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Fusion gene ID: 31233 |
FusionGeneSummary for RICTOR_FGF10 |
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Fusion gene information | Fusion gene name: RICTOR_FGF10 | Fusion gene ID: 31233 | Hgene | Tgene | Gene symbol | RICTOR | FGF10 | Gene ID | 253260 | 2255 |
Gene name | RPTOR independent companion of MTOR complex 2 | fibroblast growth factor 10 | |
Synonyms | AVO3|PIA|hAVO3 | - | |
Cytomap | 5p13.1 | 5p12 | |
Type of gene | protein-coding | protein-coding | |
Description | rapamycin-insensitive companion of mTORAVO3 homologTORC2-specific protein AVO3pianissimo | fibroblast growth factor 10FGF-10keratinocyte growth factor 2produced by fibroblasts of urinary bladder lamina propria | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q6R327 | O15520 | |
Ensembl transtripts involved in fusion gene | ENST00000357387, ENST00000296782, ENST00000503698, | ENST00000264664, | |
Fusion gene scores | * DoF score | 11 X 4 X 9=396 | 6 X 2 X 4=48 |
# samples | 12 | 6 | |
** MAII score | log2(12/396*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RICTOR [Title/Abstract] AND FGF10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RICTOR | GO:0051896 | regulation of protein kinase B signaling | 15718470 |
Tgene | FGF10 | GO:0000187 | activation of MAPK activity | 14975937 |
Tgene | FGF10 | GO:0010634 | positive regulation of epithelial cell migration | 17500053 |
Tgene | FGF10 | GO:0010838 | positive regulation of keratinocyte proliferation | 17449030 |
Tgene | FGF10 | GO:0031532 | actin cytoskeleton reorganization | 17449030 |
Tgene | FGF10 | GO:0031659 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | 17188682 |
Tgene | FGF10 | GO:0032781 | positive regulation of ATPase activity | 12804770 |
Tgene | FGF10 | GO:0034394 | protein localization to cell surface | 17449030 |
Tgene | FGF10 | GO:0042060 | wound healing | 11896977|19152659 |
Tgene | FGF10 | GO:0043410 | positive regulation of MAPK cascade | 12804770 |
Tgene | FGF10 | GO:0045739 | positive regulation of DNA repair | 14975937 |
Tgene | FGF10 | GO:0045893 | positive regulation of transcription, DNA-templated | 17500053 |
Tgene | FGF10 | GO:0046579 | positive regulation of Ras protein signal transduction | 12804770 |
Tgene | FGF10 | GO:0048538 | thymus development | 17969154 |
Tgene | FGF10 | GO:0048754 | branching morphogenesis of an epithelial tube | 17959718 |
Tgene | FGF10 | GO:0050671 | positive regulation of lymphocyte proliferation | 19152659 |
Tgene | FGF10 | GO:0050673 | epithelial cell proliferation | 19224135 |
Tgene | FGF10 | GO:0050674 | urothelial cell proliferation | 11923311 |
Tgene | FGF10 | GO:0050677 | positive regulation of urothelial cell proliferation | 11923311 |
Tgene | FGF10 | GO:0050679 | positive regulation of epithelial cell proliferation | 15690149 |
Tgene | FGF10 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17449030 |
Tgene | FGF10 | GO:0050918 | positive chemotaxis | 9740653|17449030 |
Tgene | FGF10 | GO:0051549 | positive regulation of keratinocyte migration | 17449030|19152659 |
Tgene | FGF10 | GO:0060428 | lung epithelium development | 9740653 |
Tgene | FGF10 | GO:0060447 | bud outgrowth involved in lung branching | 9740653 |
Tgene | FGF10 | GO:0060595 | fibroblast growth factor receptor signaling pathway involved in mammary gland specification | 11923311 |
Tgene | FGF10 | GO:0061033 | secretion by lung epithelial cell involved in lung growth | 10541313 |
Tgene | FGF10 | GO:0070371 | ERK1 and ERK2 cascade | 17959718 |
Tgene | FGF10 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 14975937 |
Tgene | FGF10 | GO:0071157 | negative regulation of cell cycle arrest | 17188682 |
Tgene | FGF10 | GO:0071338 | positive regulation of hair follicle cell proliferation | 16086254 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A0RL-01A | RICTOR | chr5 | 39074213 | - | FGF10 | chr5 | 44310632 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000357387 | ENST00000264664 | RICTOR | chr5 | 39074213 | - | FGF10 | chr5 | 44310632 | - |
In-frame | ENST00000296782 | ENST00000264664 | RICTOR | chr5 | 39074213 | - | FGF10 | chr5 | 44310632 | - |
intron-3CDS | ENST00000503698 | ENST00000264664 | RICTOR | chr5 | 39074213 | - | FGF10 | chr5 | 44310632 | - |
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FusionProtFeatures for RICTOR_FGF10 |
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Hgene | Tgene |
RICTOR | FGF10 |
Subunit of mTORC2, which regulates cell growth andsurvival in response to hormonal signals. mTORC2 is activated bygrowth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases toregulate the actin cytoskeleton, probably by activating one ormore Rho-type guanine nucleotide exchange factors. mTORC2 promotesthe serum-induced formation of stress-fibers or F-actin. mTORC2plays a critical role in AKT1 'Ser-473' phosphorylation, which mayfacilitate the phosphorylation of the activation loop of AKT1 on'Thr-308' by PDK1 which is a prerequisite for full activation.mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays anessential role in embryonic growth and development.{ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718,ECO:0000269|PubMed:15718470}. | Plays an important role in the regulation of embryonicdevelopment, cell proliferation and cell differentiation. Requiredfor normal branching morphogenesis. May play a role in woundhealing. {ECO:0000269|PubMed:16597617}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >RICTOR | chr5:39074213 | chr5:44310632 | ENST00000296782 | - | 2 | 39 | 1016_1058 | 32 | 1733 | Compositional bias | Ser-rich |
Hgene | >RICTOR | chr5:39074213 | chr5:44310632 | ENST00000357387 | - | 2 | 38 | 1016_1058 | 32 | 1709 | Compositional bias | Ser-rich |
Tgene | FGF10 | chr5:39074213 | chr5:44310632 | ENST00000264664 | - | 0 | 3 | 52_62 | 108 | 209 | Compositional bias | Note=Poly-Ser |
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FusionGeneSequence for RICTOR_FGF10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_FGF10_ENST00000264664_chr5_44310632_-_133aa MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTRGILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYAS >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_FGF10_ENST00000264664_chr5_44310632_-_133aa MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTRGILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYAS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_FGF10_ENST00000264664_chr5_44310632_-_399nt ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG ACCCGAGGCATCCTGGAGATAACATCAGTAGAAATCGGAGTTGTTGCCGTCAAAGCCATTAACAGCAACTATTACTTAGCCATGAACAAG AAGGGGAAACTCTATGGCTCAAAAGAATTTAACAATGACTGTAAGCTGAAGGAGAGGATAGAGGAAAATGGATACAATACCTATGCATCA TTTAACTGGCAGCATAATGGGAGGCAAATGTATGTGGCATTGAATGGAAAAGGAGCTCCAAGGAGAGGACAGAAAACACGAAGGAAAAAC >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_FGF10_ENST00000264664_chr5_44310632_-_399nt ATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGAGGAGAACGTCCCGCTGGATCTG ACCCGAGGCATCCTGGAGATAACATCAGTAGAAATCGGAGTTGTTGCCGTCAAAGCCATTAACAGCAACTATTACTTAGCCATGAACAAG AAGGGGAAACTCTATGGCTCAAAAGAATTTAACAATGACTGTAAGCTGAAGGAGAGGATAGAGGAAAATGGATACAATACCTATGCATCA TTTAACTGGCAGCATAATGGGAGGCAAATGTATGTGGCATTGAATGGAAAAGGAGCTCCAAGGAGAGGACAGAAAACACGAAGGAAAAAC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RICTOR_ENST00000357387_chr5_39074213_-_FGF10_ENST00000264664_chr5_44310632_-_1881nt GTTTCCGGTGTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGA CAGCGGCGAGGAGAACGTCCCGCTGGATCTGACCCGAGGCATCCTGGAGATAACATCAGTAGAAATCGGAGTTGTTGCCGTCAAAGCCAT TAACAGCAACTATTACTTAGCCATGAACAAGAAGGGGAAACTCTATGGCTCAAAAGAATTTAACAATGACTGTAAGCTGAAGGAGAGGAT AGAGGAAAATGGATACAATACCTATGCATCATTTAACTGGCAGCATAATGGGAGGCAAATGTATGTGGCATTGAATGGAAAAGGAGCTCC AAGGAGAGGACAGAAAACACGAAGGAAAAACACCTCTGCTCACTTTCTTCCAATGGTGGTACACTCATAGAGGAAGGCAACGTTTGTGGA TGCAGTAGAACCAATGGCTCTTTTGCCAAGAATAGTGGATATTCTTCATGAAGACAGTAGATTGAAAGGCAAAGACACGTTGCAGATGTC TGCTTGCTTAAAAGAAAGCCAGCCTTTGAAGGTTTTTGTATTCACTGCTGACATATGATGTTCTTTTAATTAGTTCTGTGTCATGTCTTA TAATCAAGATATAGGCAGATCGAATGGGATAGAAGTTATTCCCAAGTGAAAAACATTGTGGCTGGGTTTTTTGTTGTTGTTGTCAAGTTT TTGTTTTTAAACCTCTGAGATAGAACTTAAAGGACATAGAACAATCTGTTGAAAGAACGATCTTCGGGAAAGTTATTTATGGAATACGAA CTCATATCAAAGACTTCATTGCTCATTCAAGCCTAATGAATCAATGAACAGTAATACATGCAAGCATTTACTGGAAAGCACTTGGGTCAT ATCATATGCACAACCAAAGGAGTTCTGGATGTGGTCTCATGGAATAATTGAATAGAATTTAAAAATATAAACATGTTAGTGTGAAACTGT TCTAACAATACAAATAGTATGGTATGCTTGTGCATTCTGCCTTCATCCCTTTCTATTTCTTTCTAAGTTATTTATTTAATAGGATGTTAA ATATCTTTTGGGGTTTTAAAGAGTATCTCAGCAGCTGTCTTCTGATTTATCTTTTCTTTTTATTCAGCACACCACATGCATGTTCACGAC AAAGTGTTTTTAAAACTTGGCGAACACTTCAAAAATAGGAGTTGGGATTAGGGAAGCAGTATGAGTGCCCGTGTGCTATCAGTTGACTTA ATTTGCACTTCTGCAGTAATAACCATCAACAATAAATATGGCAATGCTGTGCCATGGCTTGAGTGAGAGATGTCTGCTATCATTTGAAAA CATATATTACTCTCGAGGCTTCCTGTCTCAAGAAATAGACCAGAAGGCCAAATTCTTCTCTTTCAATACATCAGTTTGCCTCCAAGAATA TACTAAAAAAAGGAAAATTAATTGCTAAATACATTTAAATAGCCTAGCCTCATTATTTACTCATGATTTCTTGCCAAATGTCATGGCGGT AAAGAGGCTGTCCACATCTCTAAAAACCCTCTGTAAATTCCACATAATGCATCTTTCCCAAAGGAACTATCAAAGAATTTGGTATGAAGC GCAACTCTCCCAGGGGCTTAAACTGAGCAAATCAAATATATACTGGTATATGTGTAACCATATACAAAAACCTGTTCTAGCTGTATGATC TAGTCTTTACAAAACCAAATAAAACTTGTTTTCTGTAAATTTAAAGAGCTTTACAAAGTTCCATAATGTAACCATATCAAAATTCATTTT >In-frame_RICTOR_ENST00000296782_chr5_39074213_-_FGF10_ENST00000264664_chr5_44310632_-_1872nt GTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGA GGAGAACGTCCCGCTGGATCTGACCCGAGGCATCCTGGAGATAACATCAGTAGAAATCGGAGTTGTTGCCGTCAAAGCCATTAACAGCAA CTATTACTTAGCCATGAACAAGAAGGGGAAACTCTATGGCTCAAAAGAATTTAACAATGACTGTAAGCTGAAGGAGAGGATAGAGGAAAA TGGATACAATACCTATGCATCATTTAACTGGCAGCATAATGGGAGGCAAATGTATGTGGCATTGAATGGAAAAGGAGCTCCAAGGAGAGG ACAGAAAACACGAAGGAAAAACACCTCTGCTCACTTTCTTCCAATGGTGGTACACTCATAGAGGAAGGCAACGTTTGTGGATGCAGTAGA ACCAATGGCTCTTTTGCCAAGAATAGTGGATATTCTTCATGAAGACAGTAGATTGAAAGGCAAAGACACGTTGCAGATGTCTGCTTGCTT AAAAGAAAGCCAGCCTTTGAAGGTTTTTGTATTCACTGCTGACATATGATGTTCTTTTAATTAGTTCTGTGTCATGTCTTATAATCAAGA TATAGGCAGATCGAATGGGATAGAAGTTATTCCCAAGTGAAAAACATTGTGGCTGGGTTTTTTGTTGTTGTTGTCAAGTTTTTGTTTTTA AACCTCTGAGATAGAACTTAAAGGACATAGAACAATCTGTTGAAAGAACGATCTTCGGGAAAGTTATTTATGGAATACGAACTCATATCA AAGACTTCATTGCTCATTCAAGCCTAATGAATCAATGAACAGTAATACATGCAAGCATTTACTGGAAAGCACTTGGGTCATATCATATGC ACAACCAAAGGAGTTCTGGATGTGGTCTCATGGAATAATTGAATAGAATTTAAAAATATAAACATGTTAGTGTGAAACTGTTCTAACAAT ACAAATAGTATGGTATGCTTGTGCATTCTGCCTTCATCCCTTTCTATTTCTTTCTAAGTTATTTATTTAATAGGATGTTAAATATCTTTT GGGGTTTTAAAGAGTATCTCAGCAGCTGTCTTCTGATTTATCTTTTCTTTTTATTCAGCACACCACATGCATGTTCACGACAAAGTGTTT TTAAAACTTGGCGAACACTTCAAAAATAGGAGTTGGGATTAGGGAAGCAGTATGAGTGCCCGTGTGCTATCAGTTGACTTAATTTGCACT TCTGCAGTAATAACCATCAACAATAAATATGGCAATGCTGTGCCATGGCTTGAGTGAGAGATGTCTGCTATCATTTGAAAACATATATTA CTCTCGAGGCTTCCTGTCTCAAGAAATAGACCAGAAGGCCAAATTCTTCTCTTTCAATACATCAGTTTGCCTCCAAGAATATACTAAAAA AAGGAAAATTAATTGCTAAATACATTTAAATAGCCTAGCCTCATTATTTACTCATGATTTCTTGCCAAATGTCATGGCGGTAAAGAGGCT GTCCACATCTCTAAAAACCCTCTGTAAATTCCACATAATGCATCTTTCCCAAAGGAACTATCAAAGAATTTGGTATGAAGCGCAACTCTC CCAGGGGCTTAAACTGAGCAAATCAAATATATACTGGTATATGTGTAACCATATACAAAAACCTGTTCTAGCTGTATGATCTAGTCTTTA CAAAACCAAATAAAACTTGTTTTCTGTAAATTTAAAGAGCTTTACAAAGTTCCATAATGTAACCATATCAAAATTCATTTTGTTAGAGCA |
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FusionGenePPI for RICTOR_FGF10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RICTOR | MTOR, RPS6KB1, MAPKAP1, PRR5, MLST8, CPS1, CLTC, HSPA4, TUBA1A, TUBA1B, TIA1, RPS3A, RPL13, ABHD16A, EHMT2, DHX36, DHRS4, PRR5L, SGK1, CUL1, RBX1, RPL23, RPS6, RPL23A, RPL26, RPS5, ELAVL1, USP9X, FBXW7, AKT1, RPTOR, PRKCA, PINK1, STK38, BRCA1, DDB1, DEPTOR, PREX1, PDIA3, YWHAB, FKBP8, GNB1, GNG2, ILK, PARD6A, GSK3B, IKBKB, CHUK, SIRT1, NBN, RNF2, PCGF6, ANTXR1, SDF4, MAPK14, GSK3A, XPO1, MKNK2, TUBG1, PLK1, PTPRH, SKP2, TSHB, IL17RA, RAPGEF5, CDC16, AVIL, PROZ, C6orf141, TUBGCP5, NCAPH2, CRYBA4, IL13RA2, AARSD1, NXF2, P4HA2, TKTL1, TSPYL1, ASB3, RUVBL2, TRIM25 | FGF10 | FGFR2, HIST1H1A, RPL26L1, SIRT1, ITIH2, HBD, FGFR1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | RICTOR | chr5:39074213 | chr5:44310632 | ENST00000296782 | - | 2 | 39 | 1_789 | 32 | 1733 | NBN |
Hgene | RICTOR | chr5:39074213 | chr5:44310632 | ENST00000357387 | - | 2 | 38 | 1_789 | 32 | 1709 | NBN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RICTOR_FGF10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RICTOR_FGF10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FGF10 | C0265269 | Lacrimoauriculodentodigital syndrome | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | FGF10 | C0008924 | Cleft Lip | 1 | CTD_human |
Tgene | FGF10 | C0008925 | Cleft Palate | 1 | CTD_human |
Tgene | FGF10 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | FGF10 | C1458155 | Mammary Neoplasms | 1 | CTD_human |