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Fusion gene ID: 31047 |
FusionGeneSummary for RFWD2_MSH4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RFWD2_MSH4 | Fusion gene ID: 31047 | Hgene | Tgene | Gene symbol | RFWD2 | MSH4 | Gene ID | 4438 |
| Gene name | mutS homolog 4 | ||
| Synonyms | - | ||
| Cytomap | 1p31.1 | ||
| Type of gene | protein-coding | ||
| Description | mutS protein homolog 4hMSH4 | ||
| Modification date | 20180523 | ||
| UniProtAcc | O15457 | ||
| Ensembl transtripts involved in fusion gene | ENST00000367669, ENST00000308769, | ENST00000263187, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RFWD2 [Title/Abstract] AND MSH4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-YL-A8SF-01A | RFWD2 | chr1 | 176118142 | - | MSH4 | chr1 | 76378381 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000367669 | ENST00000263187 | RFWD2 | chr1 | 176118142 | - | MSH4 | chr1 | 76378381 | + |
| In-frame | ENST00000308769 | ENST00000263187 | RFWD2 | chr1 | 176118142 | - | MSH4 | chr1 | 76378381 | + |
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FusionProtFeatures for RFWD2_MSH4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RFWD2 | MSH4 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Involved in meiotic recombination. Required forreciprocal recombination and proper segregation of homologouschromosomes at meiosis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 2_110 | 273 | 708 | Compositional bias | Note=Ser-rich |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 2_110 | 277 | 732 | Compositional bias | Note=Ser-rich |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 109_113 | 273 | 708 | Motif | Note=Nuclear localization signal 1 |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 195_206 | 273 | 708 | Motif | Note=Nuclear localization signal 2 |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 235_245 | 273 | 708 | Motif | Nuclear export signal |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 109_113 | 277 | 732 | Motif | Note=Nuclear localization signal 1 |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 195_206 | 277 | 732 | Motif | Note=Nuclear localization signal 2 |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 235_245 | 277 | 732 | Motif | Nuclear export signal |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 136_174 | 273 | 708 | Zinc finger | RING-type |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 136_174 | 277 | 732 | Zinc finger | RING-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 233_301 | 273 | 708 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 233_301 | 277 | 732 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 419_458 | 273 | 708 | Repeat | Note=WD 1 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 468_508 | 273 | 708 | Repeat | Note=WD 2 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 511_551 | 273 | 708 | Repeat | Note=WD 3 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 553_593 | 273 | 708 | Repeat | Note=WD 4 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 597_635 | 273 | 708 | Repeat | Note=WD 5 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 638_677 | 273 | 708 | Repeat | Note=WD 6 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 691_729 | 273 | 708 | Repeat | Note=WD 7 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 419_458 | 277 | 732 | Repeat | Note=WD 1 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 468_508 | 277 | 732 | Repeat | Note=WD 2 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 511_551 | 277 | 732 | Repeat | Note=WD 3 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 553_593 | 277 | 732 | Repeat | Note=WD 4 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 597_635 | 277 | 732 | Repeat | Note=WD 5 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 638_677 | 277 | 732 | Repeat | Note=WD 6 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 691_729 | 277 | 732 | Repeat | Note=WD 7 |
| Tgene | MSH4 | chr1:176118142 | chr1:76378381 | ENST00000263187 | + | 18 | 20 | 680_687 | 873 | 937 | Nucleotide binding | ATP |
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FusionGeneSequence for RFWD2_MSH4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RFWD2_ENST00000367669_chr1_176118142_-_MSH4_ENST00000263187_chr1_76378381_+_341aa MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKV >In-frame_RFWD2_ENST00000308769_chr1_176118142_-_MSH4_ENST00000263187_chr1_76378381_+_337aa MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RFWD2_ENST00000367669_chr1_176118142_-_MSH4_ENST00000263187_chr1_76378381_+_1023nt ATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCT TTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGC CTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGC TGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGC AACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAA TGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATT GACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCA GTGAGTAGCACCAATGGCCACAGGTGGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTT ATGTTGGAGTTACTAGTGCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTT GCAAGAAGAAATAAGAGAGAGCAAAACCAAAGGAGTACCCCTGAGATGGAAAGACAGAGAGCTGTGTACCATCTAGCCACTAGGCTTGTT CAAACTGCTCGAAACTCTCAATTGGATCCAGACAGTTTACGAATATATTTAAGTAACCTCAAGAAGAAGTACAAAGAAGATTTTCCCAGG >In-frame_RFWD2_ENST00000308769_chr1_176118142_-_MSH4_ENST00000263187_chr1_76378381_+_1011nt ATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCT TTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGC CTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGC TGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGC AACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAA TGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATT GACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCA AATGGCCACAGGTGGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTA CTAGTGCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAAT AAGAGAGAGCAAAACCAAAGGAGTACCCCTGAGATGGAAAGACAGAGAGCTGTGTACCATCTAGCCACTAGGCTTGTTCAAACTGCTCGA AACTCTCAATTGGATCCAGACAGTTTACGAATATATTTAAGTAACCTCAAGAAGAAGTACAAAGAAGATTTTCCCAGGACTGAACAAGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RFWD2_ENST00000367669_chr1_176118142_-_MSH4_ENST00000263187_chr1_76378381_+_1889nt CACCTATACCATTCATTCCAGTCTCCTCAATTCTTTCACTGTATTAAGACGGCCTGCCCTCTGGCACGTTTTCTGGAACGAAAGCGGCTT GGGACAGACAGACTCCCTTCGCCAGGGAGCCCCGACCCCGAGGGCGCGCCCTGAGCGTCTGAGCGCAGCCCCGCTGCGTCCCCAGTTGTA TCCCCCGCCACGCCCGCCTCTTCCGCCGCTCGCGCGCGCGCGCACGGCCGGCCACGGCGCGCCGGGGTTGGCTGCTACAGGGACCGCGGT GGCGGCGGCGGCCTCGACAGCGGTAGTGCCTTCTACTCCGCTTTTTTAGTTTCCTCCGCCCCCTCCCGTGGGACGCTGTTGTGTGGCTGC CTTAAAAAAAAACGCAACTTTATTGTTCCTCAGCCCCACCTCCGGCTCGGCGGGCGTCCTCAGGATGCACTGAGGCTGAGGGGAGGGGAG GCGGCGGAGGGTCGAGGTCGCGGTCCCTCTCCTCCGAGCGCCCGGCTGGAGGGGAGGGAGTCACGATGTCTGGTAGCCGCCAGGCCGGGT CGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCTTTATCCTCTTCCCCGTCGCCGCCTT CCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGCCTCGGGGGCCCGGTGCGGCCTGTGT TGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGCTGCGCGGCCAGGCCCAGCGCCGGCG TAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGCAACGGGCTCATCAACTCCTACGAGG ACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAATGTGGCCACAGCTTTTGCTACAAGT GTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATTGACCATCTGTATCCTAATTTCTTGG TGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCAGTGAGTAGCACCAATGGCCACAGGT GGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTACTAGTGCAGAAGA AGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAATAAGAGAGAGCAAA ACCAAAGGAGTACCCCTGAGATGGAAAGACAGAGAGCTGTGTACCATCTAGCCACTAGGCTTGTTCAAACTGCTCGAAACTCTCAATTGG ATCCAGACAGTTTACGAATATATTTAAGTAACCTCAAGAAGAAGTACAAAGAAGATTTTCCCAGGACTGAACAAGTTCCAGAAAAGACTG AAGAATAATCACAATTCTAATGTAATAATATATCTTAATTCAAGGAACCTAGAATTTATTTTTCTCCTTAGAGATAAGGAAAATAACATT TGCCAAATTTCATATTTTAATTGAAAATTACATTATATTAACATCACAATTGTCATCTATATATTCTATATGAAAAATATTTATTATAAC TTAACAAATGAGAACTACTTAAAGGAATGGTTTTTATGTTAGGAGAAAATACAATACACCACTTTTTTCTCACAAAAATTCACATTATTA >In-frame_RFWD2_ENST00000308769_chr1_176118142_-_MSH4_ENST00000263187_chr1_76378381_+_1362nt ATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCT TTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGC CTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGC TGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGC AACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAA TGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATT GACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCA AATGGCCACAGGTGGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTA CTAGTGCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAAT AAGAGAGAGCAAAACCAAAGGAGTACCCCTGAGATGGAAAGACAGAGAGCTGTGTACCATCTAGCCACTAGGCTTGTTCAAACTGCTCGA AACTCTCAATTGGATCCAGACAGTTTACGAATATATTTAAGTAACCTCAAGAAGAAGTACAAAGAAGATTTTCCCAGGACTGAACAAGTT CCAGAAAAGACTGAAGAATAATCACAATTCTAATGTAATAATATATCTTAATTCAAGGAACCTAGAATTTATTTTTCTCCTTAGAGATAA GGAAAATAACATTTGCCAAATTTCATATTTTAATTGAAAATTACATTATATTAACATCACAATTGTCATCTATATATTCTATATGAAAAA TATTTATTATAACTTAACAAATGAGAACTACTTAAAGGAATGGTTTTTATGTTAGGAGAAAATACAATACACCACTTTTTTCTCACAAAA ATTCACATTATTAAGACCTAAGTTCATTTATACTTACAAGTTATAGTTTAAAATATTATTGTAAATACCCTAGTTTAATAAACACCTTTC |
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FusionGenePPI for RFWD2_MSH4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RFWD2 | DET1, DDB1, CUL4A, RBX1, JUN, RFWD2, JUND, FOXO1, CRTC2, TP53, HSPA8, HSPA6, HSPA2, CCT3, TCP1, CCT6A, CCT5, CCT8, CCT7, CCT4, CCT2, CUL4B, WDR5, COPS2, COPS8, ETV5, ETV1, ETV4, MDM2, MDM4, RCHY1, YWHAZ, YWHAB, TRIB3, ELAVL1, MVP, CUL3, LRR1, DDA1, COPS3, COPS4, COPS5, COPS6, COPS7A, COPS7B, CUL1, SKP1, CUL2, TCEB2, BTBD2, KLHL42, DDB2, ERCC8, VPRBP, DCAF11, UBE2D2, PTPN11, REG1A, RB1CC1, SFN, UBE2D1, PTPN1, PARP4, TRIB1, JUNB, ETS2, ETS1, TRIB2, ZNF397, DMC1, FOSL2, FOS, STK40, CDKN1B, ATF6, STAT3, SEPSECS, SPOP, FAM120B, PPP2R2D, AGGF1, TAX1BP1, JPH1, TSKS, NFIL3, PPP2CA, CEP164, KHDRBS2, TINAG, CCT6B, ZNF263, PNPLA2, TRIM25 | MSH4 | VBP1, MSH5, MLH1, MLH3, RAD51, RPA1, GPS2, VCP, VHL, EIF3F |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000308769 | - | 6 | 19 | 643_645 | 273 | 708 | TRIB1 |
| Hgene | RFWD2 | chr1:176118142 | chr1:76378381 | ENST00000367669 | - | 6 | 20 | 643_645 | 277 | 732 | TRIB1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RFWD2_MSH4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RFWD2_MSH4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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