FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31153

FusionGeneSummary for RHBG_CCT3

check button Fusion gene summary
Fusion gene informationFusion gene name: RHBG_CCT3
Fusion gene ID: 31153
HgeneTgene
Gene symbol

RHBG

CCT3

Gene ID

57127

7203

Gene nameRh family B glycoprotein (gene/pseudogene)chaperonin containing TCP1 subunit 3
SynonymsSLC42A2CCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
Descriptionammonium transporter Rh type BRh family, B glycoproteinRhesus blood group, B glycoproteinT-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5
Modification date2018052320180523
UniProtAcc

Q9H310

P49368

Ensembl transtripts involved in fusion geneENST00000537040, ENST00000451864, 
ENST00000400992, ENST00000368246, 
ENST00000255013, ENST00000368249, 
ENST00000494874, 		ENST00000295688, 
ENST00000368259, ENST00000368261, 
ENST00000472765, ENST00000368256, 
Fusion gene scores* DoF score1 X 1 X 1=112 X 8 X 9=864
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/864*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RHBG [Title/Abstract] AND CCT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRHBG

GO:0015696

ammonium transport

15929723|18032481|18635543

HgeneRHBG

GO:0070634

transepithelial ammonium transport

18032481


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1NE-01ARHBGchr1

156339227

+CCT3chr1

156305679

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000537040ENST00000295688RHBGchr1

156339227

+CCT3chr1

156305679

-
In-frameENST00000537040ENST00000368259RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000537040ENST00000368261RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000537040ENST00000472765RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000537040ENST00000368256RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-3CDSENST00000451864ENST00000295688RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-3CDSENST00000451864ENST00000368259RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000451864ENST00000368261RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000451864ENST00000472765RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000451864ENST00000368256RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-3CDSENST00000400992ENST00000295688RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-3CDSENST00000400992ENST00000368259RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000400992ENST00000368261RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000400992ENST00000472765RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000400992ENST00000368256RHBGchr1

156339227

+CCT3chr1

156305679

-
In-frameENST00000368246ENST00000295688RHBGchr1

156339227

+CCT3chr1

156305679

-
In-frameENST00000368246ENST00000368259RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000368246ENST00000368261RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000368246ENST00000472765RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000368246ENST00000368256RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-3CDSENST00000255013ENST00000295688RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-3CDSENST00000255013ENST00000368259RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000255013ENST00000368261RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000255013ENST00000472765RHBGchr1

156339227

+CCT3chr1

156305679

-
5UTR-5UTRENST00000255013ENST00000368256RHBGchr1

156339227

+CCT3chr1

156305679

-
In-frameENST00000368249ENST00000295688RHBGchr1

156339227

+CCT3chr1

156305679

-
In-frameENST00000368249ENST00000368259RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000368249ENST00000368261RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000368249ENST00000472765RHBGchr1

156339227

+CCT3chr1

156305679

-
5CDS-5UTRENST00000368249ENST00000368256RHBGchr1

156339227

+CCT3chr1

156305679

-
intron-3CDSENST00000494874ENST00000295688RHBGchr1

156339227

+CCT3chr1

156305679

-
intron-3CDSENST00000494874ENST00000368259RHBGchr1

156339227

+CCT3chr1

156305679

-
intron-5UTRENST00000494874ENST00000368261RHBGchr1

156339227

+CCT3chr1

156305679

-
intron-5UTRENST00000494874ENST00000472765RHBGchr1

156339227

+CCT3chr1

156305679

-
intron-5UTRENST00000494874ENST00000368256RHBGchr1

156339227

+CCT3chr1

156305679

-

Top

FusionProtFeatures for RHBG_CCT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RHBG

Q9H310

CCT3

P49368

Functions as a specific ammonium transporter.{ECO:0000269|PubMed:15284342, ECO:0000269|PubMed:15929723}. Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+1101_1362442Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+11035_6162442Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+11014_3462442TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111108_124-48373Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111146_149-48373Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111171_178-48373Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+1111_13-48373Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111202_219-48373Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111241_251-48373Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111273_282-48373Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111304_304-48373Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111326_346-48373Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+11135_61-48373Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111368_393-48373Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111415_441-48373Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+11183_86-48373Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110108_12462442Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110146_14962442Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110171_17862442Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110202_21962442Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110241_25162442Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110273_28262442Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110304_30462442Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110326_34662442Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110368_39362442Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110415_44162442Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+11083_8662442Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110108_124-48410Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110146_149-48410Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110171_178-48410Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+1101_13-48410Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110202_219-48410Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110241_251-48410Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110273_282-48410Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110304_304-48410Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110326_346-48410Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+11035_61-48410Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110368_393-48410Topological domainExtracellular
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110415_441-48410Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+11083_86-48410Topological domainCytoplasmic
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111125_145-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+11114_34-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111150_170-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111179_201-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111220_240-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111252_272-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111283_303-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111305_325-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111347_367-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111394_414-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+11162_82-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+11187_107-48373TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110125_14562442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110150_17062442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110179_20162442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110220_24062442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110252_27262442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110283_30362442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110305_32562442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110347_36762442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110394_41462442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+11062_8262442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+11087_10762442TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110125_145-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+11014_34-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110150_170-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110179_201-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110220_240-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110252_272-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110283_303-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110305_325-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110347_367-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110394_414-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+11062_82-48410TransmembraneHelical
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+11087_107-48410TransmembraneHelical


Top

FusionGeneSequence for RHBG_CCT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RHBG_CCT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RHBGSH2B1CCT3SSSCA1, FANCA, RAF1, EIF2B2, PAFAH1B2, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, CDK9, RFWD2, ATG16L1, MAPK6, VHL, WDR82, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO3, HDAC5, PSMA3, FBXW8, RAD21, SH3BP4, VAV2, SIRT7, ISG15, PSMA2, CUL3, CDK2, XRCC6, INPPL1, UBASH3B, GRB2, EPS15, FBXO6, PACRG, CCT2, CCT5, CCT7, CCT8, CCT6A, CCT4, CCT6B, MARS, PSMA6, PSMA5, NOTCH1, VCP, FN1, VCAM1, ATF2, PEX14, NOS2, CAMKMT, FAM86B2, METTL18, METTL20, METTL21B, METTL21C, METTL23, ITGA4, CFTR, PAN2, CD81, IGSF8, ICAM1, HDAC3, HDAC11, HDAC6, FBXW4, PARK2, ACACA, COPA, EEF1G, LRRC47, PPP4R2, VARS, TRIM28, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, MIPOL1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, BMI1, CDK13, IKBKE, IRAK1, JAK3, MAPK8, PRKY, PTK6, SGK2, TSSK6, TYK2, WDR76, POC1A, NXF5, TXNDC9, FYCO1, WDR37, WDR83, DCAF5, WDR92, PEX7, GNB5, TSSC1, DDB2, TUBB2B, ACTR1B, SEC31B, TUBAL3, ACTL6A, PNPLA1, TTLL3, TUBA3C, TUBA3E, C17orf102, RPS6KB2, LGALS3, DCAF7, AMBRA1, ARF1, CAD, CANX, CLTC, DNAJA1, DNAJA4, EHD2, ETFA, GTF2I, HSPE1, LDHA, LDHB, PDCL3, PSMC2, SLC25A3, SUCLG2, WARS, CYP27A1, HSP90B1, KPNA4, MCM7, PC, RPN1, STOM, UQCRC2, NTRK1, BTRC, B9D1, MKS1, CETN2, AHSA1, GBA, HDAC1, PDK3, DNAJC7, XRCC3, NSMAF, NIPSNAP1, PRPF4, ACTR2, WRAP53, RFWD3, KIF21A, SEH1L, TUBA1C, ARMC6, GAN, SKI, FBXW7, MCM2, SNW1, CDC5L, ERRFI1, TTC27, CDC73, ZNF746, PPM1J, TUBD1, DCAF12, DTL, WDR70, DCAF13, JMJD4, KLHL33, KDM4B, DCAF10, KLHDC8A, KLHL8, WDR77, WDR46, RAP2C, DCAF4, DNAI2, BUB3, WDR86, ODF1, KLHDC8B, DCAF11, WDTC1, TUBG2, GNB1L, METAP2, DCAF8, ACTR3B, TBL1Y, THOC3, PDCL, WDR34, UTP18, GNB2, GANAB, SMOX, HCFC2, WDR5B, C4orf26, C1orf127, ACTR3, NOL10, MLST8, POC1B, ACTBL2, MAPK15, P4HA2, C11orf70, KLHDC2, CDK11A, TTLL9, STRADB, RPE65, PNPLA5, TUBA1B, DCAF12L2, C11orf54, RBM3, CYLD, TRIM25, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRHBGchr1:156339227chr1:156305679ENST00000255013+111416_424-48373ANK3
HgeneRHBGchr1:156339227chr1:156305679ENST00000368249+110416_42462442ANK3
HgeneRHBGchr1:156339227chr1:156305679ENST00000400992+110416_424-48410ANK3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RHBG_CCT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCCT3P49368DB11638ArtenimolT-complex protein 1 subunit gammasmall moleculeapproved|investigational

Top

RelatedDiseases for RHBG_CCT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCCT3C0019693HIV Infections1CTD_human