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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3125

FusionGeneSummary for ATF4_CDV3

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF4_CDV3
Fusion gene ID: 3125
HgeneTgene
Gene symbol

ATF4

CDV3

Gene ID

468

55573

Gene nameactivating transcription factor 4CDV3 homolog
SynonymsCREB-2|CREB2|TAXREB67|TXREBH41
Cytomap

22q13.1

3q22.1

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-4DNA-binding protein TAXREB67cAMP response element-binding protein 2cAMP-dependent transcription factor ATF-4cAMP-responsive element-binding protein 2cyclic AMP-responsive element-binding protein 2tax-reprotein CDV3 homologcarnitine deficiency-associated gene expressed in ventricle 3
Modification date2018052320180519
UniProtAcc

P18848

Q9UKY7

Ensembl transtripts involved in fusion geneENST00000404241, ENST00000337304, 
ENST00000396680, 
ENST00000264993, 
ENST00000431519, ENST00000508481, 
ENST00000420115, ENST00000511392, 
ENST00000515421, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: ATF4 [Title/Abstract] AND CDV3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF4

GO:0034976

response to endoplasmic reticulum stress

19061639

HgeneATF4

GO:0045893

positive regulation of transcription, DNA-templated

15775988|18940792

HgeneATF4

GO:0045944

positive regulation of transcription by RNA polymerase II

11478948|15775988|18940792

HgeneATF4

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

12871976


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM842661ATF4chr22

39917501

+CDV3chr3

133308388

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000404241ENST00000264993ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000404241ENST00000431519ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000404241ENST00000508481ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-3UTRENST00000404241ENST00000420115ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000404241ENST00000511392ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000404241ENST00000515421ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-3UTRENST00000337304ENST00000264993ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000337304ENST00000431519ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000337304ENST00000508481ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-3UTRENST00000337304ENST00000420115ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000337304ENST00000511392ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000337304ENST00000515421ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-3UTRENST00000396680ENST00000264993ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000396680ENST00000431519ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000396680ENST00000508481ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-3UTRENST00000396680ENST00000420115ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000396680ENST00000511392ATF4chr22

39917501

+CDV3chr3

133308388

+
5CDS-intronENST00000396680ENST00000515421ATF4chr22

39917501

+CDV3chr3

133308388

+

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FusionProtFeatures for ATF4_CDV3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF4

P18848

CDV3

Q9UKY7

Transcriptional activator. Binds the cAMP responseelement (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequencepresent in many viral and cellular promoters. Cooperates withFOXO1 in osteoblasts to regulate glucose homeostasis throughsuppression of beta-cell production and decrease in insulinproduction (By similarity). It binds to a Tax-responsive enhancerelement in the long terminal repeat of HTLV-I. Regulates theinduction of DDIT3/CHOP and asparagine synthetase (ASNS) inresponse to endoplasmic reticulum (ER) stress. In concert withDDIT3/CHOP, activates the transcription of TRIB3 and promotes ERstress-induced neuronal apoptosis by regulating thetranscriptional induction of BBC3/PUMA. Activates transcription ofSIRT4. Regulates the circadian expression of the core clockcomponent PER2 and the serotonin transporter SLC6A4. Binds in acircadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activatesthe transcription of these genes. During ER stress response,activates the transcription of NLRP1, possibly in concert withother factors (PubMed:26086088). {ECO:0000250,ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16682973,ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:26086088}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATF4_CDV3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATF4_CDV3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATF4_CDV3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATF4_CDV3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATF4C0005586Bipolar Disorder2PSYGENET
HgeneATF4C0011570Mental Depression1PSYGENET
HgeneATF4C0011581Depressive disorder1PSYGENET
HgeneATF4C0027540Necrosis1CTD_human
HgeneATF4C0036341Schizophrenia1PSYGENET
HgeneATF4C0242184Hypoxia1CTD_human
HgeneATF4C1134719Invasive Ductal Breast Carcinoma1CTD_human