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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31102

FusionGeneSummary for RGS12_NSG1

check button Fusion gene summary
Fusion gene informationFusion gene name: RGS12_NSG1
Fusion gene ID: 31102
HgeneTgene
Gene symbol

RGS12

NSG1

Gene ID

6002

27065

Gene nameregulator of G protein signaling 12neuronal vesicle trafficking associated 1
Synonyms-D4S234|D4S234E|NEEP21|P21
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionregulator of G-protein signaling 12regulator of G-protein signalling 12neuronal vesicle trafficking-associated protein 1brain neuron cytoplasmic protein 1carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa proteinneuron specific gene family member 1neuron-enriched endosomal protein of 21 kDneuron-enriched endos
Modification date2018051920180523
UniProtAcc

O14924

P42857

Ensembl transtripts involved in fusion geneENST00000543385, ENST00000336727, 
ENST00000344733, ENST00000382788, 
ENST00000306648, ENST00000338806, 
ENST00000508158, ENST00000538395, 
ENST00000421177, ENST00000513555, 
ENST00000450293, ENST00000505246, 
ENST00000506380, ENST00000397958, 
ENST00000433139, ENST00000504171, 
Fusion gene scores* DoF score6 X 6 X 4=1441 X 1 X 1=1
# samples 81
** MAII scorelog2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: RGS12 [Title/Abstract] AND NSG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-Z2-AA3V-06ARGS12chr4

3388164

+NSG1chr4

4411300

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000543385ENST00000421177RGS12chr4

3388164

+NSG1chr4

4411300

+
intron-3CDSENST00000543385ENST00000513555RGS12chr4

3388164

+NSG1chr4

4411300

+
intron-intronENST00000543385ENST00000450293RGS12chr4

3388164

+NSG1chr4

4411300

+
intron-intronENST00000543385ENST00000505246RGS12chr4

3388164

+NSG1chr4

4411300

+
intron-intronENST00000543385ENST00000506380RGS12chr4

3388164

+NSG1chr4

4411300

+
intron-intronENST00000543385ENST00000397958RGS12chr4

3388164

+NSG1chr4

4411300

+
intron-intronENST00000543385ENST00000433139RGS12chr4

3388164

+NSG1chr4

4411300

+
intron-intronENST00000543385ENST00000504171RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000336727ENST00000421177RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000336727ENST00000513555RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000336727ENST00000450293RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000336727ENST00000505246RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000336727ENST00000506380RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000336727ENST00000397958RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000336727ENST00000433139RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000336727ENST00000504171RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000344733ENST00000421177RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000344733ENST00000513555RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000344733ENST00000450293RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000344733ENST00000505246RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000344733ENST00000506380RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000344733ENST00000397958RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000344733ENST00000433139RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000344733ENST00000504171RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000382788ENST00000421177RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000382788ENST00000513555RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000382788ENST00000450293RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000382788ENST00000505246RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000382788ENST00000506380RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000382788ENST00000397958RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000382788ENST00000433139RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000382788ENST00000504171RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000306648ENST00000421177RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000306648ENST00000513555RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000306648ENST00000450293RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000306648ENST00000505246RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000306648ENST00000506380RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000306648ENST00000397958RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000306648ENST00000433139RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000306648ENST00000504171RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000338806ENST00000421177RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000338806ENST00000513555RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000338806ENST00000450293RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000338806ENST00000505246RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000338806ENST00000506380RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000338806ENST00000397958RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000338806ENST00000433139RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000338806ENST00000504171RGS12chr4

3388164

+NSG1chr4

4411300

+
3UTR-3CDSENST00000508158ENST00000421177RGS12chr4

3388164

+NSG1chr4

4411300

+
3UTR-3CDSENST00000508158ENST00000513555RGS12chr4

3388164

+NSG1chr4

4411300

+
3UTR-intronENST00000508158ENST00000450293RGS12chr4

3388164

+NSG1chr4

4411300

+
3UTR-intronENST00000508158ENST00000505246RGS12chr4

3388164

+NSG1chr4

4411300

+
3UTR-intronENST00000508158ENST00000506380RGS12chr4

3388164

+NSG1chr4

4411300

+
3UTR-intronENST00000508158ENST00000397958RGS12chr4

3388164

+NSG1chr4

4411300

+
3UTR-intronENST00000508158ENST00000433139RGS12chr4

3388164

+NSG1chr4

4411300

+
3UTR-intronENST00000508158ENST00000504171RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000538395ENST00000421177RGS12chr4

3388164

+NSG1chr4

4411300

+
Frame-shiftENST00000538395ENST00000513555RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000538395ENST00000450293RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000538395ENST00000505246RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000538395ENST00000506380RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000538395ENST00000397958RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000538395ENST00000433139RGS12chr4

3388164

+NSG1chr4

4411300

+
5CDS-intronENST00000538395ENST00000504171RGS12chr4

3388164

+NSG1chr4

4411300

+

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FusionProtFeatures for RGS12_NSG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RGS12

O14924

NSG1

P42857

Plays a role in the recycling mechanism in neurons ofmultiple receptors, including AMPAR, APP and L1CAM and acts at thelevel of early endosomes to promote sorting of receptors toward arecycling pathway. Regulates sorting and recycling of GRIA2through interaction with GRIP1 and then contributes to theregulation of synaptic transmission and plasticity by affectingthe recycling and targeting of AMPA receptors to the synapse (Bysimilarity). Is required for faithful sorting of L1CAM to axons byfacilitating trafficking from somatodendritic early endosome orthe recycling endosome (By similarity). In an other hand, inducesapoptosis via the activation of CASP3 in response to DNA damage(PubMed:20599942, PubMed:20878061). {ECO:0000250|UniProtKB:P02683,ECO:0000250|UniProtKB:Q62092, ECO:0000269|PubMed:20599942,ECO:0000269|PubMed:20878061}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RGS12_NSG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RGS12_NSG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RGS12GNAI1, GNAI3, GNAI2, CUL4A, EEF1A1, ARL4C, MTNR1ANSG1SRPK1, SRPK2, BSCL2, CCDC155


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RGS12_NSG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RGS12_NSG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRGS12C0036341Schizophrenia1CTD_human