCAGAGCGGAACTTGGAGTTCCAGGGTCCCCTGGAGATCAGCCGCTCAAACCTCTCGGATAGATACCAGGA GCTCCGGAAGCTCGTGGAGCGGTGCCAGGAGCAGAAGGCAAAGCTGGAGAAATTTTCTTCAGCACTGCAGCCAGGGACCTTGTTAGACCT TCTGCAGGTGGAAGGCATGAAGATCGAAGAAGAGTCCGAGGCCATGGCTGAGAAGTTCCTGGAGGGCGAGGTGCCCCTGGAAACGTTCCT GGAGAATTTTTCCTCCATGAGGATGCTGTCCCACCTGCGCCGGGTTCGCGTGGAAAAGCTCCAGGAAGTGGTGAGGAAGCCCAGGGCTTC CCAGGAGCTGGCCGGCGATGCCCCTCCACCCCGTCCACCACCCCCGGTGCGCCCAGTCCCCCAGGGAACACCCCCTGTGGTTGAAGAGCA GCCGCAGCCACCATTAGCCATGCCTCCCTACCCTTTGCCCTACAGCCCATCCCCCAGCCTGCCTGTGGGCCCCACTGCCCATGGAGCCCT GCCACCGGCCCCTTTCCCAGTAGTGTCCCAGCCCTCCTTCTACAGCGGGCCTCTGGGCCCCACTTACCCGGCAGCCCAGCTTGGACCCAG GGGTGCTGCGGGTTACTCCTGGTCCCCACAGAGGAGCATGCCACCCCGGCCGGGCTATCCTGGGACCCCAATGGGTGCCTCTGGGCCTGG GTACCCCTTGCGGGGAGGCAGGGCCCCCAGTCCTGGTTATCCTCAACAGTCCCCATACCCCGCAACAGGAGGAAAACCTCCCTACCCAAT ACAGCCTCAGCTCCCCAGCTTTCCAGGCCAGCCCCAGCCCTCAGTGCCCCTGCAGCCCCCTTATCCCCCCGGGCCCGCCCCTCCCTATGG GTTCCCACCACCGCCGGGGCCTGCCTGGCCTGGGTATTAGACACACTCCTGGCCCTCGGCCCCTCCCTAGTCCCACCCACGCTCAACCTT TGGCCCAGCCATCGCCGAGATTCGAGGGTCAACTGGAAGTGGCGTTGGTGCTCCCTGTGGACTTGCGTCGGCACCCAGAGGCCTTGGAGG GACAAGGCACTGGGCGGTGTGACTGGTCATGGCACTTGCTGGCCTTCTGGCCAGAGGTCCTCCTGGAAGCCCCTCCTTTCAGTGCCTGGC TGCAGCGGTGCTAGCCAGGCTGGAGTCCAGCACCTCTCGCCGGTGTCTGTGTGAGTGAGCGCATGTGCGCATTTATGAGCATCTACTTGC GGCTGCACTCAGGGCCATTTGAACCCAGTGCAGAGTTATCTCTATGAGGAGGCCCCGGGTCTCCAGCCCCCTCCATCTCCCCTGGGGTTT GGCATATTTGACATGGAGCCCCATGCCAAGGGATGCAGCTGTTGGTGTCTGTCCAGTCCATTCAAGGCTAGCCTGCCCATGCACTGTGGC AGGGGTTGGATTGGAGGGAGAGAACAGAGTTGGGAAAAACAACAGGTTTGAGTCCTATAAAGCCATAATTTAACTCCAGTAGCTGATGTC AGACAAGCTTGTCCTATGTCCTATTTGAGTGGCAGCAGCGCCAGCCCAGCAAGAAGGCTGGGGGTTGTCAAGGTTGTCCCCAGACCTTGC TTGCAGTGGTTGGAGAACCCAGGGGGCTGCCTTGGGCCCTCTGGCCAGAGGGAAGCGGGCAGCTCTAGCCCTGGAGATTGTGGTCACATT GGGGCTTGTTTAGGATTGGAGGGCCAGGTCACCTCCCCAGCCACCCTCCCTTCTCTCCTCTGGGGTCCCCACTTTAGGGCGACTTTGCCC GAGGCCCACGCATCCATCCACTCCTTTAGTGCCTTGAATCTCATTCACAAGCAGCCCCCTCCCTTCCCCTCCCCTTCTCACTCTGTTGAT GTAATCCTCCCACCCCCAGTGTCCATCCTAAGACAGGCATCAAAAGAGGCCCTAACTTTACTTCCCAAATGGTGCTTTTTAAAAAACACC ATCACTACATTAGGGGCAATTTTTTCACACCTCCCTGTCTTCAGAATGTAAAGGGTGGGGATTATGTCTCTGTTTAATATGCAGCCCCCT GCACTGTGGGGTTTGGGGCATGTTCAGTAATAAGAATGAATACAATAGACAAAGGGGGTGTGATGAGTGTTAACTTGGTTGTTCCAGAGG TAAACCAGGTCTCAGGGAAGAGCCTGGAGCTGCTATTGCTTAGGAAGTTGTACGTGCCTTGAAATGTCCACTACCTGAGGACGCAGCATC TGGTGGGCCCGGGGCTGCTGGGGCCAAGGAGGGACCTTGACCTTCTGGTGCCTGCCCCTCCCCGGCCTATGTGCCATCCGCGTGACGCTA GGTCAGCGCTGCCGGTTCTTTACCAAATGTGCTTGCTTCTCCTAAGTTATTTATAAAGAGAAATCACTAATGGACTCTACTGGTTTGAGT >In-frame_RNF121_ENST00000393713_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_2772nt GACTGCGGTGAGGGGGCGAGCCGTGAAGATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGA GGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGG TGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATGTCCAGGACCTACAGCTGGAACGGGAGATGGCACTGG CCACCAACCGGAGCCTGGCAGAGCGGAACTTGGAGTTCCAGGGTCCCCTGGAGATCAGCCGCTCAAACCTCTCGGATAGATACCAGGAGC TCCGGAAGCTCGTGGAGCGGTGCCAGGAGCAGAAGGCAAAGCTGGAGAAATTTTCTTCAGCACTGCAGCCAGGGACCTTGTTAGACCTTC TGCAGGTGGAAGGCATGAAGATCGAAGAAGAGTCCGAGGCCATGGCTGAGAAGTTCCTGGAGGGCGAGGTGCCCCTGGAAACGTTCCTGG AGAATTTTTCCTCCATGAGGATGCTGTCCCACCTGCGCCGGGTTCGCGTGGAAAAGCTCCAGGAAGTGGTGAGGAAGCCCAGGGCTTCCC AGGAGCTGGCCGGCGATGCCCCTCCACCCCGTCCACCACCCCCGGTGCGCCCAGTCCCCCAGGGAACACCCCCTGTGGTTGAAGAGCAGC CGCAGCCACCATTAGCCATGCCTCCCTACCCTTTGCCCTACAGCCCATCCCCCAGCCTGCCTGTGGGCCCCACTGCCCATGGAGCCCTGC CACCGGCCCCTTTCCCAGTAGTGTCCCAGCCCTCCTTCTACAGCGGGCCTCTGGGCCCCACTTACCCGGCAGCCCAGCTTGGACCCAGGG GTGCTGCGGGTTACTCCTGGTCCCCACAGAGGAGCATGCCACCCCGGCCGGGCTATCCTGGGACCCCAATGGGTGCCTCTGGGCCTGGGT ACCCCTTGCGGGGAGGCAGGGCCCCCAGTCCTGGTTATCCTCAACAGTCCCCATACCCCGCAACAGGAGGAAAACCTCCCTACCCAATAC AGCCTCAGCTCCCCAGCTTTCCAGGCCAGCCCCAGCCCTCAGTGCCCCTGCAGCCCCCTTATCCCCCCGGGCCCGCCCCTCCCTATGGGT TCCCACCACCGCCGGGGCCTGCCTGGCCTGGGTATTAGACACACTCCTGGCCCTCGGCCCCTCCCTAGTCCCACCCACGCTCAACCTTTG GCCCAGCCATCGCCGAGATTCGAGGGTCAACTGGAAGTGGCGTTGGTGCTCCCTGTGGACTTGCGTCGGCACCCAGAGGCCTTGGAGGGA CAAGGCACTGGGCGGTGTGACTGGTCATGGCACTTGCTGGCCTTCTGGCCAGAGGTCCTCCTGGAAGCCCCTCCTTTCAGTGCCTGGCTG CAGCGGTGCTAGCCAGGCTGGAGTCCAGCACCTCTCGCCGGTGTCTGTGTGAGTGAGCGCATGTGCGCATTTATGAGCATCTACTTGCGG CTGCACTCAGGGCCATTTGAACCCAGTGCAGAGTTATCTCTATGAGGAGGCCCCGGGTCTCCAGCCCCCTCCATCTCCCCTGGGGTTTGG CATATTTGACATGGAGCCCCATGCCAAGGGATGCAGCTGTTGGTGTCTGTCCAGTCCATTCAAGGCTAGCCTGCCCATGCACTGTGGCAG GGGTTGGATTGGAGGGAGAGAACAGAGTTGGGAAAAACAACAGGTTTGAGTCCTATAAAGCCATAATTTAACTCCAGTAGCTGATGTCAG ACAAGCTTGTCCTATGTCCTATTTGAGTGGCAGCAGCGCCAGCCCAGCAAGAAGGCTGGGGGTTGTCAAGGTTGTCCCCAGACCTTGCTT GCAGTGGTTGGAGAACCCAGGGGGCTGCCTTGGGCCCTCTGGCCAGAGGGAAGCGGGCAGCTCTAGCCCTGGAGATTGTGGTCACATTGG GGCTTGTTTAGGATTGGAGGGCCAGGTCACCTCCCCAGCCACCCTCCCTTCTCTCCTCTGGGGTCCCCACTTTAGGGCGACTTTGCCCGA GGCCCACGCATCCATCCACTCCTTTAGTGCCTTGAATCTCATTCACAAGCAGCCCCCTCCCTTCCCCTCCCCTTCTCACTCTGTTGATGT AATCCTCCCACCCCCAGTGTCCATCCTAAGACAGGCATCAAAAGAGGCCCTAACTTTACTTCCCAAATGGTGCTTTTTAAAAAACACCAT CACTACATTAGGGGCAATTTTTTCACACCTCCCTGTCTTCAGAATGTAAAGGGTGGGGATTATGTCTCTGTTTAATATGCAGCCCCCTGC ACTGTGGGGTTTGGGGCATGTTCAGTAATAAGAATGAATACAATAGACAAAGGGGGTGTGATGAGTGTTAACTTGGTTGTTCCAGAGGTA AACCAGGTCTCAGGGAAGAGCCTGGAGCTGCTATTGCTTAGGAAGTTGTACGTGCCTTGAAATGTCCACTACCTGAGGACGCAGCATCTG GTGGGCCCGGGGCTGCTGGGGCCAAGGAGGGACCTTGACCTTCTGGTGCCTGCCCCTCCCCGGCCTATGTGCCATCCGCGTGACGCTAGG TCAGCGCTGCCGGTTCTTTACCAAATGTGCTTGCTTCTCCTAAGTTATTTATAAAGAGAAATCACTAATGGACTCTACTGGTTTGAGTGC >In-frame_RNF121_ENST00000530137_chr11_71671937_+_VPS37C_ENST00000301765_chr11_60901679_-_2724nt GGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTA TGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCT ACAATGTCCAGGACCTACAGCTGGAACGGGAGATGGCACTGGCCACCAACCGGAGCCTGGCAGAGCGGAACTTGGAGTTCCAGGGTCCCC TGGAGATCAGCCGCTCAAACCTCTCGGATAGATACCAGGAGCTCCGGAAGCTCGTGGAGCGGTGCCAGGAGCAGAAGGCAAAGCTGGAGA AATTTTCTTCAGCACTGCAGCCAGGGACCTTGTTAGACCTTCTGCAGGTGGAAGGCATGAAGATCGAAGAAGAGTCCGAGGCCATGGCTG AGAAGTTCCTGGAGGGCGAGGTGCCCCTGGAAACGTTCCTGGAGAATTTTTCCTCCATGAGGATGCTGTCCCACCTGCGCCGGGTTCGCG TGGAAAAGCTCCAGGAAGTGGTGAGGAAGCCCAGGGCTTCCCAGGAGCTGGCCGGCGATGCCCCTCCACCCCGTCCACCACCCCCGGTGC GCCCAGTCCCCCAGGGAACACCCCCTGTGGTTGAAGAGCAGCCGCAGCCACCATTAGCCATGCCTCCCTACCCTTTGCCCTACAGCCCAT CCCCCAGCCTGCCTGTGGGCCCCACTGCCCATGGAGCCCTGCCACCGGCCCCTTTCCCAGTAGTGTCCCAGCCCTCCTTCTACAGCGGGC CTCTGGGCCCCACTTACCCGGCAGCCCAGCTTGGACCCAGGGGTGCTGCGGGTTACTCCTGGTCCCCACAGAGGAGCATGCCACCCCGGC CGGGCTATCCTGGGACCCCAATGGGTGCCTCTGGGCCTGGGTACCCCTTGCGGGGAGGCAGGGCCCCCAGTCCTGGTTATCCTCAACAGT CCCCATACCCCGCAACAGGAGGAAAACCTCCCTACCCAATACAGCCTCAGCTCCCCAGCTTTCCAGGCCAGCCCCAGCCCTCAGTGCCCC TGCAGCCCCCTTATCCCCCCGGGCCCGCCCCTCCCTATGGGTTCCCACCACCGCCGGGGCCTGCCTGGCCTGGGTATTAGACACACTCCT GGCCCTCGGCCCCTCCCTAGTCCCACCCACGCTCAACCTTTGGCCCAGCCATCGCCGAGATTCGAGGGTCAACTGGAAGTGGCGTTGGTG CTCCCTGTGGACTTGCGTCGGCACCCAGAGGCCTTGGAGGGACAAGGCACTGGGCGGTGTGACTGGTCATGGCACTTGCTGGCCTTCTGG CCAGAGGTCCTCCTGGAAGCCCCTCCTTTCAGTGCCTGGCTGCAGCGGTGCTAGCCAGGCTGGAGTCCAGCACCTCTCGCCGGTGTCTGT GTGAGTGAGCGCATGTGCGCATTTATGAGCATCTACTTGCGGCTGCACTCAGGGCCATTTGAACCCAGTGCAGAGTTATCTCTATGAGGA GGCCCCGGGTCTCCAGCCCCCTCCATCTCCCCTGGGGTTTGGCATATTTGACATGGAGCCCCATGCCAAGGGATGCAGCTGTTGGTGTCT GTCCAGTCCATTCAAGGCTAGCCTGCCCATGCACTGTGGCAGGGGTTGGATTGGAGGGAGAGAACAGAGTTGGGAAAAACAACAGGTTTG AGTCCTATAAAGCCATAATTTAACTCCAGTAGCTGATGTCAGACAAGCTTGTCCTATGTCCTATTTGAGTGGCAGCAGCGCCAGCCCAGC AAGAAGGCTGGGGGTTGTCAAGGTTGTCCCCAGACCTTGCTTGCAGTGGTTGGAGAACCCAGGGGGCTGCCTTGGGCCCTCTGGCCAGAG GGAAGCGGGCAGCTCTAGCCCTGGAGATTGTGGTCACATTGGGGCTTGTTTAGGATTGGAGGGCCAGGTCACCTCCCCAGCCACCCTCCC TTCTCTCCTCTGGGGTCCCCACTTTAGGGCGACTTTGCCCGAGGCCCACGCATCCATCCACTCCTTTAGTGCCTTGAATCTCATTCACAA GCAGCCCCCTCCCTTCCCCTCCCCTTCTCACTCTGTTGATGTAATCCTCCCACCCCCAGTGTCCATCCTAAGACAGGCATCAAAAGAGGC CCTAACTTTACTTCCCAAATGGTGCTTTTTAAAAAACACCATCACTACATTAGGGGCAATTTTTTCACACCTCCCTGTCTTCAGAATGTA AAGGGTGGGGATTATGTCTCTGTTTAATATGCAGCCCCCTGCACTGTGGGGTTTGGGGCATGTTCAGTAATAAGAATGAATACAATAGAC AAAGGGGGTGTGATGAGTGTTAACTTGGTTGTTCCAGAGGTAAACCAGGTCTCAGGGAAGAGCCTGGAGCTGCTATTGCTTAGGAAGTTG TACGTGCCTTGAAATGTCCACTACCTGAGGACGCAGCATCTGGTGGGCCCGGGGCTGCTGGGGCCAAGGAGGGACCTTGACCTTCTGGTG CCTGCCCCTCCCCGGCCTATGTGCCATCCGCGTGACGCTAGGTCAGCGCTGCCGGTTCTTTACCAAATGTGCTTGCTTCTCCTAAGTTAT TTATAAAGAGAAATCACTAATGGACTCTACTGGTTTGAGTGCTTCTGAGCTGGATGACCGACCGCCTGTATGTTTGTGTAATTAATTGCC 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FusionGenePPI for RNF121_VPS37C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RNF121 | NFKBIA, LPAR1, TRIM25 | VPS37C | HGS, TSG101, VPS28, PDCD6IP, CEP55, APP, UBC, MVB12A, AES, XIAP, DDIT3, GOLGA2, PKNOX1, PLSCR1, PSMA3, SH3GL1, SORBS2, DAZAP2, PDCD6, SORBS3, STAM2, TFG, TACC3, RBPMS, WWP2, HNRNPUL1, FAM168A, TFIP11, RINT1, C1orf94, MAPK1IP1L, RFX6, HOXB5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF121_VPS37C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF121_VPS37C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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