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Fusion gene ID: 31341 |
FusionGeneSummary for RNASE10_CD38 |
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Fusion gene information | Fusion gene name: RNASE10_CD38 | Fusion gene ID: 31341 | Hgene | Tgene | Gene symbol | RNASE10 | CD38 | Gene ID | 338879 | 952 |
Gene name | ribonuclease A family member 10 (inactive) | CD38 molecule | |
Synonyms | RAH1|RNASE9 | ADPRC 1|ADPRC1 | |
Cytomap | 14q11.2 | 4p15.32 | |
Type of gene | protein-coding | protein-coding | |
Description | inactive ribonuclease-like protein 10ribonuclease A H1ribonuclease, RNase A family, 10 (non-active) | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 12'-phospho-ADP-ribosyl cyclase2'-phospho-cyclic-ADP-ribose transferaseADP-ribosyl cyclase 1CD38 antigen (p45)NAD(+) nucleosidasecluster of differentiation 38cyclic ADP-ribose hydrolase 1ecto-nicotin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q5GAN6 | P28907 | |
Ensembl transtripts involved in fusion gene | ENST00000430083, ENST00000328444, | ENST00000226279, | |
Fusion gene scores | * DoF score | 1 X 1 X 2=2 | 1 X 1 X 2=2 |
# samples | 4 | 4 | |
** MAII score | log2(4/2*10)=4.32192809488736 | log2(4/2*10)=4.32192809488736 | |
Context | PubMed: RNASE10 [Title/Abstract] AND CD38 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CN-4731-01A | RNASE10 | chr14 | 20974178 | + | CD38 | chr4 | 15818134 | + |
TCGA | RV | HNSC | TCGA-CN-5369-01A | RNASE10 | chr14 | 20974178 | + | CD38 | chr4 | 15818134 | + |
TCGA | RV | HNSC | TCGA-CN-4730-01A | RNASE10 | chr14 | 20974178 | + | CD38 | chr4 | 15818134 | + |
TCGA | RV | LUSC | TCGA-56-5898-01A | RNASE10 | chr14 | 20974178 | + | CD38 | chr4 | 15818134 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000430083 | ENST00000226279 | RNASE10 | chr14 | 20974178 | + | CD38 | chr4 | 15818134 | + |
intron-3CDS | ENST00000328444 | ENST00000226279 | RNASE10 | chr14 | 20974178 | + | CD38 | chr4 | 15818134 | + |
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FusionProtFeatures for RNASE10_CD38 |
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Hgene | Tgene |
RNASE10 | CD38 |
Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved insperm adhesion to the egg zona pellucida. Does not haveribonuclease activity (By similarity). {ECO:0000250}. | Synthesizes the second messagers cyclic ADP-ribose andnicotinate-adenine dinucleotide phosphate, the former a secondmessenger for glucose-induced insulin secretion. Also has cADPrhydrolase activity. Also moonlights as a receptor in cells of theimmune system. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNASE10_CD38 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNASE10_CD38 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RNASE10 | CD38 | FCGR3A, CD3E, CD247, LCK, ZAP70, CBL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNASE10_CD38 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNASE10_CD38 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CD38 | C0001925 | Albuminuria | 1 | CTD_human |
Tgene | CD38 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CD38 | C0151744 | Myocardial Ischemia | 1 | CTD_human |