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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31182

FusionGeneSummary for RHOB_CLPTM1

check button Fusion gene summary
Fusion gene informationFusion gene name: RHOB_CLPTM1
Fusion gene ID: 31182
HgeneTgene
Gene symbol

RHOB

CLPTM1

Gene ID

388

1209

Gene nameras homolog family member BCLPTM1, transmembrane protein
SynonymsARH6|ARHB|MST081|MSTP081|RHOH6-
Cytomap

2p24.1

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionrho-related GTP-binding protein RhoBAplysia RAS-related homolog 6h6oncogene RHO H6ras homolog gene family, member Brho cDNA clone 6cleft lip and palate transmembrane protein 1cleft lip and palate associated transmembrane protein 1
Modification date2018052320180519
UniProtAcc

P62745

O96005

Ensembl transtripts involved in fusion geneENST00000272233, ENST00000546079, 
ENST00000541297, ENST00000337392, 
ENST00000589158, 
Fusion gene scores* DoF score5 X 3 X 3=452 X 2 X 2=8
# samples 52
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: RHOB [Title/Abstract] AND CLPTM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRHOB

GO:0008333

endosome to lysosome transport

10508588

HgeneRHOB

GO:0030336

negative regulation of cell migration

20460403

HgeneRHOB

GO:0070301

cellular response to hydrogen peroxide

21373644

HgeneRHOB

GO:0071479

cellular response to ionizing radiation

21373644


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF855458RHOBchr2

20648064

-CLPTM1chr19

45495560

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000272233ENST00000546079RHOBchr2

20648064

-CLPTM1chr19

45495560

+
3UTR-3CDSENST00000272233ENST00000541297RHOBchr2

20648064

-CLPTM1chr19

45495560

+
3UTR-3CDSENST00000272233ENST00000337392RHOBchr2

20648064

-CLPTM1chr19

45495560

+
3UTR-intronENST00000272233ENST00000589158RHOBchr2

20648064

-CLPTM1chr19

45495560

+

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FusionProtFeatures for RHOB_CLPTM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RHOB

P62745

CLPTM1

O96005

Mediates apoptosis in neoplastically transformed cellsafter DNA damage. Not essential for development but affects celladhesion and growth factor signaling in transformed cells. Plays anegative role in tumorigenesis as deletion causes tumor formation.Involved in intracellular protein trafficking of a number ofproteins. Targets PKN1 to endosomes and is involved in traffickingof the EGF receptor from late endosomes to lysosomes. Alsorequired for stability and nuclear trafficking of AKT1/AKT whichpromotes endothelial cell survival during vascular development.Serves as a microtubule-dependent signal that is required for themyosin contractile ring formation during cell cycle cytokinesis.Required for genotoxic stress-induced cell death in breast cancercells. {ECO:0000269|PubMed:10508588, ECO:0000269|PubMed:15226397,ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:21373644,ECO:0000269|PubMed:9478917}. May play a role in T-cell development. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RHOB_CLPTM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RHOB_CLPTM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RHOB_CLPTM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRHOBP62745DB00083Botulinum Toxin Type ARho-related GTP-binding protein RhoBbiotechapproved|investigational

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RelatedDiseases for RHOB_CLPTM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRHOBC0036421Systemic Scleroderma1CTD_human
TgeneCLPTM1C0030297Pancreatic Neoplasm1CTD_human