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Fusion gene ID: 31361 |
FusionGeneSummary for RNF10_CCDC60 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF10_CCDC60 | Fusion gene ID: 31361 | Hgene | Tgene | Gene symbol | RNF10 | CCDC60 | Gene ID | 9921 | 160777 |
| Gene name | ring finger protein 10 | coiled-coil domain containing 60 | |
| Synonyms | RIE2 | - | |
| Cytomap | 12q24.31 | 12q24.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RING finger protein 10 | coiled-coil domain-containing protein 60 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8N5U6 | Q8IWA6 | |
| Ensembl transtripts involved in fusion gene | ENST00000325954, ENST00000413266, ENST00000542701, | ENST00000536742, ENST00000327554, ENST00000539847, ENST00000546345, | |
| Fusion gene scores | * DoF score | 10 X 9 X 8=720 | 4 X 3 X 3=36 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF10 [Title/Abstract] AND CCDC60 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RNF10 | GO:0045893 | positive regulation of transcription, DNA-templated | 16335786 |
| Hgene | RNF10 | GO:0051865 | protein autoubiquitination | 24105792 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-S9-A6WL-01A | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000325954 | ENST00000536742 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| In-frame | ENST00000325954 | ENST00000327554 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| In-frame | ENST00000325954 | ENST00000539847 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| 5CDS-3UTR | ENST00000325954 | ENST00000546345 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| In-frame | ENST00000413266 | ENST00000536742 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| In-frame | ENST00000413266 | ENST00000327554 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| In-frame | ENST00000413266 | ENST00000539847 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| 5CDS-3UTR | ENST00000413266 | ENST00000546345 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| intron-3CDS | ENST00000542701 | ENST00000536742 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| intron-3CDS | ENST00000542701 | ENST00000327554 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| intron-3CDS | ENST00000542701 | ENST00000539847 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
| intron-3UTR | ENST00000542701 | ENST00000546345 | RNF10 | chr12 | 120984404 | + | CCDC60 | chr12 | 119866488 | + |
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FusionProtFeatures for RNF10_CCDC60 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF10 | CCDC60 |
| Transcriptional factor involved in the regulation of MAG(Myelin-associated glycoprotein) expression. Acts as a regulatorof Schwann cell differentiation and myelination.{ECO:0000250|UniProtKB:Q5XI59}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RNF10 | chr12:120984404 | chr12:119866488 | ENST00000325954 | + | 2 | 17 | 19_110 | 118 | 812 | Compositional bias | Note=Ser-rich |
| Hgene | RNF10 | chr12:120984404 | chr12:119866488 | ENST00000413266 | + | 2 | 17 | 19_110 | 118 | 817 | Compositional bias | Note=Ser-rich |
| Tgene | >CCDC60 | chr12:120984404 | chr12:119866488 | ENST00000327554 | + | 0 | 14 | 71_98 | 30 | 551 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RNF10 | chr12:120984404 | chr12:119866488 | ENST00000325954 | + | 2 | 17 | 225_267 | 118 | 812 | Zinc finger | RING-type |
| Hgene | >RNF10 | chr12:120984404 | chr12:119866488 | ENST00000413266 | + | 2 | 17 | 225_267 | 118 | 817 | Zinc finger | RING-type |
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FusionGeneSequence for RNF10_CCDC60 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000536742_chr12_119866488_+_222aa MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSK TFNKMPPQRGGGSSKLFSSSFNGGRRDEVPDKPMKSIKYMDKEIINLKKDLIRSRLSHCRTQRRMGKRPNREATSKQERNDNEMFHLATL >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000327554_chr12_119866488_+_639aa MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSK TFNKMPPQRGGGSSKLFSSSFNGGRRDEVPDKPMKSIKYMDKEIINLKKDLIRSRFLIQSVKIGRGYFAILREETAKKKKQQQLQKLKEE ERNKFQPAEKISEIHYGDTLLSTYDDEKLKTLGARVTRRPFTPIHSCIISPSLTEAHVEPLFRQLCALHWLLEALTIDHTHHTMKPVITC WNPKDPGGSKSTIKKINKDKSMGQKWEHFITAPKTKKFKIPTMRVTNRKPSRRGSTLSLSRASGGSSPQSSMISVNPGSDEPPSVNTQVT SSKDIEDNESSSTKPDEEPLYMNLQKLLEMVREDARRTVTIENGMQRKAPSILSVLKQNKSNSAYKEMQTTLKSSERSSSTSAESHIQPV QKKSKNRTNCDINIHYKSGVCNTMRAKFYSVAQEAGFCLQDKMEILMKRQEERGIQKFRAFVLVSNFQKDIAKMRHHISVVKGDAEEIAD HWYFDLLSKLPEDLKNFRPAKKILVKLQKFGENLDLRIRPHVLLKVLQDLRIWELCSPDIAVAIEFVREHIIHMPQEDYISWLQSRINIP >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000539847_chr12_119866488_+_146aa MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSK >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000536742_chr12_119866488_+_222aa MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSK TFNKMPPQRGGGSSKLFSSSFNGGRRDEVPDKPMKSIKYMDKEIINLKKDLIRSRLSHCRTQRRMGKRPNREATSKQERNDNEMFHLATL >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000327554_chr12_119866488_+_639aa MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSK TFNKMPPQRGGGSSKLFSSSFNGGRRDEVPDKPMKSIKYMDKEIINLKKDLIRSRFLIQSVKIGRGYFAILREETAKKKKQQQLQKLKEE ERNKFQPAEKISEIHYGDTLLSTYDDEKLKTLGARVTRRPFTPIHSCIISPSLTEAHVEPLFRQLCALHWLLEALTIDHTHHTMKPVITC WNPKDPGGSKSTIKKINKDKSMGQKWEHFITAPKTKKFKIPTMRVTNRKPSRRGSTLSLSRASGGSSPQSSMISVNPGSDEPPSVNTQVT SSKDIEDNESSSTKPDEEPLYMNLQKLLEMVREDARRTVTIENGMQRKAPSILSVLKQNKSNSAYKEMQTTLKSSERSSSTSAESHIQPV QKKSKNRTNCDINIHYKSGVCNTMRAKFYSVAQEAGFCLQDKMEILMKRQEERGIQKFRAFVLVSNFQKDIAKMRHHISVVKGDAEEIAD HWYFDLLSKLPEDLKNFRPAKKILVKLQKFGENLDLRIRPHVLLKVLQDLRIWELCSPDIAVAIEFVREHIIHMPQEDYISWLQSRINIP >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000539847_chr12_119866488_+_146aa MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000536742_chr12_119866488_+_666nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA GACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGCCTCTCCCACTGCCGG ACACAAAGGAGAATGGGGAAAAGGCCAAACAGAGAAGCCACAAGCAAGCAAGAAAGAAACGACAATGAGATGTTCCATCTGGCCACACTT CTGGATCCCACCAACATTAAGGAAGGAATCAGGATTCCCCTTCAGAAGGAAACACCATGTTTTCCAAGGGAAGTCATCTCTCCAAGTGGC >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000327554_chr12_119866488_+_1917nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA GACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGCTTTTTGATCCAGTCT GTGAAGATAGGCCGTGGATATTTTGCTATTCTGAGGGAAGAGACTGCAAAGAAAAAGAAGCAACAACAACTTCAGAAACTGAAAGAGGAG GAAAGAAATAAATTCCAGCCAGCCGAAAAGATCTCAGAAATCCACTATGGGGACACCTTATTGAGCACATATGATGATGAGAAGTTGAAG ACACTGGGAGCTAGAGTCACACGTCGCCCATTCACTCCCATCCACAGCTGCATCATTTCTCCCTCGCTAACCGAGGCTCACGTCGAGCCC CTCTTCCGCCAGCTCTGTGCTCTCCACTGGCTTCTGGAGGCCCTGACTATTGACCACACCCACCACACCATGAAGCCTGTGATCACCTGC TGGAACCCAAAGGACCCGGGTGGAAGCAAGAGCACCATTAAAAAAATCAATAAGGACAAGTCCATGGGACAGAAATGGGAGCATTTCATC ACAGCGCCAAAGACCAAGAAATTCAAAATTCCCACAATGCGAGTCACCAACCGCAAACCAAGCCGGCGAGGCTCCACACTCAGTCTGAGT CGGGCCAGTGGGGGGTCCTCTCCCCAGAGCAGCATGATCTCTGTGAACCCTGGCTCGGATGAGCCCCCAAGTGTGAACACCCAGGTGACC AGCAGCAAGGACATTGAGGACAATGAGTCATCTTCAACCAAGCCAGATGAAGAACCTCTGTATATGAATCTGCAGAAGCTCCTGGAGATG GTTCGGGAAGATGCCCGGAGGACAGTCACAATAGAAAATGGGATGCAAAGAAAAGCACCCAGCATCTTGTCAGTGCTGAAACAAAACAAG AGTAATTCTGCTTATAAGGAAATGCAGACCACTCTCAAATCAAGTGAGAGATCCAGCAGTACAAGTGCAGAAAGCCACATCCAACCAGTC CAGAAGAAGTCTAAAAACCGCACTAATTGTGACATCAACATCCACTACAAGAGTGGGGTGTGTAACACCATGAGGGCCAAGTTTTACAGC GTAGCCCAGGAGGCTGGCTTCTGCCTGCAGGACAAGATGGAAATCCTCATGAAGCGCCAAGAAGAGAGAGGTATCCAGAAGTTCCGTGCT TTTGTCCTTGTCTCAAATTTTCAAAAGGACATAGCAAAAATGAGACATCACATATCTGTAGTAAAAGGAGATGCAGAAGAAATTGCAGAC CACTGGTACTTTGATCTGTTGTCCAAACTGCCAGAGGATCTAAAGAACTTCCGCCCCGCCAAAAAGATCCTGGTGAAACTGCAGAAGTTT GGAGAAAACCTGGACTTGCGGATTCGACCCCATGTCCTCCTGAAGGTGCTGCAGGATCTGAGGATTTGGGAACTGTGCTCCCCTGACATC GCTGTGGCTATTGAGTTTGTGCGAGAACACATCATCCATATGCCTCAAGAGGATTACATCAGCTGGCTGCAGAGCCGGATCAACATACCC >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000539847_chr12_119866488_+_438nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000536742_chr12_119866488_+_666nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA GACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGCCTCTCCCACTGCCGG ACACAAAGGAGAATGGGGAAAAGGCCAAACAGAGAAGCCACAAGCAAGCAAGAAAGAAACGACAATGAGATGTTCCATCTGGCCACACTT CTGGATCCCACCAACATTAAGGAAGGAATCAGGATTCCCCTTCAGAAGGAAACACCATGTTTTCCAAGGGAAGTCATCTCTCCAAGTGGC >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000327554_chr12_119866488_+_1917nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA GACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGCTTTTTGATCCAGTCT GTGAAGATAGGCCGTGGATATTTTGCTATTCTGAGGGAAGAGACTGCAAAGAAAAAGAAGCAACAACAACTTCAGAAACTGAAAGAGGAG GAAAGAAATAAATTCCAGCCAGCCGAAAAGATCTCAGAAATCCACTATGGGGACACCTTATTGAGCACATATGATGATGAGAAGTTGAAG ACACTGGGAGCTAGAGTCACACGTCGCCCATTCACTCCCATCCACAGCTGCATCATTTCTCCCTCGCTAACCGAGGCTCACGTCGAGCCC CTCTTCCGCCAGCTCTGTGCTCTCCACTGGCTTCTGGAGGCCCTGACTATTGACCACACCCACCACACCATGAAGCCTGTGATCACCTGC TGGAACCCAAAGGACCCGGGTGGAAGCAAGAGCACCATTAAAAAAATCAATAAGGACAAGTCCATGGGACAGAAATGGGAGCATTTCATC ACAGCGCCAAAGACCAAGAAATTCAAAATTCCCACAATGCGAGTCACCAACCGCAAACCAAGCCGGCGAGGCTCCACACTCAGTCTGAGT CGGGCCAGTGGGGGGTCCTCTCCCCAGAGCAGCATGATCTCTGTGAACCCTGGCTCGGATGAGCCCCCAAGTGTGAACACCCAGGTGACC AGCAGCAAGGACATTGAGGACAATGAGTCATCTTCAACCAAGCCAGATGAAGAACCTCTGTATATGAATCTGCAGAAGCTCCTGGAGATG GTTCGGGAAGATGCCCGGAGGACAGTCACAATAGAAAATGGGATGCAAAGAAAAGCACCCAGCATCTTGTCAGTGCTGAAACAAAACAAG AGTAATTCTGCTTATAAGGAAATGCAGACCACTCTCAAATCAAGTGAGAGATCCAGCAGTACAAGTGCAGAAAGCCACATCCAACCAGTC CAGAAGAAGTCTAAAAACCGCACTAATTGTGACATCAACATCCACTACAAGAGTGGGGTGTGTAACACCATGAGGGCCAAGTTTTACAGC GTAGCCCAGGAGGCTGGCTTCTGCCTGCAGGACAAGATGGAAATCCTCATGAAGCGCCAAGAAGAGAGAGGTATCCAGAAGTTCCGTGCT TTTGTCCTTGTCTCAAATTTTCAAAAGGACATAGCAAAAATGAGACATCACATATCTGTAGTAAAAGGAGATGCAGAAGAAATTGCAGAC CACTGGTACTTTGATCTGTTGTCCAAACTGCCAGAGGATCTAAAGAACTTCCGCCCCGCCAAAAAGATCCTGGTGAAACTGCAGAAGTTT GGAGAAAACCTGGACTTGCGGATTCGACCCCATGTCCTCCTGAAGGTGCTGCAGGATCTGAGGATTTGGGAACTGTGCTCCCCTGACATC GCTGTGGCTATTGAGTTTGTGCGAGAACACATCATCCATATGCCTCAAGAGGATTACATCAGCTGGCTGCAGAGCCGGATCAACATACCC >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000539847_chr12_119866488_+_438nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000536742_chr12_119866488_+_1146nt GAGATGCTGTTTGGCGACTCGTCGCCATTCCCGGAGCAGGTCGGCCTCGGCCCAGGGGCGAGTATCCGTTGCTGTGTCGGAGACACTAGT CCCCGACACCGAGACAGCCAGCCCTCTCCCCTGCCTCGCGGCGGGAGAGCGTGTCCGGCCGGCCGGCCGGCGGGGCTCGCGCAACCTCCC TCGCCTCCCCTTCCCCCGCAGCCTCCGCCCCGCCAGGCCCGGCCCGGACTCCCGAGCCCCGGCCTCCTCGTCCTCGGTCGCCGCTGCCGC CGGGCTTAACAGCCCCGTCCGCCGCTTCTCTTCCTAGTTTGAGAAGCCAAGGAAGGAAACAGGGAAAAATGTCGCCATGAAGGCCGAGAA CCGCTGCCGCCGCCGACCCCCGCCGGCCCTGAACGCCATGAGCCTGGGTCCCCGCCGCGCCCGCTCCGCTCCGACTGCCGTCGCCGCCGA GGCCCCCGTTGATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCT CTTCGGGCAGCAGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACT CCAGTGGATCCAAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCAC AGAAAAGCAAGACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAG ATGAGGTCCCAGACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGCCTCT CCCACTGCCGGACACAAAGGAGAATGGGGAAAAGGCCAAACAGAGAAGCCACAAGCAAGCAAGAAAGAAACGACAATGAGATGTTCCATC TGGCCACACTTCTGGATCCCACCAACATTAAGGAAGGAATCAGGATTCCCCTTCAGAAGGAAACACCATGTTTTCCAAGGGAAGTCATCT >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000327554_chr12_119866488_+_2710nt GAGATGCTGTTTGGCGACTCGTCGCCATTCCCGGAGCAGGTCGGCCTCGGCCCAGGGGCGAGTATCCGTTGCTGTGTCGGAGACACTAGT CCCCGACACCGAGACAGCCAGCCCTCTCCCCTGCCTCGCGGCGGGAGAGCGTGTCCGGCCGGCCGGCCGGCGGGGCTCGCGCAACCTCCC TCGCCTCCCCTTCCCCCGCAGCCTCCGCCCCGCCAGGCCCGGCCCGGACTCCCGAGCCCCGGCCTCCTCGTCCTCGGTCGCCGCTGCCGC CGGGCTTAACAGCCCCGTCCGCCGCTTCTCTTCCTAGTTTGAGAAGCCAAGGAAGGAAACAGGGAAAAATGTCGCCATGAAGGCCGAGAA CCGCTGCCGCCGCCGACCCCCGCCGGCCCTGAACGCCATGAGCCTGGGTCCCCGCCGCGCCCGCTCCGCTCCGACTGCCGTCGCCGCCGA GGCCCCCGTTGATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCT CTTCGGGCAGCAGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACT CCAGTGGATCCAAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCAC AGAAAAGCAAGACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAG ATGAGGTCCCAGACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGCTTTT TGATCCAGTCTGTGAAGATAGGCCGTGGATATTTTGCTATTCTGAGGGAAGAGACTGCAAAGAAAAAGAAGCAACAACAACTTCAGAAAC TGAAAGAGGAGGAAAGAAATAAATTCCAGCCAGCCGAAAAGATCTCAGAAATCCACTATGGGGACACCTTATTGAGCACATATGATGATG AGAAGTTGAAGACACTGGGAGCTAGAGTCACACGTCGCCCATTCACTCCCATCCACAGCTGCATCATTTCTCCCTCGCTAACCGAGGCTC ACGTCGAGCCCCTCTTCCGCCAGCTCTGTGCTCTCCACTGGCTTCTGGAGGCCCTGACTATTGACCACACCCACCACACCATGAAGCCTG TGATCACCTGCTGGAACCCAAAGGACCCGGGTGGAAGCAAGAGCACCATTAAAAAAATCAATAAGGACAAGTCCATGGGACAGAAATGGG AGCATTTCATCACAGCGCCAAAGACCAAGAAATTCAAAATTCCCACAATGCGAGTCACCAACCGCAAACCAAGCCGGCGAGGCTCCACAC TCAGTCTGAGTCGGGCCAGTGGGGGGTCCTCTCCCCAGAGCAGCATGATCTCTGTGAACCCTGGCTCGGATGAGCCCCCAAGTGTGAACA CCCAGGTGACCAGCAGCAAGGACATTGAGGACAATGAGTCATCTTCAACCAAGCCAGATGAAGAACCTCTGTATATGAATCTGCAGAAGC TCCTGGAGATGGTTCGGGAAGATGCCCGGAGGACAGTCACAATAGAAAATGGGATGCAAAGAAAAGCACCCAGCATCTTGTCAGTGCTGA AACAAAACAAGAGTAATTCTGCTTATAAGGAAATGCAGACCACTCTCAAATCAAGTGAGAGATCCAGCAGTACAAGTGCAGAAAGCCACA TCCAACCAGTCCAGAAGAAGTCTAAAAACCGCACTAATTGTGACATCAACATCCACTACAAGAGTGGGGTGTGTAACACCATGAGGGCCA AGTTTTACAGCGTAGCCCAGGAGGCTGGCTTCTGCCTGCAGGACAAGATGGAAATCCTCATGAAGCGCCAAGAAGAGAGAGGTATCCAGA AGTTCCGTGCTTTTGTCCTTGTCTCAAATTTTCAAAAGGACATAGCAAAAATGAGACATCACATATCTGTAGTAAAAGGAGATGCAGAAG AAATTGCAGACCACTGGTACTTTGATCTGTTGTCCAAACTGCCAGAGGATCTAAAGAACTTCCGCCCCGCCAAAAAGATCCTGGTGAAAC TGCAGAAGTTTGGAGAAAACCTGGACTTGCGGATTCGACCCCATGTCCTCCTGAAGGTGCTGCAGGATCTGAGGATTTGGGAACTGTGCT CCCCTGACATCGCTGTGGCTATTGAGTTTGTGCGAGAACACATCATCCATATGCCTCAAGAGGATTACATCAGCTGGCTGCAGAGCCGGA TCAACATACCCATTGGGCCCTACAGCGCCCTGAGGTAGGCTGGGCCTGGGTTGACCAGCTGTCTCAGTGGAGGAGTGTTTGCCTATATCA TGTTCCTGTATCCTGCCTGTGTTCCTGCCTCCTGACTACCCTCATGGATGCTCTTTATGGATGACCCTTTACAGTAGGGTCATCTGGAGA CTGACTTCCAGCAACATTTTTAGAGGGGGATGGCCCCGGTGGCCCTCCCCTCAATTCCACACCCCAGACCCAACCTACCAGTCTCTGTTC TTCAATGATCCAGCCTGACTCTACCTACTTCCTCTTCAGATTCCTTCACCCTATTTACCTTCCTCAAGTACTGGAGAATAAAATTGAACT >In-frame_RNF10_ENST00000325954_chr12_120984404_+_CCDC60_ENST00000539847_chr12_119866488_+_1058nt GAGATGCTGTTTGGCGACTCGTCGCCATTCCCGGAGCAGGTCGGCCTCGGCCCAGGGGCGAGTATCCGTTGCTGTGTCGGAGACACTAGT CCCCGACACCGAGACAGCCAGCCCTCTCCCCTGCCTCGCGGCGGGAGAGCGTGTCCGGCCGGCCGGCCGGCGGGGCTCGCGCAACCTCCC TCGCCTCCCCTTCCCCCGCAGCCTCCGCCCCGCCAGGCCCGGCCCGGACTCCCGAGCCCCGGCCTCCTCGTCCTCGGTCGCCGCTGCCGC CGGGCTTAACAGCCCCGTCCGCCGCTTCTCTTCCTAGTTTGAGAAGCCAAGGAAGGAAACAGGGAAAAATGTCGCCATGAAGGCCGAGAA CCGCTGCCGCCGCCGACCCCCGCCGGCCCTGAACGCCATGAGCCTGGGTCCCCGCCGCGCCCGCTCCGCTCCGACTGCCGTCGCCGCCGA GGCCCCCGTTGATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCT CTTCGGGCAGCAGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACT CCAGTGGATCCAAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCAC AGAAAAGCAAGACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAG ATGAGGTCCCAGACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGGTGAG TGAGCCCAGCAGGGAATGATCCATAGACAACCCAACAGGCATGAGCAGGCTATGGGGTGTTGCCTACAAGTCCTTGCCCAGTCCCAGCAT >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000536742_chr12_119866488_+_685nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA GACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGCCTCTCCCACTGCCGG ACACAAAGGAGAATGGGGAAAAGGCCAAACAGAGAAGCCACAAGCAAGCAAGAAAGAAACGACAATGAGATGTTCCATCTGGCCACACTT CTGGATCCCACCAACATTAAGGAAGGAATCAGGATTCCCCTTCAGAAGGAAACACCATGTTTTCCAAGGGAAGTCATCTCTCCAAGTGGC >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000327554_chr12_119866488_+_2249nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA GACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGCTTTTTGATCCAGTCT GTGAAGATAGGCCGTGGATATTTTGCTATTCTGAGGGAAGAGACTGCAAAGAAAAAGAAGCAACAACAACTTCAGAAACTGAAAGAGGAG GAAAGAAATAAATTCCAGCCAGCCGAAAAGATCTCAGAAATCCACTATGGGGACACCTTATTGAGCACATATGATGATGAGAAGTTGAAG ACACTGGGAGCTAGAGTCACACGTCGCCCATTCACTCCCATCCACAGCTGCATCATTTCTCCCTCGCTAACCGAGGCTCACGTCGAGCCC CTCTTCCGCCAGCTCTGTGCTCTCCACTGGCTTCTGGAGGCCCTGACTATTGACCACACCCACCACACCATGAAGCCTGTGATCACCTGC TGGAACCCAAAGGACCCGGGTGGAAGCAAGAGCACCATTAAAAAAATCAATAAGGACAAGTCCATGGGACAGAAATGGGAGCATTTCATC ACAGCGCCAAAGACCAAGAAATTCAAAATTCCCACAATGCGAGTCACCAACCGCAAACCAAGCCGGCGAGGCTCCACACTCAGTCTGAGT CGGGCCAGTGGGGGGTCCTCTCCCCAGAGCAGCATGATCTCTGTGAACCCTGGCTCGGATGAGCCCCCAAGTGTGAACACCCAGGTGACC AGCAGCAAGGACATTGAGGACAATGAGTCATCTTCAACCAAGCCAGATGAAGAACCTCTGTATATGAATCTGCAGAAGCTCCTGGAGATG GTTCGGGAAGATGCCCGGAGGACAGTCACAATAGAAAATGGGATGCAAAGAAAAGCACCCAGCATCTTGTCAGTGCTGAAACAAAACAAG AGTAATTCTGCTTATAAGGAAATGCAGACCACTCTCAAATCAAGTGAGAGATCCAGCAGTACAAGTGCAGAAAGCCACATCCAACCAGTC CAGAAGAAGTCTAAAAACCGCACTAATTGTGACATCAACATCCACTACAAGAGTGGGGTGTGTAACACCATGAGGGCCAAGTTTTACAGC GTAGCCCAGGAGGCTGGCTTCTGCCTGCAGGACAAGATGGAAATCCTCATGAAGCGCCAAGAAGAGAGAGGTATCCAGAAGTTCCGTGCT TTTGTCCTTGTCTCAAATTTTCAAAAGGACATAGCAAAAATGAGACATCACATATCTGTAGTAAAAGGAGATGCAGAAGAAATTGCAGAC CACTGGTACTTTGATCTGTTGTCCAAACTGCCAGAGGATCTAAAGAACTTCCGCCCCGCCAAAAAGATCCTGGTGAAACTGCAGAAGTTT GGAGAAAACCTGGACTTGCGGATTCGACCCCATGTCCTCCTGAAGGTGCTGCAGGATCTGAGGATTTGGGAACTGTGCTCCCCTGACATC GCTGTGGCTATTGAGTTTGTGCGAGAACACATCATCCATATGCCTCAAGAGGATTACATCAGCTGGCTGCAGAGCCGGATCAACATACCC ATTGGGCCCTACAGCGCCCTGAGGTAGGCTGGGCCTGGGTTGACCAGCTGTCTCAGTGGAGGAGTGTTTGCCTATATCATGTTCCTGTAT CCTGCCTGTGTTCCTGCCTCCTGACTACCCTCATGGATGCTCTTTATGGATGACCCTTTACAGTAGGGTCATCTGGAGACTGACTTCCAG CAACATTTTTAGAGGGGGATGGCCCCGGTGGCCCTCCCCTCAATTCCACACCCCAGACCCAACCTACCAGTCTCTGTTCTTCAATGATCC >In-frame_RNF10_ENST00000413266_chr12_120984404_+_CCDC60_ENST00000539847_chr12_119866488_+_597nt ATGCCGCTGAGCTCCCCCAACGCCGCCGCCACCGCCTCCGACATGGACAAGAACAGCGGCTCCAACAGCTCCTCCGCCTCTTCGGGCAGC AGCAAAGGGCAACAGCCGCCCCGCTCCGCCTCGGCGGGGCCAGCCGGCGAGTCTAAACCCAAGAGCGATGGAAAGAACTCCAGTGGATCC AAGCGTTATAATCGCAAACGTGAACTTTCCTACCCCAAAAATGAAAGTTTTAACAACCAGTCCCGTCGCTCCAGTTCACAGAAAAGCAAG ACTTTTAACAAGATGCCTCCTCAAAGGGGCGGCGGCAGCAGCAAACTCTTTAGCTCTTCTTTTAATGGTGGAAGACGAGATGAGGTCCCA GACAAGCCAATGAAGAGCATCAAGTATATGGACAAGGAAATAATAAACCTCAAAAAGGACCTTATACGAAGCCGGTGAGTGAGCCCAGCA GGGAATGATCCATAGACAACCCAACAGGCATGAGCAGGCTATGGGGTGTTGCCTACAAGTCCTTGCCCAGTCCCAGCATCCCCCAATTCT |
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FusionGenePPI for RNF10_CCDC60 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RNF10 | CCDC90B, LRIF1, UTP14A, EEF1A1, SETDB1, TLE1, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2I, UBE2O, UBE2H, UBE2V1, UBE2J2, UBE2W, UBE2E2, UBE2U, SNCA, GRB2, TERF1, MEOX2, HSP90AA1, TRIM26, MDM2, TARDBP, UBTD1, KDM1A, ENO1, SHMT2, MOV10, NXF1, XPO1 | CCDC60 | APP, MTUS2, EGFR, FAM204A, FAM32A, UPF3B, ZNF593, DCP1B, RBM42 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RNF10 | chr12:120984404 | chr12:119866488 | ENST00000325954 | + | 2 | 17 | 101_185 | 118 | 812 | MEOX2 |
| Hgene | RNF10 | chr12:120984404 | chr12:119866488 | ENST00000413266 | + | 2 | 17 | 101_185 | 118 | 817 | MEOX2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF10_CCDC60 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF10_CCDC60 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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