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Fusion gene ID: 31222 |
FusionGeneSummary for RHPN2_SLC7A10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RHPN2_SLC7A10 | Fusion gene ID: 31222 | Hgene | Tgene | Gene symbol | RHPN2 | SLC7A10 | Gene ID | 85415 | 56301 |
| Gene name | rhophilin Rho GTPase binding protein 2 | solute carrier family 7 member 10 | |
| Synonyms | P76RBE|RHOBP | ASC1|HASC-1|asc-1 | |
| Cytomap | 19q13.11 | 19q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rhophilin-276 kDa RhoB effector proteinGTP-Rho-binding protein 2rhophilin-like Rho-GTPase binding protein | asc-type amino acid transporter 1solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10solute carrier family 7, (cationic amino acid transporter, y+ system) member 10solute carrier family 7, (neutral amino acid tran | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IUC4 | Q9NS82 | |
| Ensembl transtripts involved in fusion gene | ENST00000254260, ENST00000400226, ENST00000588683, | ENST00000253188, | |
| Fusion gene scores | * DoF score | 13 X 7 X 9=819 | 1 X 2 X 2=4 |
| # samples | 14 | 2 | |
| ** MAII score | log2(14/819*10)=-2.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: RHPN2 [Title/Abstract] AND SLC7A10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SLC7A10 | GO:0015804 | neutral amino acid transport | 10863037 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-DD-A4NA-01A | RHPN2 | chr19 | 33535155 | - | SLC7A10 | chr19 | 33703908 | - |
| TCGA | LD | OV | TCGA-36-1576-01A | RHPN2 | chr19 | 33555690 | - | SLC7A10 | chr19 | 33706879 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254260 | ENST00000253188 | RHPN2 | chr19 | 33535155 | - | SLC7A10 | chr19 | 33703908 | - |
| 5UTR-3CDS | ENST00000400226 | ENST00000253188 | RHPN2 | chr19 | 33535155 | - | SLC7A10 | chr19 | 33703908 | - |
| intron-3CDS | ENST00000588683 | ENST00000253188 | RHPN2 | chr19 | 33535155 | - | SLC7A10 | chr19 | 33703908 | - |
| Frame-shift | ENST00000254260 | ENST00000253188 | RHPN2 | chr19 | 33555690 | - | SLC7A10 | chr19 | 33706879 | - |
| 5UTR-3CDS | ENST00000400226 | ENST00000253188 | RHPN2 | chr19 | 33555690 | - | SLC7A10 | chr19 | 33706879 | - |
| intron-3CDS | ENST00000588683 | ENST00000253188 | RHPN2 | chr19 | 33555690 | - | SLC7A10 | chr19 | 33706879 | - |
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FusionProtFeatures for RHPN2_SLC7A10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RHPN2 | SLC7A10 |
| Binds specifically to GTP-Rho. May function in a Rhopathway to limit stress fiber formation and/or increase theturnover of F-actin structures in the absence of high levels ofRhoA activity. {ECO:0000269|PubMed:12221077}. | Sodium-independent, high affinity transport of smallneutral D- and L-amino acids. May play a role in the modulation ofglutamatergic transmission through mobilization of D-serine at theglutamatergic synapse. {ECO:0000269|PubMed:10863037}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 268_288 | 118 | 524 | Transmembrane | Helical |
| Tgene | >SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 310_330 | 118 | 524 | Transmembrane | Helical |
| Tgene | >SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 362_382 | 118 | 524 | Transmembrane | Helical |
| Tgene | >SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 388_408 | 118 | 524 | Transmembrane | Helical |
| Tgene | >SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 424_444 | 118 | 524 | Transmembrane | Helical |
| Tgene | >SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 448_468 | 118 | 524 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RHPN2 | chr19:33535155 | chr19:33703908 | ENST00000254260 | - | 2 | 15 | 623_626 | 61 | 687 | Compositional bias | Note=Poly-Asp |
| Hgene | >RHPN2 | chr19:33535155 | chr19:33703908 | ENST00000254260 | - | 2 | 15 | 111_460 | 61 | 687 | Domain | BRO1 |
| Hgene | >RHPN2 | chr19:33535155 | chr19:33703908 | ENST00000254260 | - | 2 | 15 | 26_100 | 61 | 687 | Domain | REM-1 |
| Hgene | >RHPN2 | chr19:33535155 | chr19:33703908 | ENST00000254260 | - | 2 | 15 | 515_593 | 61 | 687 | Domain | Note=PDZ |
| Tgene | SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 113_133 | 118 | 524 | Transmembrane | Helical |
| Tgene | SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 40_60 | 118 | 524 | Transmembrane | Helical |
| Tgene | SLC7A10 | chr19:33535155 | chr19:33703908 | ENST00000253188 | - | 1 | 11 | 72_92 | 118 | 524 | Transmembrane | Helical |
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FusionGeneSequence for RHPN2_SLC7A10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RHPN2_ENST00000254260_chr19_33535155_-_SLC7A10_ENST00000253188_chr19_33703908_-_467aa MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLNFLLLWSAVLIMYPTSLAVISMTFSNYVL QPVFPNCIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALA FLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTF GGINGYLFTYSRLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALH RPIKVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLTESMTHWGQELCFVVYPQDAPEEEENGP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RHPN2_ENST00000254260_chr19_33535155_-_SLC7A10_ENST00000253188_chr19_33703908_-_1401nt ATGACCGACGCGCTGTTGCCCGCGGCCCCCCAGCCGCTGGAGAAGGAGAACGACGGCTACTTTCGGAAGGGCTGTAATCCCCTTGCACAA ACCGGCCGGAGTAAATTGCAGAATCAAAGAGCTGCTTTGAATCAGCAGATCCTGAAAGCCGTGCGGATGAGGACCGGAGCGGAAAACCTT CTGAACTTTCTGCTGCTCTGGAGCGCCGTCCTCATCATGTACCCCACCAGCCTTGCTGTCATCTCCATGACCTTCTCCAACTACGTGCTG CAGCCCGTGTTCCCCAACTGCATCCCCCCCACCACAGCCTCCCGGGTGCTGTCCATGGCCTGCCTGATGCTCCTGACATGGGTGAACAGC TCCAGTGTGCGCTGGGCCACGCGCATCCAGGACATGTTCACAGGCGGGAAGCTGCTGGCCTTGTCCCTCATCATCGGCGTGGGCCTTCTC CAGATCTTCCAAGGACACTTCGAGGAGCTGAGGCCCAGCAATGCCTTTGCTTTCTGGATGACGCCCTCCGTGGGACACCTGGCCCTGGCC TTCCTCCAGGGCTCCTTCGCCTTCAGTGGCTGGAACTTCCTCAACTATGTCACCGAGGAGATGGTTGACGCCCGAAAGAACCTACCTCGC GCCATCTTCATCTCCATCCCACTGGTGACCTTCGTGTACACGTTCACCAACATTGCCTACTTCACGGCCATGTCCCCCCAGGAGCTGCTC TCCTCCAATGCGGTGGCTGTGACCTTCGGGGAGAAGCTGCTGGGCTACTTTTCTTGGGTCATGCCTGTCTCCGTGGCTCTGTCAACCTTC GGAGGGATCAATGGTTACCTGTTCACCTACTCCAGGCTGTGCTTCTCTGGAGCCCGCGAGGGGCACCTGCCCAGCCTGCTGGCCATGATC CACGTCAGACACTGCACCCCCATCCCCGCCCTCCTCGTCTGTTGCGGGGCCACAGCCGTCATCATGCTCGTGGGCGACACGTACACGCTC ATCAACTATGTGTCCTTCATCAACTACCTCTGCTACGGCGTCACCATCCTGGGCCTGCTGCTGCTGCGCTGGAGGCGGCCTGCACTCCAC AGGCCCATCAAGGTGAACCTTCTCATCCCCGTGGCGTACTTGGTCTTCTGGGCCTTCCTGCTGGTCTTCAGCTTCATCTCAGAGCCTATG GTCTGTGGGGTCGGCGTCATCATCATCCTTACGGGGGTGCCCATTTTCTTTCTGGGAGTGTTCTGGAGAAGCAAACCAAAGTGTGTGCAC AGACTCACAGAGTCCATGACACACTGGGGCCAGGAGCTGTGTTTCGTGGTCTACCCCCAGGACGCCCCCGAAGAGGAGGAGAATGGCCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RHPN2_ENST00000254260_chr19_33535155_-_SLC7A10_ENST00000253188_chr19_33703908_-_1664nt AGTCCGCCGTCCGCCCTCCGCGCCCGCGCCGCTAGCATGACCGACGCGCTGTTGCCCGCGGCCCCCCAGCCGCTGGAGAAGGAGAACGAC GGCTACTTTCGGAAGGGCTGTAATCCCCTTGCACAAACCGGCCGGAGTAAATTGCAGAATCAAAGAGCTGCTTTGAATCAGCAGATCCTG AAAGCCGTGCGGATGAGGACCGGAGCGGAAAACCTTCTGAACTTTCTGCTGCTCTGGAGCGCCGTCCTCATCATGTACCCCACCAGCCTT GCTGTCATCTCCATGACCTTCTCCAACTACGTGCTGCAGCCCGTGTTCCCCAACTGCATCCCCCCCACCACAGCCTCCCGGGTGCTGTCC ATGGCCTGCCTGATGCTCCTGACATGGGTGAACAGCTCCAGTGTGCGCTGGGCCACGCGCATCCAGGACATGTTCACAGGCGGGAAGCTG CTGGCCTTGTCCCTCATCATCGGCGTGGGCCTTCTCCAGATCTTCCAAGGACACTTCGAGGAGCTGAGGCCCAGCAATGCCTTTGCTTTC TGGATGACGCCCTCCGTGGGACACCTGGCCCTGGCCTTCCTCCAGGGCTCCTTCGCCTTCAGTGGCTGGAACTTCCTCAACTATGTCACC GAGGAGATGGTTGACGCCCGAAAGAACCTACCTCGCGCCATCTTCATCTCCATCCCACTGGTGACCTTCGTGTACACGTTCACCAACATT GCCTACTTCACGGCCATGTCCCCCCAGGAGCTGCTCTCCTCCAATGCGGTGGCTGTGACCTTCGGGGAGAAGCTGCTGGGCTACTTTTCT TGGGTCATGCCTGTCTCCGTGGCTCTGTCAACCTTCGGAGGGATCAATGGTTACCTGTTCACCTACTCCAGGCTGTGCTTCTCTGGAGCC CGCGAGGGGCACCTGCCCAGCCTGCTGGCCATGATCCACGTCAGACACTGCACCCCCATCCCCGCCCTCCTCGTCTGTTGCGGGGCCACA GCCGTCATCATGCTCGTGGGCGACACGTACACGCTCATCAACTATGTGTCCTTCATCAACTACCTCTGCTACGGCGTCACCATCCTGGGC CTGCTGCTGCTGCGCTGGAGGCGGCCTGCACTCCACAGGCCCATCAAGGTGAACCTTCTCATCCCCGTGGCGTACTTGGTCTTCTGGGCC TTCCTGCTGGTCTTCAGCTTCATCTCAGAGCCTATGGTCTGTGGGGTCGGCGTCATCATCATCCTTACGGGGGTGCCCATTTTCTTTCTG GGAGTGTTCTGGAGAAGCAAACCAAAGTGTGTGCACAGACTCACAGAGTCCATGACACACTGGGGCCAGGAGCTGTGTTTCGTGGTCTAC CCCCAGGACGCCCCCGAAGAGGAGGAGAATGGCCCCTGCCCACCCTCCCTGCTGCCTGCCACAGACAAGCCCTCGAAGCCACAATGAGAT TTTTGTAGAGACTGAAGCAGTTGTTTCTGTTTACATGTTGTTTATTGAGGAGGTGTTTTGGCAAAAAAGTTTTGTTTTGTTTTTTTCTGG AAAAAAAAGAAAAAAGATACGACTCTCAGAAGCCTGTTTAAGGAAGCCCTAAAATGTGGACTGGGTTTCCTGTCTTAGCACTGCCCTGCT |
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FusionGenePPI for RHPN2_SLC7A10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RHPN2 | HNF1A, SFN, RHOA, RHOB, RARG, C9orf156, BCL2L11, TRIM25 | SLC7A10 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RHPN2 | chr19:33535155 | chr19:33703908 | ENST00000254260 | - | 2 | 15 | 46_66 | 61 | 687 | Rho |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RHPN2_SLC7A10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RHPN2_SLC7A10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RHPN2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | SLC7A10 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | SLC7A10 | C3544321 | Treatment-resistant schizophrenia | 1 | PSYGENET |
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