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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31105

FusionGeneSummary for RGS12_THY1

check button Fusion gene summary
Fusion gene informationFusion gene name: RGS12_THY1
Fusion gene ID: 31105
HgeneTgene
Gene symbol

RGS12

THY1

Gene ID

6002

7070

Gene nameregulator of G protein signaling 12Thy-1 cell surface antigen
Synonyms-CD90|CDw90
Cytomap

4p16.3

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionregulator of G-protein signaling 12regulator of G-protein signalling 12thy-1 membrane glycoproteinThy-1 T-cell antigenthy-1 antigen
Modification date2018051920180527
UniProtAcc

O14924

P04216

Ensembl transtripts involved in fusion geneENST00000543385, ENST00000336727, 
ENST00000344733, ENST00000382788, 
ENST00000306648, ENST00000338806, 
ENST00000508158, ENST00000538395, 
ENST00000284240, ENST00000528522, 
ENST00000527590, ENST00000580275, 
Fusion gene scores* DoF score6 X 6 X 4=1441 X 1 X 1=1
# samples 81
** MAII scorelog2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: RGS12 [Title/Abstract] AND THY1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTHY1

GO:0002693

positive regulation of cellular extravasation

15004192

TgeneTHY1

GO:0034116

positive regulation of heterotypic cell-cell adhesion

15004192


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1XO-01ARGS12chr4

3344780

+THY1chr11

119291639

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000543385ENST00000284240RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000543385ENST00000528522RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-intronENST00000543385ENST00000527590RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000543385ENST00000580275RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000336727ENST00000284240RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000336727ENST00000528522RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-intronENST00000336727ENST00000527590RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000336727ENST00000580275RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000344733ENST00000284240RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000344733ENST00000528522RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-intronENST00000344733ENST00000527590RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000344733ENST00000580275RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000382788ENST00000284240RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000382788ENST00000528522RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-intronENST00000382788ENST00000527590RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000382788ENST00000580275RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000306648ENST00000284240RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000306648ENST00000528522RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-intronENST00000306648ENST00000527590RGS12chr4

3344780

+THY1chr11

119291639

-
5CDS-5UTRENST00000306648ENST00000580275RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000338806ENST00000284240RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000338806ENST00000528522RGS12chr4

3344780

+THY1chr11

119291639

-
intron-intronENST00000338806ENST00000527590RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000338806ENST00000580275RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000508158ENST00000284240RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000508158ENST00000528522RGS12chr4

3344780

+THY1chr11

119291639

-
intron-intronENST00000508158ENST00000527590RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000508158ENST00000580275RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000538395ENST00000284240RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000538395ENST00000528522RGS12chr4

3344780

+THY1chr11

119291639

-
intron-intronENST00000538395ENST00000527590RGS12chr4

3344780

+THY1chr11

119291639

-
intron-5UTRENST00000538395ENST00000580275RGS12chr4

3344780

+THY1chr11

119291639

-

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FusionProtFeatures for RGS12_THY1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RGS12

O14924

THY1

P04216

May play a role in cell-cell or cell-ligand interactionsduring synaptogenesis and other events in the brain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RGS12_THY1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RGS12_THY1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RGS12GNAI1, GNAI3, GNAI2, CUL4A, EEF1A1, ARL4C, MTNR1ATHY1THY1, LCK, FYN, ATXN7, ATXN1L, UBE2I, SUGP1, TIMM44, VDAC3, TIAL1, SCO2, CTTN, SARNP, UBL4A, SNRPC, ZFR, UBE4B, MRPL53, ATP6V1E1, NNT, MPLKIP, UBAP2, FAP, CLK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RGS12_THY1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RGS12_THY1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRGS12C0036341Schizophrenia1CTD_human
TgeneTHY1C0035126Reperfusion Injury1CTD_human
TgeneTHY1C0035309Retinal Diseases1CTD_human