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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 31236

FusionGeneSummary for RICTOR_ISL1

check button Fusion gene summary
Fusion gene informationFusion gene name: RICTOR_ISL1
Fusion gene ID: 31236
HgeneTgene
Gene symbol

RICTOR

ISL1

Gene ID

253260

3670

Gene nameRPTOR independent companion of MTOR complex 2ISL LIM homeobox 1
SynonymsAVO3|PIA|hAVO3ISLET1|Isl-1
Cytomap

5p13.1

5q11.1

Type of geneprotein-codingprotein-coding
Descriptionrapamycin-insensitive companion of mTORAVO3 homologTORC2-specific protein AVO3pianissimoinsulin gene enhancer protein ISL-1ISL1 transcription factor, LIM/homeodomainislet-1
Modification date2018052320180522
UniProtAcc

Q6R327

P61371

Ensembl transtripts involved in fusion geneENST00000357387, ENST00000296782, 
ENST00000503698, 
ENST00000230658, 
ENST00000511384, ENST00000505475, 
Fusion gene scores* DoF score11 X 4 X 9=3961 X 1 X 1=1
# samples 121
** MAII scorelog2(12/396*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: RICTOR [Title/Abstract] AND ISL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRICTOR

GO:0051896

regulation of protein kinase B signaling

15718470

TgeneISL1

GO:0060913

cardiac cell fate determination

19571884


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-CA-5254-01ARICTORchr5

39074213

-ISL1chr5

50680375

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000357387ENST00000230658RICTORchr5

39074213

-ISL1chr5

50680375

+
In-frameENST00000357387ENST00000511384RICTORchr5

39074213

-ISL1chr5

50680375

+
5CDS-intronENST00000357387ENST00000505475RICTORchr5

39074213

-ISL1chr5

50680375

+
In-frameENST00000296782ENST00000230658RICTORchr5

39074213

-ISL1chr5

50680375

+
In-frameENST00000296782ENST00000511384RICTORchr5

39074213

-ISL1chr5

50680375

+
5CDS-intronENST00000296782ENST00000505475RICTORchr5

39074213

-ISL1chr5

50680375

+
intron-3CDSENST00000503698ENST00000230658RICTORchr5

39074213

-ISL1chr5

50680375

+
intron-3CDSENST00000503698ENST00000511384RICTORchr5

39074213

-ISL1chr5

50680375

+
intron-intronENST00000503698ENST00000505475RICTORchr5

39074213

-ISL1chr5

50680375

+

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FusionProtFeatures for RICTOR_ISL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RICTOR

Q6R327

ISL1

P61371

Subunit of mTORC2, which regulates cell growth andsurvival in response to hormonal signals. mTORC2 is activated bygrowth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases toregulate the actin cytoskeleton, probably by activating one ormore Rho-type guanine nucleotide exchange factors. mTORC2 promotesthe serum-induced formation of stress-fibers or F-actin. mTORC2plays a critical role in AKT1 'Ser-473' phosphorylation, which mayfacilitate the phosphorylation of the activation loop of AKT1 on'Thr-308' by PDK1 which is a prerequisite for full activation.mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays anessential role in embryonic growth and development.{ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718,ECO:0000269|PubMed:15718470}. DNA-binding transcriptional activator. Recognizes andbinds to the consensus octamer binding site 5'-ATAATTAA-3' inpromoter of target genes. Plays a fundamental role in the generegulatory network essential for retinal ganglion cell (RGC)differentiation. Cooperates with the transcription factor POU4F2to achieve maximal levels of expression of RGC target genes andRGC fate specification in the developing retina. Involved in thespecification of motor neurons in cooperation with LHX3 and LDB1.Binds to insulin gene enhancer sequences. Essential for heartdevelopment. Marker of one progenitor cell population that giverise to the outflow tract, right ventricle, a subset of leftventricular cells, and a large number of atrial cells as well, itsfunction is required for these progenitors to contribute to theheart. Controls the expression of FGF and BMP growth factors inthis cell population and is required for proliferation andsurvival of cells within pharyngeal foregut endoderm and adjacentsplanchnic mesoderm as well as for migration of cardiacprogenitors into the heart (By similarity).{ECO:0000250|UniProtKB:P61372, ECO:0000250|UniProtKB:P61374}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneISL1chr5:39074213chr5:50680375ENST00000230658+06241_3499350Compositional biasNote=Gln-rich
TgeneISL1chr5:39074213chr5:50680375ENST00000230658+06181_2409350DNA bindingHomeobox
TgeneISL1chr5:39074213chr5:50680375ENST00000230658+0617_709350DomainLIM zinc-binding 1
TgeneISL1chr5:39074213chr5:50680375ENST00000230658+0679_1339350DomainLIM zinc-binding 2
TgeneISL1chr5:39074213chr5:50680375ENST00000230658+06262_2919350RegionLIM-binding domain (LID)

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRICTORchr5:39074213chr5:50680375ENST00000296782-2391016_1058321733Compositional biasSer-rich
HgeneRICTORchr5:39074213chr5:50680375ENST00000357387-2381016_1058321709Compositional biasSer-rich


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FusionGeneSequence for RICTOR_ISL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_373aa
MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYC
KRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQ
MAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQ
QQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPD

>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_350aa
MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYC
KRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQ
MAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQ

>In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_373aa
MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYC
KRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQ
MAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQ
QQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPD

>In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_350aa
MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYC
KRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQ
MAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_1119nt
ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG
ACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAA
TGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGTTAGGGATGGGAAAACCTACTGT
AAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGACTTCGTGATGCGTGCCCGCTCC
AAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATTTGCGCTTCGGGAGGACGGTCTC
TTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCTGCATCCAGCGCGGCCACTGCAA
ATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAAGACCACCCGCGTGCGGACTGTG
CTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCATGAAGGAGCAACTGGTAGAGATG
ACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAGCATCATGATGAAGCAACTCCAG
CAGCAGCAGCCCAATGACAAAACTAATATCCAGGGGATGACAGGAACTCCCATGGTGGCTGCCAGTCCAGAGAGACACGACGGTGGCTTA
CAGGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCAGAGTGACATAGATCAGCCTGCT
TTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATCAATGTCCTCTCAACTTCCAGAT

>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_1050nt
ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG
ACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAA
TGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGTTAGGGATGGGAAAACCTACTGT
AAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGACTTCGTGATGCGTGCCCGCTCC
AAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATTTGCGCTTCGGGAGGACGGTCTC
TTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCTGCATCCAGCGCGGCCACTGCAA
ATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAAGACCACCCGCGTGCGGACTGTG
CTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCATGAAGGAGCAACTGGTAGAGATG
ACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAGCATCATGATGAAGCAACTCCAG
CAGCAGCAGCCCAATGACAAAACTGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCAG
AGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATCA

>In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_1119nt
ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG
ACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAA
TGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGTTAGGGATGGGAAAACCTACTGT
AAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGACTTCGTGATGCGTGCCCGCTCC
AAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATTTGCGCTTCGGGAGGACGGTCTC
TTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCTGCATCCAGCGCGGCCACTGCAA
ATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAAGACCACCCGCGTGCGGACTGTG
CTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCATGAAGGAGCAACTGGTAGAGATG
ACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAGCATCATGATGAAGCAACTCCAG
CAGCAGCAGCCCAATGACAAAACTAATATCCAGGGGATGACAGGAACTCCCATGGTGGCTGCCAGTCCAGAGAGACACGACGGTGGCTTA
CAGGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCAGAGTGACATAGATCAGCCTGCT
TTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATCAATGTCCTCTCAACTTCCAGAT

>In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_1050nt
ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG
ACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCTGAGGGTTTCTCCGGATTTGGAA
TGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGTTAGGGATGGGAAAACCTACTGT
AAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGACTTCGTGATGCGTGCCCGCTCC
AAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATTTGCGCTTCGGGAGGACGGTCTC
TTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCTGCATCCAGCGCGGCCACTGCAA
ATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAAGACCACCCGCGTGCGGACTGTG
CTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCATGAAGGAGCAACTGGTAGAGATG
ACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAGCATCATGATGAAGCAACTCCAG
CAGCAGCAGCCCAATGACAAAACTGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCAG
AGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_2270nt
GTTTCCGGTGTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGA
CAGCGGCGAGGAGAACGTCCCGCTGGATCTGACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCA
GTATATTCTGAGGGTTTCTCCGGATTTGGAATGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTAC
ATGCTTTGTTAGGGATGGGAAAACCTACTGTAAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAG
CAAGAACGACTTCGTGATGCGTGCCCGCTCCAAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGG
GGACGAATTTGCGCTTCGGGAGGACGGTCTCTTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCT
CAGTCCCCTGCATCCAGCGCGGCCACTGCAAATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCA
GCCGGAGAAGACCACCCGCGTGCGGACTGTGCTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGA
TGCGCTCATGAAGGAGCAACTGGTAGAGATGACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAA
GAAGCGAAGCATCATGATGAAGCAACTCCAGCAGCAGCAGCCCAATGACAAAACTAATATCCAGGGGATGACAGGAACTCCCATGGTGGC
TGCCAGTCCAGAGAGACACGACGGTGGCTTACAGGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTT
CGCCTTGCAGAGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGA
AGTAGCATCAATGTCCTCTCAACTTCCAGATACACCTAACAGCATGGTAGCCAGTCCTATTGAGGCATGAGGAACATTCATTCTGTATTT
TTTTTCCCTGTTGGAGAAAGTGGGAAATTATAATGTCGAACTCTGAAACAAAAGTATTTAACGACCCAGTCAATGAAAACTGAATCAAGA
AATGAATGCTCCATGAAATGCACGAAGTCTGTTTTAATGACAAGGTGATATGGTAGCAACACTGTGAAGACAATCATGGGATTTTACTAG
AATTAAACAACAAACAAAACGCAAAACCCAGTATATGCTATTCAATGATCTTAGAAGTACTGAAAAAAAAAGACGTTTTTAAAACGTAGA
GGATTTATATTCAAGGATCTCAAAGAAAGCATTTTCATTTCACTGCACATCTAGAGAAAAACAAAAATAGAAAATTTTCTAGTCCATCCT
AATCTGAATGGTGCTGTTTCTATATTGGTCATTGCCTTGCCAAACAGGAGCTCCAGCAAAAGCGCAGGAAGAGAGACTGGCCTCCTTGGC
TGAAAGAGTCCTTTCAGGAAGGTGGAGCTGCATTGGTTTGATATGTTTAAAGTTGACTTTAACAAGGGGTTAATTGAAATCCTGGGTCTC
TTGGCCTGTCCTGTAGCTGGTTTATTTTTTACTTTGCCCCCTCCCCACTTTTTTTGAGATCCATCCTTTATCAAGAAGTCTGAAGCGACT
ATAAAGGTTTTTGAATTCAGATTTAAAAACCAACTTATAAAGCATTGCAACAAGGTTACCTCTATTTTGCCACAAGCGTCTCGGGATTGT
GTTTGACTTGTGTCTGTCCAAGAACTTTTCCCCCAAAGATGTGTATAGTTATTGGTTAAAATGACTGTTTTCTCTCTCTATGGAAATAAA
AAGGAAAAAAAAAAAGGAAACTTTTTTTGTTTGCTCTTGCATTGCAAAAATTATAAAGTAATTTATTATTTATTGTCGGAAGACTTGCCA
CTTTTCATGTCATTTGACATTTTTTGTTTGCTGAAGTGAAAAAAAAAGATAAAGGTTGTACGGTGGTCTTTGAATTATATGTCTAATTCT
ATGTGTTTTGTCTTTTTCTTAAATATTATGTGAAATCAAAGCGCCATATGTAGAATTATATCTTCAGGACTATTTCACTAATAAACATTT

>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_1081nt
GTTTCCGGTGTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGA
CAGCGGCGAGGAGAACGTCCCGCTGGATCTGACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCA
GTATATTCTGAGGGTTTCTCCGGATTTGGAATGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTAC
ATGCTTTGTTAGGGATGGGAAAACCTACTGTAAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAG
CAAGAACGACTTCGTGATGCGTGCCCGCTCCAAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGG
GGACGAATTTGCGCTTCGGGAGGACGGTCTCTTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCT
CAGTCCCCTGCATCCAGCGCGGCCACTGCAAATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCA
GCCGGAGAAGACCACCCGCGTGCGGACTGTGCTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGA
TGCGCTCATGAAGGAGCAACTGGTAGAGATGACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAA
GAAGCGAAGCATCATGATGAAGCAACTCCAGCAGCAGCAGCCCAATGACAAAACTGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACC
TTGGAAAGTACTGAGCGACTTCGCCTTGCAGAGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGG
CTCTAATTCCACTGGCAGTGAAGTAGCATCAATGTCCTCTCAACTTCCAGATACACCTAACAGCATGGTAGCCAGTCCTATTGAGGCATG

>In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000230658_chr5_50680375_+_2261nt
GTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGA
GGAGAACGTCCCGCTGGATCTGACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCT
GAGGGTTTCTCCGGATTTGGAATGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGT
TAGGGATGGGAAAACCTACTGTAAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGA
CTTCGTGATGCGTGCCCGCTCCAAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATT
TGCGCTTCGGGAGGACGGTCTCTTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCT
GCATCCAGCGCGGCCACTGCAAATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAA
GACCACCCGCGTGCGGACTGTGCTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCAT
GAAGGAGCAACTGGTAGAGATGACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAG
CATCATGATGAAGCAACTCCAGCAGCAGCAGCCCAATGACAAAACTAATATCCAGGGGATGACAGGAACTCCCATGGTGGCTGCCAGTCC
AGAGAGACACGACGGTGGCTTACAGGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGTACTGAGCGACTTCGCCTTGCA
GAGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTCCACTGGCAGTGAAGTAGCATC
AATGTCCTCTCAACTTCCAGATACACCTAACAGCATGGTAGCCAGTCCTATTGAGGCATGAGGAACATTCATTCTGTATTTTTTTTCCCT
GTTGGAGAAAGTGGGAAATTATAATGTCGAACTCTGAAACAAAAGTATTTAACGACCCAGTCAATGAAAACTGAATCAAGAAATGAATGC
TCCATGAAATGCACGAAGTCTGTTTTAATGACAAGGTGATATGGTAGCAACACTGTGAAGACAATCATGGGATTTTACTAGAATTAAACA
ACAAACAAAACGCAAAACCCAGTATATGCTATTCAATGATCTTAGAAGTACTGAAAAAAAAAGACGTTTTTAAAACGTAGAGGATTTATA
TTCAAGGATCTCAAAGAAAGCATTTTCATTTCACTGCACATCTAGAGAAAAACAAAAATAGAAAATTTTCTAGTCCATCCTAATCTGAAT
GGTGCTGTTTCTATATTGGTCATTGCCTTGCCAAACAGGAGCTCCAGCAAAAGCGCAGGAAGAGAGACTGGCCTCCTTGGCTGAAAGAGT
CCTTTCAGGAAGGTGGAGCTGCATTGGTTTGATATGTTTAAAGTTGACTTTAACAAGGGGTTAATTGAAATCCTGGGTCTCTTGGCCTGT
CCTGTAGCTGGTTTATTTTTTACTTTGCCCCCTCCCCACTTTTTTTGAGATCCATCCTTTATCAAGAAGTCTGAAGCGACTATAAAGGTT
TTTGAATTCAGATTTAAAAACCAACTTATAAAGCATTGCAACAAGGTTACCTCTATTTTGCCACAAGCGTCTCGGGATTGTGTTTGACTT
GTGTCTGTCCAAGAACTTTTCCCCCAAAGATGTGTATAGTTATTGGTTAAAATGACTGTTTTCTCTCTCTATGGAAATAAAAAGGAAAAA
AAAAAAGGAAACTTTTTTTGTTTGCTCTTGCATTGCAAAAATTATAAAGTAATTTATTATTTATTGTCGGAAGACTTGCCACTTTTCATG
TCATTTGACATTTTTTGTTTGCTGAAGTGAAAAAAAAAGATAAAGGTTGTACGGTGGTCTTTGAATTATATGTCTAATTCTATGTGTTTT
GTCTTTTTCTTAAATATTATGTGAAATCAAAGCGCCATATGTAGAATTATATCTTCAGGACTATTTCACTAATAAACATTTGGCATAGAT

>In-frame_RICTOR_ENST00000296782_chr5_39074213_-_ISL1_ENST00000511384_chr5_50680375_+_1072nt
GTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGA
GGAGAACGTCCCGCTGGATCTGACCCGAGAAAAACGTCTGATTTCCCTATGTGTTGGTTGCGGCAATCAGATTCACGATCAGTATATTCT
GAGGGTTTCTCCGGATTTGGAATGGCATGCGGCATGTTTGAAATGTGCGGAGTGTAATCAGTATTTGGACGAGAGCTGTACATGCTTTGT
TAGGGATGGGAAAACCTACTGTAAAAGAGATTATATCAGGTTGTACGGGATCAAATGCGCCAAGTGCAGCATCGGCTTCAGCAAGAACGA
CTTCGTGATGCGTGCCCGCTCCAAGGTGTATCACATCGAGTGTTTCCGCTGTGTGGCCTGCAGCCGCCAGCTCATCCCTGGGGACGAATT
TGCGCTTCGGGAGGACGGTCTCTTCTGCCGAGCAGACCACGATGTGGTGGAGAGGGCCAGTCTAGGCGCTGGCGACCCGCTCAGTCCCCT
GCATCCAGCGCGGCCACTGCAAATGGCAGCGGAGCCCATCTCCGCCAGGCAGCCAGCCCTGCGGCCCCACGTCCACAAGCAGCCGGAGAA
GACCACCCGCGTGCGGACTGTGCTGAACGAGAAGCAGCTGCACACCTTGCGGACCTGCTACGCCGCAAACCCGCGGCCAGATGCGCTCAT
GAAGGAGCAACTGGTAGAGATGACGGGCCTCAGTCCCCGTGTGATCCGGGTCTGGTTTCAAAACAAGCGGTGCAAGGACAAGAAGCGAAG
CATCATGATGAAGCAACTCCAGCAGCAGCAGCCCAATGACAAAACTGCTAACCCAGTGGAAGTACAAAGTTACCAGCCACCTTGGAAAGT
ACTGAGCGACTTCGCCTTGCAGAGTGACATAGATCAGCCTGCTTTTCAGCAACTGGTCAATTTTTCAGAAGGAGGACCGGGCTCTAATTC


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FusionGenePPI for RICTOR_ISL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RICTORMTOR, RPS6KB1, MAPKAP1, PRR5, MLST8, CPS1, CLTC, HSPA4, TUBA1A, TUBA1B, TIA1, RPS3A, RPL13, ABHD16A, EHMT2, DHX36, DHRS4, PRR5L, SGK1, CUL1, RBX1, RPL23, RPS6, RPL23A, RPL26, RPS5, ELAVL1, USP9X, FBXW7, AKT1, RPTOR, PRKCA, PINK1, STK38, BRCA1, DDB1, DEPTOR, PREX1, PDIA3, YWHAB, FKBP8, GNB1, GNG2, ILK, PARD6A, GSK3B, IKBKB, CHUK, SIRT1, NBN, RNF2, PCGF6, ANTXR1, SDF4, MAPK14, GSK3A, XPO1, MKNK2, TUBG1, PLK1, PTPRH, SKP2, TSHB, IL17RA, RAPGEF5, CDC16, AVIL, PROZ, C6orf141, TUBGCP5, NCAPH2, CRYBA4, IL13RA2, AARSD1, NXF2, P4HA2, TKTL1, TSPYL1, ASB3, RUVBL2, TRIM25ISL1ISL1, LMX1A, LHX3, ISL2, LMO2, ESR1, PECR, NR2F1, LDB2, LHX4, SSBP4, COPS5, APP, CDK6, CDKN2B, SMAD3, RELA, KDM1A, ZNF511, SSBP2, SSBP3, CRK, PLCG2, NFATC1, MAFA, MAFB, ARIH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRICTORchr5:39074213chr5:50680375ENST00000296782-2391_789321733NBN
HgeneRICTORchr5:39074213chr5:50680375ENST00000357387-2381_789321709NBN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RICTOR_ISL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RICTOR_ISL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneISL1C0005586Bipolar Disorder1PSYGENET
TgeneISL1C0005695Bladder Neoplasm1CTD_human
TgeneISL1C0027643Neoplasm Recurrence, Local1CTD_human