	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 31092

FusionGeneSummary for RGMA_SFTPC

Fusion gene summary

Fusion gene information	Fusion gene name: RGMA_SFTPC
	Fusion gene ID: 31092
		Hgene	Tgene
	Gene symbol	RGMA	SFTPC
	Gene ID	56963	6440
	Gene name	repulsive guidance molecule BMP co-receptor a	surfactant protein C
	Synonyms	RGM	BRICD6\|PSP-C\|SFTP2\|SMDP2\|SP-C
	Cytomap	15q26.1	8p21.3
	Type of gene	protein-coding	protein-coding
	Description	repulsive guidance molecule ARGM domain family, member Arepulsive guidance molecule family member a	pulmonary surfactant-associated protein CBRICHOS domain containing 6SP5pulmonary surfactant apoprotein-2 SP-Cpulmonary surfactant-associated proteolipid SPL(Val)
	Modification date	20180523	20180520
	UniProtAcc	Q96B86	P11686
	Ensembl transtripts involved in fusion gene	ENST00000425933, ENST00000543599, ENST00000329082, ENST00000542321, ENST00000538818, ENST00000557301, ENST00000557420, ENST00000556658, ENST00000556087, ENST00000555584,	ENST00000318561, ENST00000521315, ENST00000437090, ENST00000520605, ENST00000522109, ENST00000524255, ENST00000522880,
Fusion gene scores	* DoF score	4 X 3 X 2=24	6 X 6 X 4=144
	# samples	4	7
	** MAII score	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RGMA [Title/Abstract] AND SFTPC [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RGMA	GO:0045944	positive regulation of transcription by RNA polymerase II	22728873

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI336345	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000425933	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000425933	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000425933	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000425933	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000425933	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000425933	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000425933	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000543599	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000543599	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000543599	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000543599	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000543599	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000543599	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000543599	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000329082	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000329082	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000329082	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000329082	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000329082	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000329082	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000329082	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000542321	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000542321	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000542321	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000542321	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000542321	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000542321	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000542321	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000538818	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000538818	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000538818	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000538818	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000538818	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000538818	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000538818	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557301	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557301	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557301	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557301	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557301	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557301	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000557301	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557420	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557420	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557420	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557420	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557420	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000557420	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000557420	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556658	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556658	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556658	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556658	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556658	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556658	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000556658	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556087	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556087	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556087	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556087	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556087	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000556087	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000556087	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000555584	ENST00000318561	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000555584	ENST00000521315	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000555584	ENST00000437090	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000555584	ENST00000520605	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000555584	ENST00000522109	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-3CDS	ENST00000555584	ENST00000524255	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+
intron-intron	ENST00000555584	ENST00000522880	RGMA	chr15	93587025	+	SFTPC	chr8	22020597	+

Top

FusionProtFeatures for RGMA_SFTPC

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RGMA Q96B86	SFTPC P11686
	Pulmonary surfactant associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for RGMA_SFTPC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RGMA_SFTPC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for RGMA_SFTPC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for RGMA_SFTPC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SFTPC	C1970470	SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2 (disorder)	5	CTD_human;ORPHANET;UNIPROT
Tgene	SFTPC	C0019284	Diaphragmatic Hernia	1	CTD_human
Tgene	SFTPC	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene	SFTPC	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 31092

FusionGeneSummary for RGMA_SFTPC

FusionProtFeatures for RGMA_SFTPC

FusionGeneSequence for RGMA_SFTPC

FusionGenePPI for RGMA_SFTPC

RelatedDrugs for RGMA_SFTPC

RelatedDiseases for RGMA_SFTPC