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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31398

FusionGeneSummary for RNF121_MRPL21

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF121_MRPL21
Fusion gene ID: 31398
HgeneTgene
Gene symbol

RNF121

MRPL21

Gene ID

55298

219927

Gene namering finger protein 121mitochondrial ribosomal protein L21
Synonyms-L21mt|MRP-L21
Cytomap

11q13.4

11q13.3

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 12139S ribosomal protein L21, mitochondrialmitochondrial large ribosomal subunit protein bL21m
Modification date2018052320180523
UniProtAcc

Q9H920

Q7Z2W9

Ensembl transtripts involved in fusion geneENST00000361756, ENST00000533380, 
ENST00000393713, ENST00000490867, 
ENST00000545854, ENST00000530137, 
ENST00000450904, ENST00000362034, 
ENST00000567045, 
Fusion gene scores* DoF score14 X 4 X 7=3925 X 3 X 4=60
# samples 154
** MAII scorelog2(15/392*10)=-1.38589115361933
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF121 [Title/Abstract] AND MRPL21 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D9-A3Z3-06ARNF121chr11

71671937

+MRPL21chr11

68668073

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361756ENST00000450904RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000361756ENST00000362034RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000361756ENST00000567045RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000533380ENST00000450904RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000533380ENST00000362034RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000533380ENST00000567045RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000393713ENST00000450904RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000393713ENST00000362034RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000393713ENST00000567045RNF121chr11

71671937

+MRPL21chr11

68668073

-
3UTR-5UTRENST00000490867ENST00000450904RNF121chr11

71671937

+MRPL21chr11

68668073

-
3UTR-5UTRENST00000490867ENST00000362034RNF121chr11

71671937

+MRPL21chr11

68668073

-
3UTR-5UTRENST00000490867ENST00000567045RNF121chr11

71671937

+MRPL21chr11

68668073

-
5UTR-5UTRENST00000545854ENST00000450904RNF121chr11

71671937

+MRPL21chr11

68668073

-
5UTR-5UTRENST00000545854ENST00000362034RNF121chr11

71671937

+MRPL21chr11

68668073

-
5UTR-5UTRENST00000545854ENST00000567045RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000530137ENST00000450904RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000530137ENST00000362034RNF121chr11

71671937

+MRPL21chr11

68668073

-
5CDS-5UTRENST00000530137ENST00000567045RNF121chr11

71671937

+MRPL21chr11

68668073

-

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FusionProtFeatures for RNF121_MRPL21


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF121

Q9H920

MRPL21

Q7Z2W9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF121_MRPL21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF121_MRPL21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF121NFKBIA, LPAR1, TRIM25MRPL21CUL3, MRPL40, MRPL51, MRPL32, MRPS9, MRPL19, MRPL24, MRPL38, ILF2, FAF2, C1QBP, GRSF1, BTRC, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPL39, CASQ2, MRPS30, MRPL47, MRPL50, MRPL9, MRPL1, FOXL2, C6orf203, DUSP11, NBEA, MRPL42, MTIF2, GTPBP8, AUH, MRPL20, HARS2, NDUFAF7, MRPL10, FDXR, LARS2, ELAC2, TOP3A, NDUFAF5, IARS2, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF121_MRPL21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF121_MRPL21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource