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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31194

FusionGeneSummary for RHOH_N4BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: RHOH_N4BP2
Fusion gene ID: 31194
HgeneTgene
Gene symbol

RHOH

N4BP2

Gene ID

399

55728

Gene nameras homolog family member HNEDD4 binding protein 2
SynonymsARHH|TTFB3BP
Cytomap

4p14

4p14

Type of geneprotein-codingprotein-coding
Descriptionrho-related GTP-binding protein RhoHGTP-binding protein TTFTTF, translocation three fourras homolog gene family, member HNEDD4-binding protein 2BCL-3-binding protein
Modification date2018052320180519
UniProtAcc

Q15669

Q86UW6

Ensembl transtripts involved in fusion geneENST00000505618, ENST00000381799, 
ENST00000514143, 
ENST00000261435, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 3 X 1=6
# samples 43
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/6*10)=2.32192809488736
Context

PubMed: RHOH [Title/Abstract] AND N4BP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRHOH

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

11809807


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A08J-01ARHOHchr4

40198920

+N4BP2chr4

40144344

+
TCGALDBRCATCGA-A8-A09Q-01ARHOHchr4

40198920

+N4BP2chr4

40098847

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000505618ENST00000261435RHOHchr4

40198920

+N4BP2chr4

40144344

+
5UTR-3CDSENST00000381799ENST00000261435RHOHchr4

40198920

+N4BP2chr4

40144344

+
3UTR-3CDSENST00000514143ENST00000261435RHOHchr4

40198920

+N4BP2chr4

40144344

+
intron-5UTRENST00000505618ENST00000261435RHOHchr4

40198920

+N4BP2chr4

40098847

+
5UTR-5UTRENST00000381799ENST00000261435RHOHchr4

40198920

+N4BP2chr4

40098847

+
3UTR-5UTRENST00000514143ENST00000261435RHOHchr4

40198920

+N4BP2chr4

40098847

+

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FusionProtFeatures for RHOH_N4BP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RHOH

Q15669

N4BP2

Q86UW6

Negative regulator of hematopoietic progenitor cellproliferation, survival and migration. Critical regulator ofthymocyte development and T-cell antigen receptor (TCR) signalingby mediating recruitment and activation of ZAP70. Required forphosphorylation of CD3Z, membrane translocation of ZAP70 andsubsequent activation of the ZAP70-mediated pathways. Essentialfor efficient beta-selection and positive selection by promotingthe ZAP70-dependent phosphorylation of the LAT signalosome duringpre-TCR and TCR signaling. Crucial for thymocyte maturation duringDN3 to DN4 transition and during positive selection. Playscritical roles in mast cell function by facilitatingphosphorylation of SYK in Fc epsilon RI-mediated signaltransduction. Essential for the phosphorylation of LAT, LCP2,PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (Bysimilarity). Binds GTP but lacks intrinsic GTPase activity and isresistant to Rho-specific GTPase-activating proteins. Inhibits theactivation of NF-kappa-B by TNF and IKKB and the activation ofCRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42.Negatively regulates leukotriene production in neutrophils.{ECO:0000250, ECO:0000269|PubMed:11809807,ECO:0000269|PubMed:19414807}. Has 5'-polynucleotide kinase and nicking endonucleaseactivity. May play a role in DNA repair or recombination.{ECO:0000269|PubMed:12730195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RHOH_N4BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RHOH_N4BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RHOHLRIF1, UTP14A, ARHGDIA, ARHGDIB, ARHGDIGN4BP2CREBBP, BCL3, EP300, KDM6A, TP63, TP73, TOLLIP, N4BP2, CEP250, RPGRIP1L, FAM98A, FAM136A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RHOH_N4BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RHOH_N4BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource