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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 31300

FusionGeneSummary for RLF_MFSD2A

check button Fusion gene summary
Fusion gene informationFusion gene name: RLF_MFSD2A
Fusion gene ID: 31300
HgeneTgene
Gene symbol

RLF

MFSD2A

Gene ID

6018

84879

Gene namerearranged L-myc fusionmajor facilitator superfamily domain containing 2A
SynonymsZN-15L|ZNF292LMCPH15|MFSD2|NLS1
Cytomap

1p34.2

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein RlfZn-15 relatedrearranged L-myc fusion gene proteinrearranged L-myc fusion sequencezn-15-related proteinsodium-dependent lysophosphatidylcholine symporter 1major facilitator superfamily domain-containing protein 2Asodium-dependent LPC symporter 1
Modification date2018051920180329
UniProtAcc

Q13129

Q8NA29

Ensembl transtripts involved in fusion geneENST00000372771, ENST00000372811, 
ENST00000420632, ENST00000372809, 
ENST00000480630, 
Fusion gene scores* DoF score11 X 6 X 6=3966 X 6 X 3=108
# samples 117
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RLF [Title/Abstract] AND MFSD2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRLF

GO:0015074

DNA integration

1851085

HgeneRLF

GO:0051276

chromosome organization

1649386

TgeneMFSD2A

GO:0051977

lysophospholipid transport

24828044


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-24-1557-01ARLFchr1

40627308

+MFSD2Achr1

40424373

+
TCGALDOVTCGA-24-1557-01ARLFchr1

40627308

+MFSD2Achr1

40422759

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000372771ENST00000372811RLFchr1

40627308

+MFSD2Achr1

40424373

+
5CDS-intronENST00000372771ENST00000420632RLFchr1

40627308

+MFSD2Achr1

40424373

+
5CDS-intronENST00000372771ENST00000372809RLFchr1

40627308

+MFSD2Achr1

40424373

+
5CDS-intronENST00000372771ENST00000480630RLFchr1

40627308

+MFSD2Achr1

40424373

+
In-frameENST00000372771ENST00000372811RLFchr1

40627308

+MFSD2Achr1

40422759

+
5CDS-intronENST00000372771ENST00000420632RLFchr1

40627308

+MFSD2Achr1

40422759

+
5CDS-intronENST00000372771ENST00000372809RLFchr1

40627308

+MFSD2Achr1

40422759

+
5CDS-intronENST00000372771ENST00000480630RLFchr1

40627308

+MFSD2Achr1

40422759

+

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FusionProtFeatures for RLF_MFSD2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RLF

Q13129

MFSD2A

Q8NA29

May be involved in transcriptional regulation. Sodium-dependent lysophosphatidylcholine (LPC)symporter, which plays an essential role for blood-brain barrierformation and function (By similarity). Specifically expressed inendothelium of the blood-brain barrier of micro-vessels andtransports LPC into the brain (By similarity). Transport of LPC isessential because it constitutes the major mechanism by whichdocosahexaenoic acid (DHA), an omega-3 fatty acid that isessential for normal brain growth and cognitive function, entersthe brain (PubMed:26005868). Transports LPC carrying long-chainfatty acids such LPC oleate and LPC palmitate with a minimum acylchain length of 14 carbons (By similarity). Does not transportdocosahexaenoic acid in unesterified fatty acid (By similarity).Specifically required for blood-brain barrier formation andfunction, probably by mediating lipid transport (By similarity).Not required for central nervous system vascular morphogenesis (Bysimilarity). Acts as a transporter for tunicamycin, an inhibitorof asparagine-linked glycosylation (PubMed:21677192). In placenta,acts as a receptor for ERVFRD-1/syncytin-2 and is required fortrophoblast fusion (PubMed:18988732, PubMed:23177091).{ECO:0000250|UniProtKB:Q9DA75, ECO:0000269|PubMed:18988732,ECO:0000269|PubMed:21677192, ECO:0000269|PubMed:23177091,ECO:0000269|PubMed:26005868}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+01435_3831544Compositional biasNote=Poly-Lys
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+01435_3831531Compositional biasNote=Poly-Lys
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+01435_38-48544Compositional biasNote=Poly-Lys
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014102_12831544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014150_16031544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014182_25631544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014278_31031544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014332_34431544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014366_37031544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014392_39331544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014415_43731544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014459_48031544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014502_54331544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+01468_8031544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014102_12831531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014150_16031531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014182_25631531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014278_31031531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014332_34431531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014366_37031531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014392_39331531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014415_43731531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014459_48031531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014502_54331531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+01468_8031531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014102_128-48544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014150_160-48544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014182_256-48544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+0141_46-48544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014278_310-48544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014332_344-48544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014366_370-48544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014392_393-48544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014415_437-48544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014459_480-48544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014502_543-48544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+01468_80-48544Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114102_12876531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114150_16076531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114182_25676531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114278_31076531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114332_34476531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114366_37076531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114392_39376531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114415_43776531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114459_48076531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114502_54376531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014129_14931544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014161_18131544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014257_27731544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014311_33131544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014345_36531544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014371_39131544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014394_41431544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014438_45831544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+01447_6731544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+014481_50131544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+01481_10131544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014129_14931531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014161_18131531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014257_27731531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014311_33131531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014345_36531531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014371_39131531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014394_41431531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014438_45831531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+01447_6731531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+014481_50131531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+01481_10131531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014129_149-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014161_181-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014257_277-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014311_331-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014345_365-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014371_391-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014394_414-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014438_458-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+01447_67-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+014481_501-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372809+01481_101-48544TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114129_14976531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114161_18176531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114257_27776531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114311_33176531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114345_36576531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114371_39176531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114394_41476531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114438_45876531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+114481_50176531TransmembraneHelical
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+11481_10176531TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+181127_1152791915Zinc fingerC2H2-type 8
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+181172_1195791915Zinc fingerC2H2-type 9
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+181310_1335791915Zinc fingerC2H2-type 10
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+181362_1387791915Zinc fingerC2H2-type 11
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+181407_1432791915Zinc fingerC2H2-type 12
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+181444_1469791915Zinc fingerC2H2-type 13
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+181549_1574791915Zinc fingerC2H2-type 14
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+18582_604791915Zinc fingerC2H2-type 1
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+18671_696791915Zinc fingerC2H2-type 2
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+18714_736791915Zinc fingerC2H2-type 3
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+18742_766791915Zinc fingerC2H2-type 4
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+18771_795791915Zinc fingerC2H2-type 5
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+18801_825791915Zinc fingerC2H2-type 6
HgeneRLFchr1:40627308chr1:40422759ENST00000372771+18954_979791915Zinc fingerC2H2-type 7
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+181127_1152791915Zinc fingerC2H2-type 8
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+181172_1195791915Zinc fingerC2H2-type 9
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+181310_1335791915Zinc fingerC2H2-type 10
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+181362_1387791915Zinc fingerC2H2-type 11
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+181407_1432791915Zinc fingerC2H2-type 12
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+181444_1469791915Zinc fingerC2H2-type 13
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+181549_1574791915Zinc fingerC2H2-type 14
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+18582_604791915Zinc fingerC2H2-type 1
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+18671_696791915Zinc fingerC2H2-type 2
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+18714_736791915Zinc fingerC2H2-type 3
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+18742_766791915Zinc fingerC2H2-type 4
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+18771_795791915Zinc fingerC2H2-type 5
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+18801_825791915Zinc fingerC2H2-type 6
HgeneRLFchr1:40627308chr1:40424373ENST00000372771+18954_979791915Zinc fingerC2H2-type 7
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+11435_3876531Compositional biasNote=Poly-Lys
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372809+0141_4631544Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40422759ENST00000372811+0141_4631531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+1141_4676531Topological domainExtracellular
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+11468_8076531Topological domainCytoplasmic
TgeneMFSD2Achr1:40627308chr1:40424373ENST00000372811+11447_6776531TransmembraneHelical


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FusionGeneSequence for RLF_MFSD2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RLF_ENST00000372771_chr1_40627308_+_MFSD2A_ENST00000372811_chr1_40424373_+_534aa
MADGKGDAAAVAGAGAEAPAVAGAGDGVETESMVRGHRPVSPAPGASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQVGPFSASIILF
VGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQT
ERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSANHTHGTTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQ
REPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKK
TAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGIST

>In-frame_RLF_ENST00000372771_chr1_40627308_+_MFSD2A_ENST00000372811_chr1_40422759_+_579aa
MADGKGDAAAVAGAGAEAPAVAGAGDGVETESMVRGHRPVSPAPGASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQKEPKKKKQQLS
VCNKLCYALGGAPYQVTGCALGFFLQIYLLDVAQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFL
IWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVA
SQSANHTHGTTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVE
GNFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLP
WSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMAPIVLILLGLLLFKMY


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RLF_ENST00000372771_chr1_40627308_+_MFSD2A_ENST00000372811_chr1_40424373_+_1602nt
ATGGCGGACGGAAAGGGAGACGCCGCCGCTGTCGCCGGGGCTGGGGCTGAGGCTCCGGCGGTAGCGGGAGCCGGAGATGGAGTCGAGACT
GAGTCCATGGTTCGGGGTCATCGCCCCGTATCTCCAGCGCCGGGAGCCTCGGGACTGCGGCCGTGTCTGTGGCAGCTGGAGACAGAGCTG
AGGGAGCAAGAGGTGTCGGAGGTCTCATCTTTGAACTACTGCCGGAGCTTCTGCCAGGTGGGCCCTTTCTCTGCCTCCATCATCCTGTTT
GTGGGCCGAGCCTGGGATGCCATCACAGACCCCCTGGTGGGCCTCTGCATCAGCAAATCCCCCTGGACCTGCCTGGGTCGCCTTATGCCC
TGGATCATCTTCTCCACGCCCCTGGCCGTCATTGCCTACTTCCTCATCTGGTTCGTGCCCGACTTCCCACACGGCCAGACCTATTGGTAC
CTGCTTTTCTATTGCCTCTTTGAAACAATGGTCACGTGTTTCCATGTTCCCTACTCGGCTCTCACCATGTTCATCAGCACCGAGCAGACT
GAGCGGGATTCTGCCACCGCCTATCGGATGACTGTGGAAGTGCTGGGCACAGTGCTGGGCACGGCGATCCAGGGACAAATCGTGGGCCAA
GCAGACACGCCTTGTTTCCAGGACCTCAATAGCTCTACAGTAGCTTCACAAAGTGCCAACCATACACATGGCACCACCTCACACAGGGAA
ACGCAAAAGGCATACCTGCTGGCAGCGGGGGTCATTGTCTGTATCTATATAATCTGTGCTGTCATCCTGATCCTGGGCGTGCGGGAGCAG
AGAGAACCCTATGAAGCCCAGCAGTCTGAGCCAATCGCCTACTTCCGGGGCCTACGGCTGGTCATGAGCCACGGCCCATACATCAAACTT
ATTACTGGCTTCCTCTTCACCTCCTTGGCTTTCATGCTGGTGGAGGGGAACTTTGTCTTGTTTTGCACCTACACCTTGGGCTTCCGCAAT
GAATTCCAGAATCTACTCCTGGCCATCATGCTCTCGGCCACTTTAACCATTCCCATCTGGCAGTGGTTCTTGACCCGGTTTGGCAAGAAG
ACAGCTGTATATGTTGGGATCTCATCAGCAGTGCCATTTCTCATCTTGGTGGCCCTCATGGAGAGTAACCTCATCATTACATATGCGGTA
GCTGTGGCAGCTGGCATCAGTGTGGCAGCTGCCTTCTTACTACCCTGGTCCATGCTGCCTGATGTCATTGACGACTTCCATCTGAAGCAG
CCCCACTTCCATGGAACCGAGCCCATCTTCTTCTCCTTCTATGTCTTCTTCACCAAGTTTGCCTCTGGAGTGTCACTGGGCATTTCTACC
CTCAGTCTGGACTTTGCAGGGTACCAGACCCGTGGCTGCTCGCAGCCGGAACGTGTCAAGTTTACACTGAACATGCTCGTGACCATGGCT
CCCATAGTTCTCATCCTGCTGGGCCTGCTGCTCTTCAAAATGTACCCCATTGATGAGGAGAGGCGGCGGCAGAATAAGAAGGCCCTGCAG

>In-frame_RLF_ENST00000372771_chr1_40627308_+_MFSD2A_ENST00000372811_chr1_40422759_+_1737nt
ATGGCGGACGGAAAGGGAGACGCCGCCGCTGTCGCCGGGGCTGGGGCTGAGGCTCCGGCGGTAGCGGGAGCCGGAGATGGAGTCGAGACT
GAGTCCATGGTTCGGGGTCATCGCCCCGTATCTCCAGCGCCGGGAGCCTCGGGACTGCGGCCGTGTCTGTGGCAGCTGGAGACAGAGCTG
AGGGAGCAAGAGGTGTCGGAGGTCTCATCTTTGAACTACTGCCGGAGCTTCTGCCAGAAAGAACCGAAAAAGAAGAAACAACAGTTGTCT
GTTTGCAACAAGCTTTGCTATGCACTTGGGGGAGCCCCCTACCAGGTGACGGGCTGTGCCCTGGGTTTCTTCCTTCAGATCTACCTATTG
GATGTGGCTCAGGTGGGCCCTTTCTCTGCCTCCATCATCCTGTTTGTGGGCCGAGCCTGGGATGCCATCACAGACCCCCTGGTGGGCCTC
TGCATCAGCAAATCCCCCTGGACCTGCCTGGGTCGCCTTATGCCCTGGATCATCTTCTCCACGCCCCTGGCCGTCATTGCCTACTTCCTC
ATCTGGTTCGTGCCCGACTTCCCACACGGCCAGACCTATTGGTACCTGCTTTTCTATTGCCTCTTTGAAACAATGGTCACGTGTTTCCAT
GTTCCCTACTCGGCTCTCACCATGTTCATCAGCACCGAGCAGACTGAGCGGGATTCTGCCACCGCCTATCGGATGACTGTGGAAGTGCTG
GGCACAGTGCTGGGCACGGCGATCCAGGGACAAATCGTGGGCCAAGCAGACACGCCTTGTTTCCAGGACCTCAATAGCTCTACAGTAGCT
TCACAAAGTGCCAACCATACACATGGCACCACCTCACACAGGGAAACGCAAAAGGCATACCTGCTGGCAGCGGGGGTCATTGTCTGTATC
TATATAATCTGTGCTGTCATCCTGATCCTGGGCGTGCGGGAGCAGAGAGAACCCTATGAAGCCCAGCAGTCTGAGCCAATCGCCTACTTC
CGGGGCCTACGGCTGGTCATGAGCCACGGCCCATACATCAAACTTATTACTGGCTTCCTCTTCACCTCCTTGGCTTTCATGCTGGTGGAG
GGGAACTTTGTCTTGTTTTGCACCTACACCTTGGGCTTCCGCAATGAATTCCAGAATCTACTCCTGGCCATCATGCTCTCGGCCACTTTA
ACCATTCCCATCTGGCAGTGGTTCTTGACCCGGTTTGGCAAGAAGACAGCTGTATATGTTGGGATCTCATCAGCAGTGCCATTTCTCATC
TTGGTGGCCCTCATGGAGAGTAACCTCATCATTACATATGCGGTAGCTGTGGCAGCTGGCATCAGTGTGGCAGCTGCCTTCTTACTACCC
TGGTCCATGCTGCCTGATGTCATTGACGACTTCCATCTGAAGCAGCCCCACTTCCATGGAACCGAGCCCATCTTCTTCTCCTTCTATGTC
TTCTTCACCAAGTTTGCCTCTGGAGTGTCACTGGGCATTTCTACCCTCAGTCTGGACTTTGCAGGGTACCAGACCCGTGGCTGCTCGCAG
CCGGAACGTGTCAAGTTTACACTGAACATGCTCGTGACCATGGCTCCCATAGTTCTCATCCTGCTGGGCCTGCTGCTCTTCAAAATGTAC
CCCATTGATGAGGAGAGGCGGCGGCAGAATAAGAAGGCCCTGCAGGCACTGAGGGACGAGGCCAGCAGCTCTGGCTGCTCAGAAACAGAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RLF_ENST00000372771_chr1_40627308_+_MFSD2A_ENST00000372811_chr1_40424373_+_2027nt
GCCTACGCGCTGGTGGGCCGTGGGAAGATGGCGGACGGAAAGGGAGACGCCGCCGCTGTCGCCGGGGCTGGGGCTGAGGCTCCGGCGGTA
GCGGGAGCCGGAGATGGAGTCGAGACTGAGTCCATGGTTCGGGGTCATCGCCCCGTATCTCCAGCGCCGGGAGCCTCGGGACTGCGGCCG
TGTCTGTGGCAGCTGGAGACAGAGCTGAGGGAGCAAGAGGTGTCGGAGGTCTCATCTTTGAACTACTGCCGGAGCTTCTGCCAGGTGGGC
CCTTTCTCTGCCTCCATCATCCTGTTTGTGGGCCGAGCCTGGGATGCCATCACAGACCCCCTGGTGGGCCTCTGCATCAGCAAATCCCCC
TGGACCTGCCTGGGTCGCCTTATGCCCTGGATCATCTTCTCCACGCCCCTGGCCGTCATTGCCTACTTCCTCATCTGGTTCGTGCCCGAC
TTCCCACACGGCCAGACCTATTGGTACCTGCTTTTCTATTGCCTCTTTGAAACAATGGTCACGTGTTTCCATGTTCCCTACTCGGCTCTC
ACCATGTTCATCAGCACCGAGCAGACTGAGCGGGATTCTGCCACCGCCTATCGGATGACTGTGGAAGTGCTGGGCACAGTGCTGGGCACG
GCGATCCAGGGACAAATCGTGGGCCAAGCAGACACGCCTTGTTTCCAGGACCTCAATAGCTCTACAGTAGCTTCACAAAGTGCCAACCAT
ACACATGGCACCACCTCACACAGGGAAACGCAAAAGGCATACCTGCTGGCAGCGGGGGTCATTGTCTGTATCTATATAATCTGTGCTGTC
ATCCTGATCCTGGGCGTGCGGGAGCAGAGAGAACCCTATGAAGCCCAGCAGTCTGAGCCAATCGCCTACTTCCGGGGCCTACGGCTGGTC
ATGAGCCACGGCCCATACATCAAACTTATTACTGGCTTCCTCTTCACCTCCTTGGCTTTCATGCTGGTGGAGGGGAACTTTGTCTTGTTT
TGCACCTACACCTTGGGCTTCCGCAATGAATTCCAGAATCTACTCCTGGCCATCATGCTCTCGGCCACTTTAACCATTCCCATCTGGCAG
TGGTTCTTGACCCGGTTTGGCAAGAAGACAGCTGTATATGTTGGGATCTCATCAGCAGTGCCATTTCTCATCTTGGTGGCCCTCATGGAG
AGTAACCTCATCATTACATATGCGGTAGCTGTGGCAGCTGGCATCAGTGTGGCAGCTGCCTTCTTACTACCCTGGTCCATGCTGCCTGAT
GTCATTGACGACTTCCATCTGAAGCAGCCCCACTTCCATGGAACCGAGCCCATCTTCTTCTCCTTCTATGTCTTCTTCACCAAGTTTGCC
TCTGGAGTGTCACTGGGCATTTCTACCCTCAGTCTGGACTTTGCAGGGTACCAGACCCGTGGCTGCTCGCAGCCGGAACGTGTCAAGTTT
ACACTGAACATGCTCGTGACCATGGCTCCCATAGTTCTCATCCTGCTGGGCCTGCTGCTCTTCAAAATGTACCCCATTGATGAGGAGAGG
CGGCGGCAGAATAAGAAGGCCCTGCAGGCACTGAGGGACGAGGCCAGCAGCTCTGGCTGCTCAGAAACAGACTCCACAGAGCTGGCTAGC
ATCCTCTAGGGCCCGCCACGTTGCCCGAAGCCACCATGCAGAAGGCCACAGAAGGGATCAGGACCTGTCTGCCGGCTTGCTGAGCAGCTG
GACTGCAGGTGCTAGGAAGGGAACTGAAGACTCAAGGAGGTGGCCCAGGACACTTGCTGTGCTCACTGTGGGGCCGGCTGCTCTGTGGCC
TCCTGCCTCCCCTCTGCCTGCCTGTGGGGCCAAGCCCTGGGGCTGCCACTGTGAATATGCCAAGGACTGATCGGGCCTAGCCCGGAACAC
TAATGTAGAAACCTTTTTTTTTACAGAGCCTAATTAATAACTTAATGACTGTGTACATAGCAATGTGTGTGTATGTATATGTCTGTGAGC

>In-frame_RLF_ENST00000372771_chr1_40627308_+_MFSD2A_ENST00000372811_chr1_40422759_+_2162nt
GCCTACGCGCTGGTGGGCCGTGGGAAGATGGCGGACGGAAAGGGAGACGCCGCCGCTGTCGCCGGGGCTGGGGCTGAGGCTCCGGCGGTA
GCGGGAGCCGGAGATGGAGTCGAGACTGAGTCCATGGTTCGGGGTCATCGCCCCGTATCTCCAGCGCCGGGAGCCTCGGGACTGCGGCCG
TGTCTGTGGCAGCTGGAGACAGAGCTGAGGGAGCAAGAGGTGTCGGAGGTCTCATCTTTGAACTACTGCCGGAGCTTCTGCCAGAAAGAA
CCGAAAAAGAAGAAACAACAGTTGTCTGTTTGCAACAAGCTTTGCTATGCACTTGGGGGAGCCCCCTACCAGGTGACGGGCTGTGCCCTG
GGTTTCTTCCTTCAGATCTACCTATTGGATGTGGCTCAGGTGGGCCCTTTCTCTGCCTCCATCATCCTGTTTGTGGGCCGAGCCTGGGAT
GCCATCACAGACCCCCTGGTGGGCCTCTGCATCAGCAAATCCCCCTGGACCTGCCTGGGTCGCCTTATGCCCTGGATCATCTTCTCCACG
CCCCTGGCCGTCATTGCCTACTTCCTCATCTGGTTCGTGCCCGACTTCCCACACGGCCAGACCTATTGGTACCTGCTTTTCTATTGCCTC
TTTGAAACAATGGTCACGTGTTTCCATGTTCCCTACTCGGCTCTCACCATGTTCATCAGCACCGAGCAGACTGAGCGGGATTCTGCCACC
GCCTATCGGATGACTGTGGAAGTGCTGGGCACAGTGCTGGGCACGGCGATCCAGGGACAAATCGTGGGCCAAGCAGACACGCCTTGTTTC
CAGGACCTCAATAGCTCTACAGTAGCTTCACAAAGTGCCAACCATACACATGGCACCACCTCACACAGGGAAACGCAAAAGGCATACCTG
CTGGCAGCGGGGGTCATTGTCTGTATCTATATAATCTGTGCTGTCATCCTGATCCTGGGCGTGCGGGAGCAGAGAGAACCCTATGAAGCC
CAGCAGTCTGAGCCAATCGCCTACTTCCGGGGCCTACGGCTGGTCATGAGCCACGGCCCATACATCAAACTTATTACTGGCTTCCTCTTC
ACCTCCTTGGCTTTCATGCTGGTGGAGGGGAACTTTGTCTTGTTTTGCACCTACACCTTGGGCTTCCGCAATGAATTCCAGAATCTACTC
CTGGCCATCATGCTCTCGGCCACTTTAACCATTCCCATCTGGCAGTGGTTCTTGACCCGGTTTGGCAAGAAGACAGCTGTATATGTTGGG
ATCTCATCAGCAGTGCCATTTCTCATCTTGGTGGCCCTCATGGAGAGTAACCTCATCATTACATATGCGGTAGCTGTGGCAGCTGGCATC
AGTGTGGCAGCTGCCTTCTTACTACCCTGGTCCATGCTGCCTGATGTCATTGACGACTTCCATCTGAAGCAGCCCCACTTCCATGGAACC
GAGCCCATCTTCTTCTCCTTCTATGTCTTCTTCACCAAGTTTGCCTCTGGAGTGTCACTGGGCATTTCTACCCTCAGTCTGGACTTTGCA
GGGTACCAGACCCGTGGCTGCTCGCAGCCGGAACGTGTCAAGTTTACACTGAACATGCTCGTGACCATGGCTCCCATAGTTCTCATCCTG
CTGGGCCTGCTGCTCTTCAAAATGTACCCCATTGATGAGGAGAGGCGGCGGCAGAATAAGAAGGCCCTGCAGGCACTGAGGGACGAGGCC
AGCAGCTCTGGCTGCTCAGAAACAGACTCCACAGAGCTGGCTAGCATCCTCTAGGGCCCGCCACGTTGCCCGAAGCCACCATGCAGAAGG
CCACAGAAGGGATCAGGACCTGTCTGCCGGCTTGCTGAGCAGCTGGACTGCAGGTGCTAGGAAGGGAACTGAAGACTCAAGGAGGTGGCC
CAGGACACTTGCTGTGCTCACTGTGGGGCCGGCTGCTCTGTGGCCTCCTGCCTCCCCTCTGCCTGCCTGTGGGGCCAAGCCCTGGGGCTG
CCACTGTGAATATGCCAAGGACTGATCGGGCCTAGCCCGGAACACTAATGTAGAAACCTTTTTTTTTACAGAGCCTAATTAATAACTTAA
TGACTGTGTACATAGCAATGTGTGTGTATGTATATGTCTGTGAGCTATTAATGTTATTAATTTTCATAAAAGCTGGAAAGCAGCTGCCTG


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FusionGenePPI for RLF_MFSD2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RLFCNKSR2, RIT1, RIT2, GCH1, ALB, PRPF40A, KRAS, HIST1H2BG, HIST1H3A, CLK1, TRIM11MFSD2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RLF_MFSD2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RLF_MFSD2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMFSD2AC0025958Microcephaly2CTD_human
TgeneMFSD2AC4225310MICROCEPHALY 15, PRIMARY, AUTOSOMAL RECESSIVE2UNIPROT
TgeneMFSD2AC0037822Speech Disorders1CTD_human
TgeneMFSD2AC3714756Intellectual Disability1CTD_human