![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 31291 |
FusionGeneSummary for RIT1_SPATA13 |
![]() |
Fusion gene information | Fusion gene name: RIT1_SPATA13 | Fusion gene ID: 31291 | Hgene | Tgene | Gene symbol | RIT1 | SPATA13 | Gene ID | 64919 | 221178 |
Gene name | B cell CLL/lymphoma 11B | spermatogenesis associated 13 | |
Synonyms | ATL1|ATL1-alpha|ATL1-beta|ATL1-delta|ATL1-gamma|CTIP-2|CTIP2|IMD49|RIT1|ZNF856B|hRIT1-alpha | ARHGEF29|ASEF2 | |
Cytomap | 14q32.2 | 13q12.12 | |
Type of gene | protein-coding | protein-coding | |
Description | B-cell lymphoma/leukemia 11BB-cell CLL/lymphoma 11B (zinc finger protein)B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion proteinB-cell lymphoma/leukaemia 11BBCL-11BBCL11B/TRDC fusionCOUP-TF-interacting protein 2hRit1radiation- | spermatogenesis-associated protein 13APC-stimulated guanine nucleotide exchange factor 2adenomatous polyposis coli stimulated exchange factor 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q92963 | Q96N96 | |
Ensembl transtripts involved in fusion gene | ENST00000368323, ENST00000539040, ENST00000368322, | ENST00000424834, ENST00000382108, ENST00000382095, ENST00000474317, ENST00000399949, ENST00000409126, ENST00000343003, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 6 X 4 X 4=96 |
# samples | 4 | 6 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RIT1 [Title/Abstract] AND SPATA13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BX506288 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000368323 | ENST00000424834 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368323 | ENST00000382108 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368323 | ENST00000382095 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368323 | ENST00000474317 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368323 | ENST00000399949 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368323 | ENST00000409126 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368323 | ENST00000343003 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000539040 | ENST00000424834 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000539040 | ENST00000382108 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000539040 | ENST00000382095 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000539040 | ENST00000474317 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000539040 | ENST00000399949 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000539040 | ENST00000409126 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000539040 | ENST00000343003 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368322 | ENST00000424834 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368322 | ENST00000382108 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368322 | ENST00000382095 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368322 | ENST00000474317 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368322 | ENST00000399949 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368322 | ENST00000409126 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
intron-intron | ENST00000368322 | ENST00000343003 | RIT1 | chr1 | 155876313 | + | SPATA13 | chr13 | 24772401 | + |
Top |
FusionProtFeatures for RIT1_SPATA13 |
![]() |
Hgene | Tgene |
RIT1 | SPATA13 |
Plays a crucial role in coupling NGF stimulation to theactivation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1transactivation through the Ras-MAPK signaling cascade thatmediates a wide variety of cellular functions, including cellproliferation, survival, and differentiation.{ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RIT1_SPATA13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RIT1_SPATA13 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RIT1_SPATA13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RIT1_SPATA13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RIT1 | C3809233 | NOONAN SYNDROME 8 | 2 | UNIPROT |
Hgene | RIT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |