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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31272

FusionGeneSummary for RIN1_RHOD

check button Fusion gene summary
Fusion gene informationFusion gene name: RIN1_RHOD
Fusion gene ID: 31272
HgeneTgene
Gene symbol

RIN1

RHOD

Gene ID

9610

29984

Gene nameRas and Rab interactor 1ras homolog family member D
Synonyms-ARHD|RHOHP1|RHOM|Rho
Cytomap

11q13.2

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionras and Rab interactor 1ras inhibitor 1ras inhibitor JC99ras inhibitor RIN1ras interaction/interference protein 1rho-related GTP-binding protein RhoDRho-related protein HP1ras homolog Dras homolog gene family, member Aras homolog gene family, member D
Modification date2018052420180523
UniProtAcc

Q13671

O00212

Ensembl transtripts involved in fusion geneENST00000311320, ENST00000424433, 
ENST00000530056, ENST00000524804, 
ENST00000308831, ENST00000533360, 
ENST00000532559, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 4 X 8=288
# samples 113
** MAII scorelog2(1/1*10)=3.32192809488736log2(13/288*10)=-1.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RIN1 [Title/Abstract] AND RHOD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A138-01ARIN1chr11

66103788

-RHODchr11

66833367

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000311320ENST00000308831RIN1chr11

66103788

-RHODchr11

66833367

+
In-frameENST00000311320ENST00000533360RIN1chr11

66103788

-RHODchr11

66833367

+
5CDS-intronENST00000311320ENST00000532559RIN1chr11

66103788

-RHODchr11

66833367

+
5UTR-3CDSENST00000424433ENST00000308831RIN1chr11

66103788

-RHODchr11

66833367

+
5UTR-3CDSENST00000424433ENST00000533360RIN1chr11

66103788

-RHODchr11

66833367

+
5UTR-intronENST00000424433ENST00000532559RIN1chr11

66103788

-RHODchr11

66833367

+
intron-3CDSENST00000530056ENST00000308831RIN1chr11

66103788

-RHODchr11

66833367

+
intron-3CDSENST00000530056ENST00000533360RIN1chr11

66103788

-RHODchr11

66833367

+
intron-intronENST00000530056ENST00000532559RIN1chr11

66103788

-RHODchr11

66833367

+
intron-3CDSENST00000524804ENST00000308831RIN1chr11

66103788

-RHODchr11

66833367

+
intron-3CDSENST00000524804ENST00000533360RIN1chr11

66103788

-RHODchr11

66833367

+
intron-intronENST00000524804ENST00000532559RIN1chr11

66103788

-RHODchr11

66833367

+

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FusionProtFeatures for RIN1_RHOD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RIN1

Q13671

RHOD

O00212

Ras effector protein, which may serve as an inhibitorymodulator of neuronal plasticity in aversive memory formation. Canaffect Ras signaling at different levels. First, by competing withRAF1 protein for binding to activated Ras. Second, by enhancingsignaling from ABL1 and ABL2, which regulate cytoskeletalremodeling. Third, by activating RAB5A, possibly by functioning asa guanine nucleotide exchange factor (GEF) for RAB5A, byexchanging bound GDP for free GTP, and facilitating Ras-activatedreceptor endocytosis. {ECO:0000269|PubMed:15886098,ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. Involved in endosome dynamics. May coordinate membranetransport with the function of the cytoskeleton. Involved in theinternalization and trafficking of activated tyrosine kinasereceptors such as PDGFRB. Participates in the reorganization ofactin cytoskeleton; the function seems to involve WHAMM andincludes regulation of filopodia formation and actin filamentbundling. Can modulate the effect of DAPK3 in reorganization ofactin cytoskeleton and focal adhesion dissolution.{ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120,ECO:0000269|PubMed:24102721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRHODchr11:66103788chr11:66833367ENST00000308831+0546_5444211MotifEffector region
TgeneRHODchr11:66103788chr11:66833367ENST00000308831+05129_13244211Nucleotide bindingGTP
TgeneRHODchr11:66103788chr11:66833367ENST00000308831+0571_7544211Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRIN1chr11:66103788chr11:66833367ENST00000311320-110259_26828784Compositional biasNote=Pro-rich
HgeneRIN1chr11:66103788chr11:66833367ENST00000311320-110456_59828784DomainVPS9
HgeneRIN1chr11:66103788chr11:66833367ENST00000311320-110624_70628784DomainRas-associating
HgeneRIN1chr11:66103788chr11:66833367ENST00000311320-11069_16328784DomainSH2
HgeneRIN1chr11:66103788chr11:66833367ENST00000311320-110294_72728784RegionNote=Ras and 14-3-3 protein binding region
TgeneRHODchr11:66103788chr11:66833367ENST00000308831+0524_3144211Nucleotide bindingGTP


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FusionGeneSequence for RIN1_RHOD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RIN1_ENST00000311320_chr11_66103788_-_RHOD_ENST00000308831_chr11_66833367_+_195aa
MESPGESGAGSPGAPSPSSFTTGHLAREKATPPRCLSGTWSTCKXKANLCTSTSGTQQGKMTMTACGPCSTLTPASCCFASMSPARTALT
TSLTGGTQKXIISARRYPSSSWAARLTCARTNHWXTSSEETDWSLXPTTGARRWRGPWARWPTSSARLGSMTTSTPSSRRPPRWPSAAAV

>In-frame_RIN1_ENST00000311320_chr11_66103788_-_RHOD_ENST00000533360_chr11_66833367_+_103aa
MESPGESGAGSPGAPSPSSFTTGHLAREKATPPRCLSGTWSTCKXKANLCTSTSGTQQGKMTMTACGPCSTLTPASCCFASMSPARTALT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RIN1_ENST00000311320_chr11_66103788_-_RHOD_ENST00000308831_chr11_66833367_+_587nt
ATGGAAAGCCCTGGAGAGTCAGGCGCGGGCTCTCCTGGAGCCCCCAGCCCGTCCAGCTTCACTACTGGGCACCTGGCGAGAGAAAAAGCT
ACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAG
ATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACA
ACATCTTTAACCGGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAGACTGACCTGTGCAAGG
ACAAATCACTGGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTACCACAGGGGCCAGGAGATGGCGAGGTCCGTGGGCGCGG
TGGCCTACCTCGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTCCAGGAGGCCGCCGAGGTGGCCCTCAGCAGCCGCGGTC

>In-frame_RIN1_ENST00000311320_chr11_66103788_-_RHOD_ENST00000533360_chr11_66833367_+_311nt
ATGGAAAGCCCTGGAGAGTCAGGCGCGGGCTCTCCTGGAGCCCCCAGCCCGTCCAGCTTCACTACTGGGCACCTGGCGAGAGAAAAAGCT
ACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAG
ATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_RIN1_ENST00000311320_chr11_66103788_-_RHOD_ENST00000308831_chr11_66833367_+_1125nt
GTGGACACACAAGAGTTAACTGGCGGGTGTGACAGGCGGACCGCCCTCAGGAAGTGTTACTCACTGGGGATGTGCGTGCCTTGCCTTGGG
ACTGGATTCTCTTCCTGAAGCGAAGGAGCTCCCAGCCATGGAAAGCCCTGGAGAGTCAGGCGCGGGCTCTCCTGGAGCCCCCAGCCCGTC
CAGCTTCACTACTGGGCACCTGGCGAGAGAAAAAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAA
CCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTG
CTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAACATCTTTAACCGGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCC
ATCATCGTCGTGGGCTGCAAGACTGACCTGTGCAAGGACAAATCACTGGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTAC
CACAGGGGCCAGGAGATGGCGAGGTCCGTGGGCGCGGTGGCCTACCTCGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTC
CAGGAGGCCGCCGAGGTGGCCCTCAGCAGCCGCGGTCGCAACTTCTGGCGGCGGATTACCCAGGGCTTTTGCGTGGTGACCTGAGCGGCT
CGGGGCGTCCCAGCGACGCGGGAAGGGGCAGGGCGCTGACCTGCTGCTGAGCTGGCTGGGCTGGACCCGGTCCCTAGGCTGTGACCGCCG
AACTCCACTGCAACAGACGGGCGCCACCAAAGCCAGGCCCTGAGGCCTGGGAGTCCTGGACTGAGAAAGGGGGTTCCTGGGCCCACCTGC
TCTGTGTAGGGCTCGTCCTGCGGTGCCCGAGAATCACTCGCTAACCCCTATGCCCGGTCCCGGACCGACATCCTGGAGCCGCCTGTGCAG
CCTGATGCCCCCTCGTGGCTGCTCCCAGGGCTGCACCTGCCAGGACCTAATGTTCTTAGGTCCCTCTGGCCAGAACCCACACCCGGCCCC

>In-frame_RIN1_ENST00000311320_chr11_66103788_-_RHOD_ENST00000533360_chr11_66833367_+_640nt
GTGGACACACAAGAGTTAACTGGCGGGTGTGACAGGCGGACCGCCCTCAGGAAGTGTTACTCACTGGGGATGTGCGTGCCTTGCCTTGGG
ACTGGATTCTCTTCCTGAAGCGAAGGAGCTCCCAGCCATGGAAAGCCCTGGAGAGTCAGGCGCGGGCTCTCCTGGAGCCCCCAGCCCGTC
CAGCTTCACTACTGGGCACCTGGCGAGAGAAAAAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAA
CCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTG
CTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAACATCTTTAACCGGTTTCTCCCTAGGTGCTGGCTTTGCTGATTATCCATATCA
GAGCTCAGGCTGGGGAGCAAGAGAGTGGTCCACTGAGAGGGCCAGAACTCTCCAGGGCTCACACATGCCCCCCACATGCCCCCTCGCCCC
CCTGCAGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAGACTGACCTGTGCAAGGACAAATC


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FusionGenePPI for RIN1_RHOD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RIN1HRAS, RAB5A, RAB5B, RALGDS, MLLT4, RRAS2, STAM2, EGFR, SMAD2, ERBB2, ERBB3, ABL2, CALCOCO2, LZTS2, ANKS1B, COMT, ZWINT, KRAS, ANKS1A, NRAS, RRAS, YWHAZ, ISCA1, YWHAE, YWHAG, YWHAH, ABL1, RAP2B, DPP8, TESRHODDIAPH2, PLXNA1, IHH, ADCK5, ADRB2, ANKFY1, SPTB, PLXNB2, DAAM1, TTC19, CETN3, TRMT61B, DIAPH1, PCBP3, C1orf198, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RIN1_RHOD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RIN1_RHOD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRIN1C0025202melanoma1CTD_human