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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3109

FusionGeneSummary for ATE1_ANXA10

check button Fusion gene summary
Fusion gene informationFusion gene name: ATE1_ANXA10
Fusion gene ID: 3109
HgeneTgene
Gene symbol

ATE1

ANXA10

Gene ID

11101

11199

Gene namearginyltransferase 1annexin A10
Synonyms-ANX14
Cytomap

10q26.13

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionarginyl-tRNA--protein transferase 1R-transferase 1arginine-tRNA--protein transferase 1arginyl-tRNA-protein transferaseannexin A10annexin 14annexin-10
Modification date2018052320180519
UniProtAcc

O95260

Q9UJ72

Ensembl transtripts involved in fusion geneENST00000369043, ENST00000535655, 
ENST00000224652, ENST00000369040, 
ENST00000540606, ENST00000543447, 
ENST00000481784, 
ENST00000359299, 
Fusion gene scores* DoF score4 X 4 X 4=643 X 2 X 3=18
# samples 43
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATE1 [Title/Abstract] AND ANXA10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-AD-6899-01AATE1chr10

123596233

-ANXA10chr4

169060637

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369043ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
In-frameENST00000535655ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
Frame-shiftENST00000224652ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
Frame-shiftENST00000369040ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
Frame-shiftENST00000540606ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
In-frameENST00000543447ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
intron-3CDSENST00000481784ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+

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FusionProtFeatures for ATE1_ANXA10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATE1

O95260

ANXA10

Q9UJ72

Involved in the post-translational conjugation ofarginine to the N-terminal aspartate or glutamate of a protein.This arginylation is required for degradation of the protein viathe ubiquitin pathway. Does not arginylate cysteine residues (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATE1_ANXA10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ATE1_ENST00000535655_chr10_123596233_-_ANXA10_ENST00000359299_chr4_169060637_+_291aa
TVTKTCXSTFXLSAAMHKGXXLQRHTRACMAGTXLGIXGSSFRITSKMXWLASCTHHHCMMLMSSGMPXREXALMRIASLKYXLQEQMEK
FSRCEKPTACNTAITSKRTFIQRPQDTSEILSXTWSRGPERKDIQTLRWLLRMQWSYGKPVSRRRGSTKPCCKXSCATRATSSCGWFSRN
FKIFLGKIWXMPLMNVMMDTFRSCWLQLFSVFETNQPILLIDYIVQFMTLVSIIKLXSGFSLPEVKXTCXPXGNDTKSDMENPYFMISEI

>In-frame_ATE1_ENST00000543447_chr10_123596233_-_ANXA10_ENST00000359299_chr4_169060637_+_291aa
TVTKTCXSTFXLSAAMHKGXXLQRHTRACMAGTXLGIXGSSFRITSKMXWLASCTHHHCMMLMSSGMPXREXALMRIASLKYXLQEQMEK
FSRCEKPTACNTAITSKRTFIQRPQDTSEILSXTWSRGPERKDIQTLRWLLRMQWSYGKPVSRRRGSTKPCCKXSCATRATSSCGWFSRN
FKIFLGKIWXMPLMNVMMDTFRSCWLQLFSVFETNQPILLIDYIVQFMTLVSIIKLXSGFSLPEVKXTCXPXGNDTKSDMENPYFMISEI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ATE1_ENST00000535655_chr10_123596233_-_ANXA10_ENST00000359299_chr4_169060637_+_875nt
ACTGTGACAAAGACATGCTGATCAACATTCTGACTCAGCGCTGCAATGCACAAAGGATGATGATTGCAGAGGCATACCAGAGCATGTATG
GCCGGGACCTGATTGGGGATATGAGGGAGCAGCTTTCGGATCACTTCAAAGATGTGATGGCTGGCCTCATGTACCCACCACCACTGTATG
ATGCTCATGAGCTCTGGCATGCCATGAAGGGAGTAGGCACTGATGAGAATTGCCTCATTGAAATACTAGCTTCAAGAACAAATGGAGAAA
TTTTCCAGATGCGAGAAGCCTACTGCTTGCAATACAGCAATAACCTCCAAGAGGACATTTATTCAGAGACCTCAGGACACTTCAGAGATA
CTCTCATGAACTTGGTCCAGGGGACCAGAGAGGAAGGATATACAGACCCTGCGATGGCTGCTCAGGATGCAATGGTCCTATGGGAAGCCT
GTCAGCAGAAGACGGGGGAGCACAAAACCATGCTGCAAATGATCCTGTGCAACAAGAGCTACCAGCAGCTGCGGCTGGTTTTCCAGGAAT
TTCAAAATATTTCTGGGCAAGATATGGTAGATGCCATTAATGAATGTTATGATGGATACTTTCAGGAGCTGCTGGTTGCAATTGTTCTCT
GTGTTCGAGACAAACCAGCCTATTTTGCTTATAGATTATATAGTGCAATTCATGACTTTGGTTTCCATAATAAAACTGTAATCAGGATTC
TCATTGCCAGAAGTGAAATAGACCTGCTGACCATAAGGAAACGATACAAAGAGCGATATGGAAAATCCCTATTTCATGATATCAGAAATT

>In-frame_ATE1_ENST00000543447_chr10_123596233_-_ANXA10_ENST00000359299_chr4_169060637_+_875nt
ACTGTGACAAAGACATGCTGATCAACATTCTGACTCAGCGCTGCAATGCACAAAGGATGATGATTGCAGAGGCATACCAGAGCATGTATG
GCCGGGACCTGATTGGGGATATGAGGGAGCAGCTTTCGGATCACTTCAAAGATGTGATGGCTGGCCTCATGTACCCACCACCACTGTATG
ATGCTCATGAGCTCTGGCATGCCATGAAGGGAGTAGGCACTGATGAGAATTGCCTCATTGAAATACTAGCTTCAAGAACAAATGGAGAAA
TTTTCCAGATGCGAGAAGCCTACTGCTTGCAATACAGCAATAACCTCCAAGAGGACATTTATTCAGAGACCTCAGGACACTTCAGAGATA
CTCTCATGAACTTGGTCCAGGGGACCAGAGAGGAAGGATATACAGACCCTGCGATGGCTGCTCAGGATGCAATGGTCCTATGGGAAGCCT
GTCAGCAGAAGACGGGGGAGCACAAAACCATGCTGCAAATGATCCTGTGCAACAAGAGCTACCAGCAGCTGCGGCTGGTTTTCCAGGAAT
TTCAAAATATTTCTGGGCAAGATATGGTAGATGCCATTAATGAATGTTATGATGGATACTTTCAGGAGCTGCTGGTTGCAATTGTTCTCT
GTGTTCGAGACAAACCAGCCTATTTTGCTTATAGATTATATAGTGCAATTCATGACTTTGGTTTCCATAATAAAACTGTAATCAGGATTC
TCATTGCCAGAAGTGAAATAGACCTGCTGACCATAAGGAAACGATACAAAGAGCGATATGGAAAATCCCTATTTCATGATATCAGAAATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ATE1_ENST00000535655_chr10_123596233_-_ANXA10_ENST00000359299_chr4_169060637_+_2444nt
ACCTGCTTGTGTTCTTGTATTCAGGGCACTGGAGTGCGTGCCAGCTGGTCTGGAAGCAGCTCCAGCAAGTCACTTACACGGTGGCCAGGG
GCGGCCTGACTTTCAATCCGAGACCCGCCGGGAATGACTTTGGGATAATCACAACCTCCGGTCCTCAGTTTCCTTACCTGTGAAATGGGG
CTGATAACGCACAGCTGTGGGAAGCACCGGCCCAAACGCAGGGCTTGGGGACACGACCACCATCCCCGCCCACGGGTCCCCGCGCCAGGC
TTCGCTCTCCACCCCTCCCGCCGCGGGCCCCAGCGCTTCGCCGAGGTCGGCCCCGGGCGCCAAGAGGCGTGGTCGGCCCGAGCGGACCCT
CGCGGCGGCCATGGCGTCGGTGGTGGAATACAAGGGCCTCAGGGCCGGCTACCACTGCGGCTACTGCGATTCCAAGGAGGGCAAAGCGTC
CTGCGGCATGTGGGCACATTCCATGACAGTACAGGATTATCAGGATCTCATAGACCGAGGATGGCGAAGGTGCCGACCTTTACAATTTCA
GCCTTCAAAATCTCACAAGAAGGTTTTGAAAAAAATGTTGAAATTTCTAGCTAAAGGGGAGGTTCCCAAAGGAAGTTGTGAGGATGAGCC
CATGGATTCCACAATGGATGATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAAAACACTCAGTGA
TGACATCAAAGAGAGTTTAGAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGATTTCGTAGGAGA
GAAGTTGGGCTCTGGTGAACCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGGTGAGGGTGGTGAGATCATCTCCACCAAGTT
CGCAGTTCAAAGCCACACTTCTGGAGTCTTACCAGGTCTATAAACGTTACCAGATGGTTATTCACAAGAACCCACCTGATACGCCAACCG
AAAGCCAGTTCACAAGATTCCTTTGCAGTTCACCCTTGGAGGCAGAGACTCCCCCTAATGGGCCAGATTGTGGCTATGGCTCCTTTCACC
AGCAGTACTGGCTTGACGGAAAGATCATTGCTGTGGGGGTGATTGACATCCTCCCAAACTGTGTATCATCTGTGTATTTGTACTACGATC
CTGATTATTCGTTTTTGTCTTTGGGCGTCTACTCTGCACTACGAGAAATTGCTTTTACTAGGCAGCTTCATGAGAAAACTTCTCAACTCA
GCTATTATTATATGGGTTTCTACATTCATTCATGTCCCAAGATGAAATATAAGACTGTGACAAAGACATGCTGATCAACATTCTGACTCA
GCGCTGCAATGCACAAAGGATGATGATTGCAGAGGCATACCAGAGCATGTATGGCCGGGACCTGATTGGGGATATGAGGGAGCAGCTTTC
GGATCACTTCAAAGATGTGATGGCTGGCCTCATGTACCCACCACCACTGTATGATGCTCATGAGCTCTGGCATGCCATGAAGGGAGTAGG
CACTGATGAGAATTGCCTCATTGAAATACTAGCTTCAAGAACAAATGGAGAAATTTTCCAGATGCGAGAAGCCTACTGCTTGCAATACAG
CAATAACCTCCAAGAGGACATTTATTCAGAGACCTCAGGACACTTCAGAGATACTCTCATGAACTTGGTCCAGGGGACCAGAGAGGAAGG
ATATACAGACCCTGCGATGGCTGCTCAGGATGCAATGGTCCTATGGGAAGCCTGTCAGCAGAAGACGGGGGAGCACAAAACCATGCTGCA
AATGATCCTGTGCAACAAGAGCTACCAGCAGCTGCGGCTGGTTTTCCAGGAATTTCAAAATATTTCTGGGCAAGATATGGTAGATGCCAT
TAATGAATGTTATGATGGATACTTTCAGGAGCTGCTGGTTGCAATTGTTCTCTGTGTTCGAGACAAACCAGCCTATTTTGCTTATAGATT
ATATAGTGCAATTCATGACTTTGGTTTCCATAATAAAACTGTAATCAGGATTCTCATTGCCAGAAGTGAAATAGACCTGCTGACCATAAG
GAAACGATACAAAGAGCGATATGGAAAATCCCTATTTCATGATATCAGAAATTTTGCTTCAGGGCATTATAAGAAAGCACTGCTTGCCAT
CTGTGCTGGTGATGCTGAGGACTACTAAAATGAAGAGGACTTGGAGTACTGTGCACTCCTCTTTCTAGACACTTCCAAATAGAGATTTTC
TCACAAATTTGTACTGTTCATGGCACTATTAACAAAACTATACAATCATATTTTCTCTTCTATCTTTGAAATTATTCTAAGCCAAAGAAA
ACTATGAATGAAAGTATATGATACTGAATTTGCCTACTATCCTGAATTTGCCTACTATCTAATCAGCAATTAAATAAATTGTGCATGATG

>In-frame_ATE1_ENST00000543447_chr10_123596233_-_ANXA10_ENST00000359299_chr4_169060637_+_2236nt
AGCGAGGACTTCTACCGCTGCGGCTACTGCAAGAACGAGTCGGGCAGCCGCTCCAATGGCATGTGGGCACATTCCATGACAGTACAGGAT
TATCAGGATCTCATAGACCGAGGATGGCGAAGAAGTGGAAAATATGTGTACAAACCTGTCATGAATCAAACATGTTGTCCTCAGTACACA
ATAAGATGAGCCCATGGATTCCACAATGGATGATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAA
AACACTCAGTGATGACATCAAAGAGAGTTTAGAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGA
TTTCGTAGGAGAGAAGTTGGGCTCTGGTGAACCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGGCAAAGGGGCTGATTTGAG
TAAGCCTCCATGTCGAAAAGCAAAGGAAATCCGGAAAGAAAGGAAAAGGTTAAAACTAATGCAGCAGAACCCAGCTGGAGAACTTGAGGG
TTTCCAGGCTCAAGGTCACCCACCATCTTTGTTTCCACCAAAGGCTAAATCCAACCAGCCAAAATCACTCGAAGATTTAATTTTTGAGTC
TTTACCAGAGAATGCATCACACAAGTTAGAGGTGAGGGTGGTGAGATCATCTCCACCAAGTTCGCAGTTCAAAGCCACACTTCTGGAGTC
TTACCAGGTCTATAAACGTTACCAGATGGTTATTCACAAGAACCCACCTGATACGCCAACCGAAAGCCAGTTCACAAGATTCCTTTGCAG
TTCACCCTTGGAGGCAGAGACTCCCCCTAATGGGCCAGATTGTGGCTATGGCTCCTTTCACCAGCAGTACTGGCTTGACGGAAAGATCAT
TGCTGTGGGGGTGATTGACATCCTCCCAAACTGTGTATCATCTGTGTATTTGTACTACGATCCTGATTATTCGTTTTTGTCTTTGGGCGT
CTACTCTGCACTACGAGAAATTGCTTTTACTAGGCAGCTTCATGAGAAAACTTCTCAACTCAGCTATTATTATATGGGTTTCTACATTCA
TTCATGTCCCAAGATGAAATATAAGACTGTGACAAAGACATGCTGATCAACATTCTGACTCAGCGCTGCAATGCACAAAGGATGATGATT
GCAGAGGCATACCAGAGCATGTATGGCCGGGACCTGATTGGGGATATGAGGGAGCAGCTTTCGGATCACTTCAAAGATGTGATGGCTGGC
CTCATGTACCCACCACCACTGTATGATGCTCATGAGCTCTGGCATGCCATGAAGGGAGTAGGCACTGATGAGAATTGCCTCATTGAAATA
CTAGCTTCAAGAACAAATGGAGAAATTTTCCAGATGCGAGAAGCCTACTGCTTGCAATACAGCAATAACCTCCAAGAGGACATTTATTCA
GAGACCTCAGGACACTTCAGAGATACTCTCATGAACTTGGTCCAGGGGACCAGAGAGGAAGGATATACAGACCCTGCGATGGCTGCTCAG
GATGCAATGGTCCTATGGGAAGCCTGTCAGCAGAAGACGGGGGAGCACAAAACCATGCTGCAAATGATCCTGTGCAACAAGAGCTACCAG
CAGCTGCGGCTGGTTTTCCAGGAATTTCAAAATATTTCTGGGCAAGATATGGTAGATGCCATTAATGAATGTTATGATGGATACTTTCAG
GAGCTGCTGGTTGCAATTGTTCTCTGTGTTCGAGACAAACCAGCCTATTTTGCTTATAGATTATATAGTGCAATTCATGACTTTGGTTTC
CATAATAAAACTGTAATCAGGATTCTCATTGCCAGAAGTGAAATAGACCTGCTGACCATAAGGAAACGATACAAAGAGCGATATGGAAAA
TCCCTATTTCATGATATCAGAAATTTTGCTTCAGGGCATTATAAGAAAGCACTGCTTGCCATCTGTGCTGGTGATGCTGAGGACTACTAA
AATGAAGAGGACTTGGAGTACTGTGCACTCCTCTTTCTAGACACTTCCAAATAGAGATTTTCTCACAAATTTGTACTGTTCATGGCACTA
TTAACAAAACTATACAATCATATTTTCTCTTCTATCTTTGAAATTATTCTAAGCCAAAGAAAACTATGAATGAAAGTATATGATACTGAA


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FusionGenePPI for ATE1_ANXA10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATE1RAE1, SUV39H1, EHD1, HLA-DQB2, C14orf105, CNN2, CLDN10, VPS26B, MRM1, MAPK8, POU2AF1, FAM219A, TEX33, REG4, GAST, DPH3, QKI, AVP, EXT2, RAB7B, P2RX1, C16orf45, PLA2G10, RAB5A, GPR37, TOB1, PTPN14, TRIM25ANXA10BAG3, EDC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATE1_ANXA10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATE1_ANXA10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource