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Fusion gene ID: 31344 |
FusionGeneSummary for RNASE1_KCTD12 |
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Fusion gene information | Fusion gene name: RNASE1_KCTD12 | Fusion gene ID: 31344 | Hgene | Tgene | Gene symbol | RNASE1 | KCTD12 | Gene ID | 6035 | 115207 |
Gene name | ribonuclease A family member 1, pancreatic | potassium channel tetramerization domain containing 12 | |
Synonyms | RAC1|RIB1|RNS1 | C13orf2|PFET1|PFETIN | |
Cytomap | 14q11.2 | 13q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ribonuclease pancreaticHP-RNaseRIB-1RNase 1RNase ARNase upI-1ribonuclease 1ribonuclease A C1ribonuclease, RNase A family, 1 (pancreatic) | BTB/POZ domain-containing protein KCTD12potassium channel tetramerisation domain containing 12predominantly fetal expressed T1 domaintesticular tissue protein Li 100 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P07998 | Q96CX2 | |
Ensembl transtripts involved in fusion gene | ENST00000397967, ENST00000340900, ENST00000412779, ENST00000555698, ENST00000397970, | ENST00000377474, ENST00000317765, | |
Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 2 X 2 X 1=4 |
# samples | 5 | 2 | |
** MAII score | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: RNASE1 [Title/Abstract] AND KCTD12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RNASE1 | GO:0051607 | defense response to virus | 9826755 |
Hgene | RNASE1 | GO:0090501 | RNA phosphodiester bond hydrolysis | 9826755 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA778433 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000397967 | ENST00000377474 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000397967 | ENST00000317765 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000340900 | ENST00000377474 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000340900 | ENST00000317765 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000412779 | ENST00000377474 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000412779 | ENST00000317765 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000555698 | ENST00000377474 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000555698 | ENST00000317765 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000397970 | ENST00000377474 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
intron-3UTR | ENST00000397970 | ENST00000317765 | RNASE1 | chr14 | 21269808 | - | KCTD12 | chr13 | 77458281 | - |
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FusionProtFeatures for RNASE1_KCTD12 |
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Hgene | Tgene |
RNASE1 | KCTD12 |
Auxiliary subunit of GABA-B receptors that determine thepharmacology and kinetics of the receptor response. Increasesagonist potency and markedly alter the G-protein signaling of thereceptors by accelerating onset and promoting desensitization (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNASE1_KCTD12 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNASE1_KCTD12 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNASE1_KCTD12 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | RNASE1 | P07998 | DB02325 | Isopropyl Alcohol | Ribonuclease pancreatic | small molecule | approved|investigational |
Hgene | RNASE1 | P07998 | DB04272 | Citric Acid | Ribonuclease pancreatic | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for RNASE1_KCTD12 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | KCTD12 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | KCTD12 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | KCTD12 | C0525045 | Mood Disorders | 1 | PSYGENET |