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Fusion gene ID: 31236 |
FusionGeneSummary for RICTOR_ISL1 |
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Fusion gene information | Fusion gene name: RICTOR_ISL1 | Fusion gene ID: 31236 | Hgene | Tgene | Gene symbol | RICTOR | ISL1 | Gene ID | 253260 | 3670 |
Gene name | RPTOR independent companion of MTOR complex 2 | ISL LIM homeobox 1 | |
Synonyms | AVO3|PIA|hAVO3 | ISLET1|Isl-1 | |
Cytomap | 5p13.1 | 5q11.1 | |
Type of gene | protein-coding | protein-coding | |
Description | rapamycin-insensitive companion of mTORAVO3 homologTORC2-specific protein AVO3pianissimo | insulin gene enhancer protein ISL-1ISL1 transcription factor, LIM/homeodomainislet-1 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q6R327 | P61371 | |
Ensembl transtripts involved in fusion gene | ENST00000357387, ENST00000296782, ENST00000503698, | ENST00000230658, ENST00000511384, ENST00000505475, | |
Fusion gene scores | * DoF score | 11 X 4 X 9=396 | 1 X 1 X 1=1 |
# samples | 12 | 1 | |
** MAII score | log2(12/396*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RICTOR [Title/Abstract] AND ISL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RICTOR | GO:0051896 | regulation of protein kinase B signaling | 15718470 |
Tgene | ISL1 | GO:0060913 | cardiac cell fate determination | 19571884 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | COAD | TCGA-CA-5254-01A | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000357387 | ENST00000230658 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
In-frame | ENST00000357387 | ENST00000511384 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
5CDS-intron | ENST00000357387 | ENST00000505475 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
In-frame | ENST00000296782 | ENST00000230658 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
In-frame | ENST00000296782 | ENST00000511384 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
5CDS-intron | ENST00000296782 | ENST00000505475 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
intron-3CDS | ENST00000503698 | ENST00000230658 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
intron-3CDS | ENST00000503698 | ENST00000511384 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
intron-intron | ENST00000503698 | ENST00000505475 | RICTOR | chr5 | 39074213 | - | ISL1 | chr5 | 50680375 | + |
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FusionProtFeatures for RICTOR_ISL1 |
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Hgene | Tgene |
RICTOR | ISL1 |
Subunit of mTORC2, which regulates cell growth andsurvival in response to hormonal signals. mTORC2 is activated bygrowth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases toregulate the actin cytoskeleton, probably by activating one ormore Rho-type guanine nucleotide exchange factors. mTORC2 promotesthe serum-induced formation of stress-fibers or F-actin. mTORC2plays a critical role in AKT1 'Ser-473' phosphorylation, which mayfacilitate the phosphorylation of the activation loop of AKT1 on'Thr-308' by PDK1 which is a prerequisite for full activation.mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays anessential role in embryonic growth and development.{ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718,ECO:0000269|PubMed:15718470}. | DNA-binding transcriptional activator. Recognizes andbinds to the consensus octamer binding site 5'-ATAATTAA-3' inpromoter of target genes. Plays a fundamental role in the generegulatory network essential for retinal ganglion cell (RGC)differentiation. Cooperates with the transcription factor POU4F2to achieve maximal levels of expression of RGC target genes andRGC fate specification in the developing retina. Involved in thespecification of motor neurons in cooperation with LHX3 and LDB1.Binds to insulin gene enhancer sequences. Essential for heartdevelopment. Marker of one progenitor cell population that giverise to the outflow tract, right ventricle, a subset of leftventricular cells, and a large number of atrial cells as well, itsfunction is required for these progenitors to contribute to theheart. Controls the expression of FGF and BMP growth factors inthis cell population and is required for proliferation andsurvival of cells within pharyngeal foregut endoderm and adjacentsplanchnic mesoderm as well as for migration of cardiacprogenitors into the heart (By similarity).{ECO:0000250|UniProtKB:P61372, ECO:0000250|UniProtKB:P61374}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >ISL1 | chr5:39074213 | chr5:50680375 | ENST00000230658 | + | 0 | 6 | 241_349 | 9 | 350 | Compositional bias | Note=Gln-rich |
Tgene | >ISL1 | chr5:39074213 | chr5:50680375 | ENST00000230658 | + | 0 | 6 | 181_240 | 9 | 350 | DNA binding | Homeobox |
Tgene | >ISL1 | chr5:39074213 | chr5:50680375 | ENST00000230658 | + | 0 | 6 | 17_70 | 9 | 350 | Domain | LIM zinc-binding 1 |
Tgene | >ISL1 | chr5:39074213 | chr5:50680375 | ENST00000230658 | + | 0 | 6 | 79_133 | 9 | 350 | Domain | LIM zinc-binding 2 |
Tgene | >ISL1 | chr5:39074213 | chr5:50680375 | ENST00000230658 | + | 0 | 6 | 262_291 | 9 | 350 | Region | LIM-binding domain (LID) |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >RICTOR | chr5:39074213 | chr5:50680375 | ENST00000296782 | - | 2 | 39 | 1016_1058 | 32 | 1733 | Compositional bias | Ser-rich |
Hgene | >RICTOR | chr5:39074213 | chr5:50680375 | ENST00000357387 | - | 2 | 38 | 1016_1058 | 32 | 1709 | Compositional bias | Ser-rich |
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FusionGeneSequence for RICTOR_ISL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_373aa MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYC KRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQ MAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQ QQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPD >In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_350aa MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYC KRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQ MAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQ >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_373aa MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYC KRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQ MAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQ QQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPD >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_350aa MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYC KRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQ MAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQ |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_1119nt ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG ACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAA TGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGTTAGGGATGGGAAAACCTACTGT AAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGACTTCGTGATGCGTGCCCGCTCC AAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATTTGCGCTTCGGGAGGACGGTCTC TTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCTGCATCCAGCGCGGCCACTGCAA ATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAAGACCACCCGCGTGCGGACTGTG CTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCATGAAGGAGCAACTGGTAGAGATG ACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAGCATCATGATGAAGCAACTCCAG CAGCAGCAGCCCAATGACAAAACTAATATCCAGGGGATGACAGGAACTCCCATGGTGGCTGCCAGTCCAGAGAGACACGACGGTGGCTTA CAGGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCAGAGTGACATAGATCAGCCTGCT TTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATCAATGTCCTCTCAACTTCCAGAT >In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_1050nt ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG ACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAA TGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGTTAGGGATGGGAAAACCTACTGT AAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGACTTCGTGATGCGTGCCCGCTCC AAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATTTGCGCTTCGGGAGGACGGTCTC TTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCTGCATCCAGCGCGGCCACTGCAA ATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAAGACCACCCGCGTGCGGACTGTG CTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCATGAAGGAGCAACTGGTAGAGATG ACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAGCATCATGATGAAGCAACTCCAG CAGCAGCAGCCCAATGACAAAACTGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCAG AGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATCA >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_1119nt ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG ACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAA TGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGTTAGGGATGGGAAAACCTACTGT AAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGACTTCGTGATGCGTGCCCGCTCC AAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATTTGCGCTTCGGGAGGACGGTCTC TTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCTGCATCCAGCGCGGCCACTGCAA ATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAAGACCACCCGCGTGCGGACTGTG CTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCATGAAGGAGCAACTGGTAGAGATG ACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAGCATCATGATGAAGCAACTCCAG CAGCAGCAGCCCAATGACAAAACTAATATCCAGGGGATGACAGGAACTCCCATGGTGGCTGCCAGTCCAGAGAGACACGACGGTGGCTTA CAGGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCAGAGTGACATAGATCAGCCTGCT TTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATCAATGTCCTCTCAACTTCCAGAT >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_1050nt ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG ACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAA TGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGTTAGGGATGGGAAAACCTACTGT AAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGACTTCGTGATGCGTGCCCGCTCC AAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATTTGCGCTTCGGGAGGACGGTCTC TTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCTGCATCCAGCGCGGCCACTGCAA ATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAAGACCACCCGCGTGCGGACTGTG CTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCATGAAGGAGCAACTGGTAGAGATG ACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAGCATCATGATGAAGCAACTCCAG CAGCAGCAGCCCAATGACAAAACTGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCAG AGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATCA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_2270nt GTTTCCGGTGTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGA CAGCGGCGAGGAGAACGTCCCGCTGGATCTGACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCA GTATATTCTGAGGGTTTCTCCGGATTTGGAATGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTAC ATGCTTTGTTAGGGATGGGAAAACCTACTGTAAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAG CAAGAACGACTTCGTGATGCGTGCCCGCTCCAAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGG GGACGAATTTGCGCTTCGGGAGGACGGTCTCTTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCT CAGTCCCCTGCATCCAGCGCGGCCACTGCAAATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCA GCCGGAGAAGACCACCCGCGTGCGGACTGTGCTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGA TGCGCTCATGAAGGAGCAACTGGTAGAGATGACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAA GAAGCGAAGCATCATGATGAAGCAACTCCAGCAGCAGCAGCCCAATGACAAAACTAATATCCAGGGGATGACAGGAACTCCCATGGTGGC TGCCAGTCCAGAGAGACACGACGGTGGCTTACAGGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTT CGCCTTGCAGAGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGA AGTAGCATCAATGTCCTCTCAACTTCCAGATACACCTAACAGCATGGTAGCCAGTCCTATTGAGGCATGAGGAACATTCATTCTGTATTT TTTTTCCCTGTTGGAGAAAGTGGGAAATTATAATGTCGAACTCTGAAACAAAAGTATTTAACGACCCAGTCAATGAAAACTGAATCAAGA AATGAATGCTCCATGAAATGCACGAAGTCTGTTTTAATGACAAGGTGATATGGTAGCAACACTGTGAAGACAATCATGGGATTTTACTAG AATTAAACAACAAACAAAACGCAAAACCCAGTATATGCTATTCAATGATCTTAGAAGTACTGAAAAAAAAAGACGTTTTTAAAACGTAGA GGATTTATATTCAAGGATCTCAAAGAAAGCATTTTCATTTCACTGCACATCTAGAGAAAAACAAAAATAGAAAATTTTCTAGTCCATCCT AATCTGAATGGTGCTGTTTCTATATTGGTCATTGCCTTGCCAAACAGGAGCTCCAGCAAAAGCGCAGGAAGAGAGACTGGCCTCCTTGGC TGAAAGAGTCCTTTCAGGAAGGTGGAGCTGCATTGGTTTGATATGTTTAAAGTTGACTTTAACAAGGGGTTAATTGAAATCCTGGGTCTC TTGGCCTGTCCTGTAGCTGGTTTATTTTTTACTTTGCCCCCTCCCCACTTTTTTTGAGATCCATCCTTTATCAAGAAGTCTGAAGCGACT ATAAAGGTTTTTGAATTCAGATTTAAAAACCAACTTATAAAGCATTGCAACAAGGTTACCTCTATTTTGCCACAAGCGTCTCGGGATTGT GTTTGACTTGTGTCTGTCCAAGAACTTTTCCCCCAAAGATGTGTATAGTTATTGGTTAAAATGACTGTTTTCTCTCTCTATGGAAATAAA AAGGAAAAAAAAAAAGGAAACTTTTTTTGTTTGCTCTTGCATTGCAAAAATTATAAAGTAATTTATTATTTATTGTCGGAAGACTTGCCA CTTTTCATGTCATTTGACATTTTTTGTTTGCTGAAGTGAAAAAAAAAGATAAAGGTTGTACGGTGGTCTTTGAATTATATGTCTAATTCT ATGTGTTTTGTCTTTTTCTTAAATATTATGTGAAATCAAAGCGCCATATGTAGAATTATATCTTCAGGACTATTTCACTAATAAACATTT >In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_1081nt GTTTCCGGTGTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGA CAGCGGCGAGGAGAACGTCCCGCTGGATCTGACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCA GTATATTCTGAGGGTTTCTCCGGATTTGGAATGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTAC ATGCTTTGTTAGGGATGGGAAAACCTACTGTAAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAG CAAGAACGACTTCGTGATGCGTGCCCGCTCCAAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGG GGACGAATTTGCGCTTCGGGAGGACGGTCTCTTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCT CAGTCCCCTGCATCCAGCGCGGCCACTGCAAATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCA GCCGGAGAAGACCACCCGCGTGCGGACTGTGCTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGA TGCGCTCATGAAGGAGCAACTGGTAGAGATGACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAA GAAGCGAAGCATCATGATGAAGCAACTCCAGCAGCAGCAGCCCAATGACAAAACTGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACC TTGGAAAGTACTGAGCGACTTCGCCTTGCAGAGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGG CTCTAATTCCACTGGCAGTGAAGTAGCATCAATGTCCTCTCAACTTCCAGATACACCTAACAGCATGGTAGCCAGTCCTATTGAGGCATG >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_2261nt GTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGA GGAGAACGTCCCGCTGGATCTGACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCT GAGGGTTTCTCCGGATTTGGAATGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGT TAGGGATGGGAAAACCTACTGTAAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGA CTTCGTGATGCGTGCCCGCTCCAAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATT TGCGCTTCGGGAGGACGGTCTCTTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCT GCATCCAGCGCGGCCACTGCAAATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAA GACCACCCGCGTGCGGACTGTGCTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCAT GAAGGAGCAACTGGTAGAGATGACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAG CATCATGATGAAGCAACTCCAGCAGCAGCAGCCCAATGACAAAACTAATATCCAGGGGATGACAGGAACTCCCATGGTGGCTGCCAGTCC AGAGAGACACGACGGTGGCTTACAGGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCA GAGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATC AATGTCCTCTCAACTTCCAGATACACCTAACAGCATGGTAGCCAGTCCTATTGAGGCATGAGGAACATTCATTCTGTATTTTTTTTCCCT GTTGGAGAAAGTGGGAAATTATAATGTCGAACTCTGAAACAAAAGTATTTAACGACCCAGTCAATGAAAACTGAATCAAGAAATGAATGC TCCATGAAATGCACGAAGTCTGTTTTAATGACAAGGTGATATGGTAGCAACACTGTGAAGACAATCATGGGATTTTACTAGAATTAAACA ACAAACAAAACGCAAAACCCAGTATATGCTATTCAATGATCTTAGAAGTACTGAAAAAAAAAGACGTTTTTAAAACGTAGAGGATTTATA TTCAAGGATCTCAAAGAAAGCATTTTCATTTCACTGCACATCTAGAGAAAAACAAAAATAGAAAATTTTCTAGTCCATCCTAATCTGAAT GGTGCTGTTTCTATATTGGTCATTGCCTTGCCAAACAGGAGCTCCAGCAAAAGCGCAGGAAGAGAGACTGGCCTCCTTGGCTGAAAGAGT CCTTTCAGGAAGGTGGAGCTGCATTGGTTTGATATGTTTAAAGTTGACTTTAACAAGGGGTTAATTGAAATCCTGGGTCTCTTGGCCTGT CCTGTAGCTGGTTTATTTTTTACTTTGCCCCCTCCCCACTTTTTTTGAGATCCATCCTTTATCAAGAAGTCTGAAGCGACTATAAAGGTT TTTGAATTCAGATTTAAAAACCAACTTATAAAGCATTGCAACAAGGTTACCTCTATTTTGCCACAAGCGTCTCGGGATTGTGTTTGACTT GTGTCTGTCCAAGAACTTTTCCCCCAAAGATGTGTATAGTTATTGGTTAAAATGACTGTTTTCTCTCTCTATGGAAATAAAAAGGAAAAA AAAAAAGGAAACTTTTTTTGTTTGCTCTTGCATTGCAAAAATTATAAAGTAATTTATTATTTATTGTCGGAAGACTTGCCACTTTTCATG TCATTTGACATTTTTTGTTTGCTGAAGTGAAAAAAAAAGATAAAGGTTGTACGGTGGTCTTTGAATTATATGTCTAATTCTATGTGTTTT GTCTTTTTCTTAAATATTATGTGAAATCAAAGCGCCATATGTAGAATTATATCTTCAGGACTATTTCACTAATAAACATTTGGCATAGAT >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_1072nt GTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGA GGAGAACGTCCCGCTGGATCTGACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCT GAGGGTTTCTCCGGATTTGGAATGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGT TAGGGATGGGAAAACCTACTGTAAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGA CTTCGTGATGCGTGCCCGCTCCAAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATT TGCGCTTCGGGAGGACGGTCTCTTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCT GCATCCAGCGCGGCCACTGCAAATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAA GACCACCCGCGTGCGGACTGTGCTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCAT GAAGGAGCAACTGGTAGAGATGACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAG CATCATGATGAAGCAACTCCAGCAGCAGCAGCCCAATGACAAAACTGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGT ACTGAGCGACTTCGCCTTGCAGAGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTC |
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FusionGenePPI for RICTOR_ISL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RICTOR | MTOR, RPS6KB1, MAPKAP1, PRR5, MLST8, CPS1, CLTC, HSPA4, TUBA1A, TUBA1B, TIA1, RPS3A, RPL13, ABHD16A, EHMT2, DHX36, DHRS4, PRR5L, SGK1, CUL1, RBX1, RPL23, RPS6, RPL23A, RPL26, RPS5, ELAVL1, USP9X, FBXW7, AKT1, RPTOR, PRKCA, PINK1, STK38, BRCA1, DDB1, DEPTOR, PREX1, PDIA3, YWHAB, FKBP8, GNB1, GNG2, ILK, PARD6A, GSK3B, IKBKB, CHUK, SIRT1, NBN, RNF2, PCGF6, ANTXR1, SDF4, MAPK14, GSK3A, XPO1, MKNK2, TUBG1, PLK1, PTPRH, SKP2, TSHB, IL17RA, RAPGEF5, CDC16, AVIL, PROZ, C6orf141, TUBGCP5, NCAPH2, CRYBA4, IL13RA2, AARSD1, NXF2, P4HA2, TKTL1, TSPYL1, ASB3, RUVBL2, TRIM25 | ISL1 | ISL1, LMX1A, LHX3, ISL2, LMO2, ESR1, PECR, NR2F1, LDB2, LHX4, SSBP4, COPS5, APP, CDK6, CDKN2B, SMAD3, RELA, KDM1A, ZNF511, SSBP2, SSBP3, CRK, PLCG2, NFATC1, MAFA, MAFB, ARIH1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | RICTOR | chr5:39074213 | chr5:50680375 | ENST00000296782 | - | 2 | 39 | 1_789 | 32 | 1733 | NBN |
Hgene | RICTOR | chr5:39074213 | chr5:50680375 | ENST00000357387 | - | 2 | 38 | 1_789 | 32 | 1709 | NBN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RICTOR_ISL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RICTOR_ISL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ISL1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | ISL1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | ISL1 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |