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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31396

FusionGeneSummary for RNF121_ESRRG

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF121_ESRRG
Fusion gene ID: 31396
HgeneTgene
Gene symbol

RNF121

ESRRG

Gene ID

55298

2104

Gene namering finger protein 121estrogen related receptor gamma
Synonyms-ERR-gamma|ERR3|ERRg|ERRgamma|NR3B3
Cytomap

11q13.4

1q41

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 121estrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3
Modification date2018052320180519
UniProtAcc

Q9H920

P62508

Ensembl transtripts involved in fusion geneENST00000361756, ENST00000533380, 
ENST00000393713, ENST00000490867, 
ENST00000545854, ENST00000530137, 
ENST00000361525, ENST00000366940, 
ENST00000361395, ENST00000366938, 
ENST00000359162, ENST00000493603, 
ENST00000463665, ENST00000487276, 
ENST00000493748, ENST00000471371, 
ENST00000391890, ENST00000366937, 
ENST00000408911, ENST00000360012, 
Fusion gene scores* DoF score14 X 4 X 7=3925 X 4 X 4=80
# samples 155
** MAII scorelog2(15/392*10)=-1.38589115361933
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF121 [Title/Abstract] AND ESRRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneESRRG

GO:0006355

regulation of transcription, DNA-templated

23836911


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A3KC-01ARNF121chr11

71640170

+ESRRGchr1

217113015

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361756ENST00000361525RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000361756ENST00000366940RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000361756ENST00000361395RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000361756ENST00000366938RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000361756ENST00000359162RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000361756ENST00000493603RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000361756ENST00000463665RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000361756ENST00000487276RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000361756ENST00000493748RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000361756ENST00000471371RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000361756ENST00000391890RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000361756ENST00000366937RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000361756ENST00000408911RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000361756ENST00000360012RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000533380ENST00000361525RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000533380ENST00000366940RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000533380ENST00000361395RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000533380ENST00000366938RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000533380ENST00000359162RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000533380ENST00000493603RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000533380ENST00000463665RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000533380ENST00000487276RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000533380ENST00000493748RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000533380ENST00000471371RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000533380ENST00000391890RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000533380ENST00000366937RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000533380ENST00000408911RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000533380ENST00000360012RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000393713ENST00000361525RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000393713ENST00000366940RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000393713ENST00000361395RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000393713ENST00000366938RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000393713ENST00000359162RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000393713ENST00000493603RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000393713ENST00000463665RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000393713ENST00000487276RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000393713ENST00000493748RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000393713ENST00000471371RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000393713ENST00000391890RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000393713ENST00000366937RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000393713ENST00000408911RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000393713ENST00000360012RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-5UTRENST00000490867ENST00000361525RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-5UTRENST00000490867ENST00000366940RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-5UTRENST00000490867ENST00000361395RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-5UTRENST00000490867ENST00000366938RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-5UTRENST00000490867ENST00000359162RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-5UTRENST00000490867ENST00000493603RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-intronENST00000490867ENST00000463665RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-intronENST00000490867ENST00000487276RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-5UTRENST00000490867ENST00000493748RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-5UTRENST00000490867ENST00000471371RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-intronENST00000490867ENST00000391890RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-intronENST00000490867ENST00000366937RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-intronENST00000490867ENST00000408911RNF121chr11

71640170

+ESRRGchr1

217113015

-
3UTR-intronENST00000490867ENST00000360012RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-5UTRENST00000545854ENST00000361525RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-5UTRENST00000545854ENST00000366940RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-5UTRENST00000545854ENST00000361395RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-5UTRENST00000545854ENST00000366938RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-5UTRENST00000545854ENST00000359162RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-5UTRENST00000545854ENST00000493603RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-intronENST00000545854ENST00000463665RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-intronENST00000545854ENST00000487276RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-5UTRENST00000545854ENST00000493748RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-5UTRENST00000545854ENST00000471371RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-intronENST00000545854ENST00000391890RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-intronENST00000545854ENST00000366937RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-intronENST00000545854ENST00000408911RNF121chr11

71640170

+ESRRGchr1

217113015

-
5UTR-intronENST00000545854ENST00000360012RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000530137ENST00000361525RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000530137ENST00000366940RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000530137ENST00000361395RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000530137ENST00000366938RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000530137ENST00000359162RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000530137ENST00000493603RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000530137ENST00000463665RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000530137ENST00000487276RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000530137ENST00000493748RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-5UTRENST00000530137ENST00000471371RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000530137ENST00000391890RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000530137ENST00000366937RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000530137ENST00000408911RNF121chr11

71640170

+ESRRGchr1

217113015

-
5CDS-intronENST00000530137ENST00000360012RNF121chr11

71640170

+ESRRGchr1

217113015

-

Top

FusionProtFeatures for RNF121_ESRRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF121

Q9H920

ESRRG

P62508


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RNF121_ESRRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF121_ESRRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF121NFKBIA, LPAR1, TRIM25ESRRGESRRG, NCOA1, HGS, ESRRA, NRIP1, SP1, PPARGC1A, NR0B2, PARK2, NR0B1, DUT, PROX1, EBP, PNRC1, PNRC2, ARHGEF15, TLE1, APP, SRA1, SRPK1, KIFC3, MEOX2, NUP160, KIAA1598, CCDC67, SUMO1P1, PSMC5, DNMT3L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RNF121_ESRRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneESRRGP62508DB00675TamoxifenEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB02659Cholic AcidEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB00255DiethylstilbestrolEstrogen-related receptor gammasmall moleculeapproved|investigational
TgeneESRRGP62508DB00783EstradiolEstrogen-related receptor gammasmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for RNF121_ESRRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource