![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 31289 |
FusionGeneSummary for RIT1_CCT3 |
![]() |
Fusion gene information | Fusion gene name: RIT1_CCT3 | Fusion gene ID: 31289 | Hgene | Tgene | Gene symbol | RIT1 | CCT3 | Gene ID | 64919 | 7203 |
Gene name | B cell CLL/lymphoma 11B | chaperonin containing TCP1 subunit 3 | |
Synonyms | ATL1|ATL1-alpha|ATL1-beta|ATL1-delta|ATL1-gamma|CTIP-2|CTIP2|IMD49|RIT1|ZNF856B|hRIT1-alpha | CCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5 | |
Cytomap | 14q32.2 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | B-cell lymphoma/leukemia 11BB-cell CLL/lymphoma 11B (zinc finger protein)B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion proteinB-cell lymphoma/leukaemia 11BBCL-11BBCL11B/TRDC fusionCOUP-TF-interacting protein 2hRit1radiation- | T-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q92963 | P49368 | |
Ensembl transtripts involved in fusion gene | ENST00000368323, ENST00000539040, ENST00000368322, | ENST00000295688, ENST00000368259, ENST00000368261, ENST00000472765, ENST00000368256, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 12 X 8 X 9=864 |
# samples | 4 | 12 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/864*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RIT1 [Title/Abstract] AND CCT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-49-4514-01A | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000368323 | ENST00000295688 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368323 | ENST00000368259 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368323 | ENST00000368261 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368323 | ENST00000472765 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
5CDS-intron | ENST00000368323 | ENST00000368256 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000539040 | ENST00000295688 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000539040 | ENST00000368259 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000539040 | ENST00000368261 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000539040 | ENST00000472765 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
5CDS-intron | ENST00000539040 | ENST00000368256 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368322 | ENST00000295688 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368322 | ENST00000368259 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368322 | ENST00000368261 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368322 | ENST00000472765 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
5CDS-intron | ENST00000368322 | ENST00000368256 | RIT1 | chr1 | 155880241 | - | CCT3 | chr1 | 156282012 | - |
Top |
FusionProtFeatures for RIT1_CCT3 |
![]() |
Hgene | Tgene |
RIT1 | CCT3 |
Plays a crucial role in coupling NGF stimulation to theactivation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1transactivation through the Ras-MAPK signaling cascade thatmediates a wide variety of cellular functions, including cellproliferation, survival, and differentiation.{ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}. | Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RIT1_CCT3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RIT1_CCT3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RIT1 | RALGDS, PTN, LRIF1, MLLT4, RLF, VHL, NF2, KLHL12, ASB4, SRPK2, LZTR1, CAMKV, RIT2, MAD2L1BP | CCT3 | SSSCA1, FANCA, RAF1, EIF2B2, PAFAH1B2, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, CDK9, RFWD2, ATG16L1, MAPK6, VHL, WDR82, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO3, HDAC5, PSMA3, FBXW8, RAD21, SH3BP4, VAV2, SIRT7, ISG15, PSMA2, CUL3, CDK2, XRCC6, INPPL1, UBASH3B, GRB2, EPS15, FBXO6, PACRG, CCT2, CCT5, CCT7, CCT8, CCT6A, CCT4, CCT6B, MARS, PSMA6, PSMA5, NOTCH1, VCP, FN1, VCAM1, ATF2, PEX14, NOS2, CAMKMT, FAM86B2, METTL18, METTL20, METTL21B, METTL21C, METTL23, ITGA4, CFTR, PAN2, CD81, IGSF8, ICAM1, HDAC3, HDAC11, HDAC6, FBXW4, PARK2, ACACA, COPA, EEF1G, LRRC47, PPP4R2, VARS, TRIM28, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, MIPOL1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, BMI1, CDK13, IKBKE, IRAK1, JAK3, MAPK8, PRKY, PTK6, SGK2, TSSK6, TYK2, WDR76, POC1A, NXF5, TXNDC9, FYCO1, WDR37, WDR83, DCAF5, WDR92, PEX7, GNB5, TSSC1, DDB2, TUBB2B, ACTR1B, SEC31B, TUBAL3, ACTL6A, PNPLA1, TTLL3, TUBA3C, TUBA3E, C17orf102, RPS6KB2, LGALS3, DCAF7, AMBRA1, ARF1, CAD, CANX, CLTC, DNAJA1, DNAJA4, EHD2, ETFA, GTF2I, HSPE1, LDHA, LDHB, PDCL3, PSMC2, SLC25A3, SUCLG2, WARS, CYP27A1, HSP90B1, KPNA4, MCM7, PC, RPN1, STOM, UQCRC2, NTRK1, BTRC, B9D1, MKS1, CETN2, AHSA1, GBA, HDAC1, PDK3, DNAJC7, XRCC3, NSMAF, NIPSNAP1, PRPF4, ACTR2, WRAP53, RFWD3, KIF21A, SEH1L, TUBA1C, ARMC6, GAN, SKI, FBXW7, MCM2, SNW1, CDC5L, ERRFI1, TTC27, CDC73, ZNF746, PPM1J, TUBD1, DCAF12, DTL, WDR70, DCAF13, JMJD4, KLHL33, KDM4B, DCAF10, KLHDC8A, KLHL8, WDR77, WDR46, RAP2C, DCAF4, DNAI2, BUB3, WDR86, ODF1, KLHDC8B, DCAF11, WDTC1, TUBG2, GNB1L, METAP2, DCAF8, ACTR3B, TBL1Y, THOC3, PDCL, WDR34, UTP18, GNB2, GANAB, SMOX, HCFC2, WDR5B, C4orf26, C1orf127, ACTR3, NOL10, MLST8, POC1B, ACTBL2, MAPK15, P4HA2, C11orf70, KLHDC2, CDK11A, TTLL9, STRADB, RPE65, PNPLA5, TUBA1B, DCAF12L2, C11orf54, RBM3, CYLD, TRIM25, G3BP1, BRCA1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RIT1_CCT3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CCT3 | P49368 | DB11638 | Artenimol | T-complex protein 1 subunit gamma | small molecule | approved|investigational |
Top |
RelatedDiseases for RIT1_CCT3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RIT1 | C3809233 | NOONAN SYNDROME 8 | 2 | UNIPROT |
Hgene | RIT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CCT3 | C0019693 | HIV Infections | 1 | CTD_human |