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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31332

FusionGeneSummary for RMND5A_DDAH1

check button Fusion gene summary
Fusion gene informationFusion gene name: RMND5A_DDAH1
Fusion gene ID: 31332
HgeneTgene
Gene symbol

RMND5A

DDAH1

Gene ID

64795

23576

Gene namerequired for meiotic nuclear division 5 homolog Adimethylarginine dimethylaminohydrolase 1
SynonymsCTLH|GID2|GID2A|RMD5|p44CTLHDDAH|DDAH-1|DDAHI|HEL-S-16
Cytomap

2p11.2

1p22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein RMD5 homolog A44-kD protein coding for CTLH motifC-terminal to LisH motif, 44 kDaGID complex subunit 2 homolog AN(G),N(G)-dimethylarginine dimethylaminohydrolase 1NG, NG-dimethylarginine dimethylaminohydrolasedimethylargininase-1epididymis secretory protein Li 16
Modification date2018052320180523
UniProtAcc

Q9H871

O94760

Ensembl transtripts involved in fusion geneENST00000283632, ENST00000472843, 
ENST00000535924, ENST00000483110, 
ENST00000284031, ENST00000539042, 
ENST00000426972, ENST00000542148, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 3 X 3=36
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RMND5A [Title/Abstract] AND DDAH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDDAH1

GO:0000052

citrulline metabolic process

19663506

TgeneDDAH1

GO:0006527

arginine catabolic process

24895913

TgeneDDAH1

GO:0008285

negative regulation of cell proliferation

24895913

TgeneDDAH1

GO:0043116

negative regulation of vascular permeability

24895913

TgeneDDAH1

GO:1900038

negative regulation of cellular response to hypoxia

24895913


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA438826RMND5Achr2

87820724

-DDAH1chr1

85961849

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000283632ENST00000535924RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000283632ENST00000483110RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000283632ENST00000284031RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000283632ENST00000539042RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000283632ENST00000426972RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000283632ENST00000542148RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000472843ENST00000535924RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000472843ENST00000483110RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000472843ENST00000284031RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000472843ENST00000539042RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000472843ENST00000426972RMND5Achr2

87820724

-DDAH1chr1

85961849

+
intron-intronENST00000472843ENST00000542148RMND5Achr2

87820724

-DDAH1chr1

85961849

+

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FusionProtFeatures for RMND5A_DDAH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RMND5A

Q9H871

DDAH1

O94760

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) andN(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS.Has therefore a role in the regulation of nitric oxide generation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RMND5A_DDAH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RMND5A_DDAH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RMND5A_DDAH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RMND5A_DDAH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDDAH1C0023895Liver diseases1CTD_human