![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 31315 |
FusionGeneSummary for RMDN3_SMIM14 |
![]() |
Fusion gene information | Fusion gene name: RMDN3_SMIM14 | Fusion gene ID: 31315 | Hgene | Tgene | Gene symbol | RMDN3 | SMIM14 | Gene ID | 55177 | 201895 |
Gene name | regulator of microtubule dynamics 3 | small integral membrane protein 14 | |
Synonyms | FAM82A2|FAM82C|RMD-3|RMD3|ptpip51 | C4orf34 | |
Cytomap | 15q15.1 | 4p14 | |
Type of gene | protein-coding | protein-coding | |
Description | regulator of microtubule dynamics protein 3TCPTP-interacting protein 51cerebral protein 10family with sequence similarity 82, member A2family with sequence similarity 82, member Cmicrotubule-associated proteinprotein tyrosine phosphatase-interacting | small integral membrane protein 14 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q96TC7 | Q96QK8 | |
Ensembl transtripts involved in fusion gene | ENST00000260385, ENST00000338376, ENST00000558560, | ENST00000295958, ENST00000511809, ENST00000510628, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 2 X 4=32 |
# samples | 4 | 4 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RMDN3 [Title/Abstract] AND SMIM14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-AX-A3GI-01A | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000260385 | ENST00000295958 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
Frame-shift | ENST00000260385 | ENST00000511809 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
5CDS-5UTR | ENST00000260385 | ENST00000510628 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
Frame-shift | ENST00000338376 | ENST00000295958 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
Frame-shift | ENST00000338376 | ENST00000511809 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
5CDS-5UTR | ENST00000338376 | ENST00000510628 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
5UTR-3CDS | ENST00000558560 | ENST00000295958 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
5UTR-3CDS | ENST00000558560 | ENST00000511809 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
5UTR-5UTR | ENST00000558560 | ENST00000510628 | RMDN3 | chr15 | 41043624 | - | SMIM14 | chr4 | 39574083 | - |
Top |
FusionProtFeatures for RMDN3_SMIM14 |
![]() |
Hgene | Tgene |
RMDN3 | SMIM14 |
Involved in cellular calcium homeostasis regulation. Mayparticipate in differentiation and apoptosis of keratinocytes.Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967,ECO:0000269|PubMed:22131369}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RMDN3_SMIM14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RMDN3_SMIM14 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RMDN3 | YWHAB, YWHAG, YWHAZ, VAPA, PSEN1, FAM3C, ATP6V1H, ATP6V1A, HNRNPD, HNRNPDL, FAM162A, ELAVL1, ILF3, TOMM40, HSPA5, GORASP2, TIMM17B, CYSRT1, MDC1, YWHAQ, EGFL8, HLA-DPA1, GPM6A, RMDN2, VAPB, PFKFB2, RAB5C, FOXA3, FOXL1, APOOL, NEUROG3, RAF1, MAPK1, PTPN1 | SMIM14 | ELAVL1, LSM4, FATE1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RMDN3_SMIM14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RMDN3_SMIM14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |