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Fusion gene ID: 31044 |
FusionGeneSummary for RFWD2_KIF14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RFWD2_KIF14 | Fusion gene ID: 31044 | Hgene | Tgene | Gene symbol | RFWD2 | KIF14 | Gene ID | 9928 |
| Gene name | kinesin family member 14 | ||
| Synonyms | MCPH20|MKS12 | ||
| Cytomap | 1q32.1 | ||
| Type of gene | protein-coding | ||
| Description | kinesin-like protein KIF14 | ||
| Modification date | 20180523 | ||
| UniProtAcc | Q15058 | ||
| Ensembl transtripts involved in fusion gene | ENST00000367669, ENST00000308769, | ENST00000367350, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 2 X 2 X 2=8 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RFWD2 [Title/Abstract] AND KIF14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KIF14 | GO:0008284 | positive regulation of cell proliferation | 24784001 |
| Tgene | KIF14 | GO:0034446 | substrate adhesion-dependent cell spreading | 23209302 |
| Tgene | KIF14 | GO:0045184 | establishment of protein localization | 23209302 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A203-01A | RFWD2 | chr1 | 176118142 | - | KIF14 | chr1 | 200578056 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000367669 | ENST00000367350 | RFWD2 | chr1 | 176118142 | - | KIF14 | chr1 | 200578056 | - |
| In-frame | ENST00000308769 | ENST00000367350 | RFWD2 | chr1 | 176118142 | - | KIF14 | chr1 | 200578056 | - |
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FusionProtFeatures for RFWD2_KIF14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RFWD2 | KIF14 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Microtubule motor protein that binds to microtubuleswith high affinity through each tubulin heterodimer and has anATPase activity (By similarity). Plays a role in many processeslike cell division, cytokinesis and also in cell proliferation andapoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis,targets to central spindle and midbody through its interactionwith PRC1 and CIT respectively (PubMed:16431929). Regulates cellgrowth through regulation of cell cycle progression andcytokinesis (PubMed:24854087). During cell cycle progression actsthrough SCF-dependent proteasomal ubiquitin-dependent proteincatabolic process which controls CDKN1B degradation, resulting inpositive regulation of cyclins, including CCNE1, CCND1 and CCNB1(PubMed:24854087). During late neurogenesis, regulates thecerebellar, cerebral cortex and olfactory bulb development throughregulation of apoptosis, cell proliferation and cell division (Bysimilarity). Also is required for chromosome congression andalignment during mitotic cell cycle process (PubMed:15843429).Regulates cell spreading, focal adhesion dynamics, and cellmigration through its interaction with RADIL resulting inregulation of RAP1A-mediated inside-out integrin activation bytethering RADIL on microtubules (PubMed:23209302).{ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429,ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480,ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001,ECO:0000269|PubMed:24854087}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 2_110 | 273 | 708 | Compositional bias | Note=Ser-rich |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 2_110 | 277 | 732 | Compositional bias | Note=Ser-rich |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 109_113 | 273 | 708 | Motif | Note=Nuclear localization signal 1 |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 195_206 | 273 | 708 | Motif | Note=Nuclear localization signal 2 |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 235_245 | 273 | 708 | Motif | Nuclear export signal |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 109_113 | 277 | 732 | Motif | Note=Nuclear localization signal 1 |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 195_206 | 277 | 732 | Motif | Note=Nuclear localization signal 2 |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 235_245 | 277 | 732 | Motif | Nuclear export signal |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 136_174 | 273 | 708 | Zinc finger | RING-type |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 136_174 | 277 | 732 | Zinc finger | RING-type |
| Tgene | >KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 1332_1348 | 485 | 1649 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 1468_1500 | 485 | 1649 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 705_791 | 485 | 1649 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 922_1079 | 485 | 1649 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 825_891 | 485 | 1649 | Domain | Note=FHA |
| Tgene | >KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 901_1648 | 485 | 1649 | Region | Note=Required for CIT-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 233_301 | 273 | 708 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 233_301 | 277 | 732 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 419_458 | 273 | 708 | Repeat | Note=WD 1 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 468_508 | 273 | 708 | Repeat | Note=WD 2 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 511_551 | 273 | 708 | Repeat | Note=WD 3 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 553_593 | 273 | 708 | Repeat | Note=WD 4 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 597_635 | 273 | 708 | Repeat | Note=WD 5 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 638_677 | 273 | 708 | Repeat | Note=WD 6 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 691_729 | 273 | 708 | Repeat | Note=WD 7 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 419_458 | 277 | 732 | Repeat | Note=WD 1 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 468_508 | 277 | 732 | Repeat | Note=WD 2 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 511_551 | 277 | 732 | Repeat | Note=WD 3 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 553_593 | 277 | 732 | Repeat | Note=WD 4 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 597_635 | 277 | 732 | Repeat | Note=WD 5 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 638_677 | 277 | 732 | Repeat | Note=WD 6 |
| Hgene | >RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 691_729 | 277 | 732 | Repeat | Note=WD 7 |
| Tgene | KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 358_701 | 485 | 1649 | Domain | Kinesin motor |
| Tgene | KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 447_454 | 485 | 1649 | Nucleotide binding | ATP |
| Tgene | KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 1_356 | 485 | 1649 | Region | Note=Required for PRC1-binding |
| Tgene | KIF14 | chr1:176118142 | chr1:200578056 | ENST00000367350 | - | 3 | 30 | 356_737 | 485 | 1649 | Region | Required for microtubule-binding with high affinity |
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FusionGeneSequence for RFWD2_KIF14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RFWD2_ENST00000367669_chr1_176118142_-_KIF14_ENST00000367350_chr1_200578056_-_1441aa MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKV ARRNKREVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSS RSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVL TWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEI TSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDI QLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAK NELLMAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHL EQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYY VFGRHDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRR ISGCLHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQ DEESQDNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIV QQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLE NIFAESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGS YESRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKEEHQQSKSSGIDGSKNKGVPKRVYELHGSSPAVSSEECTPSRIQWV >In-frame_RFWD2_ENST00000308769_chr1_176118142_-_KIF14_ENST00000367350_chr1_200578056_-_1437aa MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRN KREVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHS VFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLL KESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLR MKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSG VLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELL MAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEI YVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGR HDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGC LHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES QDNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAV KYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFA ESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RFWD2_ENST00000367669_chr1_176118142_-_KIF14_ENST00000367350_chr1_200578056_-_4323nt ATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCT TTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGC CTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGC TGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGC AACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAA TGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATT GACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCA GTGAGTAGCACCAATGGCCACAGGTGGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTT ATGTTGGAGTTACTAGTGCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTT GCAAGAAGAAATAAGAGAGAGGTCAGCTATCACATTGAAATGAGCTTCTTTGAAGTATATAATGAAAAAATTCACGACCTTCTGGTTTGT AAAGATGAAAATGGGCAGAGAAAGCAACCACTGAGAGTGAGGGAACATCCTGTTTATGGACCATATGTTGAAGCACTGTCAATGAACATT GTCAGTTCTTACGCTGATATCCAGAGTTGGCTAGAATTGGGAAATAAACAAAGAGCTACTGCTGCTACTGGTATGAATGATAAAAGTTCC CGATCTCATTCAGTTTTCACCCTGGTGATGACCCAGACCAAGACAGAATTTGTGGAAGGGGAAGAACACGATCACAGAATAACAAGTCGA ATTAACCTAATAGATCTGGCAGGCAGTGAGCGCTGCTCTACGGCTCACACTAATGGAGATCGACTAAAGGAAGGTGTGAGTATTAATAAG TCCTTGCTAACTTTGGGAAAAGTTATATCTGCACTTTCGGAACAAGCAAACCAAAGGAGTGTTTTTATTCCTTATCGTGAATCTGTTCTT ACATGGCTGTTAAAAGAAAGTCTGGGTGGAAATTCAAAAACTGCAATGATTGCTACGATTAGTCCCGCTGCCAGCAACATAGAAGAAACA TTAAGCACACTTAGATATGCTAACCAAGCCCGTTTAATAGTCAACATTGCTAAAGTAAATGAAGATATGAACGCTAAGTTAATTAGAGAA TTGAAGGCAGAAATTGCAAAGCTAAAAGCTGCTCAGAGAAACAGTCGGAATATTGACCCTGAACGATACAGGCTCTGTCGGCAAGAAATA ACATCCTTAAGAATGAAACTGCATCAACAGGAGAGAGACATGGCAGAAATGCAAAGAGTGTGGAAAGAAAAGTTTGAACAAGCTGAAAAA AGAAAACTTCAAGAAACAAAAGAGTTACAGAAAGCAGGAATTATGTTTCAAATGGACAATCATTTACCAAACCTTGTTAATCTGAATGAA GATCCACAACTATCTGAGATGCTGCTATATATGATAAAAGAAGGAACAACTACAGTTGGAAAGTATAAACCAAACTCAAGCCATGATATT CAGTTATCTGGGGTGCTGATTGCTGATGATCATTGTACTATCAAAAATTTTGGTGGGACAGTGAGTATTATCCCAGTTGGGGAAGCAAAG ACATATGTAAATGGAAAACATATTTTGGAAATCACAGTATTACGTCATGGTGATCGAGTGATTCTTGGTGGAGATCATTATTTTAGATTT AATCATCCAGTAGAAGTCCAGAAAGGAAAAAGGCCATCTGGAAGAGATACTCCTATAAGTGAGGGTCCAAAAGACTTTGAATTTGCAAAA AATGAGTTGCTCATGGCACAGAGATCACAACTTGAAGCAGAAATAAAAGAGGCTCAGTTGAAGGCAAAGGAAGAAATGATGCAAGGAATC CAGATTGCAAAAGAAATGGCTCAGCAAGAGCTTTCTTCTCAAAAAGCTGCATATGAAAGCAAAATAAAAGCACTGGAAGCAGAACTGAGA GAAGAGTCTCAAAGGAAAAAAATGCAGGAAATAAATAACCAGAAGGCTAATCACAAAATTGAGGAATTAGAAAAGGCAAAGCAGCATCTT GAACAGGAAATATATGTCAACAAAAAGCGATTAGAAATGGAAACATTGGCTACAAAACAGGCTTTAGAAGACCATAGCATCCGCCATGCA AGAATTCTGGAAGCTTTAGAAACTGAAAAGCAAAAAATTGCTAAAGAAGTACAAATTCTACAGCAGAATCGGAATAATAGGGATAAAACT TTTACAGTGCAGACAACTTGGAGCTCTATGAAACTCTCAATGATGATTCAGGAAGCCAATGCTATCAGCAGCAAATTGAAAACATACTAT GTTTTTGGCAGACATGATATATCAGATAAAAGTAGTTCTGACACTTCTATTCGGGTTCGTAACCTGAAACTAGGAATCTCAACATTCTGG AGTCTGGAAAAGTTTGAATCTAAACTTGCAGCAATGAAAGAACTTTATGAGAGTAATGGTAGTAACAGGGGTGAAGATGCCTTTTGTGAT CCTGAAGATGAATGGGAACCCGACATTACAGATGCACCAGTTTCTTCACTTTCTAGAAGGAGGAGTAGGAGTTTGATGAAGAACAGAAGA ATTTCTGGTTGTTTACATGACATACAAGTCCATCCAATTAAGAATTTGCATTCTTCACATTCATCAGGTTTAATGGACAAATCAAGCACT ATTTACTCAAATTCAGCAGAGTCCTTTCTTCCTGGAATTTGCAAAGAATTGATTGGTTCTTCGTTAGATTTTTTTGGACAGAGTTATGAT GAAGAAAGAACTATAGCAGACAGCCTAATTAATAGTTTTCTTAAAATTTATAATGGGCTATTTGCCATTTCCAAGGCTCATGAAGAACAA GATGAAGAAAGTCAAGATAACTTGTTTTCTTCTGATCGAGCAATCCAGTCACTTACTATTCAGACTGCATGTGCTTTTGAGCAGCTAGTA GTGCTAATGAAACACTGGCTGAGTGATTTACTGCCTTGTACCAACATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTTAAAAAACTG GGAGGCTACTTACAGTTATTTTTGCAGGGATGCTGTTTGGATATTTCATCAATGATAAAAGAGGCTCAAAAGAATGCAATCCAAATTGTA CAACAAGCTGTAAAGTATGTGGGGCAGTTAGCAGTTCTGAAAGGGAGCAAGCTACATTTTCTAGAAAACGGTAACAATAAAGCTGCCAGT GTCCAGGAGGAATTCATGGATGCTGTTTGTGATGGTGTAGGCTTAGGAATGAAGATTTTATTAGATTCTGGACTGGAAAAAGCAAAAGAA CTTCAGCATGAACTCTTTAGGCAGTGTACAAAAAATGAGGTTACCAAAGAAATGAAAACTAATGCCATGGGATTGATTAGATCTCTTGAA AACATCTTTGCTGAATCGAAAATTAAAAGTTTCAGAAGGCAAGTACAAGAAGAAAACTTTGAATACCAAGATTTCAAGAGGATGGTTAAT CGTGCTCCAGAATTCTTAAAGTTAAAACATTGCTTAGAGAAAGCTATTGAAATTATTATTTCTGCACTGAAAGGATGCCATAGTGATATA AATCTTCTCCAGACTTGTGTTGAAAGTATTCGCAACTTGGCCAGTGATTTTTACAGTGACTTCAGTGTGCCTTCTACTTCTGTTGGCAGC TATGAGAGTAGAGTAACTCACATTGTCCACCAGGAACTAGAATCTCTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAAGAAAGCCCT GATTTGTTGAAACCCTGGGAAACTTATAATCAAAATACCAAAGAAGAACACCAACAATCTAAATCAAGCGGGATTGACGGCAGTAAGAAT AAAGGTGTACCAAAGCGTGTCTATGAGCTCCATGGCTCATCCCCAGCAGTGAGCTCAGAGGAATGCACACCCAGTAGGATTCAGTGGGTG >In-frame_RFWD2_ENST00000308769_chr1_176118142_-_KIF14_ENST00000367350_chr1_200578056_-_4311nt ATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCT TTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGC CTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGC TGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGC AACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAA TGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATT GACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCA AATGGCCACAGGTGGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTA CTAGTGCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAAT AAGAGAGAGGTCAGCTATCACATTGAAATGAGCTTCTTTGAAGTATATAATGAAAAAATTCACGACCTTCTGGTTTGTAAAGATGAAAAT GGGCAGAGAAAGCAACCACTGAGAGTGAGGGAACATCCTGTTTATGGACCATATGTTGAAGCACTGTCAATGAACATTGTCAGTTCTTAC GCTGATATCCAGAGTTGGCTAGAATTGGGAAATAAACAAAGAGCTACTGCTGCTACTGGTATGAATGATAAAAGTTCCCGATCTCATTCA GTTTTCACCCTGGTGATGACCCAGACCAAGACAGAATTTGTGGAAGGGGAAGAACACGATCACAGAATAACAAGTCGAATTAACCTAATA GATCTGGCAGGCAGTGAGCGCTGCTCTACGGCTCACACTAATGGAGATCGACTAAAGGAAGGTGTGAGTATTAATAAGTCCTTGCTAACT TTGGGAAAAGTTATATCTGCACTTTCGGAACAAGCAAACCAAAGGAGTGTTTTTATTCCTTATCGTGAATCTGTTCTTACATGGCTGTTA AAAGAAAGTCTGGGTGGAAATTCAAAAACTGCAATGATTGCTACGATTAGTCCCGCTGCCAGCAACATAGAAGAAACATTAAGCACACTT AGATATGCTAACCAAGCCCGTTTAATAGTCAACATTGCTAAAGTAAATGAAGATATGAACGCTAAGTTAATTAGAGAATTGAAGGCAGAA ATTGCAAAGCTAAAAGCTGCTCAGAGAAACAGTCGGAATATTGACCCTGAACGATACAGGCTCTGTCGGCAAGAAATAACATCCTTAAGA ATGAAACTGCATCAACAGGAGAGAGACATGGCAGAAATGCAAAGAGTGTGGAAAGAAAAGTTTGAACAAGCTGAAAAAAGAAAACTTCAA GAAACAAAAGAGTTACAGAAAGCAGGAATTATGTTTCAAATGGACAATCATTTACCAAACCTTGTTAATCTGAATGAAGATCCACAACTA TCTGAGATGCTGCTATATATGATAAAAGAAGGAACAACTACAGTTGGAAAGTATAAACCAAACTCAAGCCATGATATTCAGTTATCTGGG GTGCTGATTGCTGATGATCATTGTACTATCAAAAATTTTGGTGGGACAGTGAGTATTATCCCAGTTGGGGAAGCAAAGACATATGTAAAT GGAAAACATATTTTGGAAATCACAGTATTACGTCATGGTGATCGAGTGATTCTTGGTGGAGATCATTATTTTAGATTTAATCATCCAGTA GAAGTCCAGAAAGGAAAAAGGCCATCTGGAAGAGATACTCCTATAAGTGAGGGTCCAAAAGACTTTGAATTTGCAAAAAATGAGTTGCTC ATGGCACAGAGATCACAACTTGAAGCAGAAATAAAAGAGGCTCAGTTGAAGGCAAAGGAAGAAATGATGCAAGGAATCCAGATTGCAAAA GAAATGGCTCAGCAAGAGCTTTCTTCTCAAAAAGCTGCATATGAAAGCAAAATAAAAGCACTGGAAGCAGAACTGAGAGAAGAGTCTCAA AGGAAAAAAATGCAGGAAATAAATAACCAGAAGGCTAATCACAAAATTGAGGAATTAGAAAAGGCAAAGCAGCATCTTGAACAGGAAATA TATGTCAACAAAAAGCGATTAGAAATGGAAACATTGGCTACAAAACAGGCTTTAGAAGACCATAGCATCCGCCATGCAAGAATTCTGGAA GCTTTAGAAACTGAAAAGCAAAAAATTGCTAAAGAAGTACAAATTCTACAGCAGAATCGGAATAATAGGGATAAAACTTTTACAGTGCAG ACAACTTGGAGCTCTATGAAACTCTCAATGATGATTCAGGAAGCCAATGCTATCAGCAGCAAATTGAAAACATACTATGTTTTTGGCAGA CATGATATATCAGATAAAAGTAGTTCTGACACTTCTATTCGGGTTCGTAACCTGAAACTAGGAATCTCAACATTCTGGAGTCTGGAAAAG TTTGAATCTAAACTTGCAGCAATGAAAGAACTTTATGAGAGTAATGGTAGTAACAGGGGTGAAGATGCCTTTTGTGATCCTGAAGATGAA TGGGAACCCGACATTACAGATGCACCAGTTTCTTCACTTTCTAGAAGGAGGAGTAGGAGTTTGATGAAGAACAGAAGAATTTCTGGTTGT TTACATGACATACAAGTCCATCCAATTAAGAATTTGCATTCTTCACATTCATCAGGTTTAATGGACAAATCAAGCACTATTTACTCAAAT TCAGCAGAGTCCTTTCTTCCTGGAATTTGCAAAGAATTGATTGGTTCTTCGTTAGATTTTTTTGGACAGAGTTATGATGAAGAAAGAACT ATAGCAGACAGCCTAATTAATAGTTTTCTTAAAATTTATAATGGGCTATTTGCCATTTCCAAGGCTCATGAAGAACAAGATGAAGAAAGT CAAGATAACTTGTTTTCTTCTGATCGAGCAATCCAGTCACTTACTATTCAGACTGCATGTGCTTTTGAGCAGCTAGTAGTGCTAATGAAA CACTGGCTGAGTGATTTACTGCCTTGTACCAACATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTTAAAAAACTGGGAGGCTACTTA CAGTTATTTTTGCAGGGATGCTGTTTGGATATTTCATCAATGATAAAAGAGGCTCAAAAGAATGCAATCCAAATTGTACAACAAGCTGTA AAGTATGTGGGGCAGTTAGCAGTTCTGAAAGGGAGCAAGCTACATTTTCTAGAAAACGGTAACAATAAAGCTGCCAGTGTCCAGGAGGAA TTCATGGATGCTGTTTGTGATGGTGTAGGCTTAGGAATGAAGATTTTATTAGATTCTGGACTGGAAAAAGCAAAAGAACTTCAGCATGAA CTCTTTAGGCAGTGTACAAAAAATGAGGTTACCAAAGAAATGAAAACTAATGCCATGGGATTGATTAGATCTCTTGAAAACATCTTTGCT GAATCGAAAATTAAAAGTTTCAGAAGGCAAGTACAAGAAGAAAACTTTGAATACCAAGATTTCAAGAGGATGGTTAATCGTGCTCCAGAA TTCTTAAAGTTAAAACATTGCTTAGAGAAAGCTATTGAAATTATTATTTCTGCACTGAAAGGATGCCATAGTGATATAAATCTTCTCCAG ACTTGTGTTGAAAGTATTCGCAACTTGGCCAGTGATTTTTACAGTGACTTCAGTGTGCCTTCTACTTCTGTTGGCAGCTATGAGAGTAGA GTAACTCACATTGTCCACCAGGAACTAGAATCTCTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAAGAAAGCCCTGATTTGTTGAAA CCCTGGGAAACTTATAATCAAAATACCAAAGAAGAACACCAACAATCTAAATCAAGCGGGATTGACGGCAGTAAGAATAAAGGTGTACCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RFWD2_ENST00000367669_chr1_176118142_-_KIF14_ENST00000367350_chr1_200578056_-_6726nt CACCTATACCATTCATTCCAGTCTCCTCAATTCTTTCACTGTATTAAGACGGCCTGCCCTCTGGCACGTTTTCTGGAACGAAAGCGGCTT GGGACAGACAGACTCCCTTCGCCAGGGAGCCCCGACCCCGAGGGCGCGCCCTGAGCGTCTGAGCGCAGCCCCGCTGCGTCCCCAGTTGTA TCCCCCGCCACGCCCGCCTCTTCCGCCGCTCGCGCGCGCGCGCACGGCCGGCCACGGCGCGCCGGGGTTGGCTGCTACAGGGACCGCGGT GGCGGCGGCGGCCTCGACAGCGGTAGTGCCTTCTACTCCGCTTTTTTAGTTTCCTCCGCCCCCTCCCGTGGGACGCTGTTGTGTGGCTGC CTTAAAAAAAAACGCAACTTTATTGTTCCTCAGCCCCACCTCCGGCTCGGCGGGCGTCCTCAGGATGCACTGAGGCTGAGGGGAGGGGAG GCGGCGGAGGGTCGAGGTCGCGGTCCCTCTCCTCCGAGCGCCCGGCTGGAGGGGAGGGAGTCACGATGTCTGGTAGCCGCCAGGCCGGGT CGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCTTTATCCTCTTCCCCGTCGCCGCCTT CCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGCCTCGGGGGCCCGGTGCGGCCTGTGT TGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGCTGCGCGGCCAGGCCCAGCGCCGGCG TAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGCAACGGGCTCATCAACTCCTACGAGG ACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAATGTGGCCACAGCTTTTGCTACAAGT GTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATTGACCATCTGTATCCTAATTTCTTGG TGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCAGTGAGTAGCACCAATGGCCACAGGT GGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTACTAGTGCAGAAGA AGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAATAAGAGAGAGGTCA GCTATCACATTGAAATGAGCTTCTTTGAAGTATATAATGAAAAAATTCACGACCTTCTGGTTTGTAAAGATGAAAATGGGCAGAGAAAGC AACCACTGAGAGTGAGGGAACATCCTGTTTATGGACCATATGTTGAAGCACTGTCAATGAACATTGTCAGTTCTTACGCTGATATCCAGA GTTGGCTAGAATTGGGAAATAAACAAAGAGCTACTGCTGCTACTGGTATGAATGATAAAAGTTCCCGATCTCATTCAGTTTTCACCCTGG TGATGACCCAGACCAAGACAGAATTTGTGGAAGGGGAAGAACACGATCACAGAATAACAAGTCGAATTAACCTAATAGATCTGGCAGGCA GTGAGCGCTGCTCTACGGCTCACACTAATGGAGATCGACTAAAGGAAGGTGTGAGTATTAATAAGTCCTTGCTAACTTTGGGAAAAGTTA TATCTGCACTTTCGGAACAAGCAAACCAAAGGAGTGTTTTTATTCCTTATCGTGAATCTGTTCTTACATGGCTGTTAAAAGAAAGTCTGG GTGGAAATTCAAAAACTGCAATGATTGCTACGATTAGTCCCGCTGCCAGCAACATAGAAGAAACATTAAGCACACTTAGATATGCTAACC AAGCCCGTTTAATAGTCAACATTGCTAAAGTAAATGAAGATATGAACGCTAAGTTAATTAGAGAATTGAAGGCAGAAATTGCAAAGCTAA AAGCTGCTCAGAGAAACAGTCGGAATATTGACCCTGAACGATACAGGCTCTGTCGGCAAGAAATAACATCCTTAAGAATGAAACTGCATC AACAGGAGAGAGACATGGCAGAAATGCAAAGAGTGTGGAAAGAAAAGTTTGAACAAGCTGAAAAAAGAAAACTTCAAGAAACAAAAGAGT TACAGAAAGCAGGAATTATGTTTCAAATGGACAATCATTTACCAAACCTTGTTAATCTGAATGAAGATCCACAACTATCTGAGATGCTGC TATATATGATAAAAGAAGGAACAACTACAGTTGGAAAGTATAAACCAAACTCAAGCCATGATATTCAGTTATCTGGGGTGCTGATTGCTG ATGATCATTGTACTATCAAAAATTTTGGTGGGACAGTGAGTATTATCCCAGTTGGGGAAGCAAAGACATATGTAAATGGAAAACATATTT TGGAAATCACAGTATTACGTCATGGTGATCGAGTGATTCTTGGTGGAGATCATTATTTTAGATTTAATCATCCAGTAGAAGTCCAGAAAG GAAAAAGGCCATCTGGAAGAGATACTCCTATAAGTGAGGGTCCAAAAGACTTTGAATTTGCAAAAAATGAGTTGCTCATGGCACAGAGAT CACAACTTGAAGCAGAAATAAAAGAGGCTCAGTTGAAGGCAAAGGAAGAAATGATGCAAGGAATCCAGATTGCAAAAGAAATGGCTCAGC AAGAGCTTTCTTCTCAAAAAGCTGCATATGAAAGCAAAATAAAAGCACTGGAAGCAGAACTGAGAGAAGAGTCTCAAAGGAAAAAAATGC AGGAAATAAATAACCAGAAGGCTAATCACAAAATTGAGGAATTAGAAAAGGCAAAGCAGCATCTTGAACAGGAAATATATGTCAACAAAA AGCGATTAGAAATGGAAACATTGGCTACAAAACAGGCTTTAGAAGACCATAGCATCCGCCATGCAAGAATTCTGGAAGCTTTAGAAACTG AAAAGCAAAAAATTGCTAAAGAAGTACAAATTCTACAGCAGAATCGGAATAATAGGGATAAAACTTTTACAGTGCAGACAACTTGGAGCT CTATGAAACTCTCAATGATGATTCAGGAAGCCAATGCTATCAGCAGCAAATTGAAAACATACTATGTTTTTGGCAGACATGATATATCAG ATAAAAGTAGTTCTGACACTTCTATTCGGGTTCGTAACCTGAAACTAGGAATCTCAACATTCTGGAGTCTGGAAAAGTTTGAATCTAAAC TTGCAGCAATGAAAGAACTTTATGAGAGTAATGGTAGTAACAGGGGTGAAGATGCCTTTTGTGATCCTGAAGATGAATGGGAACCCGACA TTACAGATGCACCAGTTTCTTCACTTTCTAGAAGGAGGAGTAGGAGTTTGATGAAGAACAGAAGAATTTCTGGTTGTTTACATGACATAC AAGTCCATCCAATTAAGAATTTGCATTCTTCACATTCATCAGGTTTAATGGACAAATCAAGCACTATTTACTCAAATTCAGCAGAGTCCT TTCTTCCTGGAATTTGCAAAGAATTGATTGGTTCTTCGTTAGATTTTTTTGGACAGAGTTATGATGAAGAAAGAACTATAGCAGACAGCC TAATTAATAGTTTTCTTAAAATTTATAATGGGCTATTTGCCATTTCCAAGGCTCATGAAGAACAAGATGAAGAAAGTCAAGATAACTTGT TTTCTTCTGATCGAGCAATCCAGTCACTTACTATTCAGACTGCATGTGCTTTTGAGCAGCTAGTAGTGCTAATGAAACACTGGCTGAGTG ATTTACTGCCTTGTACCAACATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTTAAAAAACTGGGAGGCTACTTACAGTTATTTTTGC AGGGATGCTGTTTGGATATTTCATCAATGATAAAAGAGGCTCAAAAGAATGCAATCCAAATTGTACAACAAGCTGTAAAGTATGTGGGGC AGTTAGCAGTTCTGAAAGGGAGCAAGCTACATTTTCTAGAAAACGGTAACAATAAAGCTGCCAGTGTCCAGGAGGAATTCATGGATGCTG TTTGTGATGGTGTAGGCTTAGGAATGAAGATTTTATTAGATTCTGGACTGGAAAAAGCAAAAGAACTTCAGCATGAACTCTTTAGGCAGT GTACAAAAAATGAGGTTACCAAAGAAATGAAAACTAATGCCATGGGATTGATTAGATCTCTTGAAAACATCTTTGCTGAATCGAAAATTA AAAGTTTCAGAAGGCAAGTACAAGAAGAAAACTTTGAATACCAAGATTTCAAGAGGATGGTTAATCGTGCTCCAGAATTCTTAAAGTTAA AACATTGCTTAGAGAAAGCTATTGAAATTATTATTTCTGCACTGAAAGGATGCCATAGTGATATAAATCTTCTCCAGACTTGTGTTGAAA GTATTCGCAACTTGGCCAGTGATTTTTACAGTGACTTCAGTGTGCCTTCTACTTCTGTTGGCAGCTATGAGAGTAGAGTAACTCACATTG TCCACCAGGAACTAGAATCTCTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAAGAAAGCCCTGATTTGTTGAAACCCTGGGAAACTT ATAATCAAAATACCAAAGAAGAACACCAACAATCTAAATCAAGCGGGATTGACGGCAGTAAGAATAAAGGTGTACCAAAGCGTGTCTATG AGCTCCATGGCTCATCCCCAGCAGTGAGCTCAGAGGAATGCACACCCAGTAGGATTCAGTGGGTGTGAATACTGATGTGTAGGCACTTTT ATGACCACCCATGAAAGAAAAAGAACACTTGCTCGGTAATTTTCTTTATGCAGGAGAGTTTAAGAGAAATCAGCACAGATATTTCAAAAA AGTCCATGTCTTTTTATCTTTAAAATATCTATTTATCAAAGGCCAGACACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGG CAGATCACAAGGTCAGGAGTTTGAGACCGGCCTGGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTTGCTGGGCATGGT GGCGCGTGCCTGTAATCCCAGCTACTAGGGGGGCTGAGGCAGGAGGATCGCTTGAACCTGAGAGGCAGAGGTTGCAGTGAGCCAAGATCA TGCCACTTTACTCCAGTCTGAGCAACAGAACGAGACTTAGTCAAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAA ATATATTTTTATCTTTAAAGTGTTTAACATTGGTATACTGTCTGTAGTTGGTTCATTAGTCGTTTATAAAGGGTTATTTTCTCATGAGTG GAAACCTGAACAATCAGTTACCTTTGTGCCTATGCCTTCTCTCTCCTCAGACAGCTGGGATGTTTATGGTGAAATGGCCTGTACAAGTTT AACTAAGACAACTTAACTTGCATTGTTAATCAAAAATTCTTTTCTCAAAGGGTTAACTGGTTGCCATTTTGAATAGTATGTTCAAGGGTG TAGCTTCCTGTTTCTTTCCAAATTATAAGTAGCTACCTAAATATAGTATAATTATATATTAATAATATGGCTTGCTGGCACAGTAGTTTA CCCTGTTATCTGTGTTTCATAATGGGGGCTGTATGAATATTATTTAAAACTAATAAAATGTTGCCAGAATTATACTAAACTGTTGGATGA GATTAGGAGATCAGAGGCTGGACCTTCTCTTGATAATGCTTGTTTTGTTAAAGGTATAATGAAATAATTTGTATATGATTTGATGAAGAT TAAAGACCCTTATTTTCCACAGCTTTAAAAAAAAACCTTTATTTATGATCAAGTAATAAAGATAATATTCTACTTGTGGGATCTTACATT ACGGAAATAGTTTGACGTTTTTGACCTCAAGAGTATGTATAATTTGAAGAGATACTTTGTAACTATGCTTGGGTGATATTGAGCAGTTCC TAAAGAATAATTCATTTAAAAAAAAAGAAGAAAAAAAAAGAAGAATTCATTTAAATAACCTGATCCTTTCATTTGCCCTTTTCGAATTTA CAGATACTACTTGTACATTTGGCATAACTAGTTGAAATTGGCCATTCGTACCATGAATAAATCTGATAGTTTCCTTGTTAGGAAGAGATT GTAAGTAAATACAGTCATTGCAGTCAGAACAGTATTAGTGAACCTTGTGTGGTGTTTTCAAGCTCTTTAAAATGGTACAATGTAGCACAT TTGCTTTCATTTCTTTTTTTATTTTTGGCATTTGACCTTGTATTCTTTCTGAAGCTCTATATGTGTTTTTATTAGTCAATAATCTGGCAA GTAGCACTTTGCCTGTGCAGTTTGCTGGAGTGTAGATGTACATATGAGGATTTCCCGGGAGGTGCACTTCTTTGAAGAACTTCCTAAAGT ACCTGTATAGTAGTTTTCATCTTAATATTCAGTATTTAATCTTCAGTTTGTGCTTTGTAAACTCATGACTTAATTGGTCAGAAACTTTTT AGTGTCTTTATAAAATTTTGTATACATATTTATACTAAACACATTGTGATACTGTATTTGAATGAATGGTGAAAAAATATTTGCTATTGG >In-frame_RFWD2_ENST00000308769_chr1_176118142_-_KIF14_ENST00000367350_chr1_200578056_-_6199nt ATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCT TTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGC CTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGC TGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGC AACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAA TGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATT GACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCA AATGGCCACAGGTGGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTA CTAGTGCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAAT AAGAGAGAGGTCAGCTATCACATTGAAATGAGCTTCTTTGAAGTATATAATGAAAAAATTCACGACCTTCTGGTTTGTAAAGATGAAAAT GGGCAGAGAAAGCAACCACTGAGAGTGAGGGAACATCCTGTTTATGGACCATATGTTGAAGCACTGTCAATGAACATTGTCAGTTCTTAC GCTGATATCCAGAGTTGGCTAGAATTGGGAAATAAACAAAGAGCTACTGCTGCTACTGGTATGAATGATAAAAGTTCCCGATCTCATTCA GTTTTCACCCTGGTGATGACCCAGACCAAGACAGAATTTGTGGAAGGGGAAGAACACGATCACAGAATAACAAGTCGAATTAACCTAATA GATCTGGCAGGCAGTGAGCGCTGCTCTACGGCTCACACTAATGGAGATCGACTAAAGGAAGGTGTGAGTATTAATAAGTCCTTGCTAACT TTGGGAAAAGTTATATCTGCACTTTCGGAACAAGCAAACCAAAGGAGTGTTTTTATTCCTTATCGTGAATCTGTTCTTACATGGCTGTTA AAAGAAAGTCTGGGTGGAAATTCAAAAACTGCAATGATTGCTACGATTAGTCCCGCTGCCAGCAACATAGAAGAAACATTAAGCACACTT AGATATGCTAACCAAGCCCGTTTAATAGTCAACATTGCTAAAGTAAATGAAGATATGAACGCTAAGTTAATTAGAGAATTGAAGGCAGAA ATTGCAAAGCTAAAAGCTGCTCAGAGAAACAGTCGGAATATTGACCCTGAACGATACAGGCTCTGTCGGCAAGAAATAACATCCTTAAGA ATGAAACTGCATCAACAGGAGAGAGACATGGCAGAAATGCAAAGAGTGTGGAAAGAAAAGTTTGAACAAGCTGAAAAAAGAAAACTTCAA GAAACAAAAGAGTTACAGAAAGCAGGAATTATGTTTCAAATGGACAATCATTTACCAAACCTTGTTAATCTGAATGAAGATCCACAACTA TCTGAGATGCTGCTATATATGATAAAAGAAGGAACAACTACAGTTGGAAAGTATAAACCAAACTCAAGCCATGATATTCAGTTATCTGGG GTGCTGATTGCTGATGATCATTGTACTATCAAAAATTTTGGTGGGACAGTGAGTATTATCCCAGTTGGGGAAGCAAAGACATATGTAAAT GGAAAACATATTTTGGAAATCACAGTATTACGTCATGGTGATCGAGTGATTCTTGGTGGAGATCATTATTTTAGATTTAATCATCCAGTA GAAGTCCAGAAAGGAAAAAGGCCATCTGGAAGAGATACTCCTATAAGTGAGGGTCCAAAAGACTTTGAATTTGCAAAAAATGAGTTGCTC ATGGCACAGAGATCACAACTTGAAGCAGAAATAAAAGAGGCTCAGTTGAAGGCAAAGGAAGAAATGATGCAAGGAATCCAGATTGCAAAA GAAATGGCTCAGCAAGAGCTTTCTTCTCAAAAAGCTGCATATGAAAGCAAAATAAAAGCACTGGAAGCAGAACTGAGAGAAGAGTCTCAA AGGAAAAAAATGCAGGAAATAAATAACCAGAAGGCTAATCACAAAATTGAGGAATTAGAAAAGGCAAAGCAGCATCTTGAACAGGAAATA TATGTCAACAAAAAGCGATTAGAAATGGAAACATTGGCTACAAAACAGGCTTTAGAAGACCATAGCATCCGCCATGCAAGAATTCTGGAA GCTTTAGAAACTGAAAAGCAAAAAATTGCTAAAGAAGTACAAATTCTACAGCAGAATCGGAATAATAGGGATAAAACTTTTACAGTGCAG ACAACTTGGAGCTCTATGAAACTCTCAATGATGATTCAGGAAGCCAATGCTATCAGCAGCAAATTGAAAACATACTATGTTTTTGGCAGA CATGATATATCAGATAAAAGTAGTTCTGACACTTCTATTCGGGTTCGTAACCTGAAACTAGGAATCTCAACATTCTGGAGTCTGGAAAAG TTTGAATCTAAACTTGCAGCAATGAAAGAACTTTATGAGAGTAATGGTAGTAACAGGGGTGAAGATGCCTTTTGTGATCCTGAAGATGAA TGGGAACCCGACATTACAGATGCACCAGTTTCTTCACTTTCTAGAAGGAGGAGTAGGAGTTTGATGAAGAACAGAAGAATTTCTGGTTGT TTACATGACATACAAGTCCATCCAATTAAGAATTTGCATTCTTCACATTCATCAGGTTTAATGGACAAATCAAGCACTATTTACTCAAAT TCAGCAGAGTCCTTTCTTCCTGGAATTTGCAAAGAATTGATTGGTTCTTCGTTAGATTTTTTTGGACAGAGTTATGATGAAGAAAGAACT ATAGCAGACAGCCTAATTAATAGTTTTCTTAAAATTTATAATGGGCTATTTGCCATTTCCAAGGCTCATGAAGAACAAGATGAAGAAAGT CAAGATAACTTGTTTTCTTCTGATCGAGCAATCCAGTCACTTACTATTCAGACTGCATGTGCTTTTGAGCAGCTAGTAGTGCTAATGAAA CACTGGCTGAGTGATTTACTGCCTTGTACCAACATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTTAAAAAACTGGGAGGCTACTTA CAGTTATTTTTGCAGGGATGCTGTTTGGATATTTCATCAATGATAAAAGAGGCTCAAAAGAATGCAATCCAAATTGTACAACAAGCTGTA AAGTATGTGGGGCAGTTAGCAGTTCTGAAAGGGAGCAAGCTACATTTTCTAGAAAACGGTAACAATAAAGCTGCCAGTGTCCAGGAGGAA TTCATGGATGCTGTTTGTGATGGTGTAGGCTTAGGAATGAAGATTTTATTAGATTCTGGACTGGAAAAAGCAAAAGAACTTCAGCATGAA CTCTTTAGGCAGTGTACAAAAAATGAGGTTACCAAAGAAATGAAAACTAATGCCATGGGATTGATTAGATCTCTTGAAAACATCTTTGCT GAATCGAAAATTAAAAGTTTCAGAAGGCAAGTACAAGAAGAAAACTTTGAATACCAAGATTTCAAGAGGATGGTTAATCGTGCTCCAGAA TTCTTAAAGTTAAAACATTGCTTAGAGAAAGCTATTGAAATTATTATTTCTGCACTGAAAGGATGCCATAGTGATATAAATCTTCTCCAG ACTTGTGTTGAAAGTATTCGCAACTTGGCCAGTGATTTTTACAGTGACTTCAGTGTGCCTTCTACTTCTGTTGGCAGCTATGAGAGTAGA GTAACTCACATTGTCCACCAGGAACTAGAATCTCTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAAGAAAGCCCTGATTTGTTGAAA CCCTGGGAAACTTATAATCAAAATACCAAAGAAGAACACCAACAATCTAAATCAAGCGGGATTGACGGCAGTAAGAATAAAGGTGTACCA AAGCGTGTCTATGAGCTCCATGGCTCATCCCCAGCAGTGAGCTCAGAGGAATGCACACCCAGTAGGATTCAGTGGGTGTGAATACTGATG TGTAGGCACTTTTATGACCACCCATGAAAGAAAAAGAACACTTGCTCGGTAATTTTCTTTATGCAGGAGAGTTTAAGAGAAATCAGCACA GATATTTCAAAAAAGTCCATGTCTTTTTATCTTTAAAATATCTATTTATCAAAGGCCAGACACAGTGGCTCACGCCTGTAATCCCAGCAC TTTGGGAGGCGGGCAGATCACAAGGTCAGGAGTTTGAGACCGGCCTGGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATT TGCTGGGCATGGTGGCGCGTGCCTGTAATCCCAGCTACTAGGGGGGCTGAGGCAGGAGGATCGCTTGAACCTGAGAGGCAGAGGTTGCAG TGAGCCAAGATCATGCCACTTTACTCCAGTCTGAGCAACAGAACGAGACTTAGTCAAAATAAATAAATAAATAAATAAATAAATAAATAA ATAAATAAATAAAATATATTTTTATCTTTAAAGTGTTTAACATTGGTATACTGTCTGTAGTTGGTTCATTAGTCGTTTATAAAGGGTTAT TTTCTCATGAGTGGAAACCTGAACAATCAGTTACCTTTGTGCCTATGCCTTCTCTCTCCTCAGACAGCTGGGATGTTTATGGTGAAATGG CCTGTACAAGTTTAACTAAGACAACTTAACTTGCATTGTTAATCAAAAATTCTTTTCTCAAAGGGTTAACTGGTTGCCATTTTGAATAGT ATGTTCAAGGGTGTAGCTTCCTGTTTCTTTCCAAATTATAAGTAGCTACCTAAATATAGTATAATTATATATTAATAATATGGCTTGCTG GCACAGTAGTTTACCCTGTTATCTGTGTTTCATAATGGGGGCTGTATGAATATTATTTAAAACTAATAAAATGTTGCCAGAATTATACTA AACTGTTGGATGAGATTAGGAGATCAGAGGCTGGACCTTCTCTTGATAATGCTTGTTTTGTTAAAGGTATAATGAAATAATTTGTATATG ATTTGATGAAGATTAAAGACCCTTATTTTCCACAGCTTTAAAAAAAAACCTTTATTTATGATCAAGTAATAAAGATAATATTCTACTTGT GGGATCTTACATTACGGAAATAGTTTGACGTTTTTGACCTCAAGAGTATGTATAATTTGAAGAGATACTTTGTAACTATGCTTGGGTGAT ATTGAGCAGTTCCTAAAGAATAATTCATTTAAAAAAAAAGAAGAAAAAAAAAGAAGAATTCATTTAAATAACCTGATCCTTTCATTTGCC CTTTTCGAATTTACAGATACTACTTGTACATTTGGCATAACTAGTTGAAATTGGCCATTCGTACCATGAATAAATCTGATAGTTTCCTTG TTAGGAAGAGATTGTAAGTAAATACAGTCATTGCAGTCAGAACAGTATTAGTGAACCTTGTGTGGTGTTTTCAAGCTCTTTAAAATGGTA CAATGTAGCACATTTGCTTTCATTTCTTTTTTTATTTTTGGCATTTGACCTTGTATTCTTTCTGAAGCTCTATATGTGTTTTTATTAGTC AATAATCTGGCAAGTAGCACTTTGCCTGTGCAGTTTGCTGGAGTGTAGATGTACATATGAGGATTTCCCGGGAGGTGCACTTCTTTGAAG AACTTCCTAAAGTACCTGTATAGTAGTTTTCATCTTAATATTCAGTATTTAATCTTCAGTTTGTGCTTTGTAAACTCATGACTTAATTGG TCAGAAACTTTTTAGTGTCTTTATAAAATTTTGTATACATATTTATACTAAACACATTGTGATACTGTATTTGAATGAATGGTGAAAAAA |
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FusionGenePPI for RFWD2_KIF14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RFWD2 | DET1, DDB1, CUL4A, RBX1, JUN, RFWD2, JUND, FOXO1, CRTC2, TP53, HSPA8, HSPA6, HSPA2, CCT3, TCP1, CCT6A, CCT5, CCT8, CCT7, CCT4, CCT2, CUL4B, WDR5, COPS2, COPS8, ETV5, ETV1, ETV4, MDM2, MDM4, RCHY1, YWHAZ, YWHAB, TRIB3, ELAVL1, MVP, CUL3, LRR1, DDA1, COPS3, COPS4, COPS5, COPS6, COPS7A, COPS7B, CUL1, SKP1, CUL2, TCEB2, BTBD2, KLHL42, DDB2, ERCC8, VPRBP, DCAF11, UBE2D2, PTPN11, REG1A, RB1CC1, SFN, UBE2D1, PTPN1, PARP4, TRIB1, JUNB, ETS2, ETS1, TRIB2, ZNF397, DMC1, FOSL2, FOS, STK40, CDKN1B, ATF6, STAT3, SEPSECS, SPOP, FAM120B, PPP2R2D, AGGF1, TAX1BP1, JPH1, TSKS, NFIL3, PPP2CA, CEP164, KHDRBS2, TINAG, CCT6B, ZNF263, PNPLA2, TRIM25 | KIF14 | SVIL, SIRT7, TJP2, ZBTB1, OBSL1, SPINT2, EFNB2, SCGN, CD274, VSIG2, CA14, CD68, PNKD, NTRK1, CENPJ, MED4, CLK1, PCM1, CEP104, CEP162, CEP290, CEP120, CEP152, CNTROB, SPICE1, CEP128, CEP135, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, DCTN1, LCA5, RPGRIP1, ATP5I, URB1, TSNAX, CCDC14, TUBA1C, KLC4, HNRNPA1L2, KIAA1279, TMCO1, MCM2, EYA2, TEX28, CCDC89, EPHA1, GORASP2, SIGLECL1, CLMP, FCGRT, TMEM206, TNFRSF1A, PTPRN, TUBGCP2, TUBG1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000308769 | - | 6 | 19 | 643_645 | 273 | 708 | TRIB1 |
| Hgene | RFWD2 | chr1:176118142 | chr1:200578056 | ENST00000367669 | - | 6 | 20 | 643_645 | 277 | 732 | TRIB1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RFWD2_KIF14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RFWD2_KIF14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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