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Fusion gene ID: 31322 |
FusionGeneSummary for RMI2_MED17 |
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Fusion gene information | Fusion gene name: RMI2_MED17 | Fusion gene ID: 31322 | Hgene | Tgene | Gene symbol | RMI2 | MED17 | Gene ID | 116028 | 9440 |
Gene name | RecQ mediated genome instability 2 | mediator complex subunit 17 | |
Synonyms | BLAP18|C16orf75 | CRSP6|CRSP77|DRIP80|SRB4|TRAP80 | |
Cytomap | 16p13.13 | 11q21 | |
Type of gene | protein-coding | protein-coding | |
Description | recQ-mediated genome instability protein 2BLM-associated protein of 18 kDaRMI2, RecQ mediated genome instability 2, homolog | mediator of RNA polymerase II transcription subunit 17ARC77CRSP complex subunit 6activator-recruited cofactor 77 kDa componentcofactor required for Sp1 transcriptional activation, subunit 6, 77kDathyroid hormone receptor-associated protein complex 80 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96E14 | Q9NVC6 | |
Ensembl transtripts involved in fusion gene | ENST00000572173, ENST00000572992, ENST00000381820, ENST00000312499, ENST00000576027, | ENST00000251871, ENST00000530819, ENST00000533367, | |
Fusion gene scores | * DoF score | 8 X 8 X 2=128 | 1 X 1 X 1=1 |
# samples | 8 | 1 | |
** MAII score | log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RMI2 [Title/Abstract] AND MED17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MED17 | GO:0006357 | regulation of transcription by RNA polymerase II | 9989412 |
Tgene | MED17 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 12218053 |
Tgene | MED17 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 11867769 |
Tgene | MED17 | GO:0030521 | androgen receptor signaling pathway | 12218053 |
Tgene | MED17 | GO:0045893 | positive regulation of transcription, DNA-templated | 10198638 |
Tgene | MED17 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12037571 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG822170 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000572173 | ENST00000251871 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-5UTR | ENST00000572173 | ENST00000530819 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-intron | ENST00000572173 | ENST00000533367 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
intron-5UTR | ENST00000572992 | ENST00000251871 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
intron-5UTR | ENST00000572992 | ENST00000530819 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
intron-intron | ENST00000572992 | ENST00000533367 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-5UTR | ENST00000381820 | ENST00000251871 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-5UTR | ENST00000381820 | ENST00000530819 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-intron | ENST00000381820 | ENST00000533367 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-5UTR | ENST00000312499 | ENST00000251871 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-5UTR | ENST00000312499 | ENST00000530819 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-intron | ENST00000312499 | ENST00000533367 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-5UTR | ENST00000576027 | ENST00000251871 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-5UTR | ENST00000576027 | ENST00000530819 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
3UTR-intron | ENST00000576027 | ENST00000533367 | RMI2 | chr16 | 11444722 | - | MED17 | chr11 | 93517552 | + |
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FusionProtFeatures for RMI2_MED17 |
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Hgene | Tgene |
RMI2 | MED17 |
Essential component of the RMI complex, a complex thatplays an important role in the processing of homologousrecombination intermediates. It is required to regulate sisterchromatid segregation and to limit DNA crossover. Essential forthe stability, localization, and function of BLM, TOP3A, andcomplexes containing BLM. In the RMI complex, it is required totarget BLM to chromatin and stress-induced nuclear foci andmitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082,ECO:0000269|PubMed:18923083, ECO:0000269|PubMed:27977684}. | Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:16595664}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RMI2_MED17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RMI2_MED17 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RMI2_MED17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RMI2_MED17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MED17 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | MED17 | C3150921 | MICROCEPHALY, POSTNATAL PROGRESSIVE, WITH SEIZURES AND BRAIN ATROPHY | 1 | CTD_human;ORPHANET;UNIPROT |