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Fusion gene ID: 31273 |
FusionGeneSummary for RIN2_SYT17 |
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Fusion gene information | Fusion gene name: RIN2_SYT17 | Fusion gene ID: 31273 | Hgene | Tgene | Gene symbol | RIN2 | SYT17 | Gene ID | 54453 | 51760 |
Gene name | Ras and Rab interactor 2 | synaptotagmin 17 | |
Synonyms | MACS|RASSF4 | sytXVII | |
Cytomap | 20p11.23 | 16p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ras and Rab interactor 2RAB5 interacting protein 2RAS association (RalGDS/AF-6) domain containing protein JC265RAS association domain family 4RAS inhibitor JC265RAS interaction/interference protein 2 | synaptotagmin-17B/K proteinsynaptotagmin XVII | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8WYP3 | Q9BSW7 | |
Ensembl transtripts involved in fusion gene | ENST00000255006, ENST00000440354, ENST00000484638, | ENST00000355377, ENST00000562034, ENST00000562711, ENST00000568433, ENST00000568115, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RIN2 [Title/Abstract] AND SYT17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SYT17 | GO:1903861 | positive regulation of dendrite extension | 23999003 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI002773 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000255006 | ENST00000355377 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000255006 | ENST00000562034 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000255006 | ENST00000562711 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000255006 | ENST00000568433 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000255006 | ENST00000568115 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
intron-intron | ENST00000440354 | ENST00000355377 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
intron-intron | ENST00000440354 | ENST00000562034 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
intron-intron | ENST00000440354 | ENST00000562711 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
intron-intron | ENST00000440354 | ENST00000568433 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
intron-intron | ENST00000440354 | ENST00000568115 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000484638 | ENST00000355377 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000484638 | ENST00000562034 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000484638 | ENST00000562711 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000484638 | ENST00000568433 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
3UTR-intron | ENST00000484638 | ENST00000568115 | RIN2 | chr20 | 19982482 | + | SYT17 | chr16 | 19186627 | - |
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FusionProtFeatures for RIN2_SYT17 |
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Hgene | Tgene |
RIN2 | SYT17 |
Ras effector protein. May function as an upstreamactivator and/or downstream effector for RAB5B in endocyticpathway. May function as a guanine nucleotide exchange (GEF) ofRAB5B, required for activating the RAB5 proteins by exchangingbound GDP for free GTP. {ECO:0000269|PubMed:11733506}. | Plays a role in dendrite formation by melanocytes(PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RIN2_SYT17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RIN2_SYT17 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RIN2_SYT17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RIN2_SYT17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |