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Fusion gene ID: 31316 |
FusionGeneSummary for RMDN3_VAT1 |
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Fusion gene information | Fusion gene name: RMDN3_VAT1 | Fusion gene ID: 31316 | Hgene | Tgene | Gene symbol | RMDN3 | VAT1 | Gene ID | 55177 | 10493 |
Gene name | regulator of microtubule dynamics 3 | vesicle amine transport 1 | |
Synonyms | FAM82A2|FAM82C|RMD-3|RMD3|ptpip51 | VATI | |
Cytomap | 15q15.1 | 17q21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | regulator of microtubule dynamics protein 3TCPTP-interacting protein 51cerebral protein 10family with sequence similarity 82, member A2family with sequence similarity 82, member Cmicrotubule-associated proteinprotein tyrosine phosphatase-interacting | synaptic vesicle membrane protein VAT-1 homologmembrane protein of cholinergic synaptic vesiclesvesicle amine transport protein 1 homolog (T. californica) | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q96TC7 | Q99536 | |
Ensembl transtripts involved in fusion gene | ENST00000260385, ENST00000338376, ENST00000558560, | ENST00000355653, ENST00000587173, ENST00000420567, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 5 X 6 X 2=60 |
# samples | 4 | 6 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/60*10)=0 | |
Context | PubMed: RMDN3 [Title/Abstract] AND VAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ674218 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000260385 | ENST00000355653 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
intron-intron | ENST00000260385 | ENST00000587173 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
intron-intron | ENST00000260385 | ENST00000420567 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
intron-3UTR | ENST00000338376 | ENST00000355653 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
intron-intron | ENST00000338376 | ENST00000587173 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
intron-intron | ENST00000338376 | ENST00000420567 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
intron-3UTR | ENST00000558560 | ENST00000355653 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
intron-intron | ENST00000558560 | ENST00000587173 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
intron-intron | ENST00000558560 | ENST00000420567 | RMDN3 | chr15 | 41030709 | - | VAT1 | chr17 | 41167830 | - |
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FusionProtFeatures for RMDN3_VAT1 |
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Hgene | Tgene |
RMDN3 | VAT1 |
Involved in cellular calcium homeostasis regulation. Mayparticipate in differentiation and apoptosis of keratinocytes.Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967,ECO:0000269|PubMed:22131369}. | Possesses ATPase activity (By similarity). Plays a partin calcium-regulated keratinocyte activation in epidermal repairmechanisms. Has no effect on cell proliferation. Negativelyregulates mitochondrial fusion in cooperation with mitofusinproteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150,ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RMDN3_VAT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RMDN3_VAT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RMDN3_VAT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RMDN3_VAT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |