![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 31195 |
FusionGeneSummary for RHOH_RHOH |
![]() |
Fusion gene information | Fusion gene name: RHOH_RHOH | Fusion gene ID: 31195 | Hgene | Tgene | Gene symbol | RHOH | RHOH | Gene ID | 399 | 399 |
Gene name | ras homolog family member H | ras homolog family member H | |
Synonyms | ARHH|TTF | ARHH|TTF | |
Cytomap | 4p14 | 4p14 | |
Type of gene | protein-coding | protein-coding | |
Description | rho-related GTP-binding protein RhoHGTP-binding protein TTFTTF, translocation three fourras homolog gene family, member H | rho-related GTP-binding protein RhoHGTP-binding protein TTFTTF, translocation three fourras homolog gene family, member H | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15669 | Q15669 | |
Ensembl transtripts involved in fusion gene | ENST00000505618, ENST00000381799, ENST00000514143, | ENST00000505618, ENST00000381799, ENST00000514143, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: RHOH [Title/Abstract] AND RHOH [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RHOH | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 11809807 |
Tgene | RHOH | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 11809807 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA480541 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000505618 | ENST00000505618 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
intron-intron | ENST00000505618 | ENST00000381799 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
intron-intron | ENST00000505618 | ENST00000514143 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
intron-intron | ENST00000381799 | ENST00000505618 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
intron-intron | ENST00000381799 | ENST00000381799 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
intron-intron | ENST00000381799 | ENST00000514143 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
intron-intron | ENST00000514143 | ENST00000505618 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
intron-intron | ENST00000514143 | ENST00000381799 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
intron-intron | ENST00000514143 | ENST00000514143 | RHOH | chr4 | 40202523 | + | RHOH | chr4 | 40202800 | - |
Top |
FusionProtFeatures for RHOH_RHOH |
![]() |
Hgene | Tgene |
RHOH | RHOH |
Negative regulator of hematopoietic progenitor cellproliferation, survival and migration. Critical regulator ofthymocyte development and T-cell antigen receptor (TCR) signalingby mediating recruitment and activation of ZAP70. Required forphosphorylation of CD3Z, membrane translocation of ZAP70 andsubsequent activation of the ZAP70-mediated pathways. Essentialfor efficient beta-selection and positive selection by promotingthe ZAP70-dependent phosphorylation of the LAT signalosome duringpre-TCR and TCR signaling. Crucial for thymocyte maturation duringDN3 to DN4 transition and during positive selection. Playscritical roles in mast cell function by facilitatingphosphorylation of SYK in Fc epsilon RI-mediated signaltransduction. Essential for the phosphorylation of LAT, LCP2,PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (Bysimilarity). Binds GTP but lacks intrinsic GTPase activity and isresistant to Rho-specific GTPase-activating proteins. Inhibits theactivation of NF-kappa-B by TNF and IKKB and the activation ofCRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42.Negatively regulates leukotriene production in neutrophils.{ECO:0000250, ECO:0000269|PubMed:11809807,ECO:0000269|PubMed:19414807}. | Negative regulator of hematopoietic progenitor cellproliferation, survival and migration. Critical regulator ofthymocyte development and T-cell antigen receptor (TCR) signalingby mediating recruitment and activation of ZAP70. Required forphosphorylation of CD3Z, membrane translocation of ZAP70 andsubsequent activation of the ZAP70-mediated pathways. Essentialfor efficient beta-selection and positive selection by promotingthe ZAP70-dependent phosphorylation of the LAT signalosome duringpre-TCR and TCR signaling. Crucial for thymocyte maturation duringDN3 to DN4 transition and during positive selection. Playscritical roles in mast cell function by facilitatingphosphorylation of SYK in Fc epsilon RI-mediated signaltransduction. Essential for the phosphorylation of LAT, LCP2,PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (Bysimilarity). Binds GTP but lacks intrinsic GTPase activity and isresistant to Rho-specific GTPase-activating proteins. Inhibits theactivation of NF-kappa-B by TNF and IKKB and the activation ofCRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42.Negatively regulates leukotriene production in neutrophils.{ECO:0000250, ECO:0000269|PubMed:11809807,ECO:0000269|PubMed:19414807}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RHOH_RHOH |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RHOH_RHOH |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RHOH_RHOH |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RHOH_RHOH |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |