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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31266

FusionGeneSummary for RIMS2_BAALC

check button Fusion gene summary
Fusion gene informationFusion gene name: RIMS2_BAALC
Fusion gene ID: 31266
HgeneTgene
Gene symbol

RIMS2

BAALC

Gene ID

9699

79870

Gene nameregulating synaptic membrane exocytosis 2BAALC, MAP3K1 and KLF4 binding
SynonymsOBOE|RAB3IP3|RIM2-
Cytomap

8q22.3

8q22.3

Type of geneprotein-codingprotein-coding
Descriptionregulating synaptic membrane exocytosis protein 2RAB3 interacting protein 3Rab3-interacting proteinnon-small cell lung cancer RimL3a proteinnon-small cell lung cancer RimL3c proteinnuclear proteinrab-3-interacting molecule 2rab-3-interacting proteibrain and acute leukemia cytoplasmic proteinBAALC, MEKK1 and KLF4 bindingbrain and acute leukemia, cytoplasmic
Modification date2018052320180519
UniProtAcc

Q9UQ26

Q8WXS3

Ensembl transtripts involved in fusion geneENST00000406091, ENST00000262231, 
ENST00000507740, ENST00000522174, 
ENST00000436393, ENST00000339750, 
ENST00000309982, ENST00000438105, 
ENST00000297574, ENST00000330955, 
ENST00000306391, ENST00000523754, 
Fusion gene scores* DoF score4 X 2 X 4=326 X 2 X 5=60
# samples 67
** MAII scorelog2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RIMS2 [Title/Abstract] AND BAALC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRIMS2

GO:1903861

positive regulation of dendrite extension

23999003


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GC-A3I6-01ARIMS2chr8

104513290

+BAALCchr8

104225147

+
TCGARVBRCATCGA-BH-A18V-06ARIMS2chr8

104513290

+BAALCchr8

104225147

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000406091ENST00000309982RIMS2chr8

104513290

+BAALCchr8

104225147

+
5CDS-intronENST00000406091ENST00000438105RIMS2chr8

104513290

+BAALCchr8

104225147

+
5CDS-intronENST00000406091ENST00000297574RIMS2chr8

104513290

+BAALCchr8

104225147

+
5CDS-intronENST00000406091ENST00000330955RIMS2chr8

104513290

+BAALCchr8

104225147

+
5CDS-intronENST00000406091ENST00000306391RIMS2chr8

104513290

+BAALCchr8

104225147

+
5CDS-intronENST00000406091ENST00000523754RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-3CDSENST00000262231ENST00000309982RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000262231ENST00000438105RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000262231ENST00000297574RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000262231ENST00000330955RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000262231ENST00000306391RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000262231ENST00000523754RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-3CDSENST00000507740ENST00000309982RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000507740ENST00000438105RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000507740ENST00000297574RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000507740ENST00000330955RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000507740ENST00000306391RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000507740ENST00000523754RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-3CDSENST00000522174ENST00000309982RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000522174ENST00000438105RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000522174ENST00000297574RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000522174ENST00000330955RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000522174ENST00000306391RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000522174ENST00000523754RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-3CDSENST00000436393ENST00000309982RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000436393ENST00000438105RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000436393ENST00000297574RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000436393ENST00000330955RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000436393ENST00000306391RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000436393ENST00000523754RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-3CDSENST00000339750ENST00000309982RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000339750ENST00000438105RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000339750ENST00000297574RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000339750ENST00000330955RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000339750ENST00000306391RIMS2chr8

104513290

+BAALCchr8

104225147

+
intron-intronENST00000339750ENST00000523754RIMS2chr8

104513290

+BAALCchr8

104225147

+

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FusionProtFeatures for RIMS2_BAALC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RIMS2

Q9UQ26

BAALC

Q8WXS3

Rab effector involved in exocytosis. May act as scaffoldprotein. Plays a role in dendrite formation by melanocytes(PubMed:23999003). {ECO:0000269|PubMed:23999003}. May play a synaptic role at the postsynaptic lipid raftspossibly through interaction with CAMK2A.{ECO:0000250|UniProtKB:Q920K5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RIMS2_BAALC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RIMS2_BAALC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RIMS2RAPGEF4, YWHAH, MYC, LYNBAALCMDFI, ATXN1, CHEK2, MAP3K1, KLF4, ATP1B3, RNF2, CHD1L, CINP, OSBPL1A, AP1G1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RIMS2_BAALC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RIMS2_BAALC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRIMS2C0036341Schizophrenia1PSYGENET
HgeneRIMS2C0149925Small cell carcinoma of lung1CTD_human
TgeneBAALCC0023467Leukemia, Myelocytic, Acute1CTD_human