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Fusion gene ID: 31332 |
FusionGeneSummary for RMND5A_DDAH1 |
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Fusion gene information | Fusion gene name: RMND5A_DDAH1 | Fusion gene ID: 31332 | Hgene | Tgene | Gene symbol | RMND5A | DDAH1 | Gene ID | 64795 | 23576 |
Gene name | required for meiotic nuclear division 5 homolog A | dimethylarginine dimethylaminohydrolase 1 | |
Synonyms | CTLH|GID2|GID2A|RMD5|p44CTLH | DDAH|DDAH-1|DDAHI|HEL-S-16 | |
Cytomap | 2p11.2 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein RMD5 homolog A44-kD protein coding for CTLH motifC-terminal to LisH motif, 44 kDaGID complex subunit 2 homolog A | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1NG, NG-dimethylarginine dimethylaminohydrolasedimethylargininase-1epididymis secretory protein Li 16 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H871 | O94760 | |
Ensembl transtripts involved in fusion gene | ENST00000283632, ENST00000472843, | ENST00000535924, ENST00000483110, ENST00000284031, ENST00000539042, ENST00000426972, ENST00000542148, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 3 X 3=36 |
# samples | 4 | 4 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RMND5A [Title/Abstract] AND DDAH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DDAH1 | GO:0000052 | citrulline metabolic process | 19663506 |
Tgene | DDAH1 | GO:0006527 | arginine catabolic process | 24895913 |
Tgene | DDAH1 | GO:0008285 | negative regulation of cell proliferation | 24895913 |
Tgene | DDAH1 | GO:0043116 | negative regulation of vascular permeability | 24895913 |
Tgene | DDAH1 | GO:1900038 | negative regulation of cellular response to hypoxia | 24895913 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA438826 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000283632 | ENST00000535924 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000283632 | ENST00000483110 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000283632 | ENST00000284031 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000283632 | ENST00000539042 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000283632 | ENST00000426972 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000283632 | ENST00000542148 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000472843 | ENST00000535924 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000472843 | ENST00000483110 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000472843 | ENST00000284031 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000472843 | ENST00000539042 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000472843 | ENST00000426972 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
intron-intron | ENST00000472843 | ENST00000542148 | RMND5A | chr2 | 87820724 | - | DDAH1 | chr1 | 85961849 | + |
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FusionProtFeatures for RMND5A_DDAH1 |
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Hgene | Tgene |
RMND5A | DDAH1 |
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) andN(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS.Has therefore a role in the regulation of nitric oxide generation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RMND5A_DDAH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RMND5A_DDAH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RMND5A_DDAH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RMND5A_DDAH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DDAH1 | C0023895 | Liver diseases | 1 | CTD_human |