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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31128

FusionGeneSummary for RGS5_SPIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: RGS5_SPIN1
Fusion gene ID: 31128
HgeneTgene
Gene symbol

RGS5

SPIN1

Gene ID

8490

83985

Gene nameregulator of G protein signaling 5sphingolipid transporter 1 (putative)
SynonymsMST092|MST106|MST129|MSTP032|MSTP092|MSTP106|MSTP129HSpin1|LAT|PP2030|SPIN1|SPINL|nrs
Cytomap

1q23.3

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionregulator of G-protein signaling 5protein spinster homolog 1SPNS sphingolipid transporter 1 (putative)spinster homolog 1spinster-like protein 1
Modification date2018051920180522
UniProtAcc

O15539

Q9Y657

Ensembl transtripts involved in fusion geneENST00000367903, ENST00000534288, 
ENST00000313961, ENST00000530507, 
ENST00000527988, 		ENST00000375859, 
ENST00000541629, ENST00000469017, 
Fusion gene scores* DoF score4 X 5 X 1=205 X 6 X 1=30
# samples 56
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RGS5 [Title/Abstract] AND SPIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA440173RGS5chr1

163209027

+SPIN1chr9

91070131

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000367903ENST00000375859RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000367903ENST00000541629RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000367903ENST00000469017RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000534288ENST00000375859RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000534288ENST00000541629RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000534288ENST00000469017RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000313961ENST00000375859RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000313961ENST00000541629RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000313961ENST00000469017RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000530507ENST00000375859RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000530507ENST00000541629RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000530507ENST00000469017RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000527988ENST00000375859RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000527988ENST00000541629RGS5chr1

163209027

+SPIN1chr9

91070131

-
intron-intronENST00000527988ENST00000469017RGS5chr1

163209027

+SPIN1chr9

91070131

-

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FusionProtFeatures for RGS5_SPIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RGS5

O15539

SPIN1

Q9Y657

Inhibits signal transduction by increasing the GTPaseactivity of G protein alpha subunits thereby driving them intotheir inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha,but not to G(s)-alpha (By similarity). {ECO:0000250}. Chromatin reader that specifically recognizes and bindshistone H3 both trimethylated at 'Lys-4' and asymmetricallydimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as anactivator of Wnt signaling pathway downstream of PRMT2. In case ofcancer, promotes cell cancer proliferation via activation of theWnt signaling pathway (PubMed:24589551). Overexpression inducesmetaphase arrest and chromosomal instability. Localizes to activerDNA loci and promotes the expression of rRNA genes(PubMed:21960006). May play a role in cell-cycle regulation duringthe transition from gamete to embryo. Involved in oocyte meioticresumption, a process that takes place before ovulation to resumemeiosis of oocytes blocked in prophase I: may act by regulatingmaternal transcripts to control meiotic resumption.{ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766,ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RGS5_SPIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RGS5_SPIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RGS5_SPIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RGS5_SPIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRGS5C0020538Hypertensive disease1CTD_human
HgeneRGS5C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneRGS5C0036341Schizophrenia1PSYGENET