|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 3125 |
FusionGeneSummary for ATF4_CDV3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATF4_CDV3 | Fusion gene ID: 3125 | Hgene | Tgene | Gene symbol | ATF4 | CDV3 | Gene ID | 468 | 55573 |
| Gene name | activating transcription factor 4 | CDV3 homolog | |
| Synonyms | CREB-2|CREB2|TAXREB67|TXREB | H41 | |
| Cytomap | 22q13.1 | 3q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclic AMP-dependent transcription factor ATF-4DNA-binding protein TAXREB67cAMP response element-binding protein 2cAMP-dependent transcription factor ATF-4cAMP-responsive element-binding protein 2cyclic AMP-responsive element-binding protein 2tax-re | protein CDV3 homologcarnitine deficiency-associated gene expressed in ventricle 3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P18848 | Q9UKY7 | |
| Ensembl transtripts involved in fusion gene | ENST00000404241, ENST00000337304, ENST00000396680, | ENST00000264993, ENST00000431519, ENST00000508481, ENST00000420115, ENST00000511392, ENST00000515421, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ATF4 [Title/Abstract] AND CDV3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATF4 | GO:0034976 | response to endoplasmic reticulum stress | 19061639 |
| Hgene | ATF4 | GO:0045893 | positive regulation of transcription, DNA-templated | 15775988|18940792 |
| Hgene | ATF4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11478948|15775988|18940792 |
| Hgene | ATF4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 12871976 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM842661 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000404241 | ENST00000264993 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000404241 | ENST00000431519 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000404241 | ENST00000508481 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-3UTR | ENST00000404241 | ENST00000420115 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000404241 | ENST00000511392 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000404241 | ENST00000515421 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-3UTR | ENST00000337304 | ENST00000264993 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000337304 | ENST00000431519 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000337304 | ENST00000508481 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-3UTR | ENST00000337304 | ENST00000420115 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000337304 | ENST00000511392 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000337304 | ENST00000515421 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-3UTR | ENST00000396680 | ENST00000264993 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000396680 | ENST00000431519 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000396680 | ENST00000508481 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-3UTR | ENST00000396680 | ENST00000420115 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000396680 | ENST00000511392 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
| 5CDS-intron | ENST00000396680 | ENST00000515421 | ATF4 | chr22 | 39917501 | + | CDV3 | chr3 | 133308388 | + |
Top |
FusionProtFeatures for ATF4_CDV3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATF4 | CDV3 |
| Transcriptional activator. Binds the cAMP responseelement (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequencepresent in many viral and cellular promoters. Cooperates withFOXO1 in osteoblasts to regulate glucose homeostasis throughsuppression of beta-cell production and decrease in insulinproduction (By similarity). It binds to a Tax-responsive enhancerelement in the long terminal repeat of HTLV-I. Regulates theinduction of DDIT3/CHOP and asparagine synthetase (ASNS) inresponse to endoplasmic reticulum (ER) stress. In concert withDDIT3/CHOP, activates the transcription of TRIB3 and promotes ERstress-induced neuronal apoptosis by regulating thetranscriptional induction of BBC3/PUMA. Activates transcription ofSIRT4. Regulates the circadian expression of the core clockcomponent PER2 and the serotonin transporter SLC6A4. Binds in acircadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activatesthe transcription of these genes. During ER stress response,activates the transcription of NLRP1, possibly in concert withother factors (PubMed:26086088). {ECO:0000250,ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16682973,ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:26086088}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ATF4_CDV3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ATF4_CDV3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ATF4_CDV3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ATF4_CDV3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ATF4 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | ATF4 | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | ATF4 | C0011581 | Depressive disorder | 1 | PSYGENET |
| Hgene | ATF4 | C0027540 | Necrosis | 1 | CTD_human |
| Hgene | ATF4 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | ATF4 | C0242184 | Hypoxia | 1 | CTD_human |
| Hgene | ATF4 | C1134719 | Invasive Ductal Breast Carcinoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|